Leveraging cloud-native infrastructure for dynamic and flexible quantum-classical MLOps

In this work, we studied the use of Quantum Machine Learning (QML) algorithms for binary classification and compared their performance with classical Machine Learning (ML) methods. QML merges principles of Quantum Computing (QC) and ML, offering improved efficiency and potential quantum advantage in data-driven tasks and when solving complex problems. In binary classification, where the goal is to assign data to one of two categories, QML uses quantum algorithms to process large datasets efficiently. Quantum algorithms like Quantum Support Vector Machines (QSVM) and Quantum Neural Networks (QNN) exploit quantum parallelism and entanglement to enhance performance over classical methods. This study focuses on two common QML algorithms, Quantum Support Vector Classifier (QSVC) and QNN. We used the Qiskit software and conducted the experiments with three different datasets. Data preprocessing included dimensionality reduction using Principal Component Analysis (PCA) and standardization using scalers. The results showed that quantum algorithms demonstrated competitive performance against their classical counterparts in terms of accuracy, while QSVC performed better than QNN. These findings suggest that QML holds potential for improving computational efficiency in binary classification tasks. This opens the way for more efficient and scalable solutions in complex classification challenges and shows the complementary role of quantum computing.

Quantum Artificial Intelligence (Quantum AI) represents a rapidly developing interdisciplinary field at the intersection of quantum computing and machine learning (ML). It holds the promise of unlocking unprecedented computational capabilities for complex optimization tasks, large-scale data processing, and advanced pattern recognition. In this research, we provide a comprehensive examination of two principal quantum algorithms—the Quantum Approximate Optimization Algorithm (QAOA) and the Variational Quantum Eigensolver (VQE)—applied to classical ML challenges. Using a hybrid simulation framework that integrates TensorFlow, scikit-learn, Qiskit, and Cirq, we extensively benchmark quantum-enhanced approaches against conventional methods on both combinatorial optimization and image classification tasks. Our findings indicate that while noise and qubit limitations remain critical barriers, quantum-enhanced models can achieve competitive, and sometimes superior, performance compared to purely classical solutions. We elaborate on the practical implications of these results, discuss hardware and algorithmic constraints, and propose future research directions focusing on error mitigation, scalability, and quantum-native ML models. These insights pave the way for a new computational paradigm, in which quantum resources are harnessed to address previously intractable ML problems.

Despite the promise for performance and accuracy improvements of quantum inspired (QI) algorithms over classical machine learning (ML) algorithms, such gains have not been realized in practice. The quantum inspired algorithms can theoretically achieve significant speed up based on sampling assumptions and have thus far failed to outperform the existing classical ML models in practical applications. The speedup of quantum machine learning (QML) algorithms assume the access to data in quantum random access memory (QRAM) which is a strong assumption with current quantum architectures. QI algorithms assume sample and query (SQ) access to input vector and norms of matrices using a dynamic data structure. We explore the components of these models and the assumptions in this paper by surveying the recent works in QML and QI Machine learning (QIML) algorithms. We limit our study to QML and QIML models on achieving a speed up over classical ML techniques rather than individual proofs of these algorithms. This study highlights the assumptions being made that are currently not practical for QML and QIML algorithms in achieving performance advantage over classical ML algorithms.

Machine learning has radically changed the way problems in various disciplines are solved but faces limitations in tackling increasingly complex and high-dimensional data. Quantum machine learning emerges as a burgeoning paradigm, harnessing the principles of quantum mechanics to potentially surpass classical approaches. This paper delves into the core concepts of quantum machine learning, exploring its algorithms and challenges. The incorporation of quantum mechanics in machine learning algorithms offers a more expressive way to represent data compared to classical methods by capturing intricate relationships within complex datasets. Superposition and entanglement empower the development of algorithms that can tackle computationally expensive tasks in classical machine learning, particularly in high-dimensional spaces. Limited qubit count and susceptibility to noise in current quantum computers hinder the practical implementation of quantum machine learning for large-scale problems. Designing and optimizing efficient quantum algorithms tailored to specific machine learning tasks remains an active area of research. The paper concludes by highlighting the immense potential of quantum machine learning to revolutionize various fields, from materials science and drug discovery to finance and artificial intelligence.

The ability to accurately classify disease subtypes is of vital importance, especially in oncology where this capability could have a life saving impact. Here we report a classification between two subtypes of non-small cell lung cancer, namely Adenocarcinoma versus Squamous cell carcinoma. The data consists of approximately 20,000 gene expression values for each of 104 patients. The data was curated from Kuner (Geo lung cancer data set—gse10245, 2009, http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE10245 ) and Golumbic (Geo lung cancer data set—gse18842, 2010, http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE18842 ). We used a combination of classical and quantum machine learning models to successfully classify these patients. We utilized feature selection methods based on univariate statistics in addition to XGBoost (Guestrin and Chen in Xgboost: a scalable tree boosting system, 2007, https://dl.acm.org/citation.cfm?id=1273596 ). A novel and proprietary data representation method developed by one of the authors called QCrush was also used as it was designed to incorporate a maximal amount of information under the size constraints of the D-Wave quantum annealing computer. The machine learning was performed by a quantum Boltzmann machine. This paper will report our results, the various classical methods, and the quantum machine learning approach we utilized.

The quantum kernel method is one of the key approaches to quantum machine learning, which has the advantage of not requiring optimization and its theoretical simplicity. By virtue of these properties, several experimental demonstrations and discussions of the potential advantages have been developed so far. However, as is the case in classical machine learning, not all quantum machine learning models could be regarded as kernel methods. In this work, we explore a quantum machine learning model with a deep parametrized quantum circuit and aim to go beyond the conventional quantum kernel method. In this case, the expressive power and performance are expected to be enhanced, while the training process might be a bottleneck because of the barren plateaus. Moreover, the high computational cost of gradient-based optimization and the large search space of the gradient-free optimization directly make the training intractable. However, we find that parameters of a deep enough quantum circuit do not move much from their initial values during training, allowing for a first-order expansion with respect to the parameters. This behavior is similar to that of the neural tangent kernel in classical machine learning, and such a quantum machine learning with deep variational quantum circuits can be described by another emergent kernel, the . We show that the proposed quantum tangent kernel has the potential to outperform the conventional quantum kernel method by performing a classification task on an ansatz-generated dataset. This work provides a different direction beyond the conventional quantum kernel method and explores the potential power of quantum machine learning with deep parametrized quantum circuits. Published by the American Physical Society 2024

In the realm of artificial intelligence (AI), the integration of quantum computing with machine learning (ML) has sparked a significant shift in how we approach problems that were once deemed computationally infeasible. Quantum Machine Learning (QML) represents an exciting intersection of quantum mechanics and machine learning, potentially revolutionizing areas such as optimization, pattern recognition, and data analysis. Although quantum computing itself is still in its infancy, the synergy between quantum theory and classical machine learning algorithms promises to unlock new capabilities that classical computing could never achieve. This paper delves into the latest advancements in Quantum Machine Learning, its theoretical underpinnings, practical applications, and the challenges that researchers face as they explore this rapidly growing field.

Recent advances in quantum computing and machine learning have brought about a promising intersection of these two fields, leading to the emergence of quantum machine learning (QML). However, the integration of quantum computing and machine learning poses several challenges. One of the prominent challenges lies in the presence of barren plateaus (BP) in QML algorithms, particularly in quantum neural networks (QNNs). Recent studies have successfully identified the fundamental causes underlying the existence of BP in QNNs. This paper presents a framework designed to explore the interplay of multiple factors contributing to the BP problem in quantum neural networks (QNNs), which poses a critical challenge for the practical applications of QML. We focus on the combined influence of data encoding, qubit entanglement, and ansatz expressibility in hybrid quantum neural networks (HQNNs) for multi-class classification tasks. Our framework aims to empirically analyze the joint impact of these factors on the training landscape of HQNNs. Our results show that the occurrence of the BP problem in HQNNs is contingent upon the expressibility of the underlying ansatz and the type of the adopted data encoding technique. Additionally, we observe that qubit entanglement also plays a role in exacerbating the BP problem. Leveraging various evaluation metrics for classification tasks, we systematically evaluate the performance of HQNNs and provide recommendations tailored to different constraint scenarios. Our findings emphasize the significance of our framework in addressing the practical success of QNNs.

As the limits of classical machine learning (ML) become increasingly evident—especially in terms of computational scalability and data processing—quantum computing emerges as a promising frontier capable of addressing these challenges. Quantum Machine Learning (QML) represents the intersection of quantum computing and traditional ML, aiming to leverage quantum phenomena such as superposition, entanglement, and quantum parallelism to enhance learning capabilities, accelerate training, and solve complex problems that are intractable for classical algorithms. This paper provides a comprehensive overview of the evolving field of QML, beginning with the theoretical foundations of quantum computing and its synergy with classical machine learning principles. We explore key QML algorithms, including quantum support vector machines (QSVM), variational quantum classifiers (VQC), quantum neural networks (QNN), and hybrid quantum-classical approaches that exemplify the practical integration of both paradigms. We further examine real-world applications of QML across domains such as drug discovery, finance, climate modeling, and optimization, where quantum enhancements have begun to show early but promising results. Despite its theoretical potential, QML faces substantial limitations, including quantum hardware instability, limited qubit scalability, noise sensitivity, and unresolved challenges in quantum data encoding and interpretability. In synthesizing recent advancements and persistent obstacles, this paper highlights the importance of continued interdisciplinary research, algorithmic refinement, and hardware evolution. We also outline future directions that could lead QML from experimental promise to practical utility, including developments in quantum error correction, benchmarking standards, and application-specific quantum architectures

Structural rearrangements play a central role in the organization and function of complex biomolecular systems. In principle, Molecular Dynamics (MD) simulations enable us to investigate these thermally activated processes with an atomic level of resolution. In practice, an exponentially large fraction of computational resources must be invested to simulate thermal fluctuations in metastable states. Path sampling methods focus the computational power on sampling the rare transitions between states. One of their outstanding limitations is to efficiently generate paths that visit significantly different regions of the conformational space. To overcome this issue, we introduce a new algorithm for MD simulations that integrates machine learning and quantum computing. First, using functional integral methods, we derive a rigorous low-resolution spatially coarse-grained representation of the system’s dynamics, based on a small set of molecular configurations explored with machine learning. Then, we use a quantum annealer to sample the transition paths of this low-resolution theory. We provide a proof-of-concept application by simulating a benchmark conformational transition with all-atom resolution on the D-Wave quantum computer. By exploiting the unique features of quantum annealing, we generate uncorrelated trajectories at every iteration, thus addressing one of the challenges of path sampling. Once larger quantum machines will be available, the interplay between quantum and classical resources may emerge as a new paradigm of high-performance scientific computing. In this work, we provide a platform to implement this integrated scheme in the field of molecular simulations.

Quantum Machine Learning (QML) is the emerging confluence of quantum computing and artificial intelligence that promises to solve computational problems inaccessible to classical systems. Using quantum principles such as superposition, entanglement, and interference, QML promises exponential speed-ups and new paradigms for data processing in machine learning tasks. This review gives an overview of QML, from advancements in quantum-enhanced classical ML to native quantum algorithms and hybrid quantum-classical frameworks. It varies from applications in optimization, drug discovery, and quantum-secured communications, showcasing how QML can change healthcare, finance, and logistics industries. Even though this approach holds so much promise, significant challenges remain to be addressed-noisy qubits, error correction, and limitations in data encoding-that must be overcome by interdisciplinary research soon. The paper tries to collate the state of the art of QML in theoretical underpinnings, practical applications, and directions into the future.

One-time programs, computer programs which self-destruct after being run only once, are a powerful building block in cryptography and would allow for new forms of secure software distribution. However, ideal one-time programs have been proved to be unachievable using either classical or quantum resources. Here we relax the definition of one-time programs to allow some probability of error in the output and show that quantum mechanics offers security advantages over purely classical resources. We introduce a scheme for encoding probabilistic one-time programs as quantum states with prescribed measurement settings, explore their security, and experimentally demonstrate various one-time programs using measurements on single-photon states. These include classical logic gates, a program to solve Yao’s millionaires problem, and a one-time delegation of a digital signature. By combining quantum and classical technology, we demonstrate that quantum techniques can enhance computing capabilities even before full-scale quantum computers are available.

Medical decision-making is increasingly integrating quantum computing (QC) and machine learning (ML) to analyze complex datasets, improve diagnostics, and enable personalized treatments. While QC holds the potential to accelerate optimization, drug discovery, and genomic analysis as hardware capabilities advance, current implementations remain limited compared to classical computing in many practical applications. Meanwhile, ML has already demonstrated significant success in medical imaging, predictive modeling, and decision support. Their convergence, particularly through quantum machine learning (QML), presents opportunities for future advancements in processing high-dimensional healthcare data and improving clinical outcomes. This review examines the foundational concepts, key applications, and challenges of these technologies in healthcare, explores their potential synergy in solving clinical problems, and outlines future directions for quantum-enhanced ML in medical decision-making.

QCAE-QOC-SVM: A hybrid quantum machine learning model for DoS and Fuzzy attack detection on autonomous vehicle CAN bus.

Quantum machine learning [QML] is a new formulation on quantum hardware platform will try to achieve more enhanced data analysis and prediction which classical computer will not be able to generate. Classical computers are having computational limitations in terms of large volume data processing. Quantum machine are not to replace classical machines but quantum computers will solve operational difficulties of classical machines in terms of computational time. Quantum machine learning accelerates the supervised, unsupervised, and reinforcement learning methods. Classical ML methods such as SVM, PCA, Clustering, Neural networks are giving promising results but classical machines are inadequate to perform certain computations. Proposed Quantum machine learning would result in complex and weird patterns. Quantum support vector machine(QSVM) is a method used in supervised learning for classification and regression. QSVM uses high-dimensional feature space possibly on infinite dimension called as enhanced feature space for generating hyperplane. This hyperplane will classify non-linear and complex data on multiclass domain to achieve improved accuracy in less computational time. This paper investigates various strategies for quantum enhanced machine learning algorithm in supervised learning method. KeywordsQuantum computingMachine learningQubitQuantum machine learningSupport vector machine