Leveraging Data Locality in Quantum Convolutional Classifiers.

Early diagnosis and treatment is very essential in monitoring Brain tumor using MRI images. Convolutional Neural Networks (CNN) and Machine Learning (ML) classifiers have been widely used but there is not much work on how feature selection techniques would affect the performance of the CNN. Secondly, there is a need for investigation concerning small dataset adaptability and ML-CNN comparisons. To improve the classification accuracy, we integrate Univariate, Recursive Feature Elimination (RFE), Recursive Feature Elimination with Cross Validation (RFECV) with CNN in this study. Preprocessing, feature extraction & selection was carried out on the dataset consisting of 253 MRI images and they are classified using CNN and ML models (Logistic Regression, Decision Tree, Random Forest, Naïve Bayes). With the results 96%, CNN with Univariate Feature Selection performed better than ML classifiers, and other selection techniques. The results demonstrate that feature selection is necessary to get the best performance out of CNN models operating on small datasets. Future studies should be based on different deep learning architectures to improve classification and application in other datasets.

The evolution and improvements of deep learning are being used to tackle any research obstacles that could be converted into classification problems in all spheres of life. Each Deep convolutional neural network (DCNN) design's output is determined by the depth and value of the hyperparameters, which explains why so many of them have been proposed. These DCNN architectures must be created entirely from scratch, and they can only be used for the applications for which they were intended. Transfer learning may be used to modify these pre-trained networks so they are more appropriate for particular purposes. This article aims to evaluate the empirical performance of the applicability of pre-trained DCNN models to identify human face presentation threats (FPAD). Human FPAD is one of the most significant and crucial areas of research right now because of the introduction of ambient computing, which necessitates contact-free identification of persons with the help of their biometric traits. Six pre-trained DCNN models are taken into account for an experimental evaluation in human FPAD alias VGG19, VGG16, DensNet121, MobileNet, Xception, and InceptionV3. The investigation makes use of the NUAA and Replay-Attack benchmark FPAD datasets. Thepade's sorted block truncation coding (SBTC) 10-ary features are merged with deep learning features produced from the finest performing finetuned DCNNs to enhance the FPAD capabilities of analyzed machine learning (ML) classifiers. The integration of features of Thepade's SBTC 10-ary and DCNN has considerably increased the FPAD accuracy of ML classifiers with slightly more computations of feature extraction.

Malware detection at the hardware level has emerged recently as a promising solution to improve the security of computing systems. Hardware-based malware detectors take advantage of Machine Learning (ML) classifiers to detect pattern of malicious applications at run-time. These ML classifiers are trained using low-level features such as processor Hardware Performance Counters (HPCs) data which are captured at run-time to appropriately represent the application behaviour. Recent studies show the potential of standard ML-based classifiers for detecting malware using analysis of large number of microarchitectural events, more than the very limited number of HPC registers available in today’s microprocessors which varies from 2 to 8. This results in executing the application more than once to collect the required data, which in turn makes the solution less practical for effective run-time malware detection. Our results show a clear trade-off between the performance of standard ML classifiers and the number and diversity of HPCs available in modern microprocessors. This paper proposes a machine learning-based solution to break this trade-off to realize effective run-time detection of malware. We propose ensemble learning techniques to improve the performance of the hardware-based malware detectors despite using a very small number of microarchitectural events that are captured at run-time by existing HPCs, eliminating the need to run an application several times. For this purpose, eight robust machine learning models and two well-known ensemble learning classifiers applied on all studied ML models (sixteen in total) are implemented for malware detection and precisely compared and characterized in terms of detection accuracy, robustness, performance (accuracy × robustness), and hardware overheads. The experimental results show that the proposed ensemble learning-based malware detection with just 2 HPCs using ensemble technique outperforms standard classifiers with 8 HPCs by up to 17%. In addition, it can match the robustness and performance of standard ML-based detectors with 16 HPCs while using only 4 HPCs allowing effective run-time detection of malware.

COVID-19 is highly infectious and causes acute respiratory disease. Machine learning (ML) and deep learning (DL) models are vital in detecting disease from computerized chest tomography (CT) scans. The DL models outperformed the ML models. For COVID-19 detection from CT scan images, DL models are used as end-to-end models. Thus, the performance of the model is evaluated for the quality of the extracted feature and classification accuracy. There are four contributions included in this work. First, this research is motivated by studying the quality of the extracted feature from the DL by feeding these extracted to an ML model. In other words, we proposed comparing the end-to-end DL model performance against the approach of using DL for feature extraction and ML for the classification of COVID-19 CT scan images. Second, we proposed studying the effect of fusing extracted features from image descriptors, e.g., Scale-Invariant Feature Transform (SIFT), with extracted features from DL models. Third, we proposed a new Convolutional Neural Network (CNN) to be trained from scratch and then compared to the deep transfer learning on the same classification problem. Finally, we studied the performance gap between classic ML models against ensemble learning models. The proposed framework is evaluated using a CT dataset, where the obtained results are evaluated using five different metrics The obtained results revealed that using the proposed CNN model is better than using the well-known DL model for the purpose of feature extraction. Moreover, using a DL model for feature extraction and an ML model for the classification task achieved better results in comparison to using an end-to-end DL model for detecting COVID-19 CT scan images. Of note, the accuracy rate of the former method improved by using ensemble learning models instead of the classic ML models. The proposed method achieved the best accuracy rate of 99.39%.

ObjectiveWe implement 2 different multitask learning (MTL) techniques, hard parameter sharing and cross-stitch, to train a word-level convolutional neural network (CNN) specifically designed for automatic extraction of cancer data from unstructured text in pathology reports. We show the importance of learning related information extraction (IE) tasks leveraging shared representations across the tasks to achieve state-of-the-art performance in classification accuracy and computational efficiency.Materials and MethodsMultitask CNN (MTCNN) attempts to tackle document information extraction by learning to extract multiple key cancer characteristics simultaneously. We trained our MTCNN to perform 5 information extraction tasks: (1) primary cancer site (65 classes), (2) laterality (4 classes), (3) behavior (3 classes), (4) histological type (63 classes), and (5) histological grade (5 classes). We evaluated the performance on a corpus of 95 231 pathology documents (71 223 unique tumors) obtained from the Louisiana Tumor Registry. We compared the performance of the MTCNN models against single-task CNN models and 2 traditional machine learning approaches, namely support vector machine (SVM) and random forest classifier (RFC).ResultsMTCNNs offered superior performance across all 5 tasks in terms of classification accuracy as compared with the other machine learning models. Based on retrospective evaluation, the hard parameter sharing and cross-stitch MTCNN models correctly classified 59.04% and 57.93% of the pathology reports respectively across all 5 tasks. The baseline models achieved 53.68% (CNN), 46.37% (RFC), and 36.75% (SVM). Based on prospective evaluation, the percentages of correctly classified cases across the 5 tasks were 60.11% (hard parameter sharing), 58.13% (cross-stitch), 51.30% (single-task CNN), 42.07% (RFC), and 35.16% (SVM). Moreover, hard parameter sharing MTCNNs outperformed the other models in computational efficiency by using about the same number of trainable parameters as a single-task CNN.ConclusionsThe hard parameter sharing MTCNN offers superior classification accuracy for automated coding support of pathology documents across a wide range of cancers and multiple information extraction tasks while maintaining similar training and inference time as those of a single task–specific model.

As robots and machines become more reliable, developing tools that utilize their potential in manufacturing and beyond is an important step being addressed by many, including the LIMDA team at the University of Alberta. A common and effective means to improve artificial performance is through optical character recognition methods. Within the category of artificial intelligence under classification machine learning, research has focussed on the benefits of convolutional neural networks (CNN) and the improvement provided compared to its parent method, neural networks. Neural networks serious flaw comes from memorization and the lack of learning about what the images contain, while CNN's combat those issues. CNN’s are designed to connect information received by the network and begins to closely mimic how humans experience learns. Using the programming language Python and machine learning libraries such as Tensorflow and Keras, different versions of CNN’s were tested against datasets containing low-resolution images with handwritten characters. The first two CNN’s were trained against the MNIST database against digits 0 through 9. The results from these tests illustrated the benefits of elements like max-pooling and the addition of convolutional layers. Taking that knowledge a final CNN was written to prove the accuracy of the algorithm against alphabet characters. After training and testings were complete the network showed an average 99.34% accuracy and 2.23% to the loss function. Time-consuming training epochs that don’t wield higher or more impressive results could also be eliminated. These and similar CNN’s have proven to yield positive results and in future research could be implemented into the laboratory to improve safety. Continuing to develop this work will lead to better translators for language, solid text to digital text transformation, and aides for the visual and speech impaired.

In recent years, COVID-19 has been regarded as the most dangerous pandemic for several countries. On various social media platforms, such as Twitter, Facebook, and Instagram, a variety of rumours, hypes, and news are published. This might have a detrimental impact on people’s life. As a result, social media platforms have always had a difficult time authenticating this fake information. Different machine learning (ML) and deep learning (DL) classifiers were used in this work to categorize the continuing impacts of tweets and forecast their after-effects. Support vector machine (SVM), random forest (RF), decision tree (DT), and k-nearest neighbor (KNN) were used for classification, while AdaBoost and convolutional neural network (CNN) were utilized for future effects. The tweets dataset from Kaggle was used to train the SVM, RF, KNN, and DT models, which were then assessed on multiple evaluation criteria such as accuracy, precision, recall, and F1-score, using a 70 : 30 ratio. The CNN and AdaBoost, on the other hand, have been taught to detect the mean square error, root mean square error, and mean absolute error. With 0.74 and 0.73 percent score out of 1, respectively, RF and SVM exhibit the best accuracy in impact when classifying the outcomes on the obtained dataset. In terms of a regression problem, CNN beat the ADA Regressor across the board.

3-D optimized classification and characterization artificial intelligence paradigm for cardiovascular/stroke risk stratification using carotid ultrasound-based delineated plaque: Atheromatic™ 2.0

The study presents an enhanced AlexNet-based deep learning system for binary classification of melanoma skin cancer as either benign or malignant using two paired dermatoscopic and clinical image datasets. The study evaluates the resilience of the models across different image sets with common preprocessing and specific data augmentation, using a melanoma dataset containing 10,000 images and a benign versus malignant dataset with 3,600 images. The AlexNet refinement exceeded several standard machine learning (ML) classifiers and other deep architectures on the two datasets with practical training times, gaining 97.12% and 96.21% in balanced accuracy. The training proceeded with SGD as optimiser and cross-entropy as loss on 256×256 images. Benchmarking against support vector machine (SVM), k-nearest neighbour (KNN), and other convolutional neural networks (CNNs) designs shows that the selected architecture and hyperparameters achieved the highest performance on cost-effective computation for the routine melanoma triage. The report highlights the need for external validation, incorporation into dermatological workflows, and explainability to improve trust, diminish dataset bias, and support the safe clinical deployment in practice.

Development of machine learning solutions for prediction of functional and clinical significance of cancer driver genes and mutations are paramount in modern biomedical research and have gained a significant momentum in a recent decade. In this work, we integrate different machine learning approaches, including tree based methods, random forest and gradient boosted tree (GBT) classifiers along with deep convolutional neural networks (CNN) for prediction of cancer driver mutations in the genomic datasets. The feasibility of CNN in using raw nucleotide sequences for classification of cancer driver mutations was initially explored by employing label encoding, one hot encoding, and embedding to preprocess the DNA information. These classifiers were benchmarked against their tree-based alternatives in order to evaluate the performance on a relative scale. We then integrated DNA-based scores generated by CNN with various categories of conservational, evolutionary and functional features into a generalized random forest classifier. The results of this study have demonstrated that CNN can learn high level features from genomic information that are complementary to the ensemble-based predictors often employed for classification of cancer mutations. By combining deep learning-generated score with only two main ensemble-based functional features, we can achieve a superior performance of various machine learning classifiers. Our findings have also suggested that synergy of nucleotide-based deep learning scores and integrated metrics derived from protein sequence conservation scores can allow for robust classification of cancer driver mutations with a limited number of highly informative features. Machine learning predictions are leveraged in molecular simulations, protein stability, and network-based analysis of cancer mutations in the protein kinase genes to obtain insights about molecular signatures of driver mutations and enhance the interpretability of cancer-specific classification models.

Errors in measurements are key to weighting the value of data, but are often neglected in machine learning (ML). We show how convolutional neural networks (CNNs) are able to learn about the context and patterns of signal and noise, leading to improvements in the performance of classification methods. We construct a model whereby two classes of objects follow an underlying Gaussian distribution, and where the features (the input data) have varying, but known, levels of noise—in other words, each data point has a different error bar. This model mimics the nature of scientific data sets, such as those from astrophysical surveys, where noise arises as a realization of random processes with known underlying distributions. The classification of these objects can then be performed using standard statistical techniques (e.g. least squares minimization), as well as ML techniques. This allows us to take advantage of a maximum likelihood approach to object classification, and to measure the amount by which the ML methods are incorporating the information in the input data uncertainties. We show that, when each data point is subject to different levels of noise (i.e. noises with different distribution functions, which is typically the case in scientific data sets), that information can be learned by the CNNs, raising the ML performance to at least the same level of the least squares method—and sometimes even surpassing it. Furthermore, we show that, with varying noise levels, the confidence of the ML classifiers serves as a proxy for the underlying cumulative distribution function, but only if the information about specific input data uncertainties is provided to the CNNs.

Magnetic resonance imaging (MRI)-guided radiation therapy (RT) treatment planning is limited by the fact that the electron density distribution required for dose calculation is not readily provided by MR imaging. We compare a selection of novel synthetic CT generation algorithms recently reported in the literature, including segmentation-based, atlas-based and machine learning techniques, using the same cohort of patients and quantitative evaluation metrics. Six MRI-guided synthetic CT generation algorithms were evaluated: one segmentation technique into a single tissue class (water-only), four atlas-based techniques, namely, median value of atlas images (ALMedian), atlas-based local weighted voting (ALWV), bone enhanced atlas-based local weighted voting (ALWV-Bone), iterative atlas-based local weighted voting (ALWV-Iter), and a machine learning technique using deep convolution neural network (DCNN). Organ auto-contouring from MR images was evaluated for bladder, rectum, bones, and body boundary. Overall, DCNN exhibited higher segmentation accuracy resulting in Dice indices (DSC) of 0.93±0.17, 0.90±0.04, and 0.93±0.02 for bladder, rectum, and bones, respectively. On the other hand, ALMedian showed the lowest accuracy with DSC of 0.82±0.20, 0.81±0.08, and 0.88±0.04, respectively. DCNN reached the best performance in terms of accurate derivation of synthetic CT values within each organ, with a mean absolute error within the body contour of 32.7±7.9HU, followed by the advanced atlas-based methods (ALWV: 40.5±8.2HU, ALWV-Iter: 42.4±8.1HU, ALWV-Bone: 44.0±8.9HU). ALMedian led to the highest error (52.1±11.1HU). Considering the dosimetric evaluation results, ALWV-Iter, ALWV, DCNN and ALWV-Bone led to similar mean dose estimation within each organ at risk and target volume with less than 1% dose discrepancy. However, the two-dimensional gamma analysis demonstrated higher pass rates for ALWV-Bone, DCNN, ALMedian and ALWV-Iter at 1%/1mm criterion with 94.99±5.15%, 94.59±5.65%, 93.68±5.53% and 93.10±5.99% success, respectively, while ALWV and water-only resulted in 86.91±13.50% and 80.77±12.10%, respectively. Overall, machine learning and advanced atlas-based methods exhibited promising performance by achieving reliable organ segmentation and synthetic CT generation. DCNN appears to have slightly better performance by achieving accurate automated organ segmentation and relatively small dosimetric errors (followed closely by advanced atlas-based methods, which in some cases achieved similar performance). However, the DCNN approach showed higher vulnerability to anatomical variation, where a greater number of outliers was observed with this method. Considering the dosimetric results obtained from the evaluated methods, the challenge of electron density estimation from MR images can be resolved with a clinically tolerable error.

Machine learning has achieved remarkable success across diverse domains. Nevertheless, concerns about interpretability in black-box models, especially within Deep Neural Networks (DNNs), have become pronounced in safety-critical fields like healthcare and finance. Classical machine learning (ML) classifiers, known for their higher interpretability, are preferred in these domains. Similar to DNNs, classical ML classifiers can exhibit bugs that could lead to severe consequences in practice. Test input prioritization has emerged as a promising approach to ensure the quality of an ML system, which prioritizes potentially misclassified tests so that such tests can be identified earlier with limited manual labeling costs. However, when applying to classical ML classifiers, existing DNN test prioritization methods are constrained from three perspectives: 1) Coverage-based methods are inefficient and time-consuming; 2) Mutation-based methods cannot be adapted to classical ML models due to mismatched model mutation rules; 3) Confidence-based methods are restricted to a single dimension when applying to binary ML classifiers, solely depending on the model’s prediction probability for one class. To overcome the challenges, we propose MLPrior, a test prioritization approach specifically tailored for classical ML models. MLPrior leverages the characteristics of classical ML classifiers (i.e., interpretable models and carefully engineered attribute features) to prioritize test inputs. The foundational principles are: 1) tests more sensitive to mutations are more likely to be misclassified, and 2) tests closer to the model’s decision boundary are more likely to be misclassified. Building on the first concept, we design mutation rules to generate two types of mutation features (i.e., <bold xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">model mutation features</b> and <bold xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">input mutation features</b> ) for each test. Drawing from the second notion, MLPrior generates <bold xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">attribute features</b> of each test based on its attribute values, which can indirectly reveal the proximity between the test and the decision boundary. For each test, MLPrior combines all three types of features of it into a final vector. Subsequently, MLPrior employs a pre-trained ranking model to predict the misclassification probability of each test based on its final vector and ranks tests accordingly. We conducted an extensive study to evaluate MLPrior based on 185 subjects, encompassing natural datasets, mixed noisy datasets, and fairness datasets. The results demonstrate that MLPrior outperforms all the compared test prioritization approaches, with an average improvement of 14.74%∼66.93% on natural datasets, 18.55%∼67.73% on mixed noisy datasets, and 15.34%∼62.72% on fairness datasets.

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by motor and non-motor symptoms, among which vocal impairment is one of the earliest and most prevalent. In recent years, voice analysis supported by machine learning (ML) and deep learning (DL) has emerged as a promising non-invasive method for early PD detection. We conducted a systematic review searching PubMed, Scopus, IEEE Xplore, and Web of Science databases for studies published between 2020 and September 2025. A total of 69 studies met the inclusion criteria and were analyzed in terms of dataset characteristics, speech tasks, feature extraction techniques, model architectures, validation strategies, and performance outcomes. Classical ML models such as Support Vector Machines (SVMs) and Random Forests (RFs) achieved high accuracy on small, homogeneous datasets, while DL architectures, particularly Convolutional Neural Networks (CNNs), Recurrent Neural Networks (RNNs), and Transformer-based foundation models, demonstrated greater robustness and scalability across languages and recording conditions. Despite these advances, persistent challenges such as dataset heterogeneity, class imbalance, and inconsistent validation practices continue to hinder reproducibility and clinical translation. Overall, the field is transitioning from handcrafted feature-based pipelines toward self-supervised, representation-learning frameworks that promise improved generalizability. Future progress will depend on the development of large, multilingual, and openly accessible datasets, standardized evaluation protocols, and interpretable AI frameworks to ensure clinically reliable and equitable voice-based PD diagnostics.

This paper proposes a novel deep learning architecture involving combinations of Convolutional Neural Networks (CNN) layers and Recurrent neural networks (RNN) layers that can be used to perform segmentation and classification of 5 cardiac rhythms based on ECG recordings. The algorithm is developed in a sequence to sequence setting where the input is a sequence of five second ECG signal sliding windows and the output is a sequence of cardiac rhythm labels. The novel architecture processes as input both the spectrograms of the ECG signal as well as the heartbeats' signal waveform. Additionally, we are able to train the model in the presence of label noise. The model's performance and generalizability is verified on an external database different from the one we used to train. Experimental result shows this approach can achieve an average F1 scores of 0.89 (averaged across 5 classes). The proposed model also achieves comparable classification performance to existing state-of-the-art approach with considerably less number of training parameters.