Leveraging Explainable AI for Dementia Classification: A Machine Learning Approach

Multiple sclerosis (MS) is a heterogeneous immune-mediated disorder of the central nervous system, and primary progressive MS (PPMS) is characterized by insidious injury independent of clinical relapses from disease onset. Predicting disease progression remains an unmet need across the MS disease spectrum. We evaluated statistical and machine learning (ML) models for predicting progression in 596 patients with PPMS from ORATORIO, a randomized, placebo (PBO)-controlled, phase 3 clinical study of ocrelizumab (OCR). Using baseline clinical, magnetic resonance imaging, and biomarker (neurofilament light chain [NfL]) data, we trained 6 ML models to predict a progression event (logistic regression, support vector machines, random forest, neural network, gradient boosting, and extreme gradient boosting) and the time to progression (Cox proportional hazards [PH]) on upper limb function, as measured by 20% confirmed worsening on the 9-hole peg test (9HPT). Predictive performance was similar across the six ML models (area under the curve = 0.63 to 0.67) and was modest using the Cox PH model (C-index = 0.76, an improvement over previous studies). In the Cox PH model, treatment arm, baseline 9HPT, neurologic functional system scores, and serum NfL levels were identified as factors associated with progression; model performance was similar across the OCR, PBO, and combined OCR + PBO treatment arms. Accounting for potential interactions with treatment arm resulted in similar predictive performance. To our knowledge, this is the first study to systematically evaluate ML models and statistical methods for predicting progression in PPMS using a well-characterized clinical trial cohort.

Background and aimsThe birth weight of a newborn is a crucial factor that affects their overall health and future well-being. Low birth weight (LBW) is a widespread global issue, which the World Health Organization defines as weighing less than 2,500 g. LBW can have severe negative consequences on an individual’s health, including neonatal mortality and various health concerns throughout their life. To address this problem, this study has been conducted using BDHS 2017–2018 data to uncover important aspects of LBW using a variety of machine learning (ML) approaches and to determine the best feature selection technique and best predictive ML model.MethodsTo pick out the key features, the Boruta algorithm and wrapper method were used. Logistic Regression (LR) used as traditional method and several machine learning classifiers were then used, including, DT (Decision Tree), SVM (Support Vector Machine), NB (Naïve Bayes), RF (Random Forest), XGBoost (eXtreme Gradient Boosting), and AdaBoost (Adaptive Boosting), to determine the best model for predicting LBW. The model’s performance was evaluated based on the specificity, sensitivity, accuracy, F1 score and AUC value.ResultsResult shows, Boruta algorithm identifies eleven significant features including respondent’s age, highest education level, educational attainment, wealth index, age at first birth, weight, height, BMI, age at first sexual intercourse, birth order number, and whether the child is a twin. Incorporating Boruta algorithm’s significant features, the performance of traditional LR and ML methods including DT, SVM, NB, RF, XGBoost, and AB were evaluated where LR, had a specificity, sensitivity, accuracy and F1 score of 0.85, 0.5, 85.15% and 0.915. While the ML methods DT, SVM, NB, RF, XGBoost, and AB model’s respective accuracy values were 85.35%, 85.15%, 84.54%, 81.18%, and 84.41%. Based on the specificity, sensitivity, accuracy, F1 score and AUC, RF (specificity = 0.99, sensitivity = 0.58, accuracy = 85.86%, F1 score = 0.9243, AUC = 0.549) outperformed the other methods. Both the classical (LR) and machine learning (ML) models’ performance has improved dramatically when important characteristics are extracted using the wrapper method. The LR method identified five significant features with a specificity, sensitivity, accuracy and F1 score of 0.87, 0.33, 87.12% and 0.9309. The region, whether the infant is a twin, and cesarean delivery were the three key features discovered by the DT and RF models, which were implemented using the wrapper technique. All three models had the identical F1 score of 0.9318. However, “child is twin” was recognized as a significant feature by the SVM, NB, and AB models, with an F1 score of 0.9315. Ultimately, with an F1 score of 0.9315, the XGBoost model recognized “child is twin” and “age at first sex” as relevant features. Random Forest again beat the other approaches in this instance.ConclusionsThe study reveals Wrapper method as the optimal feature selection technique. The ML method outperforms traditional methods, with Random Forest (RF) being the most effective predictive model for Low-Birth-Weight prediction. The study suggests that policymakers in Bangladesh can mitigate low birth weight newborns by considering identified risk factors.

Accurate and early diagnosis of HIV/AIDS is critical for effective treatment and reducing disease transmission. This study evaluates the performance of several machine learning models, including Logistic Regression, Decision Tree, Random Forest, Gradient Boosting, Support Vector Machine (SVM), K-Nearest Neighbors (KNN), and Naive Bayes, for classifying HIV/AIDS infection status. A dataset comprising 50,000 samples was used, and models were assessed based on accuracy, precision, recall, and F1 score using stratified ten-fold cross-validation to ensure robust evaluation. The results reveal significant trade-offs between sensitivity and specificity across the models. Gradient Boosting achieved the highest accuracy (70.85%) and precision (57.81%), making it suitable for confirmatory testing where minimizing false positives is critical. Conversely, Naive Bayes demonstrated the highest recall (57.99%) and F1 score (51.04%), emphasizing its effectiveness in early-stage diagnostics where sensitivity is paramount. SVM exhibited the highest precision (59.87%) but struggled with recall (11.28%), reflecting its conservative nature in classifying positive cases. These findings underscore the importance of selecting models tailored to specific diagnostic objectives. While Naive Bayes is ideal for comprehensive screening programs, Gradient Boosting and SVM are better suited for confirmatory testing. This research provides valuable insights into the strengths and limitations of machine learning models for medical diagnostics, paving the way for developing more robust, hybrid approaches to optimize sensitivity and specificity in HIV/AIDS classification.

Background Patients with atrial fibrillation (AF) after successful transcatheter aortic valve implantation (TAVI) are at heightened risk of ischaemic stroke (IS) and bleeding. However, risk scores, such as CHA2DS2-VA and HAS-BLED, provide modest prediction of IS and bleeding. Although traditional statistical methods (e.g., Cox regression) allow for identifying patients at higher risk for these events, a machine learning (ML) approach may enhance risk prediction by capturing complex non-linear associations. Purpose To develop and evaluate ML models predicting clinical events in patients with AF after TAVI with established risk scores for IS and bleeding. Methods Patient-level data from the ENVISAGE-TAVI AF trial were used to develop ML models for the prediction of IS, major gastrointestinal bleeding (MGIB), all clinically relevant bleeding (major or clinically relevant nonmajor bleeding), and net adverse clinical events (NACE; composite of death from any cause, myocardial infarction, IS, systemic thromboembolic event, valve thrombosis, or major bleeding). For each outcome, 10 ML algorithms were trained, optimised, and ranked by performance using nested cross-validation. The model with the highest F1 score (harmonic mean of precision and recall) for each outcome was selected and validated on a separate hold-out set (25%). SHAP (SHapley Additive exPlanations) values were calculated to determine the average magnitude of feature contributions. Using F1 scores, the best model of each outcome was compared with logistic regression models trained exclusively on CHA2DS2-VA (IS) and HAS-BLED (bleeding) scores. Results Of 1377 patients on treatment, 41 had IS, 83 had MGIB, 375 had clinically relevant bleeding, and 255 had NACE. The predictive abilities of a linear discriminant analysis algorithm for IS (F1 score=0.08) and CHA2DS2-VA (F1 score=0.09) were similarly low and numerically better than HAS-BLED (F1 score=0.05; Figure 1). Prediction of MGIB was similarly low for a logistic-lasso algorithm (F1 score=0.11), CHA2DS2-VA (F1 score=0.09), and HAS-BLED (F1 score=0.12). For all clinically relevant bleeding, the predictive performance of a naïve-Bayes algorithm (F1 score=0.39) was similar to that of CHA2DS2-VA (F1 score=0.38) and HAS-BLED (F1 score=0.41). The predictive ability of a logistic regression algorithm for NACE (F1 score=0.33) was numerically better than CHA2DS2-VA (F1 score=0.22) or HAS-BLED (F1 score=0.27). Low event rates were generally observed to limit the predictive power of ML models and scores. All 4 algorithms identified novel predictors of events (Figure 2). Conclusion ML models allow for risk assessment for IS, MGIB, all clinically relevant bleeding, and NACE, and were comparable to traditional risk scores. While further development and validation in larger datasets will be required, these initial models reveal potential new predictors of IS and bleeding events that may be important to consider in future studies.

Social determinants of health (SDOH) play a critical role in the onset and progression of chronic kidney disease (CKD). Despite the well-established role of SDOH, previous studies have not fully incorporated these factors in predicting CKD in Type 2 diabetes patients. To bridge this gap, this study aimed to develop and evaluate the machine learning (ML) models that incorporate SDOH to enhance CKD risk prediction in Type 2 diabetes patients. Data were obtained from the 2023 Behavioral Risk Factor Surveillance System (BRFSS), a national survey that collects comprehensive health-related data from adults across the United States. Missing data were addressed using the K-nearest neighbor imputation method, and the Synthetic Minority Oversampling Technique (SMOTE) was applied to balance class distributions. Potential predictive features were selected using correlation coefficient analysis. The dataset was partitioned into training (80%) and testing (20%) subsets, with a 3-fold cross-validation strategy applied to the training data. Seven ML models were developed for CKD risk prediction, including logistic regression (LR), decision tree (DT), K-nearest neighbor (KNN), random forest (RF), eXtreme Gradient Boosting (XGBoost), and an artificial neural network (ANN). Model performance was evaluated using multiple metrics, including the area under the receiver operating characteristic curve (AUROC), precision, recall, F1 score, accuracy, and false positive rate. The study included 19,912 Type 2 diabetes patients (weighted sample size: 818,878), among whom 2,924 (weighted 13.92%) had CKD, and 16,988 (weighted 86.08%) did not. Over half of the CKD group (50.4%) were aged 65 or older. The proportion of female patients was higher in both groups, comprising 53.8% of the CKD group and 50.5% of the non-CKD group. Among the ML models evaluated, the RF model demonstrated the highest predictive performance for CKD, with an AUROC of 0.89 (95% CI: 0.88 - 0.90), followed by the DT model (0.84, 95% CI: 0.83 - 0.85) and XGBoost (0.83, 95% CI: 0.82 - 0.84). The RF model achieved an accuracy of 0.81 (95%CI: 0.81 - 0.81), a precision of 0.79 (95%CI: 0.79 - 0.79), a recall of 0.85 (95%CI: 0.85 - 0.85), and an F1 score of 0.82 (95%CI: 0.82 - 0.82). Additionally, the RF model exhibited strong calibration, reinforcing its reliability as a predictive tool for CKD risk in individuals with Type 2 diabetes. The study findings underscore the potential of ML models, particularly the RF model, in accurately predicting CKD among individuals with Type 2 diabetes. This approach not only enhances the precision of CKD prediction but also highlights the importance of addressing social and environmental disparities in disease prevention and management. Leveraging ML models with SDOH can lead to earlier interventions, more personalized treatment plans, and improved health outcomes for vulnerable populations. The online version contains supplementary material available at 10.1007/s40200-025-01621-9.

Blood pressure abnormality detection and Interpretation utilizing Explainable Artificial Intelligence

Student’s mental health problems have been explored previously in higher education literature in various contexts including empirical work involving quantitative and qualitative methods. Nevertheless, comparatively few research could be found, aiming for computational methods that learn information directly from data without relying on set parameters for a predetermined equation as an analytical method. This study aims to investigate the performance of Machine learning (ML) models used in higher education. ML models considered are Naïve Bayes, Support Vector Machine, K-Nearest Neighbor, Logistic Regression, Stochastic Gradient Descent, Decision Tree, Random Forest, XGBoost (Extreme Gradient Boosting Decision Tree), and NGBoost (Natural) algorithm. Considering the factors of mental health illness among students, we follow three phases of data processing: segmentation, feature extraction, and classification. We evaluate these ML models against classification performance metrics such as accuracy, precision, recall, F1 score, and predicted run time. The empirical analysis includes two contributions: 1. It examines the performance of various ML models on a survey-based educational dataset, inferring a significant classification performance by a tree-based XGBoost algorithm; 2. It explores the feature importance [variables] from the datasets to infer the significant importance of social support, learning environment, and childhood adversities on a student’s mental health illness.

ADHD (attention deficit hyperactivity disorder) is a neurodevelopmental disorder characterized by harmful levels of inattention, disorganization, and/or hyperactivity-impulsivity. In childhood, these symptoms often overlap with those of other disorders, and they tend to persist into adulthood, interfering with relationships and academic and work life. Diagnosis, traditionally made by assessing the patient, i.e., testing and listening to relatives and teachers, has already been aided by neuroimaging. However, the visual analysis of such images to make a psychiatric diagnosis is a complex and sometimes time-consuming task. For this reason, computer-aided diagnostic tools have increasingly evolved that, when combined with machine learning (ML) techniques, can accelerate, facilitate, and maximize the accuracy of diagnoses. Nevertheless, research evaluating ML models for classifying ADHD considering severity using images of the brain SPECT (Single Photon Emission Computed Tomography) is still very sparse. For this reason, this article aims to evaluate the performance of the ML methods: k-NN (k-Nearest Neighbors), Naive Bayes, Decision Tree, MLP (Multilayer Perceptron) and SVM (Support Vector Machine) in the classification of ADHD. The main goal of this analysis is to check whether the subjects have the disorder or not, and to classify the severity of those who have it using SPECT images. A database was created from SPECT images and diagnostic reports. After pre-processing these data, the best hyperparameters for the ML methods were searched, trained/tested and finally statistically compared. The best results were obtained with SVM and k-NN, with 98% accuracy. Although ADHD diagnosis by neuroimaging is not yet a standard clinical procedure, we argue that this study can contribute to ADHD diagnosis research and support methods for the development of CAD (computer-aided diagnosis) systems.

BackgroundAcute kidney injury (AKI) is the most common and serious complication of sepsis, accompanied by high mortality and disease burden. The early prediction of AKI is critical for timely intervention and ultimately improves prognosis. This study aims to establish and validate predictive models based on novel machine learning (ML) algorithms for AKI in critically ill patients with sepsis.MethodsData of patients with sepsis were extracted from the Medical Information Mart for Intensive Care III (MIMIC- III) database. Feature selection was performed using a Boruta algorithm. ML algorithms such as logistic regression (LR), k-nearest neighbors (KNN), support vector machine (SVM), decision tree, random forest, Extreme Gradient Boosting (XGBoost), and artificial neural network (ANN) were applied for model construction by utilizing tenfold cross-validation. The performances of these models were assessed in terms of discrimination, calibration, and clinical application. Moreover, the discrimination of ML-based models was compared with those of Sequential Organ Failure Assessment (SOFA) and the customized Simplified Acute Physiology Score (SAPS) II model.ResultsA total of 3176 critically ill patients with sepsis were included for analysis, of which 2397 cases (75.5%) developed AKI during hospitalization. A total of 36 variables were selected for model construction. The models of LR, KNN, SVM, decision tree, random forest, ANN, XGBoost, SOFA and SAPS II score were established and obtained area under the receiver operating characteristic curves of 0.7365, 0.6637, 0.7353, 0.7492, 0.7787, 0.7547, 0.821, 0.6457 and 0.7015, respectively. The XGBoost model had the best predictive performance in terms of discrimination, calibration, and clinical application among all models.ConclusionThe ML models can be reliable tools for predicting AKI in septic patients. The XGBoost model has the best predictive performance, which can be used to assist clinicians in identifying high-risk patients and implementing early interventions to reduce mortality.

BackgroundWhile machine learning (ML) models are increasingly used to predict outcomes in health care, their practical effect on health care operations, such as bed capacity management, remains underexplored. There is a variety of traditionally used evaluation metrics to analyze ML models; however, decision makers in health care settings require a deeper understanding of their implications for resource management. Traditional performance measures often fail to provide this practical insight.MethodsIn this work, we conduct a simulation study to evaluate the impact of ML-driven length-of-stay (LOS) predictions on intensive care unit (ICU) bed capacity management. Two classification models differing in terms of explainability and interpretability, logistic regression (LR) and extreme gradient boosting (XGB), are applied to predict ICU-LOS. We use the HiRID dataset containing high-frequency data of more than 33,000 patients. The predictions of the ML models are integrated into a simulation framework that replicates real-world ICU bed management, allowing for the assessment of the practical implications of using these algorithms in a clinical setting.ResultsThe application of both classification models results in improved capacity control regarding the key performance indicators in the simulation study, with XGB outperforming LR. While LR leads to slight overoccupancy in the ICU, slight underoccupancy can be observed when XGB is applied.ConclusionOur study bridges the gap between predictive accuracy and practical application by emphasizing the importance of evaluating ML models within the context of ICU capacity management. The simulation-based approach offers a more relevant assessment for health care practitioners, providing actionable insights that go beyond classical performance measures and directly address the needs of decision makers in clinical practice.HighlightsWe apply multiple classification models for ICU-LOS prediction using time-series data. This approach enables an update of the initial prediction resulting in the possibility of efficiently managing intensive care capacities.We present a simulation-based approach to evaluate ML algorithms and their impact on bed capacity management in real-world clinical settings.Our work provides in-depth insights into the impact of using ML techniques as decision support systems in the ICU and can lead to increased acceptance in practice.

Introduction Spine trauma represents a major cause of disability and substantial healthcare costs. Despite classification systems and risk scores, outcome prediction following spine trauma remains challenging. Machine learning (ML) approaches offer multidimensionality but vary widely in methodology, performance, and clinical application. This systematic review aims to characterize the use of ML for outcome prediction and prognostication in spine trauma. Methods A systematic search of PubMed, Embase, Scopus, Web of Science, and Cochrane Library was performed for publications from January 2015 to May 2025. Studies reporting ML for predicting clinical outcomes in spine trauma patients were identified using pre-defined criteria. Primary outcomes were types and performance metrics of ML models for spine trauma prognostication. Secondary outcomes included cost-effectiveness, clinical utility and implementation feasibility. Results Twenty-seven studies were included, of which 26 were published from 2020 onwards. Only one study was prospective, while the rest were retrospective. Commonly used ML algorithms for spine trauma prognosis were logistic regression (LR), extreme gradient boosting (XGBoost), Random Forest (RF), light gradient boosting machine (LightGBM), and support vector machine (SVM). Outcomes predicted include mortality, neurological function or recovery, ambulation and walking, self-care and independence, complications, treatment failure, length of stay, and discharge destination. Most studies employed internal testing and validation; only four reported external validation. Seven studies reported direct comparison with non-ML models or risk scores, demonstrating comparable or superior performance of ML models. Performance metrics include area under the curve (AUC), accuracy, sensitivity, specificity, precision, F1-score, Brier score, and others. The highest AUC was reported by a nomogram constructed using consensus clustering to predict postoperative pulmonary infection in patients with acute cervical spinal cord injury (internal validation; AUC 0.993; 95% CI 0.981–1.000). Quality of evidence varied between studies, but risk of bias was a concern. Conclusions Existing evidence on ML for spine trauma prognosis is characterized by retrospective study designs, homogeneous cohorts, and lack of external validation, limiting their generalizability and real-world application. While ML approaches demonstrate encouraging predictive performance for spine trauma outcomes, their clinical adoption is limited by methodological heterogeneity. More robust validation, standardized reporting, and comparison with traditional tools are needed before ML models can reliably inform clinical decision-making.

Accurate precipitation forecasting is a vital task for many domains, such as agriculture, water management, flood prevention, and crop yield estimation. The use of machine learning (ML) approaches has improved precipitation forecasting accuracy, exhibiting promising results in capturing the intricate connections between various meteorological variables and precipitation patterns. However, given the vast array of available ML models, a comparative analysis is imperative for identifying the most effective models for precipitation prediction. This study aims to examine the capacities of ML algorithms to forecast precipitation based on weather data for the city of Casablanca, Morocco, which faces challenges in water management and climate change adaptation. Eight different ML models’ performances are compared: linear regression, polynomial regression, K-nearest neighbors (KNN), support vector machine (SVM), decision tree (DT), random forest (RF), XGBoost, and an ensemble learning model. These models are evaluated based on their mean absolute error (MAE), mean squared error (MSE), and R-squared (R2 ) value to determine their effectiveness. The study showcases the potential of ML models in predicting precipitation by utilizing meteorological parameters such as temperature, humidity, wind speed, and pressure.

Accurate real-time bus arrival information is essential for an efficient public transport network, as it significantly impacts passenger experience, system reliability, reduced waiting times, dwell times, and operational efficiency. In Sri Lanka's public transport system, current bus arrival time computations primarily rely on static data, neglecting real-time information and critical factors influencing travel times. This highlights the need to identify the unique variables affecting bus arrival times within the Sri Lankan context and to develop robust prediction models that account for these influences. While traditional methods such as Historical Average Models, Regression, Time Series Analysis, and Kalman Filtering have been used in previous research for short-term travel time predictions, Machine Learning (ML) approaches have proven to deliver superior accuracy. ML models are regarded as the most effective for heterogeneous, lane-less traffic conditions with varying traffic volumes, such as those found in Sri Lanka. ML techniques excel in processing large, high-quality datasets and provide accurate predictions by accounting for all relevant variables influencing travel times. Although research has been conducted on developing various basic ML models for travel time prediction, there is a noticeable gap in studies comparing these models to determine the most suitable one for the Sri Lankan context. A Long- Short Term Memory (LSTM) neural network is a deep learning model that is capable of handling long-term dependencies. In the context of bus travel time prediction, LSTMs can leverage historical traffic and travel data to capture temporal patterns and fluctuations that influence travel times. By evaluating LSTMs against basic machine learning models, this study seeks to explore the advantages of applying deep learning techniques to transportation forecasting, ultimately contributing to more accurate and efficient predictive systems in transit planning. The ML models selected in this study include two basic traditional models K- Nearest Neighbours (KNN) and Support Vector Regression (SVR) and four advanced models that utilize ensemble techniques and advanced optimization as Random Forest Regression (RFR), Ada Boost, XG Boost and Gradient Boosting Machine (GBM). The performance of these models was compared with the LSTM model to identify the gap in their accuracies.

Postal traffic and transport face challenges related to the rapid growth of parcel volumes, increasing demands for sustainability, and the need for integration into the smart transportation concept. This study explores the application of machine learning (ML) models for the classification of postal delivery times, with the aim of improving service efficiency and quality. As a case study, the Postal Center Zenica, one of the seven organizational units of the Public Enterprise “BH Pošta” in Bosnia and Herzegovina, was analyzed. The available dataset comprised 11,138 instances, which were cleaned and filtered, then expanded through two iterations of data augmentation using an autoencoder neural network. Five ML models, Random Forest, Support Vector Machine (SVM), Extreme Gradient Boosting (XGBoost), k-Nearest Neighbors (kNN), and Multi-Layer Perceptron (MLP), were developed and compared, with hyperparameters optimized using the Bayesian method and evaluated through standard classification metrics. The results indicate that the data augmentation method significantly improves model performance, particularly in the classification of delayed shipments, with ensemble, especially Random Forest and XGBoost, emerging as the most robust solutions. Beyond contributions in the context of postal traffic and transport, the proposed methodological framework demonstrates interdisciplinary relevance, as it can also be applied in telecommunication traffic classes, where similar network dynamics require reliable predictive models.

This study aimed to utilize various machine learning algorithms to develop a predictive model for the progression of severe community-acquired pneumonia (SCAP) in children to critical severe community-acquired pneumonia (cSCAP). Retrospective analysis of clinical data of SCAP patients admitted to the Department of Pediatric Intensive Care Medicine at the First Affiliated Hospital of Bengbu Medical University from January 2021 to April 2023. Logistic regression (LR) and Least Absolute Shrinkage and Selection Operator (LASSO) were jointly employed to screen model variables. The selected variables were then incorporated into seven algorithms, namely LR, Decision Tree (DT), Random Forest (RF), Extreme Gradient Boosting (XGBoost), Naive Bayes (NB), k-Nearest Neighbor (KNN), and Support Vector Machine (SVM), to establish a predictive model for the progression of SCAP in children to a critically severe stage. The effectiveness of the model was evaluated based on the area under the receiver operating characteristic curve (AUC), accuracy, sensitivity, specificity, positive predictive value, negative predictive value, and F1 score. Finally, the Shapley Additive Explanation (SHAP) algorithm was used to interpret the established machine learning model. A total of 211 patients were included. Red Cell Distribution Width–Coefficient of Variation (RDW-CV), procalcitonin (PCT), blood urea nitrogen (BUN), and lactate dehydrogenase (LDH) were selected as predictors. The XGBoost model outperformed six other algorithms, with an AUC of 0.98 (95% CI,0.93–1.00 ), accuracy 0.89 (95% CI, 0.78–0.94), sensitivity 0.98 (95% CI, 0.95–1.00), and specificity 0.75 (95% CI, 0.45–0.87). SHAP analysis identified PCT, LDH, RDW-CV, and BUN as the most important contributors, supporting their clinical relevance for early risk stratification. This study developed an accurate predictive model for the cSCAP in children using machine learning techniques, providing clinical support for decision-making by clinicians.