Machine Learning Framework for the Methyl Chloride Production Process

Performance evaluation of machine learning techniques in predicting cumulative absolute velocity

It is challenging to predict which patients who meet criteria for subcortical ischemic vascular disease (SIVD) will ultimately progress to subcortical vascular cognitive impairment (SVCI). We collected clinical information, neuropsychological assessments, T1 imaging, diffusion tensor imaging, and resting-state functional magnetic resonance imaging from 83 patients with SVCI and 53 age-matched patients with SIVD without cognitive impairment. We built an unsupervised machine learning model to isolate patients with SVCI. The model was validated using multimodal data from an external cohort comprising 45 patients with SVCI and 32 patients with SIVD without cognitive impairment. The accuracy, sensitivity, and specificity of the unsupervised machine learning model were 86.03%, 79.52%, and 96.23% and 80.52%, 71.11%, and 93.75% for internal and external cohort, respectively. We developed an accurate and accessible clinical tool which requires only data from routine imaging to predict patients at risk of progressing from SIVD to SVCI. Our unsupervised machine learning model provides an accurate and accessible clinical tool to predict patients at risk of progressing from subcortical ischemic vascular disease (SIVD) to subcortical vascular cognitive impairment (SVCI) and requires only data from imaging routinely used during the diagnosis of suspected SVCI. The model yields good accuracy, sensitivity, and specificity and is portable to other cohorts and to clinical practice to distinguish patients with SIVD at risk for progressing to SVCI. The model combines assessment of diffusion tensor imaging and functional magnetic resonance imaging measures in patients with SVCI to analyze whether the "disconnection hypothesis" contributes to functional and structural changes and to the clinical presentation of SVCI.

IntroductionIn swine disease surveillance, obtaining labeled data for supervised learning models can be challenging because many farms lack standardized diagnostic routines and consistent health monitoring systems. Unsupervised learning is particularly suitable in such scenarios because it does not require labeled data, allowing for detecting anomalies without predefined labels. This study evaluates the effectiveness of unsupervised machine learning models in detecting anomalies in productivity indicators in swine breeding herds.MethodsAnomalies, defined as deviations from expected patterns, were identified in indicators such as abortions per 1000 sows, prenatal losses, preweaning mortality, total born, liveborn, culled sows per 1000 sows, and dead sows per 1000 sows. Three unsupervised models - Isolation Forest, Autoencoder, and K-Nearest Neighbors (KNN) - were applied to data from two swine production systems. The herd-week was used as the unit of analysis, and anomaly scores above the 75th percentile were used to flag anomalous weeks. A permutation test assessed differences between anomalous and non-anomalous weeks. Performance was evaluated using F1-score, precision, and recall, with true anomalous weeks defined as those coinciding with reported health challenges, including porcine reproductive and respiratory syndrome (PRRS) and Seneca Valley virus outbreaks. A total of 8,044 weeks were analyzed.ResultsThe models identified 336 anomalous weeks and 1,008 non-anomalous weeks in Production System 1, and 1,675 anomalous weeks and 5,025 non-anomalous weeks in Production System 2. The results from the permutation test revealed significant differences in productivity indicators between anomalous and non-anomalous weeks, especially during PRRS outbreaks, with more subtle changes observed during Seneca Valley virus outbreaks. The models performed well in detecting the PRRSV anomaly, achieving perfect precision (100%) across all models for both production systems. For anomalies like SVV the models showed lower performance compared to PRRSV.DiscussionThese findings suggest that unsupervised machine learning models are promising tools for early disease detection in swine herds, as they can identify anomalies in productivity data that may signal health challenges.

Assessing the quality of groundwater, a primary source of water in many sectors, is of paramount importance. To this end, modeling the geospatial distribution of chemical contaminants in groundwater can be of great utility. Machine learning (ML) models are being increasingly used to overcome the shortcomings of conventional predictive techniques. We report here a systematic review of the nature and utility of various supervised and unsupervised ML models during the past two decades of machine learning groundwater hazard mapping (MLGHM). We identified and reviewed 284 relevant MLGHM journal articles that met our inclusion criteria. Firstly, trend analysis showed (i) an exponential increase in the number of MLGHM studies published between 2004 and 2025, with geographical distribution outlining Iran, India, the US, and China as the countries with the most extensively studied areas; (ii) nitrate as the most studied target, and groundwater chemicals as the most frequently considered category of predictive variables; (iii) that tree-based ML was the most popular model for feature selection; (iv) that supervised ML was far more favored than unsupervised ML (94% vs. 6% of models) with tree-based category—mostly random forest (RF)—as the most popular supervised ML. Secondly, compiling accuracy-based comparisons of ML models from the explored literature revealed that RF, deep learning, and ensembles (mostly meta-model ensembles and boosting ensembles) were frequently reported as the most accurate models. Thirdly, a critical evaluation of MLGHM models in terms of predictive accuracy, along with several other factors such as models’ computational efficiency and predictive power—which have often been overlooked in earlier review studies—resulted in considering the relative merits of commonly used MLGHM models. Accordingly, a flowchart was designed by integrating several MLGHM key criteria (i.e., accuracy, transparency, training speed, number of hyperparameters, intended scale of modeling, and required user’s expertise) to assist in informed model selection, recognising that the weighting of criteria for model selection may vary from problem to problem. Lastly, potential challenges that may arise during different stages of MLGHM efforts are discussed along with ideas for optimizing MLGHM models.

Using AI to Predict Patient's Atypical Prescription Based on Individual's Feature-Set

Machine learning (ML) techniques play a significant role in detecting abnormal link operations in wireless networks. However, during the design and development process of a ML-based model, numerous factors including input data transformation, scaling methods, choice of ML techniques and their associated parametrization, influence the final model performance. In this paper, we discuss the design and development process of wireless link anomaly detection models followed by the model ranking process for selecting the most suitable models given the required application criteria. Under this premise, we consider four different data representations, four anomaly types, six scaling methods and six distinct ML techniques along with their associated parametrization trials leading to over twenty thousand anomaly detection models for wireless links. We show that the most suitable supervised ML models are able to detect anomalies with an F1 score of at least 88% and up to perfect score, whereas unsupervised ML models can attain an F1 score of up to 96% depending on the anomaly type, and on average, amongst 20,352 available models, the supervised SVM model can be readily adopted to efficiently detect any type of anomaly with an F1 score of at least 94%, particularly when trained on encoded data representations using the combination of "mean and deviation scaling" and "non-linear RBF kernel".

BackgroundPhysical activity (PA) level is associated with multiple health benefits during early childhood. However, inconsistency in the methods for quantification of PA levels among preschoolers remains a problem.ObjectiveThis study aimed to develop PA intensity cut points for wrist-worn accelerometers by using machine learning (ML) approaches to assess PA in preschoolers.MethodsWrist- and hip-derived acceleration data were collected simultaneously from 34 preschoolers on 3 consecutive preschool days. Two supervised ML models, receiver operating characteristic curve (ROC) and ordinal logistic regression (OLR), and one unsupervised ML model, k-means cluster analysis, were applied to establish wrist-worn accelerometer vector magnitude (VM) cut points to classify accelerometer counts into sedentary behavior, light PA (LPA), moderate PA (MPA), and vigorous PA (VPA). Physical activity intensity levels identified by hip-worn accelerometer VM cut points were used as reference to train the supervised ML models. Vector magnitude counts were classified by intensity based on three newly established wrist methods and the hip reference to examine classification accuracy. Daily estimates of PA were compared to the hip-reference criterion.ResultsIn total, 3600 epochs with matched hip- and wrist-worn accelerometer VM counts were analyzed. All ML approaches performed differently on developing PA intensity cut points for wrist-worn accelerometers. Among the three ML models, k-means cluster analysis derived the following cut points: ≤2556 counts per minute (cpm) for sedentary behavior, 2557-7064 cpm for LPA, 7065-14532 cpm for MPA, and ≥14533 cpm for VPA; in addition, k-means cluster analysis had the highest classification accuracy, with more than 70% of the total epochs being classified into the correct PA categories, as examined by the hip reference. Additionally, k-means cut points exhibited the most accurate estimates on sedentary behavior, LPA, and VPA as the hip reference. None of the three wrist methods were able to accurately assess MPA.ConclusionsThis study demonstrates the potential of ML approaches in establishing cut points for wrist-worn accelerometers to assess PA in preschoolers. However, the findings from this study warrant additional validation studies.

A continuous supply of electricity is necessary to maintain an acceptable standard of life, and the power distribution system's overhead line components play a crucial role in this matter. In Pakistan, identifying defective parts often necessitates human involvement. An unmanned aerial vehicle was used to gather a collection of 10,343 photos to automate this procedure. Using supervised and unsupervised machine learning methods, a number of automated anomaly detection systems were created. Support vector machine, random forest, VGG16, and ResNet50 were used as supervised machine learning models, and a convolutional auto‐encoder was used as the unsupervised machine learning model. VGG16 achieved the best accuracy of 99.00% while random forest achieved the worst accuracy of 72.49%. The convolutional auto‐encoder was successful in distinguishing between normal and abnormal components. The aforementioned machine learning models can be put on unmanned aerial vehicles to immediately identify defective parts.

Federated learning is a collaborative and distributed machine learning model that addresses the privacy issues in centralized machine learning models. It emerges as a promising technique that addresses the data sharing concerns for data-private multi-institutional collaborations. However, most existing federated learning systems deal with centralized coordinators and are vulnerable to attacks and privacy breaches. We propose a blockchain-empowered coordinator-less decentralized, federated learning platform “Rahasak-ML” to solve issues in centralized coordinator-based federated learning systems by providing better transparency and trust. It uses an incremental learning approach to train the model by multiple peers in the blockchain network. Rahasak-ML is integrated into the Rahasak blockchain as its data analytics and machine learning platform. Each peer in the blockchain can establish supervised or unsupervised machine learning models with the existing data on its own off-chain storage. Once a peer generates a model, it can be incrementally/continuously trained and aggregated by other peers through the blockchain using the federated learning approach without requiring a centralized coordinator. The model parameters sharing, local model generation, incremental model training, and model sharing functions are implemented in the Rahasak-ML platform. We discussed the promise of Rahasak-ML machine learning in medicine.KeywordsFederated learningBlockchainMedicineDrug discoveryBig data

Morphotype stratification of radix entomolaris in mandibular molars

This research examines passion and self-efficacy through experience and knowledge, as motivational factors that support entrepreneurs within the gig economy (GE). It sheds light on entrepreneurs’ sources of passion in the GE literature. The sample is composed of all the 1164 entrepreneurship activities offered worldwide through Airbnb, Tour by Locals, and Withlocals on 5 May 2022. The study is supported by unsupervised machine learning models and seeks to find latent topics emerging from the analysis of the entrepreneurs’ descriptions and exposes the main correlated clustered dimensions. There are six main motivators behind GE platforms as a first step toward entrepreneurship: Experience, Passion for share, Knowledge, Classic traditions, Empowered community and local activities, and Well-being. It also confirms the correlation between passion and self-efficacy through experience, pointing them as main factors behind entrepreneurship in the GE. Five of the six sources of passion previously pointed by theory were found: Passion for growth, for people, for product/service, for innovation and for social mission. This study discloses self-efficacy and the sources of passion and points directions to practitioners involved in entrepreneurial activities in the GE ecosystem. This work used machine learning models to access quantitatively a paradigm that is inductive by nature. The results point to well-being as a significant factor to be addressed in future research regarding entrepreneurship. This research only studies individuals involved in the GE; as such, further studies should cohort new populations from different fields.

The complexity of the Internet and the volume of network traffic have dramatically increased in the last few years, making it more challenging to design scalable Network Traffic Monitoring and Analysis (NTMA) systems. Critical NTMA applications such as the detection of network attacks and anomalies require fast mechanisms for on-line analysis of thousands of events per second, as well as efficient techniques for off-line analysis of massive historical data. The high-dimensionality of network data provided by current network monitoring systems opens the door to the massive application of machine learning approaches to improve the detection and classification of network attacks and anomalies, but this higher dimensionality comes with an extra data processing overhead. In this paper we present Big-DAMA, a big data analytics framework (BDAF) for NTMA applications. Big-DAMA is a flexible BDAF, capable to analyze and store big amounts of both structured and unstructured heterogeneous data sources, with both stream and batch processing capabilities. Big-DAMA uses off-the-shelf big data storage and processing engines to offer both stream data processing and batch processing capabilities, decomposing separate engines for stream, batch and query, following a Data Stream Warehouse (DSW) paradigm. Big-DAMA implements several algorithms for anomaly detection and network security using supervised and unsupervised machine learning (ML) models, using off-the-shelf ML libraries. We apply Big-DAMA to the detection of different types of network attacks and anomalies, benchmarking multiple supervised ML models. Evaluations are conducted on top of real network measurements collected at the WIDE backbone network, using the well-known MAWILab dataset for attacks labeling. Big-DAMA can speed up computations by a factor of 10 when compared to a standard Apache Spark cluster, and can be easily deployed in cloud environments, using hardware virtualization technology.

Background: Although transplantation of patch-shaped autologous skeletal muscle-derived cells has been introduced to ischemic cardiomyopathy (ICM) or non-ICM patients, we found responders or non-responders to this treatment exist and how to predict the responsiveness to this treatment is crucial for the improvement of the effectiveness. In this study, we revealed the clinical features associated with the responders using a machine learning based-model, which was discriminated between the responder and the non-responders in this treatment. Methods and Results: We used the retrospective databases of 23 ICM patients and 23 non-ICM patients undergoing autologous myoblast patch transplantation to develop machine learning models to discriminate 3-year VAD free survival. Sixty-nine pre-transplantation clinical futures were selected to train the models. In ICM models, there were 4 VADs or deaths, and in non-ICM models, there were 10 VADs or deaths during the 3-year follow-up periods. Using these databases, we trained multiple machine learning models and evaluated the models with the leave-one-out method. In ICM, k nearest neighbor demonstrated the best performance, showing the accuracy was 95.7%, and the AUC was 0.95. The features associated with 3-year VAD free survival in ICM were NYHA classification, cardiac index, and left ventricular ejection fraction. In non-ICM, k nearest neighbor demonstrated the best performance among the trained classifiers, demonstrating the accuracy was 95.7%, and the AUC was 0.93. The features associated with 3-year VAD free survival in non-ICM were pulmonary capillary wedge pressure, pulmonary vascular resistance, and albumin. Conclusion: We found the features associated with 3-year VAD free survival in autologous myoblast patch transplantation in ICM and non-ICM. Focusing on these features may facilitate optimal candidate selection in ICM and non-ICM for regenerative therapy.

The main contribution of this paper is to introduce a framework for integrating Machine Learning (ML), Human, and Virtual Reality (VR) into one platform to promote a collaborative visualisation environment that can assist in better analysis and improve the human-machine teaming capability. This platform was demonstrated using a case study in ana-lysing road traffic conditions. The ‘Ab-normal Machine Learning Road Traffic Detection in VR (AbnMLRTD-VR)’ prototype system was developed to assist the human analyst. The proposed system has two main integrative components: a data-driven ML model and a 3D real-time visualisation in a VR environment. An unsupervised ML model was built using real traffic data. The AbnMLRTD-VR system highlights the outliers in the road sections in actual road contexts of a road traffic network. This gives the human analyst a 3D real-time immersive visualisation in a VR environment to evaluate road conditions. The AbnMLRTD-VR system demonstrated that it could help minimise the need for human pre-labelling of the data. It enables the visualisation of the road traffic conditions more meaningfully and to understand the context of the road traffic conditions of road sections at any given time.

Artificial intelligence has become ubiquitous. Machine learning, a branch of artificial intelligence, leads the current technological revolution through its remarkable ability to learn and perform on data sets of varying types. Machine learning applications are expected to change contemporary medicine as they are brought into mainstream clinical practice. In the field of cardiac arrhythmia and electrophysiology, machine learning applications have enjoyed rapid growth and popularity. To facilitate clinical acceptance of these methodologies, it is important to promote general knowledge of machine learning in the wider community and continue to highlight the areas of successful application. The authors present a primer to provide an overview of common supervised (least squares, support vector machine, neural networks and random forest) and unsupervised (k-means and principal component analysis) machine learning models. The authors also provide explanations as to how and why the specific machine learning models have been used in arrhythmia and electrophysiology studies.