- News Article
1
- 10.1016/s0140-6736(14)61660-3
US President's science panel advises on antibiotic resistance
- Sep 01, 2014
- The Lancet
- Susan Jaffe
US President's science panel advises on antibiotic resistance
Renowned chemist, respected leader, and inspiring mentor
US President's science panel advises on antibiotic resistance
US President's science panel advises on antibiotic resistance
Contributors
Contributors
From the chair
Happy New Year! I hope 2009 brings us all health, happiness, and prosperity! "The Eighth Annual ACM-SIGMIS Reception," held at the International Conference on Information Systems (ICIS2008) in Paris, France was a delightful and successful networking event. Thanks to everyone who attended for encouraging guests to join SIGMIS! Next year's reception is planned for Saturday, December 14, 2009, from 5:30 -- 7:00pm, prior to ICIS2009 to be held in Phoenix, Arizona USA, December 15-18, 2009. Please plan on attending our forthcoming: Conference: ACM-SIGMIS CPR (Computer Personnel Research) 2009 Conference and Doctoral Student Consortiumd Theme: "New Concepts and Practices in Preparing, Recruiting, and Retaining IS Professionals in the Global Context" When: May 28-30, 2009 (Doctoral Consortium: May 28, 2009) Where: University of Limerick Campus, Limerick, Ireland URL: http://www.sigmis.org/CPR_2009_Home_Page.htm. For more information regarding ACM-SIGMIS CPR2009, please contact the Conference Co-Chairs: Norah Power, University of Limerick, norah.power@ul.ie Kate Kaiser, Marquette University, kate.kaiser@mu.edu. For information regarding the Doctoral Consortium, please contact the Doctoral Consortium Co-Chairs: Deb Armstrong, Florida State University, djarmstrong@cob.fsu.edu Cindy Riemenschneider, University of Arkansas, cindy_riemenschneider@baylor.edu. The refereed conference proceedings will be published by ACM and distributed at the conference. Additionally, an award for best doctoral consortium paper will be presented. We invite you to consider hosting a future SIGMIS CPR (Computer Personnel Research) Conference. Those interested should email Conrad Shayo at cshayo@csusb.edu) or me at janice.sipior@villanova.edu. Our astute Data Base editorial team, including Editor-in-Chief Tom Stafford, University of Memphis; Global Co-Editor Patrick Y.K. Chau, The University of Hong Kong; Managing Editor Colleen Schwarz, Louisiana State University; and Technical Editor Loel Kim, University of Memphis, has been doing an excellent job in maintaining the high quality and furthering the respected reputation of this quarterly ref-ereed publication. I invite you to send your best research to Data Base at: http://the-database.org. Finally, I encourage you to vote in the 2009 SIGMIS elections this spring. I would like to thank Deb Armstrong, Florida State University, for serving as Chair of the Nominating Committee. The elections will be conducted electronically. Watch for the election announcement and visit the electronic voting site to review biographical information of candidates and cast your vote. Thanks for your continued support of SIGMIS. Your participation, comments, and suggestions are always welcome. We look forward to seeing you at SIGMIS CPR'09 in Limerick!
Read moreCurrent technological trends & advancements in vector purification
Elisa Manzotti speaks to Ying Cai, Nathalie Clement, Chantelle Gaskin, Matt Roach & Ashish Saksule. Ying Cai is the Sr. Director of Process Development at Ultragenyx Pharmaceutical. She heads AAV downstream process development and formulation development functions, also a CMC lead of AAV clinical programs. Prior to joining Ultragenyx, Ying worked at Sanofi, Biogen, Merck, and a few CDMOs. Ying has over 20 years’ experience in the development, validation, manufacturing and commercialization of different modalities including AAV, plasmid DNA, oligonucleotides, antibodies, antibody conjugates, and fusion proteins. Ying holds a Ph.D. in Chemical Engineering from the University of Arkansas at Fayetteville and a B.S. in Biochemical Engineering from Zhejiang University in China. Nathalie Clement has more than 25 years of experience in the field of Gene Therapy, with a strong expertise in viral vectors, specifically adeno-associated vectors, in the academic and industry settings. Her research focus has strongly been focused on optimizing processes to support large-scale production of high quality rAAV stocks and their implementation into the GMP settings. During her thesis work at the University Libre of Brussels, Belgium, she developed new recombinant viruses derived from the parvovirus Minute Virus of Mice (MVM) for cancer-selective gene therapy treatments. She then joined Dr. Michael Linden’s laboratory at Mount Sinai School of Medicine, New York, where she developed novel recombinant AAV vectors and directed the AAV Vector Core. She next joined the Powell Gene Therapy Center in 2008 as the Associate Director to supervise AAV production and testing at research, preclinical and clinical grades. She led the Process and Development Group and the Quality Control group responsible for the production and release of all AAV pre-clinical and clinical lots. During her time at UF she oversaw manufacturing, release and stability campaigns of more than 7 AAV INDs from start to finish, including CMC preparations and interactions with FDA. More recently, she spent several months at Resilience, Alachua, Florida, as the Director of Process and Development of the Viral Vaccines and Gene Therapy franchises. IN that role she oversaw viral vaccine and AAV production scales up to 200L in suspension format and in the icellis 500 platform for adherent platforms of a variety of viruses and AAV vectors. Currently Nathalie is taking a break before starting a new adventure in 2022. Chantelle Gaskin is a Field Applications Scientist, specializing in protein and viral vector purification and downstream process development. She held leadership positions at Applied Genetic Technology Corporation and Brammer Bio, prior to joining the Thermo Fisher Scientific Bioproduction Division in 2020. With over 10 years of experience in gene therapy, Chantelle has accumulated comprehensive knowledge of standard industry practices and regulatory standards, applying this knowledge to advance development of therapies for a variety of indications including ocular, CNS and systemic disease. Chantelle holds a Master’s degree in Chemistry from University of Florida and a Bachelor’s in Chemistry from Smith College. Matt Roach leads the AAV Process Development group at Precision BioSciences, which is focused on designing and implementing new strategies for the production and purification of adeno-associated virus. Matt completed his Bachelor’s degree in Biological Sciences at North Carolina State University and his Master’s degree in Microbiology and Cell Science at the University of Florida. Prior to Precision, Matt spent time at Pfizer working on the purification of AAV and the Biomanufacturing Training and Education Center training industry professionals on downstream bioprocessing operations. Ashish Saksule is the Cell and Gene Therapy process development lead and technical expert on bioprocessing platforms for viral vectors (Lentivirus and Adeno-associated virus vector) and non-viral vectors with more than 7 years of experience. Ashish has graduate degree in Chemical Engineering from Michigan Tech University, and Biotechnology graduate degree from Harvard University. His experience spans research & drug development, clinical stage and CRO/CMO settings. Ashish is currently working at Takeda within Global Gene Therapy and have previously worked at MilliporeSigma and Miltenyi Biotec.
Read moreInfluence of Placement on Response of Crops to Calcium Phosphates1
Agronomy JournalVolume 39, Issue 10 p. 859-868 Article Influence of Placement on Response of Crops to Calcium Phosphates1 C. W. Whittaker, C. W. Whittaker Chemist, formerly Senior Chemist (present address, Lakeland, Florida) and Associate Chemist, respectively, Bureau of Plant Industry, Soils, and Agricultural Engineering.Search for more papers by this authorD. G. Coe, D. G. Coe Chemist, formerly Senior Chemist (present address, Lakeland, Florida) and Associate Chemist, respectively, Bureau of Plant Industry, Soils, and Agricultural Engineering.Search for more papers by this authorR. P. Bartholomew, R. P. Bartholomew Formerly Professor of Agronomy and Head of Department, now Associate Director, University of Arkansas, College of Agriculture and Agricultural Experiment Stations, Fayetteville, Ark.Search for more papers by this authorG. W. Volk, G. W. Volk Formerly Associate Professor and Associate Soil Chemist of the Schools of Agriculture and the Agricultural Experiment Station of the Alabama Polytechnic Institute, Auburn, Ala., now Chief of the Department of Agronomy at the Ohio Agricultural Experiment Station, Wooster, Ohio, and Chairman of the Department of Agronomy at Ohio State University.Search for more papers by this authorL. F. Rader Jr., L. F. Rader Jr. Chemist, formerly Senior Chemist (present address, Lakeland, Florida) and Associate Chemist, respectively, Bureau of Plant Industry, Soils, and Agricultural Engineering.Search for more papers by this author C. W. Whittaker, C. W. Whittaker Chemist, formerly Senior Chemist (present address, Lakeland, Florida) and Associate Chemist, respectively, Bureau of Plant Industry, Soils, and Agricultural Engineering.Search for more papers by this authorD. G. Coe, D. G. Coe Chemist, formerly Senior Chemist (present address, Lakeland, Florida) and Associate Chemist, respectively, Bureau of Plant Industry, Soils, and Agricultural Engineering.Search for more papers by this authorR. P. Bartholomew, R. P. Bartholomew Formerly Professor of Agronomy and Head of Department, now Associate Director, University of Arkansas, College of Agriculture and Agricultural Experiment Stations, Fayetteville, Ark.Search for more papers by this authorG. W. Volk, G. W. Volk Formerly Associate Professor and Associate Soil Chemist of the Schools of Agriculture and the Agricultural Experiment Station of the Alabama Polytechnic Institute, Auburn, Ala., now Chief of the Department of Agronomy at the Ohio Agricultural Experiment Station, Wooster, Ohio, and Chairman of the Department of Agronomy at Ohio State University.Search for more papers by this authorL. F. Rader Jr., L. F. Rader Jr. Chemist, formerly Senior Chemist (present address, Lakeland, Florida) and Associate Chemist, respectively, Bureau of Plant Industry, Soils, and Agricultural Engineering.Search for more papers by this author First published: 01 October 1947 https://doi.org/10.2134/agronj1947.00021962003900100002xCitations: 1 1 Contribution from the Division of Soils, Fertilizers, and Irrigation, Bureau of Plant Industry, Soils, and Agricultural Engineering, Agricultural Research Administration, U. S. Dept. of Agriculture, Beltsville, Md., in cooperation with the Alabama and Arkansas experiment stations. Part of this material was presented as Paper No. 6, of the Division of Fertilizer Chemistry of the American Chemical Society, Chicago, September 9, 1946. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Citing Literature Volume39, Issue10October 1947Pages 859-868 RelatedInformation
Read moreTeam‐based Learning in Gross Anatomy Improves Academic Performance and Perceptions of Teamwork
As healthcare becomes more interdisciplinary in patient care, it is essential for students to master group problem solving and develop an appreciation for team collaboration. Team‐based learning (TBL) is a student centered teaching method that fosters high‐level cognitive learning and collaborative group dynamics. The study objective was to determine the effect of TBL in a gross anatomy laboratory on academic performance, quality of learning in team interactions, and student perceptions of teamwork.Subjects were Doctor of Physical Therapy students at the University of Central Arkansas from 2010‐2013. The comparison group (n=102) received a traditional cadaveric gross anatomy lab. The experimental group (n=109) received a TBL hybrid approach wherein students alternated between traditional cadaveric dissections and TBL learning modules. We compared examination scores, overall course grades and survey data between groups.The experimental group scored significantly higher on 3 of 4 written exams (p=0.014, p=0.015, p=0.001) and the overall course average (p=0.048). All students had positive attitudes towards the TBL method. The experimental group significantly rated perceptions of collaborating with peers as both positive (p<0.000) and necessary (p<0.000) and felt problem solving in a group was effective for learning (p<0.000). Also, the experimental group experienced growth throughout the course, improving their perceptions of teamwork as necessary for student success (p<0.000).Our results support the implementation of TBL in the gross anatomy lab as an effective method for improving academic performance and developing positive attitudes toward interprofessional communication and teamwork.
Read moreUsing a Mock Course to Teach Nurse Educator Students How to Build a Course for Online Delivery.
By Laura C. Hall, DNP, RN, CNL-BC, School of Nursing, University of Central Arkansas, Conway, [email protected].
Pandemic Pivoting: The Use of Home Wi-Fi Accounts and Fast-Food Parking Lots for Teachers’ Internet Connectivity
Click to increase image sizeClick to decrease image size Additional informationNotes on contributorsTrina HarlowTrina Harlow, Assistant Professor of Art Education, Department of Art and Design, University of Central Arkansas in Conway; Adjunct Faculty, University of North Texas in Denton. Email: drtrinaharlow@gmail.com. Website: https://www.onlineartteachers.comYang YangYang Yang, Associate Professor, Department of Special Education, Counseling and Student Affairs, College of Education, Kansas State University in Manhattan. Email: yyang001@k-state.eduSarah AckermannSarah Ackermann, Executive Director for Teaching Innovation, Division of Online and Strategic Learning, Ball State University in Muncie, Indiana. Email: sarahcress@gmail.comBeth DobbersteinBeth Dobberstein, Doctoral Student, University of Wisconsin in Milwaukee. Email: bethel@uwm.eduBob ReekerBob Reeker, K–5 Visual Art Specialist & Interventionist, Robinson Elementary School in Lincoln, Nebraska. Email: bobreeker@gmail.comTim NeedlesTim Needles, Art Teacher/Technology Integration Specialist, Smithtown School District in Smithtown, New York; Adjunct Professor, Five Towns College in Dix Hills, New York. Email: needlesart@gmail.com
Read moreFaculty and student perceptions of outstanding university teachers in the USA and Russia
The majority of research that relates teacher characteristics to student learning in the university has come from Western universities. Using various methodologies, research continues to examine the characteristics of outstanding university teachers. Much of that research in the USA assesses faculty and student perspectives. However, there are nearly no cross‐cultural comparisons on this issue. We examined faculty and student perspectives about outstanding university teachers in the USA and in Russia. Faculty members and students at the University of Central Arkansas, Orel State University and Moscow City University rated the qualities of outstanding teachers on the Teacher Behaviors Checklist (TBC). Results showed significant positive correlations for the relative importance of teacher characteristics across the six participant groups. There did not appear to be any substantial differences between the American and Russian counterparts for 21 of the 28 specific teacher characteristics. The comparison of American and Russian faculty and students suggests more universality than cross‐cultural differences in the characteristics of outstanding university teachers.
Read moreHistorically Black Colleges and Universities Can Promote Leadership and Excellence in STEM (Editor’s Commentary)
In 2012, President Barack Obama introduced a plan to increase the number of science, technology, engineering and math (STEM) graduates by 1 million over the next 10 years through the President's Council of Advisors on Science and Technology initiative (Seadler, 2012). Historically Black colleges and universities (HBCUs) play a pivotal role in helping the United States of America achieve a national priority to expand careers in STEM disciplines. HBCUs graduate 40 percent of Black students graduating with degrees in biological science, physics, chemistry, astronomy, environment sciences and mathematics (Jackson, 2013; Owens et al., 2012; Palmer, Davis, & Thompson, 2010).The purpose of this article is to elucidate factors that are important to the long-term success of HBCUs in preparing STEM students, by summarizes data from the Minority Male STEM Initiative (MMSI), which was collected by The Association of Public and Land-grant Universities (APLU). Although the surveys focused on the needs of minority males, both male and female STEM students participated in the surveys. The purpose of the MMSI surveys were to understand how university administrators, STEM faculty, and students of color in STEM disciplines currently navigate the path to recruiting, retaining and graduating underrepresented students in STEM disciplines.The original study focused on STEM students from 1,442 underrepresented students across 14 institutions, including 3 HBCUs. However, this report will outline findings that are relevant to HBCUs. Details of the survey instruments, procedures, methods of recruitment, and participants are available in A Quest for Excellence (Toldson & Esters, 2012). Survey results revealed a variety of characteristics and practices of the institutions, faculty, and administrators who prepare minority students for STEM fields.Lesson Learned from STEM Faculty and University AdministratorsContent analysis methods were used to summarize faculty members' and administrators' optional open-ended comments regarding their universities' commitment to recruiting, retaining and graduating minority students in STEM fields. The number of unique comments made about university practices were identified and then manually sorted into three broad categories: proactive practices, ambivalence or indifference, and obstructive practices. SPSS Text Analysis for Surveys was used to facilitate manual coding and sorting of the comments into more discrete categories.Recruitment and OutreachFaculty and administrators were asked to describe any recruitment or outreach activities by their institution specifically designed to encourage underrepresented students to consider a major and career in the STEM disciplines. Of the more than 200 faculty members and administrators who took the survey, only 33 provided a response to this inquiry.Institutions with proactive practices were able to list specific programs and initiatives that bolstered outreach efforts. Specific programs listed included the National Science Foundation (NSF) Bridge to the Doctorate Program, Alliance for Minority Participation (AMP), Upward Bound, and university-initiated minority programs. Many other university representatives gave statements that reiterated their commitment, which listed specific programs. Several respondents noted that they were not aware of any university initiatives to recruit students of color in STEM disciplines. Key terms included scholarships, mentors, faculty, community, research experiences, and learning community.Evaluating SuccessFaculty and administrators were asked how their institution evaluates the success of its efforts to attract, recruit, retain, and graduate students of color in STEM fields. In total, 43 participating faculty members and administrators responded to the inquiry. Most of the respondents who indicated that they have a formal evaluation process were mandated to collect data to maintain external funding. …
Read moreAbout the Authors
About the Authors
Mycobacterial Glycophosphoinositides: the Work of Clinton E. Ballou
Biosynthesis of Mannophosphoinositides by Mycobacterium phlei. The Family of Dimannophosphoinositides(Brennan, P., and Ballou, C. E. (1967) J. Biol. Chem. 242, 3046–3056)Biosynthesis of Mannophosphoinositides by Mycobacterium phlei. Enzymatic Acylation of the Dimannophosphoinositides(Brennan, P., and Ballou, C. E. (1968) J. Biol. Chem. 243, 2975–2984) Biosynthesis of Mannophosphoinositides by Mycobacterium phlei. The Family of Dimannophosphoinositides (Brennan, P., and Ballou, C. E. (1967) J. Biol. Chem. 242, 3046–3056) Biosynthesis of Mannophosphoinositides by Mycobacterium phlei. Enzymatic Acylation of the Dimannophosphoinositides (Brennan, P., and Ballou, C. E. (1968) J. Biol. Chem. 243, 2975–2984) Clinton Edward Edgerton Ballou was born in King Hill, Idaho in 1923. After graduating from high school, he enrolled in a premed program at Boise Junior College, but his interests quickly turned to chemistry after he dissected a poorly embalmed cat in a comparative anatomy course. After 2 years at Boise, Ballou pursued a degree in chemistry at Oregon State College in Corvallis where he became involved in two research projects: the first during his junior year synthesizing new antimalarial drugs with Bert Christensen, and the second during his senior year studying the guinea pig “antistiffness factor” with Willem van Wagtendonk. The military draft was in effect as Ballou entered his last year of college so he decided to join the U. S. Navy after graduating in 1944. He was discharged 2 years later and decided to apply for graduate study in biochemistry with Karl Paul Link at the University of Wisconsin-Madison. As detailed in a previous Journal of Biological Chemistry (JBC) Classic (1JBC Classics: Campbell H.A. Link K.P. J. Biol. Chem. 1941; 138 (Stahmann, M. A., Huebner, C. F., and Link, K. P. (1941) J. Biol. Chem.138, 513–527; Overman, R. S., Stahmann, M. A., Huebner, C. F., Sullivan, W. R., Spero, L., Doherty, D. G., Ikawa, M., Graf, L., Roseman, S., and Link, K. P. (1944) J. Biol. Chem.153, 5–24 (http://www.jbc.org/cgi/content/full/280/8/e5)): 21-33Abstract Full Text PDF Google Scholar), Link's research centered on blood anticoagulants, and when Ballou arrived in his laboratory in 1946, the primary focus was the structure-function relationship of coumarin anticoagulants. Ballou was immediately intrigued when he learned of a failed attempt to synthesize the glucoside of dicumarol because the acetylated intermediate was degraded in the alkali conditions used for deacetylation. Because glycosides are acetals, which are typically acid-labile and alkali-stable, Ballou decided to study a variety of synthetic compounds to try to understand the structural basis for alkali sensitivity. This research formed the core of his doctoral dissertation, and his exposure to carbohydrate chemistry influenced the direction of his career. After earning his Ph.D. in 1950, Ballou did a year-long postdoctoral fellowship with E. L. Hirst in the Department of Chemistry at the University of Edinburgh. There he studied the structure of maple sapwood starch. At the end of the year, Ballou returned to the U. S. to work with Hermann O. L. Fischer (the son of Nobel laureate Hermann Emil Fischer) at the University of California, Berkeley. Ballou explained his choice: “I was attracted to Fischer in part because of his research on phosphorylated sugars but also because during graduate school I had drawn heavily on the published works of his father, Emil Fischer. I guess the idea of being associated with the son of Emil Fischer just seemed ‘real cool’ to me” (2Ballou C.E. My brief encounter with the phosphoinositides and IP3..J. Biol. Chem. 2004; 279: 54975-54982Abstract Full Text Full Text PDF PubMed Scopus (2) Google Scholar). The 1950s was a time of active research on biosynthetic pathways involving short chain phosphorylated sugars, and collaborating with Fischer and Donald MacDonald, Ballou undertook the syntheses of several such metabolic intermediates, including d-glyceric acid 2-phosphate, d-glyceraldehyde 3-phosphate, dihydroxyacetone phosphate, hydroxypyruvic acid 3-phosphate, and d-erythrose 4-phosphate. He also became interested in inositol chemistry as a result of studies on the cyclitols in sugar pine heartwood. In 1955, Ballou was appointed to the biochemistry faculty at Berkeley and went about setting up an independent research program. He decided to work on inositol-containing phospholipids and was able to synthesize and characterize d-myoinositol 1-phosphate. He also spent several years isolating and characterizing myoinositol polyphosphates from beef brain phosphoinositide. This culminated in his discovery of d-myoinositol l,4,5-trisphosphate or IP3. More information on Ballou's studies of these phosphoinositides can be found in his JBC Reflections (2Ballou C.E. My brief encounter with the phosphoinositides and IP3..J. Biol. Chem. 2004; 279: 54975-54982Abstract Full Text Full Text PDF PubMed Scopus (2) Google Scholar). Ballou became eligible for sabbatical leave in 1961 and decided to spend a year at the National Center for Scientific Research (CNRS) in France studying the glycophosphoinositides of mycobacteria with Edgar Lederer. There he collaborated with Erna Vilkas on experiments to establish the linkages of both the phosphatidyl and the mannosyl groups to the myoinositol ring (3Ballou C.E. Vilkas E. Lederer E. Structural studies on the myo-inositol phospholipids of Mycobacterium tuberculosis (var. bovis, strain BCG)..J. Biol. Chem. 1963; 238: 69-76Abstract Full Text PDF PubMed Google Scholar). Upon his return to Berkeley, Ballou and Yuan Chuan Lee determined the structures of the family of mannosyl phosphoinositides in Mycobacterium smegmatis (4Lee Y.C. Ballou C.E. Structural studies on the myo-inositol mannosides from the glycolipids of Mycobacterium tuberculosisMycobacterium phlei..J. Biol. Chem. 1964; 239: 1316-1327Abstract Full Text PDF PubMed Google Scholar, 5Ballou C.E. Lee Y.C. The structure of myoinositol mannoside from Mycobacterium tuberculosis glycolipid..Biochemistry. 1964; 3: 682-685Crossref PubMed Scopus (28) Google Scholar, 6Lee Y.C. Ballou C.E. Complete structures of the glycophospholipids of mycobacteria..Biochemistry. 1965; 4: 1395-1404Crossref PubMed Scopus (85) Google Scholar). Ballou and his postdoctoral fellow Patrick Brennan then began to look at the biosynthesis of the intact dimannophosphoinositides on Mycobacterium phlei, which is the subject of the two JBC Classics reprinted here. In the first Classic, Ballou and Brennan used subcellular fractions of M. phlei to catalyze the biosynthesis of several mannosyl derivatives of phosphatidylmyoinositol and reported that the major products are a family of three dimannophosphoinositides (A, B, and C) that differ in the number of fatty acyl groups they contain (four, three, and two, respectively). On the basis of their results, they proposed that guanosine diphosphate mannose acts as the sugar donor in the conversion of phosphatidylmyoinositol to phosphatidylmyoinositol dimannoside (dimannophosphoinositide C), which is then acylated in a two-step process to first yield dimannophosphoinositide B and then dimannophosphoinositide A. In the second JBC Classic, Ballou and Brennan provide further evidence for their proposed biosynthesis scheme by using an enzyme from M. phlei to specifically incorporate labeled fatty acids into the dimannophosphoinositides. They showed that label from [14C]palmityl-CoA is incorporated into dimannophosphoinositide C to yield dimannophosphoinositide B. After a short incubation period, this molecule is converted to dimannophosphoinositide A, but with longer incubation periods the product is deacylated to isomeric forms of dimannophosphoinositides B and C. Brennan continued to work on these glycophosphoinositides after completing his postdoctoral fellowship with Ballou and eventually showed that the lipoglycans (lipomannan (LM) and lipoarabinomannan (LAM)) were multiglycosylated extensions of Ballou's phosphatidylinositol mannosides and are very important in the pathogenesis of tuberculosis and leprosy. More recent research has defined the biochemistry and genetics of synthesis of these molecules. Brennan is currently University Distinguished Professor in the Department of Microbiology, Immunology, and Pathology at Colorado State University. He served on the editorial board of the Journal of Biological Chemistry for several years and was also named Colorado State University Researcher of the Year in 1992. In 1991, Ballou became Professor Emeritus of Biochemistry at the University of California, Berkeley, although he continued research and teaching for a few years. In recognition of his contributions to science, Ballou has received many awards and honors including election to the National Academy of Sciences (1975), the American Chemical Society's Claude Hudson Award in Carbohydrate Chemistry (1981), the Welch Foundation Lectureship (1972), the University of Notre Dame Reilly Lectureship (1976), the Duke University Belfort Lectureship (1977), a National Science Foundation Senior Fellowship (1961), and a University of California Berkeley Citation (1992). Ballou also served as an editorial board member for the Journal of Biological Chemistry.
Read moreA word from the editor
Welcome to the third issue of the ACM Computers in Entertainment magazine! In this exciting issue we present eight articles on a diversity of entertainment technology topics including Internet movie piracy, performing arts, animatronics, robotics, music, games, and interactive television. To get started, the Interviews section features video interviews with our distinguished advisory board members Leonard Kleinrock and Richard Edlund. Leonard talks about nomadic computing, embedded technology, smart spaces, ubiquitous computing, ethics, the roles of the government, and the future of the Internet. Richard speaks of movie visual effects, digital cinema, digital cameras, and technical Oscars. In the Movies and Performing Arts section, Sai Ho Kwok investigates the file-sharing patterns of pirated movies over BitTorrent peer-to-peer networks and offers suggestions on the design of an anti-piracy strategy. W. Scott Meador et al. describe an experimental dance performance featuring live-motion capture, real-time computer graphics, and multi-image projection produced by a cross-departmental team of faculty and students at Purdue University. In the Animatronics and Robotics section, Ray Dominey et al. discuss their integrated technology for raising the level of interactivity and realistic animatronics in amusement park dark rides. John D. Decuir et al. detail their use of Sonys AIBO entertainment robots to improve young childrens reading comprehension in a classroom setting. In the Music and Games section, Magy Seif El-Nasr et al. present a real-time lighting design to automatically adjust lighting in an interactive scene where the camera and character movements are unpredictable. Myriam Desainte-Catherine et al. examine their research on early-learning games using a joystick as a Dolabip instrument for electro-acoustic music education in schools. In the Synopsis - Books and Software section, Eddie Schwalb introduces the technologies, standards, and business issues for interactive television (iTV). Doug Twilleager et al. provide an overview of the server, desktop, and mobile technologies that are available to build a networked game with Java technology. I hope you will enjoy this issue of the online magazine. Before you dive into the exciting content, I would like to share with you the latest headline news about our distinguished editorial board advisors Alan Kay and Quincy Jones: On April 19, 2004, Dr. Alan Kay was named the 2003 winner of the A.M. Turing Award for pioneering many of the ideas at the root of contemporary object-oriented programming languages, leading the team that developed Smalltalk, and for fundamental contributions to personal computing. The A.M. Turing Award is the most prestigious technical award in computer science and is accompanied by a prize of $100,000. Earlier this year, Alan and his colleagues won the engineerings highest award - the Charles Stark Draper Prize from the National Academy of Engineering - for their vision, conception, and development of the worlds first practical networked personal computers. Both the Draper Prize and Turing Award are considered the equivalent of Nobel Prizes for their fields - engineering and computer science, respectively. In June, Alan was named winner of the 2004 Kyoto Prize in advanced technology, his third major scientific award this year. On May 16, 2004, nearly half a million people attended Mr. Quincy Jones all-star humanitarian concert "We Are the Future" at Romes Circus Maximus. In the tradition of "We Are the World,"the successful concert marked the launch of a worldwide initiative aspiring to create a sustainable chain of support for children in war-ravaged cities. The concert was broadcast on MTV, MTG/VIASAT, XM Radio, and Yahoo! webcasts. More information can be found at http://www.wearethefuture.com/concert_press.html I wish to express my admiration and gratitude to the legendary Alan Kay and Quincy Jones for their immense contributions to society. We are most fortunate to be working with the most innovative and philanthropic individuals in the world. A growing list of our distinguished editorial board members can be found at http://www.acm.org/pubs/cie/acmcie_editorial_board.pdf Now its time to dive into the magazine and send me your comments and feedback. Thank you very much for your continuing support. Sincerely, Newton Lee Editor-in-Chief ACM Computers in Entertainment Los Angeles June 2004
Read moreThe Vision Is Set, Now Help Chronicle the Change
The Vision and Change effort to explore and implement needed changes in undergraduate biology education has been ongoing since 2006. It is now time to take stock of changes that have occurred at the faculty and single-course levels, and to consider how to accomplish the larger-scale changes needed at departmental and institutional levels. This article is a continuation of our efforts to keep people informed about the next steps for Vision and Change, in particular ongoing activities that need community (your) input, and what resources are available to support the Vision stated in 2009: “the biology we teach should reflect the biology we do” (American Association for the Advancement of Science [AAAS], 2011 ).
Read moreACS has two new Congressional fellows
The American Chemical Society has chosen two new Congressional fellows for 1985-86. Irene B. Glowinski will be working with the House Science & Technology Committee's Subcommittee on Investigations & Oversight on biomedical and biotechnology issues. And Carol M. Schiller has accepted a position on the personal staff of Sen. Frank R. Lautenberg (D.-N.J.), where she will be working on environmental pollution issues. Glowinski comes to the program from the National Cancer Institute, which she joined in 1982 as a staff fellow. Her work there involved designing and performing experiments related to the metabolic activation and genotoxicity of aromatic amines and cloning and expression of genes important in carcinogenesis. Glowinski received a B.S. degree in chemistry from American University in 1975 and a Ph.D. in pharmacology from the University of Michigan in 1980. She is an accomplished bell ringer. Since 1975 Schiller has been a senior scientist at the National Institute of Environmental Health Sciences' l...
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