Metaheuristics for empirical software measurements

BackgroundDespite the interest in machine learning (ML) algorithms for analyzing real-world data (RWD) in healthcare, the use of ML in predicting time-to-event data, a common scenario in clinical practice, is less explored. ML models are capable of algorithmically learning from large, complex datasets and can offer advantages in predicting time-to-event data. We reviewed the recent applications of ML for survival analysis using RWD in healthcare.MethodsPUBMED and EMBASE were searched from database inception through March 2023 to identify peer-reviewed English-language studies of ML models for predicting time-to-event outcomes using the RWD. Two reviewers extracted information on the data source, patient population, survival outcome, ML algorithms, and the Area Under the Curve (AUC).ResultsOf 257 citations, 28 publications were included. Random survival forests (N = 16, 57%) and neural networks (N = 11, 39%) were the most popular ML algorithms. There was variability across AUC for these ML models (median 0.789, range 0.6–0.950). ML algorithms were predominately considered for predicting overall survival in oncology (N = 12, 43%). ML survival models were often used to predict disease prognosis or clinical events (N = 27, 96%) in the oncology, while less were used for treatment outcomes (N = 1, 4%).ConclusionsThe ML algorithms, random survival forests and neural networks, are mainly used for RWD to predict survival outcomes such as disease prognosis or clinical events in the oncology. This review shows that more opportunities remain to apply these ML algorithms to inform treatment decision-making in clinical practice. More methodological work is also needed to ensure the utility and applicability of ML models in survival outcomes.

Systematic literature review of machine learning based software development effort estimation models

The purpose of this analysis is to assess the use of machine learning (ML) algorithms in the prediction of postoperative outcomes, including complications, recurrence, and death in transsphenoidal surgery. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we systematically reviewed all papers that used at least one ML algorithm to predict outcomes after transsphenoidal surgery. We searched Scopus, PubMed, and Web of Science databases for studies published prior to May 12, 2021. We identified 13 studies enrolling 5,048 patients. We extracted the general characteristics of each study; the sensitivity, specificity, area under the curve (AUC) of the ML models developed as well as the features identified as important by the ML models. We identified 12 studies with 5,048 patients that included ML algorithms for adenomas, three with 1807 patients specifically for acromegaly, and five with 2105 patients specifically for Cushing's disease. Nearly all were single-institution studies. The studies used a heterogeneous mix of ML algorithms and features to build predictive models. All papers reported an AUC greater than 0.7, which indicates clinical utility. ML algorithms have the potential to predict postoperative outcomes of transsphenoidal surgery and can improve patient care. Ensemble algorithms and neural networks were often top performers when compared with other ML algorithms. Biochemical and preoperative features were most likely to be selected as important by ML models. Inexplicability remains a challenge, but algorithms such as local interpretable model–agnostic explanation or Shapley value can increase explainability of ML algorithms. Our analysis shows that ML algorithms have the potential to greatly assist surgeons in clinical decision making.

P125. Development of a novel ensemble machine learning algorithm for prediction of complications and readmission after anterior cervical spinal fusion

This study highlights drought forecasting for understanding the semi-arid area in India, where drought phenomena play vital role in the irrigation, drinking water supplies, and sustaining the ecological with economic balance for every nation. Therefore, drought forecasting is important for the future drought planning based on the machine learning (ML) models. Hence, The Standardized Precipitation Index (SPI) at 3- and 6-month periods have been selected and used for future drought forecasting scenarios in area. The combinations of ten inputs SPI-1- and SPI-10 were used for predicting modeling for SPI-3 and SPI-6 timescales, that modeling developed based on the historical SPI datasets from 1989 to 2019 years. The SPI-3 and SPI-6 maximum and minimum values are shown SPI-3 (2.03 and -5.522) and SPI-6 (1.94 and -6.93). The SPI is a popular method for estimating the drought analysis and has been used everywhere at global level. The developed models have been compared with each other, with the best combination of input variables selected using subset regression models and sensitivity studies. After that, the active input parameters were used for forecasting of SPI-3 and SPI-6 values to understanding of drought in semi-arid area. The finest input variables combination have been used in the Ml models and established the novel five models such as robust linear regression, bagged trees, boosted trees, support vector regression (SVM-Linear), and Matern Gaussian Process Regression (Matern GPR) models. Such kind of models first time has been applied for the forecasting of future drought conditions. Whole models were fine and improved modeling by using hyperparameters tuning, bagging, and boosting models. Entire ML models’ accuracy was compared using different statistical metrics. Compared with five ML models accuracy, we have found that the Matern GPR model better accuracy than other ML models. The best model accuracy is R2 = 0.95 and 0.93, RMSE, MSE, MAE, MARE, and NSE values, respectively, for predicting SPI-3 and SPI-6 values in the area. Therefore, the Matern GPR model was identified as the finest ML algorithm for predicting SPI-3 and SPI-6 associated with other algorithms. This research demonstrates the Matern GPR model's efficacy in predicting multiscale SPI-3 and SPI-6 under climate variations. It can be helpful in soil and water resource conservation planning and management and understanding droughts in the entire basin areas of the country India.

The integration of machine learning (ML) algorithms into audit processes represents a significant advancement in the field of auditing, offering substantial benefits in terms of efficiency, accuracy, and risk management. This review examines the transformative potential of ML in auditing, highlighting its key benefits and the challenges that must be addressed to fully leverage its capabilities. Machine learning algorithms, with their ability to analyze large datasets and identify patterns, enhance the accuracy and thoroughness of audits. Traditional auditing methods often rely on sampling and manual checks, which can miss anomalies and fraudulent activities. In contrast, ML algorithms can process entire datasets, uncovering subtle patterns and irregularities that may indicate fraud or errors. This comprehensive analysis reduces the risk of oversight and improves the reliability of audit findings. One of the primary benefits of ML in auditing is its capacity for anomaly detection. ML models can be trained on historical data to understand normal financial behavior and flag deviations that might signify irregularities. This ability to detect anomalies in real-time enables auditors to identify potential issues promptly, reducing the time lag between occurrence and detection of fraud. Predictive analytics, powered by ML, further enhances audit processes by forecasting future risks based on historical data. This proactive approach allows auditors to anticipate and mitigate risks before they materialize, contributing to more robust risk management strategies. Despite these advantages, integrating ML into audit processes presents several challenges. Ensuring data quality and integrity is crucial, as ML algorithms are only as good as the data they analyze. Poor-quality data can lead to inaccurate predictions and conclusions. Additionally, the "black box" nature of some ML algorithms can pose transparency issues, making it difficult for auditors to explain how specific conclusions were reached, which is critical for stakeholder trust and regulatory compliance. Another significant challenge is the potential for algorithmic bias. ML models can inadvertently perpetuate existing biases in the data, leading to unfair or skewed audit outcomes. Continuous monitoring and validation of ML algorithms are necessary to detect and mitigate such biases. In conclusion, while integrating machine learning algorithms into audit processes offers substantial benefits in terms of accuracy, efficiency, and risk management, it also necessitates careful attention to data quality, transparency, and bias mitigation. Addressing these challenges is essential to fully realize the potential of ML in enhancing audit practices. Keywords: Benefits, Challenges, Audit Processes, Algorithms, ML.

Satellite-based aerosol optical property retrieval over land, especially size-related parameters, is challenging. This study proposed a novel two-stage machine learning (ML) algorithm for retrieving aerosol optical depth (AOD), Ångström exponent (AE), fine mode fraction (FMF), and fine mode AOD (FAOD)) over land using MODIS observed reflectance. The new ML algorithm consists of three steps: (1) first, all samples extracted from AERONET measurements were used to train the ML model, (2) then, to reduce the extreme estimation bias of the model, divided low-value and high-value samples were used to train low-value and high-value ML models, respectively, and (3) finally, the three ML models were integrated into the final retrieval based on the weight interpolation. Independent site network validation results show that the new ML algorithm has a Pearson correlation coefficient (R) of 0.894 (0.638, 0.661, 0.865) and root mean square error (RMSE) of 0.146 (0.258, 0.245, 0.153) for the AOD (AE, FMF, FAOD) retrieval, which significantly outperforms the validation metrics of MODIS operational products, with AOD (AE, FMF, FAOD) RMSE of 0.130-0.156 (0.536-0.569, 0.313, 0.191). The inter-comparison of aerosol products shows that the spatial patterns of AOD, AE, FMF, and FAOD of the new ML algorithm are in good agreement with those of the MODIS and POLDER products. These results illustrate that the new ML algorithm has good performance and transferability and indicate the ability of ML methods to be applied to multispectral instruments (such as MODIS) to retrieve multiple aerosol properties.

Abstract. As air pollution is regarded as the single largest environmental health risk in Europe it is important that communication to the public is up to date and accurate and provides means to avoid exposure to high air pollution levels. Long- and short-term exposure to outdoor air pollution is associated with increased risks of mortality and morbidity. Up-to-date information on present and coming days' air quality helps people avoid exposure during episodes with high levels of air pollution. Air quality forecasts can be based on deterministic dispersion modelling, but to be accurate this requires detailed information on future emissions, meteorological conditions and process-oriented dispersion modelling. In this paper, we apply different machine learning (ML) algorithms – random forest (RF), extreme gradient boosting (XGB), and long short-term memory (LSTM) – to improve 1, 2, and 3 d deterministic forecasts of PM10, NOx, and O3 at different sites in Greater Stockholm, Sweden. It is shown that the deterministic forecasts can be significantly improved using the ML models but that the degree of improvement of the deterministic forecasts depends more on pollutant and site than on what ML algorithm is applied. Also, four feature importance methods, namely the mean decrease in impurity (MDI) method, permutation method, gradient-based method, and Shapley additive explanations (SHAP) method, are utilized to identify significant features that are common and robust across all models and methods for a pollutant. Deterministic forecasts of PM10 are improved by the ML models through the input of lagged measurements and Julian day partly reflecting seasonal variations not properly parameterized in the deterministic forecasts. A systematic discrepancy by the deterministic forecasts in the diurnal cycle of NOx is removed by the ML models considering lagged measurements and calendar data like hour and weekday, reflecting the influence of local traffic emissions. For O3 at the urban background site, the local photochemistry is not properly accounted for by the relatively coarse Copernicus Atmosphere Monitoring Service ensemble model (CAMS) used here for forecasting O3 but is compensated for using the ML models by taking lagged measurements into account. Through multiple repetitions of the training process, the resulting ML models achieved improvements for all sites and pollutants. For NOx at street canyon sites, mean squared error (MSE) decreased by up to 60 %, and seven metrics, such as R2 and mean absolute percentage error (MAPE), exhibited consistent results. The prediction of PM10 is improved significantly at the urban background site, whereas the ML models at street sites have difficulty capturing more information. The prediction accuracy of O3 also modestly increased, with differences between metrics. Further work is needed to reduce deviations between model results and measurements for short periods with relatively high concentrations (peaks) at the street canyon sites. Such peaks can be due to a combination of non-typical emissions and unfavourable meteorological conditions, which are rather difficult to forecast. Furthermore, we show that general models trained using data from selected street sites can improve the deterministic forecasts of NOx at the station not involved in model training. For PM10 this was only possible using more complex LSTM models. An important aspect to consider when choosing ML algorithms is the computational requirements for training the models in the deployment of the system. Tree-based models (RF and XGB) require fewer computational resources and yield comparable performance in comparison to LSTM. Therefore, tree-based models are now implemented operationally in the forecasts of air pollution and health risks in Stockholm. Nevertheless, there is big potential to develop generic models using advanced ML to take into account not only local temporal variation but also spatial variation at different stations.

Propofol is a widely used sedative-hypnotic agent for critically-ill patients requiring invasive mechanical ventilation (IMV). Despite its clinical benefits, propofol is associated with increased risks of hypertriglyceridemia. Early identification of patients at risk for propofol-associated hypertriglyceridemia is crucial for optimizing sedation strategies and preventing adverse outcomes. Machine learning (ML) models offer a promising approach for predicting individualized patient risks of propofol-associated hypertriglyceridemia. We propose the development of a ML model aimed at predicting the risk of propofol-associated hypertriglyceridemia in ICU patients receiving IMV. The study will utilize retrospective data from four Mayo Clinic sites. Nested cross-validation (CV) will be employed, with a 10-fold inner CV loop for model tuning and selection as well as an outer loop using leave-one-site-out CV for external validation. Feature selection will be conducted using Boruta and LASSO-penalized logistic regression. Data preprocessing steps include missing data imputation, feature scaling, and dimensionality reduction techniques. Six ML algorithms will be tuned and evaluated. Bayesian optimization will be used for hyperparameter selection. Global model explainability will be assessed using permutation importance, and local model explainability will be assessed using SHapley Additive exPlanations (SHAP). The proposed ML model aims to provide a reliable and interpretable tool for clinicians to predict the risk of propofol-associated hypertriglyceridemia in ICU patients. The final model will be deployed in a web-based clinical risk calculator. The model development process and performance measures obtained during nested cross-validation will be described in a study publication to be disseminated in a peer-reviewed journal. The proposed study has received ethics approval from the Mayo Clinic Institutional Review Board (IRB #23-007416). Robust external validation using a nested cross-validation (CV) framework will help assess the generalizability of models produced from the modeling pipeline across different hospital settings.A diverse set of machine learning (ML) algorithms and advanced hyperparameter tuning techniques will be employed to identify the most optimal model configuration.Integration of feature explainability will enhance the clinical applicability of the ML models by providing transparency in predictions, which can improve clinician trust and encourage adoption.Reliance on retrospective data may introduce biases due to inconsistent or erroneous data collection, and the computational intensity of the validation approach may limit replication and future model expansion in resource-constrained settings.

Machine learning (ML) models provide more choices to patients with diabetes mellitus (DM) to more properly manage blood glucose (BG) levels. However, because of numerous types of ML algorithms, choosing an appropriate model is vitally important. In a systematic review and network meta-analysis, this study aimed to comprehensively assess the performance of ML models in predicting BG levels. In addition, we assessed ML models used to detect and predict adverse BG (hypoglycemia) events by calculating pooled estimates of sensitivity and specificity. PubMed, Embase, Web of Science, and Institute of Electrical and Electronics Engineers Explore databases were systematically searched for studies on predicting BG levels and predicting or detecting adverse BG events using ML models, from inception to November 2022. Studies that assessed the performance of different ML models in predicting or detecting BG levels or adverse BG events of patients with DM were included. Studies with no derivation or performance metrics of ML models were excluded. The Quality Assessment of Diagnostic Accuracy Studies tool was applied to assess the quality of included studies. Primary outcomes were the relative ranking of ML models for predicting BG levels in different prediction horizons (PHs) and pooled estimates of the sensitivity and specificity of ML models in detecting or predicting adverse BG events. In total, 46 eligible studies were included for meta-analysis. Regarding ML models for predicting BG levels, the means of the absolute root mean square error (RMSE) in a PH of 15, 30, 45, and 60 minutes were 18.88 (SD 19.71), 21.40 (SD 12.56), 21.27 (SD 5.17), and 30.01 (SD 7.23) mg/dL, respectively. The neural network model (NNM) showed the highest relative performance in different PHs. Furthermore, the pooled estimates of the positive likelihood ratio and the negative likelihood ratio of ML models were 8.3 (95% CI 5.7-12.0) and 0.31 (95% CI 0.22-0.44), respectively, for predicting hypoglycemia and 2.4 (95% CI 1.6-3.7) and 0.37 (95% CI 0.29-0.46), respectively, for detecting hypoglycemia. Statistically significant high heterogeneity was detected in all subgroups, with different sources of heterogeneity. For predicting precise BG levels, the RMSE increases with a rise in the PH, and the NNM shows the highest relative performance among all the ML models. Meanwhile, current ML models have sufficient ability to predict adverse BG events, while their ability to detect adverse BG events needs to be enhanced. PROSPERO CRD42022375250; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=375250.

This study presents a comparative analysis of the classification performance of facial and emotion recognition systems using Machine Learning (ML) and Deep Learning (DL) algorithms. The primary objective of this work is to evaluate the applicability of emotion recognition in fields such as psychotherapy and crime analysis, using the FER-2013 dataset.The study was conducted with ML algorithms such as Support Vector Machines (SVM), Random Forest (RF), K-Nearest Neighbor (KNN), Decision Trees, and Gradient Boosting, as well as the DL algorithm, Convolutional Neural Network (CNN). Supported by the application of feature selection, preprocessing, and feature extraction techniques, the model’s performance was measured using standard metrics such as accuracy, precision, F1-score, and AUC-ROC.The experimental results showed that the highest classification accuracy (46.61%) was achieved with the CNN model. While the ML models generally offered lower accuracy, they provided advantages in terms of computational efficiency in specific scenarios.This study aims to contribute to the literature by providing a comparative analysis of ML and DL algorithms and by highlighting the effect of data preprocessing on performance. The findings set targets for future work, such as real-time system integration and hybrid model development.

Predicting adolescent psychopathology from early life factors: A machine learning tutorial

Recent technological advances allowed an exponential expansion of biological sequence data, and the extraction of meaningful information through Machine Learning (ML) algorithms. This knowledge improved the understanding of the mechanisms related to several fatal diseases, e.g., Cancer and COVID-19, helping to develop innovative solutions, such as CRISPR-based gene editing, coronavirus vaccine, and precision medicine. These advances benefit our society and economy, directly impacting peoples lives in various areas, such as health care, drug discovery, forensic analysis, and food analysis. Nevertheless, ML approaches applied to biological data require representative, quantitative, and informative features. Necessarily, as many ML algorithms can handle only numerical data, sequences need to be translated into a feature vector. This process, known as feature extraction, is a fundamental step for the elaboration of high-quality ML-based models in bioinformatics, by allowing the feature engineering stage, with the design and selection of suitable features. Feature engineering, ML algorithm selection, and hyperparameter tuning are often manual and time-consuming processes, requiring extensive domain knowledge, and performed manually by a human expert. To deal with this problem, we developed a new package, BioAutoML, which automatically runs an end-to-end ML pipeline. BioAutoML extracts numerical and informative features from biological sequence databases, automating feature selection, recommendation of ML algorithm(s), and tuning of hyperparameters, using Automated ML (AutoML). BioAutoML has two components, divided into four modules, (1) automated feature engineering (feature extraction and selection modules) and (2) Metalearning (algorithm recommendation and hyperparameter tuning modules). Our experimental results, assessing the relevance of our proposal, indicate robust results for different problem domains, such as SARS-CoV-2, anticancer peptides, HIV sequences, and non-coding RNAs. According to our systematic review, our proposal is innovative compared to available studies in the literature, being the first study to propose automated feature engineering and metalearning for biological sequences. BioAutoML has a high potential to significantly reduce the expertise required to use ML pipelines, aiding researchers in combating diseases, particularly in low- and middle-income countries. This initiative can provide biologists, physicians, epidemiologists, and other stakeholders with an opportunity for widespread use of these techniques to enhance the health and well-being of their communities.

Surgical site infection (SSI) following a neurosurgical operation is a complication that impacts morbidity, mortality, and economics. Currently, machine learning (ML) algorithms are used for outcome prediction in various neurosurgical aspects. The implementation of ML algorithms to learn from medical data may help in obtaining prognostic information on diseases, especially SSIs. The purpose of this study was to compare the performance of various ML models for predicting surgical infection after neurosurgical operations. A retrospective cohort study was conducted on patients who had undergone neurosurgical operations at tertiary care hospitals between 2010 and 2017. Supervised ML algorithms, which included decision tree, naive Bayes with Laplace correction, k-nearest neighbors, and artificial neural networks, were trained and tested as binary classifiers (infection or no infection). To evaluate the ML models from the testing data set, their sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV), as well as their accuracy, receiver operating characteristic curve, and area under the receiver operating characteristic curve (AUC) were analyzed. Data were available for 1471 patients in the study period. The SSI rate was 4.6%, and the type of SSI was superficial, deep, and organ/space in 1.2%, 0.8%, and 2.6% of cases, respectively. Using the backward stepwise method, the authors determined that the significant predictors of SSI in the multivariable Cox regression analysis were postoperative CSF leakage/subgaleal collection (HR 4.24, p < 0.001) and postoperative fever (HR 1.67, p = 0.04). Compared with other ML algorithms, the naive Bayes had the highest performance with sensitivity at 63%, specificity at 87%, PPV at 29%, NPV at 96%, and AUC at 76%. The naive Bayes algorithm is highlighted as an accurate ML method for predicting SSI after neurosurgical operations because of its reasonable accuracy. Thus, it can be used to effectively predict SSI in individual neurosurgical patients. Therefore, close monitoring and allocation of treatment strategies can be informed by ML predictions in general practice.

Developing Machine Learning (ML) algorithms for heterogeneous/mixed data is a longstanding problem. Many ML algorithms are not applicable to mixed data, which include numeric and non-numeric data, text, graphs and so on to generate interpretable models. Another longstanding problem is developing algorithms for lossless visualization of multidimensional mixed data. The further progress in ML heavily depends on success interpretable ML algorithms for mixed data and lossless interpretable visualization of multidimensional data. The later allows developing interpretable ML models using visual knowledge discovery by end-users, who can bring valuable domain knowledge which is absent in the training data. The challenges for mixed data include: (1) generating numeric coding schemes for non-numeric attributes for numeric ML algorithms to provide accurate and interpretable ML models, (2) generating methods for lossless visualization of n-D non-numeric data and visual rule discovery in these visualizations. This paper presents a classification of mixed data types, analyzes their importance for ML and present the developed experimental toolkit to deal with mixed data. It combines the Data Types Editor, VisCanvas data visualization and rule discovery system which is available on GitHub.