Mining microbe\u2013disease interactions from literature via a transfer learning model

This study aimed to compare the axial cranial ultrasound images of normal and open neural tube defect (NTD) fetuses using a deep learning (DL) model and to assess its predictive accuracy in identifying open NTD.It was a prospective case-control study. Axial trans-thalamic fetal ultrasound images of participants with open fetal NTD and normal controls between 14 and 28 weeks of gestation were taken after consent. The images were divided into training, testing, and validation datasets randomly in the ratio of 70:15:15. The images were further processed and classified using DL convolutional neural network (CNN) transfer learning (TL) models. The TL models were trained for 50 epochs. The data was analyzed in terms of Cohen kappa score, accuracy score, area under receiver operating curve (AUROC) score, F1 score validity, sensitivity, and specificity of the test.A total of 59 cases and 116 controls were fully followed. Efficient net B0, Visual Geometry Group (VGG), and Inception V3 TL models were used. Both Efficient net B0 and VGG16 models gave similar high training and validation accuracy (100 and 95.83%, respectively). Using inception V3, the training and validation accuracy was 98.28 and 95.83%, respectively. The sensitivity and specificity of Efficient NetB0 was 100 and 89%, respectively, and was the best.The analysis of the changes in axial images of the fetal cranium using the DL model, Efficient Net B0 proved to be an effective model to be used in clinical application for the identification of open NTD. · Open spina bifida is often missed due to the nonrecognition of the lemon sign on ultrasound.. · Image classification using DL identified open spina bifida with excellent accuracy.. · The research is clinically relevant in low- and middle-income countries..

Brain Tumor is a deadly diagnosis that, if not detected early on, can cause significant damage to a patient’s brain, disrupting the body’s functions and even leading to death. However, the conventional method of detecting brain tumors is conducting MRI scans which a medical expert then consults for diagnosis. While time-consuming, this method also leaves room for human error, especially in cases where the tumor is in its early stages. Thus, the diagnosis of brain tumors must be made accurately in the least time possible. This paper aims to prevent premature mortality, provide health in resource-constrained settings, and seek patients’ healthy lives, which can be done through timely and accurate diagnosis of brain tumors. In this paper, three different deep transfer learning models are used after adding fine-tuned layers to detect brain tumors in a dataset of 251 Magnetic Resonance Imaging (MRI) scans. The transfer learning models used are VGG16, InceptionV3, and ResNet50, with fine-tuned Dropout, Flatten, and Dense added layers. The highest accuracy was achieved with the VGG16 model, which had an accuracy of 91.58%. Thus, deep learning models are proven effective in detecting brain tumors without the unwanted expense of time and resources.

Brain tumors are among the most common and fatal types of cancer.Accurate and timely diagnosis of these tumors is essential for disease management and successful patient prognosis.Additionally, the precise identification of the tumor type is crucial in determining the treatment path.By recognizing the type of tumor, doctors can select the most appropriate treatment method, which may include surgery, radiation therapy, chemotherapy, or a combination of these methods.Furthermore, the tumor type helps predict disease progression and the quality of life post-treatment.In recent years, deep learning has been a powerful tool for various image-processing tasks, including brain tumor detection.In this paper, various deep learning models such as CNN, RNN, VGG16, InceptionV3, and ResNet101 are evaluated for classifying brain tumor types from the Figshare dataset based on MRI images of glioma, meningioma, pituitary tumors, and no tumor.Finally, a suitable deep model based on ResNet101 combined with transfer learning is proposed.Based on various metrics and statistical tests, the findings indicate that deep learning models can be effectively used for brain tumor detection.Among these, the ResNet101 model achieved an accuracy of 98.37% in classifying the four tumor classes.This study demonstrates that deep learning holds significant potential for improving brain tumor detection accuracy.

Deep learning-based fault diagnosis of servo motor bearing using the attention-guided feature aggregation network

Skin lesion classification plays a crucial role in dermatology, aiding in the early detection, diagnosis, and management of life-threatening malignant lesions. However, standalone transfer learning (TL) models failed to deliver optimal performance. In this study, we present an attention-enabled ensemble-based deep learning technique, a powerful, novel, and generalized method for extracting features for the classification of skin lesions. This technique holds significant promise in enhancing diagnostic accuracy by using seven pre-trained TL models for classification. Six ensemble-based DL (EBDL) models were created using stacking, softmax voting, and weighted average techniques. Furthermore, we investigated the attention mechanism as an effective paradigm and created seven attention-enabled transfer learning (aeTL) models before branching out to construct three attention-enabled ensemble-based DL (aeEBDL) models to create a reliable, adaptive, and generalized paradigm. The mean accuracy of the TL models is 95.30%, and the use of an ensemble-based paradigm increased it by 4.22%, to 99.52%. The aeTL models’ performance was superior to the TL models in accuracy by 3.01%, and aeEBDL models outperformed aeTL models by 1.29%. Statistical tests show significant p-value and Kappa coefficient along with a 99.6% reliability index for the aeEBDL models. The approach is highly effective and generalized for the classification of skin lesions.

In recent years, deep learning has achieved remarkable advancements in medical image analysis, particularly through Convolutional Neural Networks (CNNs) and Transformer-based architectures. This study aims to evaluate and compare the performance of five transfer learning models (DenseNet169, InceptionV3, MobileNetV2, VGG16 and Xception) and a Vision Transformer (ViT) model for the classification of skin cancer using the “Skin Cancer: Malignant vs. Benign” dataset .In the first phase, the ViT model achieved the highest overall performance with 93.79% recall, 92.22% precision, 93.00% F1-score and 92.42% accuracy. Although InceptionV3 and MobileNetV2 demonstrated strong recall values, they did not match the overall accuracy of ViT. In the second phase, image enhancement techniques—grayscale conversion, thresholding, Canny edge detection, dilation, and erosion were applied to emphasize lesion boundaries and improve contrast. Using these enhanced images, the ViT model again achieved the best performance, with 95.49% recall, 94.17% precision, 94.83% F1-score, and 94.39% accuracy. These results indicate that the ViT architecture provides superior accuracy and reliability in complex and enhanced medical images. Furthermore, the study demonstrates that incorporating image preprocessing techniques can significantly enhance the performance of deep learning models in medical imaging applications.

White blood cells (WBCs) play a vital role in immune responses against infections and foreign agents. Different WBC types exist, and anomalies within them can indicate diseases like leukemia. Previous research suffers from limited accuracy and inflated performance due to the usage of less important features. Moreover, these studies often focus on fewer WBC types, exaggerating accuracy. This study addresses the crucial task of classifying WBC types using microscopic images. This study introduces a novel approach using extensive pre-processing with data augmentation techniques to produce a more significant feature set to achieve more promising results. The study conducts experiments employing both conventional deep learning and transfer learning models, comparing performance with state-of-the-art machine and deep learning models. Results reveal that a pre-processed feature set and convolutional neural network classifier achieves a significantly better accuracy of 0.99. The proposed method demonstrates superior accuracy and computational efficiency compared to existing state-of-the-art works.

Alzheimer’s Disease(AD) is a type of Dementia affecting the brain cells. An intense amount of research has been done on the subject of Alzheimer’s Disease Detection and even now huge amounts of research are going on towards this subject. Over time different deep learning models have been implemented including various transfer learning models. In this work a comprehensive analysis of eight transfer learning models has been done to classify AD in 4 classes; Non-Demented, Very Mild-Demented, Mild-Demented and Moderate Demented. The transfer learning models implemented here are: DenseNet-169, Inception ResNet-V2, MobileNet-V2, ResNet-101, Inception-V3, ResNet-50, VGG-16, VGG-19. The transfer learning model with the highest scores gave an accuracy of 98.0%and precision of 98.01%, which is a good score for medical imaging problems.

This paper examines efficient methods for the calculation of open circuit voltage distortion in salient pole synchronous generators with damper windings. It then proceeds to examine the role of damper bars in the level of distortion. The simplified finite element method employed is inclusive of eddy current effects, dynamic field current and full interaction of all MMF sources. It allows accurate total harmonic distortion values to be calculated approximately 25 to 30 times quicker than a fully rotating finite element simulation. Tests have been conducted on eight built machines and results compared to both analytical and alternative finite element methods. The proposed method has an average reduction in error of 55%, compared to an existing analytical method. The presence of damper bars and their position within the pole face is examined, and shown to have a large influence over the level of total harmonic distortion produced. (6 pages)

The classification process is also used in artificial intelligence (AI), which is intelligence created by a computer, so that it can mimic actions like humans in general and can capture events that occur in the surrounding environment. Seeing the very high development of the international coffee trade, it can be concluded that if there is a type of coffee that has the best quality, it will be sought after by coffee importing countries. Batik is cloth that is painted using canting and liquid wax to form motifs or patterns that have high artistic value. Batik has a variety of unique and distinctive patterns that reflect the region where the batik motif originates. One area that has batik motifs in Indonesia is batik in the North Coastal Region of Java Island. In this area, various batiks are produced according to the characteristics of the area itself. Regarding information related to the introduction of types of batik motifs, perhaps it comes from people who have batik skills and batik craftsmen who best understand batik as a whole, while the general public does not really know about batik motifs. Because batik has different motifs and batik motifs in some areas have motifs that are almost uniform but not the same. One of the technologies that can be used is deep learning. The purpose of this study is to propose a Convolutional Neural Network (CNN) and Transfer Learning (TL) model to be implemented in an intelligent system for the process of image classification of coffee bean types. The method used in this study is the PSOCNN transfer learning model VGG16 From the results of tests carried out on 2 models, namely the CNN model, the PSOCNN transfer learning model VGG16. it was found that the highest accuracy was obtained when classifying batik motives images using the PSOCNN-transfer learning model VGG16, which was 83%. The level of accuracy that is increased when compared to the usual CNN model indicates that the use of transfer learning has a good effect on the level of accuracy obtained. Although an increase of 6% is significant, but with this increase it opens up opportunities to increase even higher by using other transfer learning models

BackgroundTo introduce a three-dimensional convolutional neural network (3D CNN) leveraging transfer learning for fusing PET/CT images and clinical data to predict EGFR mutation status in lung adenocarcinoma (LADC).MethodsRetrospective data from 516 LADC patients, encompassing preoperative PET/CT images, clinical information, and EGFR mutation status, were divided into training (n = 404) and test sets (n = 112). Several deep learning models were developed utilizing transfer learning, involving CT-only and PET-only models. A dual-stream model fusing PET and CT and a three-stream transfer learning model (TS_TL) integrating clinical data were also developed. Image preprocessing includes semi-automatic segmentation, resampling, and image cropping. Considering the impact of class imbalance, the performance of the model was evaluated using ROC curves and AUC values.ResultsTS_TL model demonstrated promising performance in predicting the EGFR mutation status, with an AUC of 0.883 (95%CI = 0.849–0.917) in the training set and 0.730 (95%CI = 0.629–0.830) in the independent test set. Particularly in advanced LADC, the model achieved an AUC of 0.871 (95%CI = 0.823–0.919) in the training set and 0.760 (95%CI = 0.638–0.881) in the test set. The model identified distinct activation areas in solid or subsolid lesions associated with wild and mutant types. Additionally, the patterns captured by the model were significantly altered by effective tyrosine kinase inhibitors treatment, leading to notable changes in predicted mutation probabilities.ConclusionPET/CT deep learning model can act as a tool for predicting EGFR mutation in LADC. Additionally, it offers clinicians insights for treatment decisions through evaluations both before and after treatment.

Tuberculosis (TB) remains a leading infectious disease worldwide, and early, reliable screening using chest X-rays (CXRs) is essential in low-resource settings. The scarcity of labeled TB-positive CXR images limits the effectiveness of deep learning models. This study investigates whether Conditional Generative Adversarial Networks (CGANs) can generate realistic TB-positive CXR images to balance training data and improve the classification performance of fine-tuned deep transfer learning (DTL) models. We trained a CGAN (LSGAN formulation) to synthesize class-conditional grayscale CXR images at 128x128 resolution and used the generated images to augment the Shenzhen TB dataset. Three pre-trained DTL architectures (DenseNet121, VGG16, and MobileNetV3Small) were fine-tuned on both original and CGAN-augmented datasets. Experiments used stratified 70/10/20 train/validation/test splits and a fixed random seed (random_state=42) to ensure reproducibility. Model performance was evaluated using accuracy, precision, recall (sensitivity), F1-score, confusion matrices, and ROC/AUC curves. The experiments were executed on an NVIDIA Tesla P100 GPU (16GB) in a Kaggle runtime environment; total CGAN+classifier processing reported a wall-clock runtime of 39 minutes 30 seconds for the baseline experimental run. CGAN augmentation produced consistent improvements across models: DenseNet121 improved from 93.0% to 94.6% test accuracy, VGG16 improved from 96.3% to 96.8%, and MobileNetV3Small improved from 93.0% to 93.5%. Class-conditional GAN augmentation can modestly but usefully improve DTL classifier performance in TB detection when labeled data are scarce, though further cross-dataset validation is required before clinical deployment.

PurposeTo conduct a head-to-head comparison between deep learning (DL) and radiomics models across institutions for predicting microvascular invasion (MVI) in hepatocellular carcinoma (HCC) and to investigate the model robustness and generalizability through rigorous internal and external validation.MethodsThis retrospective study included 2304 preoperative images of 576 HCC lesions from two centers, with MVI status determined by postoperative histopathology. We developed DL and radiomics models for predicting the presence of MVI using B-mode ultrasound, contrast-enhanced ultrasound (CEUS) at the arterial, portal, and delayed phases, and a combined modality (B + CEUS). For radiomics, we constructed models with enlarged vs. original regions of interest (ROIs). A cross-validation approach was performed by training models on one center’s dataset and validating the other, and vice versa. This allowed assessment of the validity of different ultrasound modalities and the cross-center robustness of the models. The optimal model combined with alpha-fetoprotein (AFP) was also validated. The head-to-head comparison was based on the area under the receiver operating characteristic curve (AUC).ResultsThirteen DL models and 25 radiomics models using different ultrasound modalities were constructed and compared. B + CEUS was the optimal modality for both DL and radiomics models. The DL model achieved AUCs of 0.802–0.818 internally and 0.667–0.688 externally across the two centers, whereas radiomics achieved AUCs of 0.749–0.869 internally and 0.646–0.697 externally. The radiomics models showed overall improvement with enlarged ROIs (P < 0.05 for both CEUS and B + CEUS modalities). The DL models showed good cross-institutional robustness (P > 0.05 for all modalities, 1.6–2.1% differences in AUC for the optimal modality), whereas the radiomics models had relatively limited robustness across the two centers (12% drop-off in AUC for the optimal modality). Adding AFP improved the DL models (P < 0.05 externally) and well maintained the robustness, but did not benefit the radiomics model (P > 0.05).ConclusionCross-institutional validation indicated that DL demonstrated better robustness than radiomics for preoperative MVI prediction in patients with HCC, representing a promising solution to non-standardized ultrasound examination procedures.

We aimed at comparing intratumoral and peritumoral deep learning, radiomics, and fusion models in predicting KRAS mutations in rectal cancer using endorectal ultrasound imaging. This study included 304 patients with rectal cancer from Fujian Medical University Union Hospital. The patients were randomly divided into a training group (213 patients) and a test group (91 patients) at a 7:3 ratio. Radiomics and deep learning models were established using primary tumor and peritumoral images. In the optimally performing regions-of-interest, two fusion strategies, a feature-based and a decision-based model, were employed to build the fusion models. The Shapley additive explanation (SHAP) method was used to evaluate the significance of features in the optimal radiomics, deep learning, and fusion models. The performance of each model was assessed using the area under the receiver operating characteristic curve (AUC) and decision curve analysis (DCA). In the test cohort, both the radiomics and deep learning models exhibited optimal performance with a 10-pixel patch extension, yielding AUC values of 0.824 and 0.856, respectively. The feature-based DLRexpand10_FB model attained the highest AUC (0.896) across all study sets. In addition, the DLRexpand10_FB model demonstrated excellent sensitivity, specificity, and DCA. SHAP analysis underscored the deep learning feature (DL_1) as the most significant factor in the hybrid model. The feature-based fusion model DLRexpand10_FB can be employed to predict KRAS gene mutations based on pretreatment endorectal ultrasound images of rectal cancer. The integration of peritumoral regions enhanced the predictive performance of both the radiomics and deep learning models.

Electricity load forecasting is a crucial undertaking within all the deregulated markets globally. Among the research challenges on a global scale, the investigation of deep transfer learning (DTL) in the field of electricity load forecasting represents a fundamental effort that can inform artificial intelligence applications in general. In this paper, a comprehensive study is reported regarding day-ahead electricity load forecasting. For this purpose, three sequence-to-sequence (Seq2seq) deep learning (DL) models are used, namely the multilayer perceptron (MLP), the convolutional neural network (CNN) and the ensemble learning model (ELM), which consists of the weighted combination of the outputs of MLP and CNN models. Also, the study focuses on the development of different forecasting strategies based on DTL, emphasizing the way the datasets are trained and fine-tuned for higher forecasting accuracy. In order to implement the forecasting strategies using deep learning models, load datasets from three Greek islands, Rhodes, Lesvos, and Chios, are used. The main purpose is to apply DTL for day-ahead predictions (1–24 h) for each month of the year for the Chios dataset after training and fine-tuning the models using the datasets of the three islands in various combinations. Four DTL strategies are illustrated. In the first strategy (DTL Case 1), each of the three DL models is trained using only the Lesvos dataset, while fine-tuning is performed on the dataset of Chios island, in order to create day-ahead predictions for the Chios load. In the second strategy (DTL Case 2), data from both Lesvos and Rhodes concurrently are used for the DL model training period, and fine-tuning is performed on the data from Chios. The third DTL strategy (DTL Case 3) involves the training of the DL models using the Lesvos dataset, and the testing period is performed directly on the Chios dataset without fine-tuning. The fourth strategy is a multi-task deep learning (MTDL) approach, which has been extensively studied in recent years. In MTDL, the three DL models are trained simultaneously on all three datasets and the final predictions are made on the unknown part of the dataset of Chios. The results obtained demonstrate that DTL can be applied with high efficiency for day-ahead load forecasting. Specifically, DTL Case 1 and 2 outperformed MTDL in terms of load prediction accuracy. Regarding the DL models, all three exhibit very high prediction accuracy, especially in the two cases with fine-tuning. The ELM excels compared to the single models. More specifically, for conducting day-ahead predictions, it is concluded that the MLP model presents the best monthly forecasts with MAPE values of 6.24% and 6.01% for the first two cases, the CNN model presents the best monthly forecasts with MAPE values of 5.57% and 5.60%, respectively, and the ELM model achieves the best monthly forecasts with MAPE values of 5.29% and 5.31%, respectively, indicating the very high accuracy it can achieve.