Moving From "Parent Involvement" to Family-Centered Services

New Service Delivery Models: Connecting SLPs with Teachers and Curriculum

Role of Intervention Strategies for At-risk Preterm Infants

The Adverse Effects of a Language Disorder

Diversity and Learner-Centered Education

No AccessPerspectives on School-Based IssuesArticle1 Dec 2004Sharpen Your Focus! Using Evidence-Based Practices in Standards-Based Therapy Units Debbie Lozo, and Vicky Carter Debbie Lozo Cobb County School DistrictMarietta, GA Google Scholar More articles by this author and Vicky Carter Cobb County School DistrictMarietta, GA Google Scholar More articles by this author https://doi.org/10.1044/sbi5.4.11 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationTrack Citations ShareFacebookTwitterLinked In References Anderson, R.G, & NagyW. E. (1992). The vocabulary conundrum,.American Educator, Winter,–14–18, 44–47. Google Scholar Applebee, A. N. (1977). A sense of story..Theory into practice,, 16,342–347. Google Scholar Arwood, E. L., & Mclnroy, J. (1994). Reading: It’s so easy to see-pictured language.Portland, OR: APRICOT. Google Scholar Beck, I. L., & McKeown, M. G. (1991). Conditions of vocabulary acquisition.. In R. Barr, M. L. Kamil, P. B. Mosenthal, & P. D. 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How to Fit Response to Intervention Into a Heavy Workload

No AccessPerspectives on Aural Rehabilitation and Its InstrumentationArticle1 May 2003Multicultural Issues In Audiology Karen Beverly-Ducker Karen Beverly-Ducker Google Scholar More articles by this author https://doi.org/10.1044/arii11.1.12 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationTrack Citations ShareFacebookTwitterLinked In References ASHA. (2000). 2000 Omnibussurvey: Practice trends in audiology. Rockville, MD: Author. Google Scholar ASHA. (2002). 2002 Omnibus survey Practice trends in audiology. Rockville, MD: Author. Google Scholar Ballachanda, B. B. (2001a). Audiological assessment of “We, the foreign born.”.Division 14, Communication Disorders and Sciences in Culturally and Linguistically Diverse Populations Newsletter, 7(1), 11–13. ASHAWireGoogle Scholar Ballachanda, B. B. (2001b). Meeting the needs of multicultural clients.Advance for Audiologists, 3(5), 50–53. Google Scholar Bierman, N., & Nungesser, N. (2002). 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Minimal Residual Disease following Allogeneic Hematopoietic Stem Cell Transplantation

Recommendations for Post-Prostatectomy Radiation Therapy in the United States Before and After the Presentation of Randomized Trials

Post-translational modification by covalent attachment of isoprenoid lipids (prenylation) regulates the functions and biological activities of several proteins implicated in the oncogenic transformation and metastatic progression of cancer. The largest group of prenylated proteins contains a CAAX motif at the C-terminal that serves as a substrate for a series of post-translational modifications that convert these otherwise hydrophilic proteins to lipidated proteins, thus facilitating membrane association. C17orf37 (chromosome 17 open reading frame 37), also known as C35/Rdx12/MGC14832, located in the 17q12 amplicon, is overexpressed in human cancer, and its expression correlates with the migratory and invasive phenotype of cancer cells. Here we show that C17orf37 contains a functional CAAX motif and is post-translationally modified by protein geranylgeranyltransferase-I (GGTase-I). Geranylgeranylation of C17orf37 at the CAAX motif facilitates association of the protein to the inner leaflet of plasma membrane, enhances migratory phenotype of cells by inducing increased filopodia formation, and potentiates directional migration. A prenylation-deficient mutant of C17orf37 is functionally inactive and fails to trigger dissemination of tail vein-injected cells in a mouse model of metastasis. These findings demonstrate that prenylation is required for the function of the C17orf37 protein in cancer cells and imply that the post-translational modification may functionally regulate metastatic progression of disease.

No AccessAmerican Journal of Speech-Language PathologyViewpoint1 Nov 1998Whistleblowing in Speech-Language Pathology Mary Pannbacker Mary Pannbacker Louisiana State University Medical Center, Shreveport Google Scholar More articles by this author https://doi.org/10.1044/1058-0360.0704.18 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationTrack Citations ShareFacebookTwitterLinked In References American Academy of Audiology. (1996–1997). Code of ethics.American Academy of Audiology Membership, 221–222. Google Scholar American Speech-Language-Hearing Association. (1992a, May). Asha’s proposed long range strategic plan.Asha, 34, 32–36. Google Scholar American Speech-Language-Hearing Association. (1992b). ESB accreditation manual. Rockville, MD: Author. Google Scholar American-Speech-Language-Hearing Association. (1994a, March). Code of ethics.Asha, 36(Suppl. 13), 1–2. Google Scholar American-Speech-Language-Hearing Association. (1994b, March). 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Google Scholar Additional Resources FiguresReferencesRelatedDetailsCited byContemporary Issues in Communication Science and Disorders38:Spring (11-19)1 Mar 2011Professional Code of Ethics: The Case of Speech-Language Pathologists in KuwaitTareq Alshatti, Fauzia Abdalla and Fatima DikrallahAmerican Journal of Speech-Language Pathology9:1 (93-94)1 Feb 2000In Response to "Whistleblowing in Speech-Language Pathology"American Journal of Speech-Language Pathology9:1 (94-94)1 Feb 2000Response to ASHA Board of EthicsMary Pannbacker Volume 7Issue 4November 1998Pages: 18-24 Get Permissions Add to your Mendeley library HistoryReceived: Dec 23, 1997Accepted: Mar 30, 1998 Published in issue: Nov 1, 1998 Metrics Topicsasha-topicsasha-article-typesleader-topicsKeywordsethical dilemmasaccusationethical violationsdocumentationCopyright & PermissionsCopyright © 1998 American Speech-Language-Hearing AssociationPDF downloadLoading ...

RecQ helicases are believed to function in repairing replication forks stalled by DNA damage and may also play a role in the intra-S-phase checkpoint, which delays the replication of damaged DNA, thus permitting repair to occur. Since little is known regarding the effects of DNA damage on RecQ helicases, and because the replication and recombination defects in Werner syndrome cells may reflect abnormal processing of damaged DNA associated with the replication fork, we examined the effects of specific bulky, covalent adducts at N(6) of deoxyadenosine (dA) or N(2) of deoxyguanosine (dG) on Werner (WRN) syndrome helicase activity. The adducts are derived from the optically active 7,8-diol 9,10-epoxide (DE) metabolites of the carcinogen benzo[a]pyrene (BaP). The results demonstrate that WRN helicase activity is inhibited in a strand-specific manner by BaP DE-dG adducts only when on the translocating strand. These adducts either occupy the minor groove without significant perturbation of DNA structure (trans adducts) or cause base displacement at the adduct site (cis adducts). In contrast, helicase activity is only mildly affected by intercalating BaP DE-dA adducts that locally perturb DNA double helical structure. This differs from our previous observation that intercalating dA adducts derived from benzo[c]phenanthrene (BcPh) DEs inhibit WRN activity in a strand- and stereospecific manner. Partial unwinding of the DNA helix at BaP DE-dA adduct sites may make such adducted DNAs more susceptible to the action of helicase than DNA containing the corresponding BcPh DE-dA adducts, which cause little or no destabilization of duplex DNA. The single-stranded DNA binding protein RPA, an auxiliary factor for WRN helicase, enabled the DNA unwinding enzyme to overcome inhibition by either the trans-R or cis-R BaP DE-dG adduct, suggesting that WRN and RPA may function together to unwind duplex DNA harboring specific covalent adducts that otherwise block WRN helicase acting alone.

Social functioning in patients with first-episode psychosis

Activated protein C (APC) reduces mortality in severe sepsis patients and exhibits beneficial effects in multiple animal injury models. APC anticoagulant activity involves inactivation of factors Va and VIIIa, whereas APC cytoprotective activities involve the endothelial protein C receptor and protease-activated receptor-1 (PAR-1). The relative importance of the anticoagulant activity of APC versus the direct cytoprotective effects of APC on cells for the in vivo benefits is unclear. To distinguish cytoprotective from the anticoagulant activities of APC, a protease domain mutant, 5A-APC (RR229/230AA and KKK191-193AAA), was made and compared with recombinant wild-type (rwt)-APC. This mutant had minimal anticoagulant activity but normal cytoprotective activities that were dependent on endothelial protein C receptor and protease-activated receptor-1. Whereas anticoagulantly active rwt-APC inhibited secondary-extended thrombin generation and concomitant thrombin-dependent activation of thrombin activable fibrinolysis inhibitor (TAFI) in plasma, secondary-extended thrombin generation and the activation of TAFI were essentially unopposed by 5A-APC due to its low anticoagulant activity. Compared with rwt-APC, 5A-APC had minimal profibrinolytic activity and preserved TAFI-mediated anti-inflammatory carboxypeptidase activities toward bradykinin and presumably toward the anaphlatoxins, C3a and C5a, which are well known pathological mediators in sepsis. Thus, genetic engineering can selectively alter the multiple activities of APC and provide APC mutants that retain the beneficial cytoprotective effects of APC while diminishing bleeding risk due to reduction in APC's anticoagulant and APC-dependent profibrinolytic activities.

In search of the optimal therapy for congenital hypothyroidism