• Home
  • Search
  • Multi-objective Optimisation, Sensitivity and Robustness Analysis in FBA Modelling
  • Cite Icon11
  • https://doi.org/10.1007/978-3-642-33636-2_9Copy DOI Icon

Multi-objective Optimisation, Sensitivity and Robustness Analysis in FBA Modelling

  • Jan 1, 2012
  • Jole Costanza +4 more
Show More
  • Abstract
  • Literature Map
  • References
  • Citations
  • Similar Papers
Abstract

Abstract In this work, we propose a computational framework to design in silico robust bacteria able to overproduce multiple metabolites. To this end, we search the optimal genetic manipulations, in terms of knockout, which also guarantee the growth of the organism. We introduce a multi-objective optimisation algorithm, called Genetic Design through Multi-Objective (GDMO), and test it in several organisms to maximise the production of key intermediate metabolites such as succinate and acetate. We obtain a vast set of Pareto optimal solutions; each of them represents an organism strain. For each solution, we evaluate the fragility by calculating three robustness indexes and by exploring reactions and metabolite interactions. Finally, we perform the Sensitivity Analysis of the metabolic model, which finds the inputs with the highest influence on the outputs of the model. We show that our methodology provides effective vision of the achievable synthetic strain landscape and a powerful design pipeline.KeywordsCell MetabolismBiological CADSensitive and Fragile PathwaysGenetic DesignMulti-Objective optimisationFlux balance analysisSensitivity and Robustness Analysis

Similar Papers
  • PDF
  • Research Article
  • Citations3

Least Squares Support Vector Machine for Ranking Solutions of Multi-Objective Water Resources Allocation Optimization Models

  • Apr 05, 2017
  • Water
  • Weilin Liu +2
  • Research Article
  • Citations83

Multi-objective optimization of machining and micro-machining processes using non-dominated sorting teaching–learning-based optimization algorithm

  • Mar 21, 2016
  • Journal of Intelligent Manufacturing
  • R Venkata Rao +2
  • PDF
  • Research Article
  • Citations2

Multiobjective Optimization of Propagation Path in Automotive Product Design Change Based on MOPSO

  • Jun 17, 2022
  • Mobile Information Systems
  • Jinting Ni +1
  • Research Article
  • Citations12

Multi-Objective Shape Optimization Design for Liquefied Natural Gas Cryogenic Helical Corrugated Steel Pipe

  • May 25, 2017
  • Journal of Offshore Mechanics and Arctic Engineering
  • Zhixun Yang +4
  • Research Article
  • Citations8

Are You Concerned about Limited Function Evaluations: Data-Augmented Pareto Set Learning for Expensive Multi-Objective Optimization

  • Mar 24, 2024
  • Proceedings of the AAAI Conference on Artificial Intelligence
  • Yongfan Lu +2
  • Research Article
  • Citations12

Multi-objective design optimization of a large-scale directdrive permanent magnet generator for wind energy conversion systems

  • May 08, 2014
  • Frontiers in Energy
  • Arash Hasssanpour Isfahani +2
  • Research Article
  • Citations23

Multiobjective Optimization for Heat Transfer Performance of Micro-Fins and Signal Integrity of Key Interconnect Technologies in 3-D Integrated Chips

  • Aug 01, 2022
  • IEEE Transactions on Components, Packaging and Manufacturing Technology
  • Wei He +2
  • Research Article
  • Citations18

Multimodal Multiobjective Differential Evolutionary Optimization With Species Conservation

  • Feb 01, 2024
  • IEEE Transactions on Systems, Man, and Cybernetics: Systems
  • Junzhong Ji +2
  • Research Article
  • Citations13

Hybrid multi-objective Harris Hawk optimization algorithm based on elite non-dominated sorting and grid index mechanism

  • Aug 01, 2022
  • Advances in Engineering Software
  • Min Wang +6
  • Conference Article
  • Citations11

Pareto Analysis with Uncertainty

  • Oct 01, 2011
  • Martijn Hendriks +2
  • Research Article
  • Citations21

A systematic approach for watershed ecological restoration strategy making: An application in the Taizi River Basin in northern China

  • May 22, 2018
  • Science of The Total Environment
  • Mengdi Li +7
  • Research Article
  • Citations21

Investigation of material removal rate and surface roughness using multi-objective optimization for micro-milling of inconel 718

  • May 16, 2019
  • Industrial Lubrication and Tribology
  • Xiaohong Lu +4
  • Book Chapter

Producing Smart Pareto Sets for Multi-objective Topology Optimisation Problems

  • Dec 06, 2017
  • David J Munk +3
  • Research Article
  • Citations18

Integrated multi-objective robust optimization and sensitivity analysis with irreducible and reducible interval uncertainty

  • Sep 18, 2009
  • Engineering Optimization
  • M Li +5
  • PDF
  • Research Article
  • Citations2

A Novel Ranking Method Based on Subjective Probability Theory for Evolutionary Multiobjective Optimization

  • Jan 01, 2011
  • Mathematical Problems in Engineering
  • Shuang Wei +1
Cactus Communications logo

Copyright 2026 Cactus Communications. All rights reserved.