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It has been a little more than 50 years since we discovered IgE, a key molecule for the allergic response and a target for treating allergies and severe asthma.Here, I trace my career, from the kindling of my interest in immunochemistry to groundbreaking discoveries in the biology and chemistry of immunoglobulins.I describe my service to the broader community of immunologists and my role in shaping departments and research institutes.My course starts in Japan and includes Southern California, Baltimore, and Denver.