- Research Article
2
- 10.14309/00000434-201210001-01692
Risk Factors for Depression in the Elderly Inflammatory Bowel Disease Population
- Oct 01, 2012
- American Journal of Gastroenterology
- Millie Long + 5 more +5
Purpose: Depression is common among patients with inflammatory bowel disease (IBD). Less is known about depression in the elderly population with IBD. Within an elderly IBD population, we aimed to 1) assess factors associated with depression and 2) determine whether depression is associated with disease activity, quality of life, or medication adherence. Methods: We identified elderly (≥65 years) individuals within Crohn's and Colitis Foundation of America (CCFA) Partners, an online cohort of over 10,000 patients living with self-reported IBD. Individuals were asked to complete the short- geriatric depression scale (GDS), a 15 question validated tool used to assess depression in the elderly population. A score of ≥5 on this scale suggests depression. We used bivariate statistics to determine whether demographic or disease related factors, disease activity (as measured by the short Crohn's disease activity index (sCDAI) or simple clinical colitis activity index (SCCAI), quality of life (measured by the short inflammatory bowel disease questionnaire (SIBDQ) and medication adherence (measured by the Morisky medication adherence scale (MMAS)) were associated with depression. We then used logistic regression to estimate the independent effects of depression on medication adherence. Results: A total of 359 elderly individuals with IBD completed the GDS. The mean age was 70.2 years (sd 4.7), with a mean disease duration of 25.6 years (sd 17.6). The prevalence of depression was 22.6%. Neither age, disease duration, nor gender differed by depression status. Lower education levels were significantly associated with depression (p=0.001). For both Crohn's disease (CD) and ulcerative colitis (UC), those with depression had significantly increased disease activity when compared to those without (sCDAI 52.5 versus 29, p=0.005 and SCCAI 5 versus 2, p=0.003). Depressed patients also had significantly lower health related quality of life (SIBDQ 4.6 versus 5.7, p<0.001) and lower medication adherence (p=0.01). Those with depression were more likely to have reduced medication adherence, even after controlling for disease activity (OR 2.49; 95% CI 1.26-4.92). Conclusion: Depression is common in this geriatric IBD cohort. Traditional risk factors for depression in the elderly, such as female gender and advancing age, are not associated with depression in geriatric IBD. Depression is independently associated with reduced medication adherence. The short GDS is a feasible tool for depression screening in the elderly IBD population that may allow for improved recognition and outcomes.
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