Non-Invasive Multichannel Vagus Nerve Stimulator With Heart Rate Measurement for Closed-Loop Control

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This study aims to develop a multichannel stimulation system integrating electrocardiogram (ECG)-based heart rate and heart rate variability (HRV) measurement capabilities within a non-invasive vagus nerve stimulator (nVNS). Furthermore, the study proposes the implementation of personalized stimulation with closed-loop control. The system employs five electrodes to simultaneously quantify vagus nerve stimulation and ECG signals, which are evaluated in real time, and the stimulation intensity and pattern are modified via a smartphone application. These attributes offer the potential to effectively enhance autonomic nervous system dysfunction. Subsequent studies will substantiate the therapeutic efficacy and safety of the system through clinical trials and incorporate additional vital signs such as respiration and blood pressure to extend its applicability to a variety of autonomic nervous system disorders.