On the relationship between autobiographical memory and perceptual learning.

The phenomenon of temporally graded retrograde amnesia (loss of information acquired before the onset of amnesia) suggests that the hippocampus, and possibly other medial temporal lobe (MTL) structures, have a time-limited role in memory. In three experiments, we made a first attempt to use fMRI to assess activity in the hippocampal region (the CA fields of the hippocampus, the dentate gyrus, and the subiculum) and the adjacent parahippocampal gyrus (parahippocampal, entorhinal, and perirhinal cortices) during recognition memory testing as a function of study-test interval. Experiment 1 (n = 5) demonstrated activity in the hippocampal region and parahippocampal gyrus for targets relative to foils during recognition memory performance following a single study-test delay of about one-half hour. In Experiment 2, 15 participants studied line drawings at each of three different times prior to scanning: one-half hour, 1 day, and 1 week. fMRI data were then collected during recognition memory testing, using targets from all three delays and foils. While an overall effect of targets vs. foils was found in both the hippocampal region and the parahippocampal gyrus, there was no effect of study-test interval on target activity. In Experiment 3 (n = 13), behavioral performance (reaction time and accuracy) was equated across the three delays. Again, no effect of study-test interval was observed. It is possible that the time span sampled in our study (one-half hour to 1 week) was too short to observe changes in activity. Alternatively, activity in the MTL during memory testing may occur even when these structures are not necessary for retrieval.

Two studies examined the cognitive units of sentence memory using a perceptual recognition task. Four candidate cognitive units were considered: concepts, propositions, integrated propositions, and nonintegrated propositions. Subjects first received a list of acquisition sentences and then were asked to reproduce sentences presented under a white-noise mask. These masked sentences were replicas of the acquisition sentences, were formed of recombined clauses from the acquisition sentences, or were formed of recombined words from the acquisition sentences. Reproduction accuracy was employed as the dependent measure. Results supported propositions (operationalized by clauses) as cognitive units of episodic memory. No conclusive evidence was obtained for concepts, integrated propositions, or nonintegrated propositions as cognitive units. The utility of perceptual recognition tasks for studying the cognitive units of episodic memory is discussed.

Emotional and neutral stimuli may differ in recognition memory. Research focusing on consolidation and encoding processes has offered several explanations of this differentiation. In this study, two experiments were conducted to test how recognition memory differs from emotional and neutral stimuli in the light of these explanations. In Experiment 1, the effects of different retention intervals and an interference task were tested. Consolidation studies claim that both retention intervals and interference tasks provide memory advantages for emotional stimuli compared to neutral stimuli. In Experiment 2, the effects of presentation style (pure or mixed lists) and semantic relatedness were tested and were suggested as effective during the encoding process. Experiment 1 included 120 student participants and 60 students participated in Experiment 2. Participants’ recognition memory performance was measured using signal detection analysis. Data from Experiment 1 indicated that neither the retention interval nor the interference task had significant effects on emotional recognition memory. However, emotion had a significant effect because participants presented a more liberal response bias toward emotional than neutral words and demonstrated a poorer recognition of these words than the neutral ones. Experiment 2 indicated that neither the presentation style nor semantic relatedness had significant effects on emotional recognition memory. On the other hand, emotion had a significant effect consistent with the first experiment. The liberal response bias shift and poorer recognition accuracy of emotional compared to neutral words were replicated. As a result, these two experiments using signal detection analysis demonstrated that the variables expected to be effective during the consolidation and encoding processes did not affect emotional recognition memory. However, the finding that emotion causes poorer recognition accuracy and higher liberal response bias in both experiments suggests that the function of emotion in memory may be the provision of liberal response bias rather than accuracy.

ABSTRACTIntroduction: Determining whether the etiology of amnestic Mild Cognitive Impairment (aMCI) is Alzheimer’s disease (AD) is challenging. Recognition memory (RM) performance could be helpful in identifying individuals with cognitive patterns indicative of underlying AD. In order to better identify such patterns, we examined RM discriminability in aMCI and its associations with nonmemory cognitive domains impaired in AD.Methods: Participants were 97 individuals diagnosed with aMCI (Mage = 74.48 years) who underwent comprehensive neuropsychological evaluation. Zero-order correlations and hierarchical linear regression analyses were conducted to determine associations between discriminability on the HVLT-R and specific tasks within the domains of executive function (EF) and language, controlling for age and education. Logistic regression was conducted to determine whether performance on individual tasks was predictive of group membership defined as impaired or unimpaired on RM performance.Results: While 100% of the aMCI group showed impaired delayed recall on a word list, we found that 69% were impaired on RM discriminability, while 31% were not. Discriminability impairment groups did not differ on demographics or global cognition. For the entire aMCI group, performance in the language domain and, specifically, on a confrontation naming task significantly predicted RM discriminability. Confrontation naming was predictive of RM impairment group membership.Conclusions: Our results demonstrate individuals with aMCI are heterogeneous and show variability in RM discriminability. RM performance was associated with measures of language, elucidating patterns of cognition potentially marking those more likely to progress to AD. Future studies need to address this finding in a longitudinal sample.

Background Episodic memory impairment is a hallmark of Alzheimer’s disease (AD) and is already present in its prodromal stage. While recall deficits are well established as predictors of memory performance, the role of recognition memory—particularly the dissociation between familiarity and recollection—remains less explored. Objective This systematic review aims to synthesize current evidence on recognition memory performance in healthy controls (HC), individuals with mild cognitive impairment (MCI), and those with AD, with a focus on the distinct contributions of familiarity and recollection processes. Methods We searched PubMed (MEDLINE), Science Direct, PubPsych, and TRIP Medical databases for studies published until November 2025, which investigated recognition memory performance in individuals with MCI and AD including validated memory tools (such as scales, indices, scores, tests, and assessments). Forty-six studies (n = 3996) met the criteria and were included. Methodological quality was evaluated using the Newcastle-Ottawa scale. This study is registered with PROSPERO, CRD42022343750. Results Most studies were cross-sectional and conducted in memory clinics or research centers, with considerable heterogeneity in sample size and assessment tools. The majority utilized experimental paradigms to differentiate familiarity and recollection, though traditional memory tests remain prevalent. Across studies, recollection was consistently impaired in MCI and AD, while familiarity showed a more variable pattern—often preserved in early MCI but impaired in advanced stages and AD. Structural and functional neuroimaging studies revealed that hippocampal atrophy is closely linked to recollection deficits, while alterations in entorhinal and parahippocampal cortices are associated with familiarity impairment. Combined deficits in recall and recognition, especially when recognition impairment reflects encoding failure, robustly predict conversion to dementia. Conclusions Recognition memory assessment, particularly the dissociation between familiarity and recollection, provides valuable information for early detection and prognosis in the AD continuum. Incorporating nuanced recognition memory measures into clinical practice may improve diagnostic specificity and facilitate timely interventions. Further longitudinal research is needed to validate recognition memory as a predictor of dementia progression and to standardize its assessment in diverse populations.

In humans, monetary reward can promote behavioral performance including response times, accuracy, and subsequent recognition memory. Recent studies have shown that the dopaminergic system plays an essential role here, but the link to interindividual differences remains unclear. To further investigate this issue, we focused on previously described polymorphisms of genes affecting dopaminergic neurotransmission: DAT1 40 base pair (bp), DAT1 30 bp, DRD4 48 bp, and cannabinoid receptor type 1 (CNR1). Specifically, 669 healthy humans participated in a delayed recognition memory paradigm on two consecutive days. On the first day, male vs. female faces served as cues predicting an immediate monetary reward upon correct button presses. Subsequently, participants performed a remember/know recognition memory task on the same day and 1 day later. As predicted, reward increased accuracy and accelerated response times, which were modulated by DAT 30 bp. However, reward did not promote subsequent recognition memory performance and there was no interaction with any genotype tested here. Importantly, there were differential effects of genotype on declarative long-term memory independent of reward: (a) DAT1 40 bp was linked to the quality of memory with a more pronounced difference between recollection and familiarity in the heterozygous and homozygous 10-R as compared to homozygous 9-R; (b) DAT1 30 bp was linked to memory decay, which was most pronounced in homozygous 4-R; (c) DRD4 48 bp was linked to overall recognition memory with higher performance in the short allele group; and (d) CNR1 was linked to overall memory with reduced performance in the homozygous short group. These findings give new insights into how polymorphisms, which are related to dopaminergic neuromodulation, differentially affect long-term recognition memory performance.

In this paper, we report four experiments aimed at extending the distinction between recognition memory and perceptual memory introduced by Jacoby and Dallas (1981). In Experiment 1, we show that dissociation of the two types of memory can be demonstrated with pictures as stimuli and with naming latency and recognition scores as responses. The depth-of-processing manipulation affects recognition but not naming, whereas both are influenced by prior exposure. Experiment 2 is a replication of the naming procedure, with a smaller set of stimuli and instructions emphasizing speed. Experiments 3 and 4 extend the paradigm to include children from 5 to 10 years old. Experiment 3 demonstrates the usual effect of depth of processing on recognition, but, in contrast to the adult data of Experiment 1, there is an analogous effect upon subsequent naming latencies. Examination of the data suggests this may be a spurious result. If not, it means either that the two memory types are not independent in children or that the “deep” subjects were implicitly naming during encoding. In Experiment 4, we test perceptual memory directly, replacing naming latency with tachistoscopic recognition. This results only in an effect of prior exposure, and not depth of processing. The results support the idea that perceptual memory is distinguishable from recognition memory, and that it is developmentally stable.

Monkeys Recall and Reproduce Simple Shapes from Memory

The attitudes and reactions of rehabilitation nurses and nursing students toward patients with disabilities are important to the patients' adjustment and care over time. The purpose of this research study was to examine the effect of prior work experience and clinical experience in a rehabilitation setting on students' attitudes toward the disabled. The study involved the administration of Yuker, Block, and Young's (1966) Attitudes Toward Disabled Persons Scale (ATDP). Nursing students (N = 225) appropriately completed the ATDP before and 1 month after attending an educational workshop on care of people with disabilities. Prior work experience with such people was found to have a significant impact on student attitudes. Subjects with prior work experience in a rehabilitation setting had significantly higher scores on the ATDP, indicating more positive attitudes toward people with disabilities, than did subjects without this experience. Students who had clinical experience in a rehabilitation setting had higher scores on the ATDP than students without it, but the difference was not statistically significant.

This study evaluated the validity and clinical utility of the Recognition Memory Test (RMT) as a measure of memory in severe traumatic brain injury (TBI). RMT scores for 86 TBI inpatients were related to injury severity, lesion location, and other memory indices. Only recognition memory for words (RMW) was significantly (p<0 01) related to duration of posttraumatic amnesia and a measure of "day to day" memory. Both RMT subtests showed expected modality-specific relationships with other clinical memory tasks. Patients with normal CT and right sided CT lesions tended to be more frequently impaired on recognition memory for faces (RMF) than RMW.

Repetition priming has been shown to be independent of recognition memory. Thus, the severely amnesic patient E.P. has demonstrated intact stem completion priming and perceptual identification priming, despite at-chance performance on recognition memory tasks. It has also been shown that perceptual fluency can influence feelings of familiarity, in the sense that items perceived more quickly tend to be identified as familiar. If studied items are identified more fluently, due to perceptual priming, and fluency leads to familiarity, why do severely amnesic patients perform no better than chance on recognition memory tasks? One possibility is that severely amnesic patients do not exhibit normal fluency. Another possibility is that fluency is not a sufficiently strong cue for familiarity. In two experiments, 2 severely amnesic patients, 3 moderately amnesic patients, and 8 controls saw words slowly clearing from a mask. The participants identified each word as quickly as possible and then made a recognition (old/new) judgment. All the participants exhibited fluency, in that old responses were associated with shorter identification times than new responses were. In addition, for the severely amnesic patients, priming was intact, and recognition memory performance was at chance. We next calculated how much priming and fluency should elevate the probability of accurate recognition. The tendency to identify studied words rapidly (.6) and the tendency to label these rapidly identified words old (.6) would result in 36% of the studied words being labeled old. Other studied words were identified slowly (.4) but were still labeled old (.4), resulting in an additional 16% of studied words labeled old. Thus, the presence of fluency increases the probability of accurate recognition judgments to only 52% (chance = 50%). This finding explains why amnesic patients can exhibit both priming and fluency yet still perform at chance on recognition tests.

The amnesic patient E.P. has demonstrated normal levels of repetition priming and at-chance recognition performance (S. B. Hamann & L. R. Squire, 1997), suggesting that the sense of familiarity used to make a recognition memory judgment is not based on the same mechanism responsible for repetition priming. However, the recognition tests previously used may have discouraged the use of familiarity and encouraged reliance on episodic memory. This issue was addressed in 5 experiments with E.P., 3 other amnesic patients with hippocampal damage, and 8 healthy controls. In Experiments 1-3, which were designed to discourage the use of episodic memory, the amnesic patients were impaired and E.P. performed at chance. In Experiments 4 and 5A, a stem-completion priming task was combined with a recognition memory task on each trial. E.P.'s priming was intact, yet his recognition memory performance was at chance. This suggests that although recognition memory judgments may be made on the basis of familiarity, repetition priming is not the source of this feeling of familiarity.

Employee testing and evaluation often requires a sensitive measure of memory capability. Recognition memory is tested by those tasks which require the determination of the identity of previously presented information. In order to obtain an accurate estimate of one's discriminability in recognition memory, the decrement in sensitivity has to be distinguished from a mere criterion shift or response bias. Previous researchers found that vigilance decrements result from a decrease in perceptual sensitivity when signal discrimination loads memory and signal event rate is high. In the present study, discriminability over time was combined with various memory loads in a recognition memory experiment. Eight subjects were tested in two fifty-minute sessions, using 360 three-digit random numbers. A one-way ANOVA showed that the lag factor was significant for two parametric sensitivity measures. When the lag increased by five or more intervening numbers, a significant decrement in sensitivity was found. Below this level of memory load, no decrements in sensitivity were found.

In order to examine the relation between recognition memory and priming effects, we have tracked the recovery of recognition memory and word completion ability during the hours after individual treatment given as part of a prescribed course of electroconvulsive therapy (ECT). Recognition memory was tested by a three-alternative, forced-choice method. In the word completion test, the initial letters of previously presented words were given as cues, and subjects were asked to complete each cue to form the first word that came to mind. Patients receiving bilateral ECT markedly improved their recognition memory performance 45 min to 9 hr after treatment. Word completion performance was normal at 45 min after treatment and did not change thereafter. Despite exhibiting normal priming effects, patients prescribed bilateral ECT scored at chance levels on recognition tests given 45 min after treatment. These findings support the view that recognition memory and priming are independent memory processes, and they suggest that the processes that support priming make little if any contribution to recognition memory. The results are considered in terms of neuropsychological evidence from amnesic patients for the existence of multiple memory systems.

Objective: It is commonly thought that memory deficits in frontal patients are a result of impairments in executive functions which impact upon storage and retrieval processes. Yet, few studies have specifically examined the relationship between memory performance and executive functions in frontal patients. Furthermore, the contribution of more general cognitive processes such as fluid intelligence and demographic factors such as age, education, and premorbid intelligence has not been considered.Method: Our study examined the relationship between recall and recognition memory and performance on measures of fluid intelligence, executive functions and premorbid intelligence in 39 frontal patients and 46 healthy controls.Results: Recall memory impairments in frontal patients were strongly correlated with fluid intelligence, executive functions and premorbid intelligence. These factors were all found to be independent predictors of recall performance, with fluid intelligence being the strongest predictor. In contrast, recognition memory impairments were not related to any of these factors. Furthermore, age and education were not significantly correlated with either recall or recognition memory measures.Conclusion: Our findings show that recall memory in frontal patients was related to fluid intelligence, executive functions and premorbid intelligence. In contrast, recognition memory was not. These findings suggest that recall and recognition memory deficits following frontal injury arise from separable cognitive factors. Recognition memory tests may be more useful when assessing memory functions in frontal patients.