Polyfunctional Acrylic Non-isocyanate Hydroxyurethanes as Photocurable Thermosets for 3D Printing

PurposeSkin cancer is the most common tumor in the population. There are different therapeutic modalities. Brachytherapy is one of the techniques used, in which it is necessary to build customized moulds for some patients. Currently, these moulds are made by hand using rudimentary techniques. We present a new procedure based on 3D printing and the analysis of the clinical workflow.Material and methodsMoulds can be made either by hand or by automated 3D printing. For making moulds by hand, a patient’s alginate negative is created and, from that, the gypsum cast and customized moulds are made by hand from the patient’s negative template. The new process is based on 3D printing. The first step is to take a 3D scan of the surface of the patient and then, 3D modelling software is used to obtain an accurate anatomical reconstruction of the treatment area. We present the clinical workflow using 3D scanning and printing technology, comparing its costs with the usual custom handmade mould protocol.ResultsThe time spent for the new process is 6.25 hours, in contrast to the time spent for the conventional process, which is 9.5 hours. We found a 34% reduction in time required to create a mould for brachytherapy treatment. The labor cost of the conventional process is 211.5 vs. 152.5 hours, so the reduction is 59 hours. There is also a 49.5% reduction in the financial costs, mostly due to lack of need of a computed tomography (CT) scan of the gypsum and the mould. 3D scanning and printing offers financial benefits and reduces the clinical workload.ConclusionsAs the present project demonstrates, through the application of 3D printing technologies, the costs and time spent during the process in the clinical workload in brachytherapy treatment are reduced. Overall, 3D printing is a promising technique for brachytherapy that might be well received in the community.

3D Printing, sometimes referred to as additive manufacturing, has made the concept of personalized medicine a reality. The primary objective of 3D and 4D printing is to produce intricate, customized pharmaceuticals at a reasonable cost. With improvements in materials, resolution, and speed, 3D printing technology is quickly developing. It includes faster construction, cost efficiency through reduced waste, design flexibility for complex structures, and sustainability through optimized material usage. An extensive literature survey was done on 3D and 4D printing of pharmaceuticals using PubMed, Elsevier, ScienceDirect, and Springer. The results were then filtered based on the titles, abstracts, and accessibility of the complete texts. The search engine Google Scholar was accessed for literature data mining. From the data mining, it was found that from the year 2009 to 2024 the number of research publications surged more than 200 times on the current topic. Even though 3-D and 4-D printing technologies have advanced significantly in a short amount of time, the most often used ones are still stereolithography, nozzle-based deposition, inkjet, and selective laser sintering. Their use has been modified for the production of nanoparticles, polypills, tablets, and implants, etc. Pharma's aspirations for tailored medications are being revolutionized by 3D printing, but cost, flexibility, and bioequivalence still need to be investigated. The present review offers a thorough analysis of various 3D and 4D printing methods and emphasizes the major advantages and disadvantages and major key challenges of 3D and 4D printing related to pharmaceuticals. Compared to 3D Printing, 4D printing offers better quality, efficacy, and functionality.

Three-dimensional (3D) printing technologies enables fast prototyping of complex 3D objects with ever improving printing qualities. To date, 3D printing has been found useful in areas such as manufacturing, industrial design, aerospace, dental and medical industries, and many others. In this article, we review recent advances of 3D printing technologies for terahertz (THz) applications. Different 3D printing technologies and printable materials are first discussed and compared. 3D-printed THz components and devices, which are categorized as waveguides/fibers, antennas, and quasi-optical components, are further demonstrated. It is found that the performances and functionalities of 3D-printed THz devices have been greatly enhanced, while the operating frequencies have been increased from the lower end of THz range to over 1 THz region. With further development of novel materials and printing techniques, it is believed that 3D printing technologies will play an important role in the realization of THz components for efficient control and manipulation of THz waves.

For decades we have used printers to print superheroes on the pages of comic books but could printing technologies actually be used to print real life superheroes? 3D and functional printing technologies have advanced greatly in recent years and even though these technologies cannot be used to print heroes themselves, they can certainly be used for equipment manufacturing. One character that could or may use 3D printing to rapidly produce prototypes and final versions of new technologies is Tony Stark. As the inventor and primary user of the Iron Man suit, Stark has designed a wearable suit that is not only a weapon but also protects him. However, in battle the suit can become damaged and require urgent repairs. To aid in these repairs, Tony Stark could turn to 3D printing technologies to produce new components for the suit. In this paper we will outline 3D printing technologies and describe their current applications. We will then discuss how 3D printing is being used to print electronics and the ramifications for Tony Stark, his Iron Man suit and the potential use for a real Iron Man suit.

Three-dimensional (3D) printing technology is becoming a promising method for fabricating highly complex ceramics owing to the arbitrary design and the infinite combination of materials. Insufficient density is one of the main problems with 3D printed ceramics, but concentrated descriptions of making dense ceramics are scarce. This review specifically introduces the principles of the four 3D printing technologies and focuses on the parameters of each technology that affect the densification of 3D printed ceramics, such as the performance of raw materials and the interaction between energy and materials. The technical challenges and suggestions about how to achieve higher ceramic density are presented subsequently. The goal of the presented work is to comprehend the roles of critical parameters in the subsequent 3D printing process to prepare dense ceramics that can meet the practical applications.

Food 3D printing technology holds significant potential for personalized nutrition and the customization of 3D structures with specific shapes and textures. This emerging technology is driving significant innovations in food processing and manufacturing. This article reviews the current research and development opportunities in food 3D printing, with a focus on various types of 3D food printing technologies. We offer novel insights into the behavioral characteristics of various 3D printing techniques during the printing process, while also highlighting that the successful development of 3D-printed food products relies on four critical factors: (1) adaptability, (2) printability, (3) food safety, and (4) consumer acceptance. Special emphasis is placed on the application and potential challenges of 3D printing technology, aiming to foster technological breakthroughs and industrial applications, ultimately offering consumers safer, smarter, and more personalized food choices.

Background: Using 3D printing technology, novel items can be created from various materials, including edible ones, addressing the growing importance of sustainable food chains and personalized nutrition. As the latest advancement in additive manufacturing, 3D printing meets diverse customer demands by producing customized food items tailored to individual nutritional needs. Objectives: This literature evaluation focuses on the applications, technical advancements, and future possibilities of 3D food printing. By assessing recent developments, the study explores its adaptability and transformative potential in addressing global issues such as sustainability and personalized nutrition. Methods: To include up-to-date and relevant data, PubMed, Google Scholar, and Scopus were searched for research on "3D Food Printing," "Food Technology," "Food Formulation," and "Customized Diet" from 2018 to 2024. Data extraction and synthesis were conducted on 31 reports selected from 687 search results after removing duplicates and applying filters. Discussions: The study highlights the use of 3D food printers for creating dairy products, fish and meat, pasta, biscuits, chocolates, and cereal-based foods. Applications span industries such as space food, elderly and school children's nutrition, military food, hospitals, and restaurants. Future research directions include food characterization through color analysis, moisture content, water activity, physiochemical properties, and microbiological studies. Conclusions: This study highlights the potential advantages of 3D food printing technology, including healthier food options, novel dining experiences, and diet customization. It underscores its transformative capacity to impact the global economy while addressing sustainability and personalized nutrition challenges.

Recent developments in three-dimensional (3D) printing technology offer immense potential in fabricating scaffolds and implants for various biomedical applications, especially for bone repair and regeneration. As the availability of autologous bone sources and commercial products is limited and surgical methods do not help in complete regeneration, it is necessary to develop alternative approaches for repairing large segmental bone defects. The 3D printing technology can effectively integrate different types of living cells within a 3D construct made up of conventional micro- or nanoscale biomaterials to create an artificial bone graft capable of regenerating the damaged tissues. This article reviews the developments and applications of 3D printing in bone tissue engineering and highlights the numerous conventional biomaterials and nanomaterials that have been used in the production of 3D-printed scaffolds. A comprehensive overview of the 3D printing methods such as stereolithography (SLA), selective laser sintering (SLS), fused deposition modeling (FDM), and ink-jet 3D printing, and their technical and clinical applications in bone repair and regeneration has been provided. The review is expected to be useful for readers to gain an insight into the state-of-the-art of 3D printing of bone substitutes and their translational perspectives.

Background: Three-dimensional (3D) printing technology has rapidly emerged as a transformative tool in medicine, enabling the conversion of two-dimensional scans into highly accurate 3D models. This technology, especially when combined with artificial intelligence (AI) and advanced materials, offers numerous applications in surgical planning, simulation-based training, and patient-specific care. Methods: This review examines current literature and case studies on the use of 3D printing technology in various fields of medicine, especially in surgical specialties. Key applications include surgical planning, mock surgeries, biopsy guide creation, and customized implant fabrication across various surgical fields. Results: 3D printing is transforming surgery by enabling precise visualization of tumors and critical structures, significantly enhancing preoperative planning for conditions such as bone, soft tissue (e.g., neuroblastomas), renal, and maxillofacial tumors. In reconstruction surgeries, patient-specific 3D-printed implants ensure better anatomical compatibility, particularly in maxillofacial, neurosurgical, and vascular applications. Puncture guides improve procedural accuracy in interventions like percutaneous nephrolithotripsy. Detailed anatomical models aid in simulation-based training, increasing preparedness for complex procedures. Additionally, patient-specific implants and AI-integrated decision support systems are paving the way for more personalized and efficient surgical care. Conclusions: 3D printing technology, especially when combined with AI, is reshaping modern surgery by improving both accuracy, safety, and personalized healthcare. Its applications extend across multiple specialties, offering new possibilities in surgical planning, training, and patient-specific treatments. As AI and bioprinting continue to evolve, the potential for real-time applications, such as live-printed tissue implants and enhanced decision support, could drive the next phase of innovation in various fields.

Three-dimensional (3D) printing technology has arrived and is changing a philisophy of “management.” A 3D-printed product is made from a powder or resin and can virtually shape any item from a digital graphics file. This new printing device, however, poses several unforeseen questions. The 3D printing technology calls for time and cost considerations. Once a private firm actually begins to operationalize the new technology, it will have to measure both merit and demerit in terms of a ‘before-and after adaptation’ perspective, in addition to a future prospect of further advantages the device might bring. Similarly, perhaps this is the most important, the use of this new technology might part away with the significant role and function of the core technology in production of different matters. Considering these topics, this study attempts to focus on the 3D printing technology and its influence on technology management. It specifically discusses the impact of 3D printing technology applied to manufacturing companies on their cost, time, quality and activities. To answer this question, a cost structure is developed using the IDKKH method. The cost calculation is also considered using the Cost-Matrix method. After making model and matrix, possibilities are shown as research collaborators and outsourcing selection to organize with the concept of technology management. Through these analyses, problems are clarified, and the discussions indicate the results of introducing 3D printing technology, R & D innovation, and technology management

This study evaluates the three-dimensional (3D) printing materials used in Fused Deposition Modeling (FDM) printing technology. 3D printing technology has been developing strongly, becoming an effective support tool in production and research. The 3D printing process involves many stages, with many parameters affecting the quality and properties of the product, in which 3D printing material is one of many essential factors affecting that process. The study conducts a comprehensive assessment of the most common materials in 3D printing technology to determine the advantages and limitations of precisely five types of materials: Polylactic acid, acrylonitrile butadiene styrene, polyethylene terephthalate glycol-modified, thermoplastic polyurethane, and acrylonitrile styrene acrylate. With 3D printing, parameters such as sintering temperature, printing speed, and layer thickness are kept constant. These parameters are applied equally to all five material samples. The experiment evaluates the tensile strength of materials. The study results provide an overview of the properties and applicability of 3D printing materials, helping to select materials suitable for specific FDM 3D printing technology applications.

Bolus is commonly used in radiation therapy to improve radiation dose distribution to the target volume, but commercially available products do not always conform well to the patient surface. Tumor control may be compromised, particularly for superficial tumors, if bolus does not conform well and air gaps exist between the patient surface and the bolus. Three-dimensional (3D) printing technology allows the creation of highly detailed, variable shaped objects, making it an attractive and affordable option for customized, patient-specific bolus creation. The use of 3D printing in the clinical setting remains limited. Therefore, the objective of this study was to assess the implications on time and clinical fit using a workflow for 3D printing of customized bolus in companion animals with spontaneous tumors treated with radiation therapy. The primary aim of this study was to evaluate the time required to create a clinical 3D printed bolus. The secondary aims were to evaluate the clinical fit of the bolus and to verify the skin surface dose. Time to segmentation and 3D printing were documented, while the clinical fit of the bolus was assessed in comparison to the bolus created in the treatment planner. The mean and median time from segmentation to generation of 3D printed boluses was 6.15 h and 5.25 h, respectively. The 3D printed bolus was significantly less deviated from the planned bolus compared to the conventional bolus (p = 0.0078) with measured dose under the bolus within 5% agreement of expected dose in 88% of the measurements. Clinically acceptable 3D printed customized bolus was successfully created for treatment within one working day. The most significant impact on time is the 3D printing itself, which therefore has minimal implications on personnel and staffing. Quality assurance steps are recommended when implementing a 3D printing workflow to the radiotherapy clinic.

Many insect species that could benefit humanity cannot be reared or domesticated because of the lack of adequate artificial diets. In the case of insect pests which are controlled via the Sterile Insect Technique, the prospects of improving biological traits of mass-reared individuals hinge on the development of new diet formulations. 3D food printing technology holds unique potential to create customized artificial diets simulating the shape, texture, and distribution of nutrient and non-nutrient components (e.g., dietary fiber and secondary metabolites) of natural insect foods. We present an overview on the use of state-of-the-art 3D printing technology to develop artificial diets that mimic the dynamic nature of natural insect diets, characterized by compartmentalized food components. The challenges and limitations of 3D food printing technology for its application in the field of diet development and artificial insect rearing are discussed, and future research priorities are highlighted. Examples are provided of beneficial and pestiferous insect species that could be reared on 3D-printed diets such as the cocoa pod borer and tephritid flies.

Three-dimensional (3D) printing technologies are transforming the design and manufacture of components and products across many disciplines, but their application in the construction industry is still limited. Material deposition processes can achieve infinite geometries. They have advanced from rapid prototyping and model-scale markets to applications in the fabrication of functional products, large objects, and the construction of full-scale buildings. Many international projects have been realised in recent years, and the construction industry is beginning to make use of such dynamic technologies. Advantages of integrating 3D printing with house construction are significant. They include the capacity for mass customisation of designs and parameters to meet functional and aesthetic purposes, the reduction in construction waste from highly precise placement of materials, and the use of recycled waste products in layer deposition materials. With the ultimate goal of improving construction efficiency and decreasing building costs, the researchers applied Strand 7 Finite Element Analysis software to a numerical model designed for 3D printing a cement mix that incorporates the recycled waste product high-density polyethylene (HDPE). The result: construction of an arched, truss-like roof was found to be structurally feasible in the absence of steel reinforcements, and lab-sized prototypes were manufactured according to the numerical model with 3D printing technology. 3D printing technologies can now be customised to building construction. This paper discusses the applications, advantages, limitations, and future directions of this innovative and viable solution to affordable housing construction.

Replica artefacts are a well-established feature of Roman archaeology, particularly as used in experimental archaeology, by re-enactors, and in museum education. 3D scanning offers a new methodology for the accurate production of such artefacts, which can then be used both in scholarly research and in public engagement activities. This article describes methodologies for 3D scanning and 3D printing, together with appropriate craft techniques, in the creation of replica musical instruments from the collection of UCL's Petrie Museum of Egyptian Archaeology in London. While there were some challenges in replica creation, discussed in further detail, 'functional replicas' were successfully made, that, we argue, replicate sufficiently accurately those features of the objects under investigation from a research perspective. These were the decibel levels (sound power levels), and, for some objects, frequency (pitch) ranges produced, and the variety of sounds that they could produce. This evidence makes an important contribution to our understanding of the contexts of use of the original instruments. Sound recordings virtually modelled in a likely use location, the courtyard of a typical house from Roman-period Egypt, were also produced and assist in our conceptualisation of the wider acoustic environment. Sound recordings and replicas were additionally used for public engagement purposes in a temporary exhibition at the Petrie Museum, and their contribution to museum education is assessed. 3D scanning and printing technology are demonstrated to be valuable techniques for the production of accurate replicas, which can be used successfully to contribute to scholarly research and museum education in new ways. Appendices include .stl files that may be downloaded and 3D printed, to make copies of the replicas for use in new research and education projects.