web.media.mit.edu/∼ankit/bokode/ A bokode is a 3 mm wide circle of encoded data that can be decoded by a digital camera located up to several meters away. This is not commercially available technology, but it has the potential to replace barcodes and kindred encoding systems. The development team for this new technology is based at MIT and there are many added features beyond reading textual data (Fig. 1). Bokodes exploit the bokeh effect of ordinary camera's lenses, which means that optical phase data in the coded spot is readable when the camera is made to be deliberately out of focus (this is explained at the site). The value-added aspect of bokodes is that distance and orientation of a bokode from a camera can be deduced by processing. The illustration is from the MIT group developing bokodes. Bokode laser pointers. A camera mounted at the front of a room can assign an identifier to all bokodes in range and precisely report where each device is pointing. This means that the class can be issued with cheap pointers, uniquely identifiable, and requiring no batteries. www.bioscience.heacademy.ac.uk/journal/ The late Professor Ed Wood (1941–2008) had many connections with biochemical education and his final editing task has now been published. This is a printed book titled Bioscience Education Collected papers volumes 1–8 and runs to 626 pages. The first edition of Bioscience Education came out in May 2003, when Ed Wood was Director of the Bioscience Education group. For the compilation of volumes 1–8, Ed Wood wrote a preface, in which he emphasized the high standard of editorial review for the journal and how this resulted in a collection of articles that are not ephemeral, but based on underlying fundamentals of teaching. The preface begins “In the last 10–20 years university teaching has undergone a number of profound changes. The universities have not only increased in size (number of students) but also they have increased in number. Furthermore, the electronic revolution began in earnest, leading to the concept of “e-learning” - use of computers, computer-based assessments, asynchronous learning, and an ‘anytime, anyplace’ ethos to course provision. The Internet has pervaded almost all aspects of university life and more recently the Web 2.0 technologies encourage users to alter the content and so become active contributors, rather than passive recipients of information. Such technologies have tremendous potential to improve communication between staff, between staff and students, and between student and student, yet the rapid rate of development means a sense of alienation and being left behind by the ‘digital natives’ is also a real possibility. Additionally, against a background of reducing resource for teaching, increasing class sizes and a much more disparate set of students entering the universities there has been a tremendous emphasis on research activity (almost certainly not pedagogic research in science departments). In the UK this has exacerbated the disparity in recognition, reward and emphasis between research and teaching activities and arguably has rewarded the former much more than the latter.” The book is organized by affinity of content under the section titles; The technology of teaching, Computer based/internet resources, Assessment, Multiple choice questions, Scientific writing/reading, Peer assessment/teaching, Ethics teaching, Laboratory projects, Skills training, and Miscellaneous. The book is free by request to the website given. www.ncbi.nlm.nih.gov/pubmed/19762644 Investigators from a consortium of institutions have constructed a complete model, including three-dimensional protein structures, of the central metabolic pathways of the bacterium Thermotoga maritima. This is the most comprehensive model of metabolism so far produced and is overlaid with atomic resolution structures of the proteins. Analysis of the model shows the important role of a small number of essential protein shapes; providing new insights into the evolution of protein networks (i.e. a single shape can be adapted to perform kindred reactions). The published network has 478 proteins characterized by biochemical studies, structural genomics, and computer modeling. The research may also have applications in energy research because bacteria like T. maritima can be engineered to produce hydrogen as a source of clean energy. The work has been published as Three-dimensional structural view of the central metabolic network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544–9. When extended and applied to humans the modeling could help identify drug reactions before clinical trials. www.bdc.ib.unicamp.br/rbebbm/ With 30,000 accesses per week this site is remarkably popular. I was led to it on the commendation of Manuel Costa and others in the BAMBED special edition on biochemical education in Latin America and Portugal (volume 37(5)). At an IUBMB meeting in Salvador Brazil (2007), I saw the enthusiasm of young Brazilians for a career in the molecular life sciences. Brazil, with 192 million people is the fifth most populous country behind China, India, USA, and Indonesia. Most education in Brazil is in the native language of Portuguese, but Brazilians are mindful of teaching and communicating in English to be part of the global community. This website has a wealth of teaching material by way of articles, animations, and teaching aids. The languages are a hybrid of English and Portuguese, often both for a single item. I became a registered user to get access to the free content. I also contributed some of my own material. As Brazil builds its economic standing, we can expect to see biochemical education get ever stronger in Brazil. www.cshperspectives.org Cold Spring Harbor offer several paid subscription titles and have now added a new title Perspectives in Biology that is free online. This journal offers comprehensive surveys of topics in molecular, cell and developmental biology, genetics, neuroscience, immunology, cancer biology, and molecular pathology. Eminent researchers have been commissioned to contribute articles of a high standard that will build to be comprehensive across the target research areas. November 2009 is the fifth of the monthly issues and has feature articles on NF-κB signaling in inflammation and cancer, auxin as a patterning signal for plants and membrane dynamics in cell polarity. Back issue articles are listed in groups by subject content (e.g. Symmetry Breaking in Biology has 18 entries). You can get Twitter or RSS feeds to alert you when new articles are available. The reviews are fulsome and could be used in coursework for student literature studies. www.sloanconsortium.org The Sloan Consortium (USA) supports the integration of online education into the total delivery of higher education. This nonprofit organization does have cost-recovery fees for membership and some services. The consortium particularly aims to facilitate sharing of effective practices to improve online education. At the website, you can find a catalog of degree and certificate programs offered by accredited members. For institutions reviewing their practices the consortium provides speakers and consultants to hosts conferences and workshops. Nevertheless it was the consortium's Journal of Asynchronous Learning Networks that attracted my initial attention. Access to the full journal content requires membership, but there is much to be garnered from abstracts of the articles. The following abstract from the journal is from the article The Road to Retention: A Closer Look at Institutions that Achieve High Course Completion Rates. “From 2003 to 2007, enrollment in online courses in the US nearly doubled, from 1.98 million to 3.94 million. By 2007, the 12.9% growth rate of online enrollments far exceeded the 1.2% growth of the overall higher education student population. Online education will continue to grow as a significant percentage of the 19 million enrollments in postsecondary education projected for 2010. In a climate of shifting demographics and economies, demand for higher education grows. Understanding how students succeed online can lead to far greater access and success, contributing significantly to initiatives for doubling the number of United States college graduates. Yet a barrier to greater access via online education is the belief that online retention rates are lower than in other delivery modes.” For non-members a pdf copy of the article is $5.95. www.youtube.com/education Beginning October 2009 YouTube has presented material from 45 universities in a strand that it has dedicated to education. According to their own promotion, YouTube EDU is a global classroom where everyone can watch and engage with a range of videos that have been uploaded by some of the world's great universities. Harvard is prominently featured. My first impression was that it was a jumble of short news-like bites on subjects of general interest, aimed at browsing visitors. Even pulling up the subcategory of science resulted in choices of mostly short items that focused heavily on the environment. An exception that caught my attention was a lecture submitted by the University of Maryland that took 84 min with questions at the end. The speaker was Steve Fuller, Professor of Sociology at the University of Warwick, UK. The talk revisited C.P. Snow's analysis of the divide between arts and science, sometimes called the science wars. Fuller claims that few recent commentators are familiar with the historical thinking that links Snow's concerns from the mid twentieth century to concerns of the present. It was interesting to me to listen to a speaker reminding me of the many philosophical insights of Snow and numerous other ancient and modern philosophers. After this diversion I found that entering biochemistry into the YouTube search field returned 342 matches. The biochemistry offerings are mostly conventional-length lectures on standard topics in main-stream biochemistry courses. www.ted.com Technology Entertainment And Design (TED) started out in 1984 as a conference to bring together innovators in the three areas of the title. This convergence brings to mind the often quoted phrase attributed to Lenin that “everything is connected to everything”. Whatever we do in education, we are connected with the core interests reflected by TED. The group claim to be dedicated to ideas worth spreading and they offer videos from the famous (e.g. Al Gore and Jane Goodall), the talented and the well qualified. It has been described as YouTube for intellectuals. However, with annual conferences, prizes, and community chats it is much more than that. The home page offers feature talks and you will get extra details by passing your mouse over each panel. There is a section on science and be sure to click on view all tags after browsing the default feature talks. I was well rewarded when I chose a presentation by Jonathan Drori titled “Why we're storing billions of seeds”. I encountered only excellence in my sampling of the big and small issues that are covered by TED. research.microsoft.com/apps/pubs/default.aspx?id=76529 This site leads to a article titled Cyberchondria: Studies of the Escalation of Medical Concerns in Web Search, authored by Ryen White and Eric Horvitz who are research staff employed by Microsoft. Cyberchondria is a term coined to describe hypochondriac behavior generated by undiscerning use of medical data obtained from the web. While the term cyberchondria is interesting in itself, the bigger-picture problem this represents is that of students believing flawed information from the web. The assertion that branched chain amino acids promote athletic strength is one of the flawed “facts” that comes to mind (it is not supported by reputable studies). As teachers we need to give students the skill to develop a baloney-meter (Carl Sagan's phrase) to appreciate credible and relevant information from the web, or wherever it is sourced. A way of looking at cyberchondria is as a form of medical-student-disease, which applies when medical students suffer the symptoms of the disease they are studying. A headache is unlikely to be viral encephalitis, but that does not stop a hypochondriac from worrying that it is the cause. The research for this article on cyberchondria involved a survey of 515 individuals who made health-related searches. Susceptible individuals suffered high anxiety and disruption of their work. Because the writers are employed by Microsoft the article has a focus that is not so much to fix the cyberchondriac, as to fix web-searching protocols and the structure of the content to avoid cyberchondria. The concluding comments to the article are “Search engine architects have a responsibility to ensure that searchers do not experience unnecessary concern generated by the definitions of relevance and the ranking algorithms their engines use. They must be cognizant of the potential challenges of cyberchondria, and focus on serving medical search results that are reliable, complete, and timely, as well as topically relevant. Directly tackling cyberchondria is an opportunity to leverage readily available expertise in the information-retrieval and medical informatics communities in areas, such as document ranking, user modeling, machine learning, and user interface design for the direct benefit of the many people turning to the Web to interpret common medical symptoms.”
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