Predictive factors for bladder function recovery following cervical OPLL surgery: a comprehensive analysis.

The authors performed a retrospective study of clinical and radiological data obtained in 27 Chinese patients with myelopathy induced by ossification of the ligamentum flavum (OLF) who underwent surgery between March 1990 and March 2002. The factors related to surgical outcome of thoracic OLF-induced myelopathy were also assessed. The preoperative clinical features and radiological findings were reviewed retrospectively. Preoperative and postoperative neurological status was assessed using the Japanese Orthopaedic Association (JOA) scoring system and the Nurick Scale. The ossified lesions were classified into five types (lateral, extended, enlarged, fused, and tuberous). Multiple linear regression and logistic regression analyses were performed to establish the factors affecting surgical outcome. The patients' chief complaints were lower-limb weakness and gait disturbance (93%), numbness and sensory deficit (89%), and low-back pain (48%). The coexisting pathological entities were disc herniation, canal stenosis, and ossification of posterior longitudinal ligament. The ossified ligamentum flavum was mainly located at the T10-12 (67%) and T1-3 (15%) levels. Symptoms in 26 patients improved but resolved completely in only 14 after surgery. The mean overall JOA score was 5.3 +/- 1.9 preoperatively and 7.9 +/- 2.3 postoperatively. There is a significant difference between the pre- and postoperative neurological status (p < 0.05) determined by the Student t-test. The recovery rate was 46.3 +/- 9.4%. Multiple regression analysis revealed negative correlation between the duration of preoperative symptoms and surgical outcome as well as a positive correlation between the preoperative JOA score and surgical outcome. Logistic regression analysis demonstrated that fecal and/or urinary incontinence, positive patellar and/or ankle clonus, and intramedullary high T2-weighted magnetic resonance (MR) imaging signal change had negative effects on the surgical outcome. The clinical and radiological features of OLF in the Chinese population are similar to those observed in the Japanese population. The duration of preoperative symptoms and JOA score are the most important predictors of the postoperative JOA score and recovery rate. The patients with fecal and/or urinary incontinence, positive patellar and/or ankle clonus, and intramedullary high T2-weighted MR imaging signal change were at higher risk of poor outcome after surgery.

The purpose of this research is to compare the clinical efficacy, postoperative complication and surgical trauma between anterior cervical corpectomy and fusion versus posterior laminoplasty for the treatment of oppressive myelopathy owing to cervical ossification of the posterior longitudinal ligament (OPLL). Systematic review and meta-analysis. An comprehensive search of literature was implemented in three electronic databases (Embase, Pubmed, and the Cochrane library). Randomized or non-randomized controlled studies published since January 1990 to July 2017 that compared anterior cervical corpectomy and fusion (ACCF) versus posterior laminoplasty (LAMP) for the treatment of cervical oppressive myelopathy owing to OPLL were acquired. Exclusion criteria were non-human studies, non-controlled studies, combined anterior and posterior operative approach, the other anterior or posterior approaches involving cervical discectomy and fusion and laminectomy with (or without) instrumented fusion, revision surgeries, and cervical myelopathy caused by cervical spondylotic myelopathy. The quality of the included articles was evaluated according to GRADE. The main outcome measures included: preoperative and postoperative Japanese Orthopedic Association (JOA) score; neuro-functional recovery rate; complication rate; reoperation rate; preoperative and postoperative C2-C7 Cobb angle; operation time and intraoperative blood loss; and subgroup analysis was performed according to the mean preoperative canal occupying ratio (Subgroup A:the mean preoperative canal occupying ratio <60%, and Subgroup B:the mean preoperative canal occupying ratio ≥60%). A total of 10 studies containing 735 patients were included in this meta-analysis. And all of the selected studies were non-randomized controlled trials with relatively low quality as assessed by GRADE. The results revealed that there was no obvious statistical difference in preoperative JOA score between the ACCF and LAMP groups in both subgroups. Also, in subgroup A (the mean preoperative canal occupying ratio <60%), no obvious statistical difference was observed in the postoperative JOA score and neurofunctional recovery rate between the ACCF and LAMP groups. But, in subgroup B (the mean preoperative canal occupying ratio ≥60%), the ACCF group illustrated obviously higher postoperative JOA score and neurofunctional recovery rate than the LAMP group (P<0.01, WMD 1.89 [1.50, 2.28] and P<0.01, WMD 24.40 [20.10, 28.70], respectively). Moreover, the incidence of both complication and reoperation was markedly higher in the ACCF group compared with LAMP group (P<0.05, OR 1.76 [1.05, 2.97] and P<0.05, OR 4.63 [1.86, 11.52], respectively). In addition, the preoperative cervical C2-C7 Cobb angle was obviously larger in the LAMP group compared with ACCF group (P<0.05, WMD -5.77 [-9.70, -1.84]). But no statistically obvious difference was detected in the postoperative cervical C2-C7 Cobb angle between the two groups. Furthermore, the ACCF group showed significantly more operation time as well as blood loss compared with LAMP group (P<0.01, WMD 111.43 [40.32,182.54], and P<0.01, WMD 111.32 [61.22, 161.42], respectively). In summary, when the preoperative canal occupying ratio<60%, no palpable difference was tested in postoperative JOA score and neurofunctional recovery rate. But, when the preoperative canal occupying ratio ≥60% ACCF was associated with better postoperative JOA score and the recovery rate of neurological function compared with LAMP. Synchronously, ACCF in the cure for cervical myelopathy owing to OPLL led to more surgical trauma and more incidence of complication and reoperation. On the other hand, LAMP had gone a diminished postoperative C2-C7 Cobb angle, that might be a cause of relatively higher incidence of postoperative late neurofunctional deterioration. In brief, when the preoperative canal occupying ratio <60%, LAMP seems to be effective and safe. However, when the preoperative canal occupying ratio ≥60%, we prefer to choose ACCF while complications could be controlled by careful manipulation and advanced surgical techniques. No matter which option you choose, benefits and risks ought to be balanced.

A circumferential decompression-based surgical strategy for multilevel ossification of thoracic posterior longitudinal ligament

Laminoplasty is the preferred operation for most patients with cervical myelopathy due to multilevel ossification of the posterior longitudinal ligament (OPLL). Recent studies have demonstrated several significant risk factors for poor clinical outcomes after laminoplasty, including older age, lower preoperative Japanese Orthopaedic Association (JOA) score, postoperative change in cervical alignment, cervical kyphosis, and high occupying ratio of the OPLL (that is, the ratio of the greatest anteroposterior thickness of the OPLL to the anteroposterior diameter of the spinal canal at the same level on a lateral image). However, the impact of dynamic factors on clinical outcomes is unclear. The purpose of this study is to assess the impact of dynamic factors on the clinical outcome after laminoplasty for cervical myelopathy due to OPLL. A consecutive series of patients who underwent laminoplasty for cervical myelopathy due to OPLL between 2003 and 2009 was retrospectively reviewed. The indication for laminoplasty at the authors' hospital included preoperative straight or lordotic alignment of the cervical spine and an occupying ratio of OPLL less than 60%. The JOA score and recovery rate were used to evaluate clinical outcomes. A poor clinical outcome was defined as a recovery rate of less than 50%. Patient factors examined along with outcome included age, preoperative JOA score, preoperative somatosensory evoked potentials, preoperative motor evoked potentials, body mass index, and presence of high intensity on MRI. Radiographic measures included the preoperative C2-7 lordotic angle, preoperative C2-7 range of motion (ROM), preoperative segmental ROM at the level of myelopathy, and the occupying ratio of OPLL. There were 45 patients (33 males and 12 females). The mean follow-up period was 4 years (range 2-6.8 years). The mean patient age was 66.9 years (range 50-85 years). The mean JOA score significantly increased from 9.1 before surgery to 13.1 at the final follow-up. The mean recovery rate was 51.2%. Nineteen patients (42%) had a recovery rate of less than 50%. Patient factors were not associated with surgical outcomes. Only the preoperative C2-7 ROM was significantly greater in the poor surgical outcome group (23.1° vs 14.1°). Receiver operating characteristic curve analysis showed that the optimal preoperative C2-7 ROM cutoff was 20°. Logistic regression analysis revealed that patients with a preoperative C2-7 ROM of greater than 20° had a 4.6 times higher risk (p = 0.021) of a poor clinical outcome, indicating that dynamic factors may have an impact on the surgical outcome of laminoplasty. Fusion surgery may be a useful strategy in patients with preoperative hypermobility of the cervical spine.

The objective of this study was to select factors related to the prognosis and curative effect for posterolateral fusion (PLF) of lumbar low-grade isthmic spondylolisthesis (LGIS). Of 125 patients who accepted PLF treatment, 119 obtained solid union in this prospective study. Statistical analysis was used to evaluate factors related to the prognosis and curative effect. Spondylolisthetic position (L4, L5), gender and postoperative percent disc height were not significant factors for the prognosis and curative effect. Length of disease history (LDH), preoperative Japanese Orthopaedic Association (JOA) score and postoperative percentage of slipping (% slip) were significantly related to postoperative JOA score and postoperative improved JOA score. LDH and postoperative % slip were significantly related to postoperative recovery rate. LDH, preoperative JOA score and postoperative % slip were independent related factors for the prognosis and improvement of LGIS. LDH and postoperative % slip were independent related factors for the curative effect. However, age, gender, spondylolisthetic position and postoperative percent disc height were not significant factors.

Friday, September 28, 2018 4:05 PM–5:05 PM abstracts: new concepts: cervical spine: 244. Which is better for C2 involved ossification of posterior longitudinal ligament (OPLL): Dome-like laminoplasty or double-door laminoplasty?

ObjectivesThe purpose of the present study was to explore and analyze the long-term outcomes and factors that affect the prognosis of expansive open-door laminoplasty with lateral mass screw fusion in treatment of cervical spondylotic myelopathy (CSM).MethodsWe retrospectively reviewed 49 patients with multilevel CSM who had undergone expansive open-door laminoplasty with lateral mass screws fixation and fusion in our hospital between February 2008 and February 2012. The average follow-up period was 4.6 years. The clinical data of patients, including age, sex, operation records, pre- and postoperation Japanese Orthopedic Association (JOA) scores, cervical spine canal stenosis, and cervical curvature, were collected. Increased signal intensity (ISI) on T2-weighted magnetic resonance imaging and ossification of the posterior longitudinal ligament were also observed. Paired t-test was used to analyze the treatment effectiveness and recovery of neuronal function. The prognostic factors were analyzed with multivariable linear regression model.ResultsForty-nine patients with CSM with a mean age of 59.44 years were enrolled in this study. The average of preoperative JOA score was 9.14±2.25, and postoperative JOA score was 15.31±1.73. There was significant difference between the pre- and postoperative JOA scores. The clinical improvement rate was 80.27%. On follow-up, five patients had complaints of neck and shoulder pain, but no evidence of C5 nerve palsy was found. Developmental cervical spine canal stenosis was present in all patients before surgery. Before surgery, ISI was observed in eight patients, while ossification of the posterior longitudinal ligament was found in 12 patients. The average of preoperative cervical curvature was 21.27°±8.37° and postoperative cervical curvature was 20.09°±1.29°, and there was no significant difference between the pre- and postoperative cervical curvatures. Multivariable linear regression analysis results showed that the postoperation JOA scores were significantly affected by age, preoperative JOA scores, and preoperative ISI. Except one case of epidural hematoma, there were no complications associated with the surgery.ConclusionTreatment of CSM with posterior open-door laminoplasty with lateral mass screw fusion is effective with few complications. In addition, the normal cervical lordosis was well maintained. Age, preoperative JOA scores, and preoperative ISI were the independent factors that significantly affect disease prognosis and surgical outcomes.

Prospective analysis of clinical evaluation and self-assessment by patients after decompression surgery for degenerative lumbar canal stenosis

Circumspinal decompression with dekyphosis stabilization was prospectively performed with thoracic myelopathy due to ossification of posterior longitudinal ligament (OPLL). Neurologic outcome was reviewed. To evaluate how easily, safely, and completely the thoracic OPLL can be removed or floated by circumspinal decompression with dekyphosis stabilization. Anterior decompression is the best for the spinal cord recovery to treat thoracic myelopathy caused by OPLL on the concave side of the spinal cord. However, anterior approach for removal of OPLL plaque is technically demanding. This is an operative procedure. Wide laminectomy is performed. Bilateral gutters along the dural tube are made using a diamond drill into the vertebral body covering the extent of the OPLL to be removed anteriorly. Posterior instrumentation is applied for stabilization of the spine and reducing thoracic kyphosis by approximately 5 to 10 degrees (dekyphosis stabilization). Four weeks after the first step, anterior decompression is performed with direct vision with the landmark of gutters using an operative microscope, followed by interbody fusion. Fifteen patients with thoracic myelopathy due to OPLL had the first-step operation, and 11 patients underwent circumspinal decompression (both the first and second operation). Kyphosis in the stabilization area reduced from 30.7 to 24.7 degrees on average in 15 patients. In 2 of the 15 patients, the spinal cord was shifted posteriorly and completely decompressed by only the first-step operation in the postoperative myelography or magnetic resonance imaging. The second-step operation was cancelled, and their Japanese Orthopedic Association scores improved from 6 to 10 points and from 4 to 10.5 point, respectively at final follow-up. In other 13 patients, the spinal cord was still compressed by the OPLL plaque. In 2 of the 13 patients, the second-step operation was cancelled because their general condition was impaired. Their preoperative Japanese Orthopedic Association scores were 2.0 and 2.5, and final scores were 5.5 and 5.5 points, respectively. Remaining 11 patients who underwent circumspinal decompression (both the first and second operation) neurologically improved and maintained from 4.0 points to 9.1 points on average at final follow-up. The OPLL plaque in the thoracic spine might be most easily, safely, and completely removed or floated, and the spinal cord is circumferentially decompressed through circumspinal decompression with dekyphosis stabilization.

Study design:Systematic review and meta-analysis.Background:Anchor screw fixation and mini-plate fixation are widely used in unilateral open-door laminoplasty. There is a great controversy over the preferred fixation method. The purpose of this study is to evaluate the clinical outcomes between anchor screw fixation and mini-plate fixation for the treatment of multilevel cervical spondylotic myelopathy (MCSM).Methods:Related studies that compared the clinical effectiveness of anchor screw fixation and mini-plate fixation in cervical laminoplasty for the treatment of MCSM were acquired by a comprehensive search in PubMed, Embase, the Cochrane library, CNKI, VIP, and WANFANG up to March, 2018. Included studies were evaluated according to eligibility criteria. The main end points included: preoperative Japanese Orthopedic Association (JOA) scores, postoperative JOA scores, JOA scores improvement rate, preoperative and postoperative cervical range of motion (ROM), preoperative and postoperative cervical curvature index (CCI), lamina open angle, operation time, blood loss, C5 nerve palsy rate and axial symptoms rate.Results:Papers in English and Chinese were searched for the initial review, but only 12 articles in Chinese were included in this meta-analysis. All of the selected studies were of high quality as indicated by the Newcastle–Ottawa scale (NOS). Among 809 patients, 372 underwent anchor screw fixation and 437 underwent mini-plate fixation. The results of this meta-analysis indicated that no significant difference was found in preoperative JOA score, JOA scores improvement rate, preoperative CCI, preoperative ROM, C5 palsy rate and blood loss. However, compared with mini-plate fixation, anchor screw fixation patients showed higher axial symptoms rate [RR = 1.75, 95% CI (1.31, 2.35), P <.05], lower postoperative JOA scores [SMD = −0.38, 95% CI (−0.62, −0.15), P <.05], lower postoperative CCI [SMD = −0.64, 95% CI (−0.94, −0.33), P <.05], lower postoperative ROM [SMD = −1.11, 95% CI (−2.18, −0.04), P <.05], smaller lamina open angle [SMD = −1.98, 95% CI (−3.71, −0.24), P <.05], shorter operation time [SMD = −0.33, 95% CI (−0.59, −0.07), P <.05].Conclusions:Compared with anchor screw fixation, mini-plate fixation in cervical laminoplasty appears to achieve better clinical and radiographic outcomes with fewer surgical complications. However, future well-designed, randomized controlled trials are still needed to further confirm our results.

AB0319 Is DAS28 a Useful Tool for Evaluating Hip Joint Disorders in Rheumatoid Arthritis?

To investigate the effect of ultrasonic bone curette in anterior cervical spine surgery. A clinical data of 63 patients with cervical spondylosis who were admitted between September 2019 and June 2021 and met the selection criteria was retrospectively analyzed. Among them, 32 cases were operated with conventional instruments (group A) and 31 cases with ultrasonic bone curette (group B). There was no significant difference between the two groups (P>0.05) in gender, age, surgical procedure, surgical segment and number of occupied cervical space, disease type and duration, comorbidities, and preoperative Japanese Orthopaedic Association (JOA) score, cervical dysfunction index (NDI), and pain visual analogue scale (VAS) score. The operation time, intraoperative bleeding, postoperative drainage, postoperative hospital stay, and the occurrence of postoperative complications were recorded in both groups. Before operation and at 1, 3, and 6 months after operation, the JOA score and NDI were used to evaluate the function and the postoperative JOA improvement rate was calculated, and VAS score was used to evaluate the pain improvement. The anteroposterior and lateral cervical X-ray films were taken at 1, 3, and 6 months after operation to observe whether there was any significant loosening and displacement of internal fixators. Compared with group A, group B had shorter operation time and postoperative hospital stay, less intraoperative bleeding and postoperative drainage, and the differences were significant (P<0.05). All incisions healed by first intention in the two groups, and postoperative complications occurred in 5 cases (15.6%) in group A and 2 cases (6.5%) in group B, showing no significant difference (P>0.05). All patients were followed up 6-12 months (mean, 7.9 months). The JOA score and improvement rate gradually increased in groups A and B after operation, while the VAS score and NDI gradually decreased. There was no significant difference in VAS score between 3 months and 1 month in group B (P>0.05), and there were significant differences between the other time points of each indicator in the two groups (P<0.05). At 1, 3, and 6 months after operation, the JOA score and improvement rate in group B were better than those in group A (P<0.05). X-ray films examination showed that there was no screw loosening or titanium plate displacement in the two groups after operation, and the intervertebral cage or titanium mesh significantly sank. Compared with traditional instruments, the use of ultrasonic bone curette assisted osteotomy in anterior cervical spine surgery has the advantages of shorter operation time, less intraoperative bleeding, less postoperative drainage, and shorter hospital stay.

Comparison of fusion versus non-fusion surgery for retro-odontoid pseudotumor with atlanto-axial subluxation

Comparison of the Prognostic Value of Different Quantitative Measurements of Increased Signal Intensity on T2-Weighted MRI in Cervical Spondylotic Myelopathy

Objective To study the clinic efficacy of anterior arch resection, atlantoaxial joint release combined with posterior fixation and fusion for odontoid malunion associated with irreducible atlantoaxial dislocation. Methods From February 2007 to February 2012,6 patients (5 males, 1 female) were diagnosed with odontoid malunion associated with irreducible atlanto-axial dislocation. The ages ranged from 36 to 57 years (average 45.5 years). There were traumatic histories and spinal injury symptoms in all patients. The preoperative Japanese Orthopaedic Association (JOA) score was 7.5±2.2 (range, 4-10), and the space available for the cord (SAC) of preoperation ranged from 5 to 11 mm (8.1±2.5 mm). All cases received anterior arch resection, atlantoaxial joint release combined with posterior fixation and fusion. They all wore cervical collar for 3 months after operation. The function of spinal cord was observed and atlanto-axial reduction and fusion was evaluated by postoperative X-ray and CT scan. Results All the patients underwent surgery successfully and their atlanto-axial reductions were complete. 6 cases were followed up for 12-20 months (average 16 months). No instrument failure or dislocation was observed during follow-up. Bone graft fusion was achieved 3 months after operation. The JOA score at the last follow-up was 10-15 (average 14.7±2.1), which showed significant difference compared with preoperative score. The average improving rate of JOA was 75.5%. The SAC at the last follow-up was 11-17mm (average 13.5±2.6 mm), which had significant difference compared with preoperative score. On the 5th day after operation, one patient experienced exudation and poor healing of posterior incision which was resolved by lateral position avoiding compression of wound. The posterior incision healed within 3 weeks. On the 3th day after operation, apathy occurred in one case and laboratory tests showed hypernatremia and hypokalemia. The consciousness of the patient recovered within 1 day after venous fluid infusion timely. Conclusion Anterior arch resection, atlantoaxial joint release combined with posterior fixation and fusion is a safe and efficient method with satisfactory short-term outcome for odontoid malunion associated with irreducible atlantoaxial dislocation. Key words: Odontoid process; Spinal fractures; Fracture healing; Atlanto-axial joint; Dislocations; Spinal cord compression