Primer on large language models: an educational overview for intensivists

In today’s rapidly evolving business landscape, Artificial Intelligence (AI), and specifically Large Language Models (LLMs), are redefining how organizations operate, make decisions, and engage with customers. AI-driven technologies have become indispensable, providing businesses with powerful tools to streamline operations, derive actionable insights from vast data, and foster more meaningful customer interactions. For business leaders, scholars, and practitioners alike, understanding the transformative potential of AI isn’t just advantageous—it’s essential to staying competitive in an increasingly data-driven world.This editorial delves into recent scholarly advancements in LLM applications within business contexts, analyzing studies that explore AI’s potential across various domains, from decision support to creative industries. By introducing a structured framework, this editorial highlights key insights and contributions from recent studies, assessing their value to academia and industry. The following comparative analysis sheds light on how these innovations shape our understanding of AI’s role in business while pointing to future research directions.Puyt and Madsen's (2024) study stands out as a foundational exploration of LLM accuracy, assessing ChatGPT-4's ability to recount the history of the SWOT analysis-a vital business strategy tool. Their findings reveal that, while ChatGPT-4 effectively conveys general concepts, it struggles with detailed historical information, often producing inaccuracies or "hallucinations." This gap underscores the need for LLMs to be trained with verified academic data, particularly for strategic business applications that demand precision. This study not only contributes to the literature by proposing methods to evaluate AI accuracy in historical contexts but also highlights the importance of rigorous information vetting in industry settings where reliability is crucial.In contrast, Raikov et al. (2024) explore a hybrid intelligence model that combines LLM capabilities with explainable AI (XAI) principles to enhance human-machine collaboration. Their approach emphasizes cognitive semantics, improving transparency and decision-making efficiency. The hybrid model's real-time adaptability addresses the needs of complex, regulated industries such as finance and healthcare, where trust in AI decisions is paramount. Academically, this study provides a valuable addition to XAI literature by demonstrating how LLMs can bridge the gap between AI autonomy and human oversight, making it a model for future human-AI interactions in complex business environments.Another significant study by Mariotti and colleagues (2024) examines the integration of LLMs with enterprise knowledge graphs to enhance data-driven decision-making. By enabling organizations to leverage knowledge graphs for more accurate and scalable data retrieval, this research provides a robust framework for businesses seeking efficient knowledge management systems. The academic contribution here lies in advancing the dialogue between LLMs and knowledge graphs, emphasizing ethical data handling and quality standards essential for industry applications. For enterprises, the study offers practical solutions to achieve streamlined data management, balancing automation with privacy and security. 2024) take a different approach, investigating LLMs' role in creative industries, specifically within fashion design. They introduce a hybrid intelligence model that supports creative processes, allowing AI to complement rather than replace human ingenuity. While LLMs in this field demonstrate potential in automating repetitive design tasks and enhancing customer personalization, the study reveals limitations in AI's ability to handle spatial and stylistic nuances. This study's academic contribution lies in promoting human-AI co-creation, inspiring further research into AI applications across diverse creative sectors, including media and marketing.Collectively, these studies not only illuminate LLMs' transformative potential in business but also highlight critical ethical and operational considerations. Ensuring accuracy, transparency, and data privacy are vital to responsibly integrating AI into business workflows. Future research should focus on enhancing LLM accuracy, refining hybrid intelligence models, and exploring creative AI applications, all while maintaining ethical standards. As LLMs evolve, interdisciplinary collaborations will be essential to harness their full potential, making AI an ethical, effective, and innovative force in the business world.

The integration of artificial intelligence (AI), including the recent appearance of revolutionary large language models (LLMs), marks a transformative era in the field of negotiations, reshaping traditional practices and presenting a range of opportunities and challenges. This article delves into the evolving interplay between negotiation and various AI technologies, as they now combine massive computational power with user-friendly interfaces capable of fluent, multi-topic conversations. The article categorizes AI's role in negotiation into assistance, semi-automation, and automation, each offering unique advantages and addressing different negotiation needs. While AI's ability to compensate for human limitations in rationality, emotion, and computational capacity is promising, it also raises concerns regarding biases, ethical considerations, and the reliability of automated decision-making. The burgeoning AI and negotiation collaboration necessitates a balanced approach, harnessing AI's potential to enhance negotiation outcomes while conscientiously navigating its challenges. This article aims to foster understanding of and influence the future trajectory of negotiation and AI, highlighting the need for ongoing research and development to ensure ethical, effective, and equitable negotiation practices in an AI-augmented future.

The integration of Artificial Intelligence (AI) and medical treatment not only makes the clinical diagnosis more accurate, but also makes the patient's rehabilitation more systematic and professional, especially after the advent of the Large Language Model(LLM) in the past 2 years. This paper discusses 3 clinical cases of 2 kinds of LLMs: ChatGPT (GPT-3.5) and GPT-4 in Physical Medicine and Rehabilitation (PM&R), and shows their powerful analytical reasoning ability. In the first experiment, ChatGPT and the leading professional doctors in the industry were asked to classify the emergency records of ophthalmology during the 10-year period, infer the severity of each patient's illness and determine the nursing requirements. In the later experiment, GPT-4, an upgraded version of GPT-3.5, delayed the diagnosis of medical history data of patients aged 65 and over, to study the clinical diagnosis opinions and systematic treatment scheme of GPT-4 as a "professional doctor". ChatGPT and GPT-4 participated in the examination with 12 categories of neurosurgery medical fields, which was shown in the last experiment, aiming at studying their medical professional level and discussing their clinical reliability and effectiveness, as well as LLMs' ability of reasoning questions step by step. The experimental results show that these 2 kinds of large language models have professional and powerful ability to analyze actual projects, and their performance even far exceeds that of professional clinicians. At the same time, the existing defects of the models and their more applications in the medical field in the future are prospected.

Artificial General Intelligence (AGI) is set to profoundly impact the traditional upstream geoenergy industry (i.e., geothermal energy, oil and gas industry) by introducing unprecedented efficiencies and innovations. This paper explores AGI's foundational principles and its transformative applications, particularly focusing on the advancements brought about by large language models (LLMs) and extensive computer vision systems in the upstream sectors of the industry. The integration of Artificial Intelligence (AI) has already begun reshaping the upstream geoenergy landscape, offering enhancements in production optimization, downtime reduction, safety improvements, and advancements in exploration and drilling techniques. These technologies streamline logistics, minimize maintenance costs, automate monotonous tasks, refine decision-making processes, foster team collaboration, and amplify profitability through error reduction and actionable insights extraction. Despite these advancements, the deployment of AI technologies faces challenges, including the necessity for skilled professionals for implementation and the limitations of model training on constrained datasets, which affects the models' adaptability across different contexts. The advent of generative AI, exemplified by innovations like ChatGPT and the Segment Anything Model (SAM), heralds a new era of high-density innovation. These developments highlight a shift towards natural language interfaces and domain-knowledge-driven AI, promising more accessible and tailored solutions for the upstream geoenergy industry. This review articulates the vast potential AGI holds for tackling complex operational challenges within the upstream geoenergy industry, requiring near-human levels of intelligence. We discussed the promising applications, the hurdles of large-scale AGI model deployment, and the necessity for domain-specific knowledge in maximizing the benefits of these technologies.

Introduction Advances in large language models (LLMs) have opened new avenues for healthcare applications. Recently, ChatGPT-4 successfully achieved the pass mark >80% in 5 of 10 sleep medicine examination domains, indicating a strong foundational knowledge of sleep medicine. However, the ability to answer USMLE-type multiple-choice questions may not equate to the capacity to offer accurate and comprehensive answers to clinical queries or real-world case scenarios. Current literature exhibits a significant gap in validation research examining the clinical utility of LLMs in evidence-based medicine practice. This investigation aims to evaluate the potential usefulness and reliability of LLMs as adjunctive clinical decision-support tools (namely, “curbside consultants”) in sleep medicine. Methods Six clinical sleep queries and six case scenarios were presented to 6 LLMs including 3 general-purpose LLMs (ChatGPT-4o, Gemini-1.5-Pro, and Llama-3.1-405B) and 3 medical-specialized LLMs (OpenEvidence, Clara AI, and MediGPT). Performance assessment was conducted independently utilizing two independently developed 5-point Likert scales evaluating two primary domains: answer content (accuracy, relevance, comprehensiveness/depth, clarity/coherence, and unique insightfulness) and reference quality (accuracy, relevance, currentness, comprehensiveness/depth, and searchability). Benchmark answers were established through consensus among four sleep medicine specialists. Analysis of variance was used to compare the performance of the LLMs. Results The medical LLMs demonstrated superior overall performance compared to the general LLMs (P< 0.001). The primary distinction was observed in reference quality metrics, where medical LLMs significantly outperformed general LLMs across all parameters: accuracy, relevance, and searchability (p< 0.001), currentness (p=0.001), and comprehensiveness/depth (p=0.010). Notably, Open Evidence achieved the highest reference quality (p< 0.001). In contrast, the answer content analysis revealed no significant overall differences between medical and general LLMs (p=0.659). Most answer content-related metrics, including accuracy, relevance, or unique insightfulness, did not differ significantly (p>0.050). An exception was clarify/coherence, where medical LLMs were superior to general LLMs (p=0.030). Furthermore, MediGPT and ChatGPT-4o displayed better content comprehensiveness/depth relative to other LLMs (p< 0.001). These two LLMs exhibited comparable performance in overall metrics (p=0.615), answer contents (p=0.922), and reference quality (p=0.621). Conclusion Both medical-specialized and general-purpose LLMs show promise as adjunctive decision-support tools in clinical practice. However, substantial improvements in reference quality are critically needed across most LLM platforms. Support (if any)

In today's rapidly evolving business landscape, Artificial Intelligence (AI) stands as the proverbial 'elephant in the room,' profoundly shaping diverse sectors and contexts. While debates rage among policymakers, practitioners, and politicians about regulating AI's widespread use, it's undeniable that AI represents a long-awaited digital technology poised to revolutionize organizational performance. Amidst the post-COVID era, the allure of AI has intensified, yet the critical question lingers: Can firms effectively harness AI and other technologies, such as Generative AI and Large Language Models (LLMs), to enhance their existing systems? Through a systematic literature review, a clear correlation between firms’ implementation of AI, including the cutting-edge Generative AI, and their ability to adapt to changing market dynamics, drive operational excellence, and unlock new avenues for growth are explored. Moreover, key drivers of AI and digital adoption, such as the imperative for data-driven decision-making, the quest for customer-centricity, and the drive for sustainable business practices are explored. Our research not only highlights the transformative potential of AI and digital technologies but also provides actionable insights for business leaders navigating the complexities of technology adoption. By understanding the motivations, challenges, and strategic imperatives driving firms' technology choices, including the integration of Generative AI and LLMs, organizations can chart a path towards sustainable growth and competitive advantage in the digital age. This study underscores the revolutionary impact of Generative AI in digital transformation, offering a comprehensive understanding of their role in shaping the future of business.

Evaluating gpt-4 for zero-shot classification of bleeding and clotting events: Can large language models serve as second reviewers?

BackgroundThe exponential growth of medical knowledge presents a paradox for modern medical education. While access to information is immediate, applying it in a clinically meaningful way remains a challenge. Large language models (LLMs), such as ChatGPT, are widely used for information retrieval, yet their role in dynamic, high-pressure clinical learning remains poorly understood.ObjectiveThis study aims to evaluate whether unstructured access to an LLM improves decision-making, teamwork, and confidence in trauma education for medical students.MethodsThis randomized controlled pilot study involved 41 final-year medical students participating in a trauma simulation session. Students self-selected into teams of 4 to 6 and were randomized to either an LLM-assisted group (ChatGPT-4o mini) or a control group without LLM access. All teams completed 18 video-based trauma scenarios requiring time-sensitive clinical decisions. Prompting was unrestricted. Confidence and trauma exposure were assessed using pre- or postquestionnaires. Facilitators rated teamwork (1-5), decision accuracy, and response times. Knowledge retention was measured 4 weeks later via an online quiz.ResultsConfidence in trauma management improved in both groups (P<.001), with larger gains in the non-LLM group (P=.02). LLM support did not enhance the decision accuracy or speed and was associated with longer response times in some complex cases. Teams without LLMs demonstrated more active discussion and scored higher in teamwork ratings (median 5.0 [IQR 5.0-5.0] vs median 3.5 [IQR 3.0-4.5]; P=.08). Students primarily used the LLM for fact-checking but reported vague or overly general responses. Knowledge retention was high across both groups and did not differ significantly (P=.33).ConclusionsWhile students appreciated the inclusion of artificial intelligence (AI), unstructured LLM use did not improve performance and may have disrupted the group reasoning. The use of non-English prompting likely contributed to lower AI performance, underscoring the importance of language alignment in LLM applications. This pilot study highlights the need for structured AI integration and targeted instruction in AI literacy. Simulation-based trauma education proved effective and well received, but optimizing the educational value of LLMs will require thoughtful curricular design. Further studies with more students are needed to define best practices for LLM use in clinical education.

With the widespread adoption of large language models (LLMs) in code generation tasks, geospatial code generation has emerged as a critical frontier in the integration of artificial intelligence and geoscientific analysis. This growing trend underscores the urgent need for systematic evaluation methodologies to assess the generation capabilities of LLMs in geospatial contexts. In particular, geospatial computation and visualization tasks in the JavaScript environment rely heavily on the orchestration of diverse frontend libraries and ecosystems, posing elevated demands on a model’s semantic comprehension and code synthesis capabilities. To address this challenge, we propose GeoJSEval—the first multimodal, function-level automatic evaluation framework for LLMs in JavaScript-based geospatial code generation tasks. The framework comprises three core components: a standardized test suite (GeoJSEval-Bench), a code submission engine, and an evaluation module. It includes 432 function-level tasks and 2071 structured test cases, spanning five widely used JavaScript geospatial libraries that support spatial analysis and visualization functions, as well as 25 mainstream geospatial data types. GeoJSEval enables multidimensional quantitative evaluation across metrics such as accuracy, output stability, resource consumption, execution efficiency, and error type distribution. Moreover, it integrates boundary testing mechanisms to enhance robustness and evaluation coverage. We conduct a comprehensive assessment of 20 state-of-the-art LLMs using GeoJSEval, uncovering significant performance disparities and bottlenecks in spatial semantic understanding, code reliability, and function invocation accuracy. GeoJSEval offers a foundational methodology, evaluation resource, and practical toolkit for the standardized assessment and optimization of geospatial code generation models, with strong extensibility and promising applicability in real-world scenarios. This manuscript represents the peer-reviewed version of our earlier preprint previously made available on arXiv.

Biomedical ultrasound imaging, as one of the most common, safe, and cost-effective modalities in clinical diagnosis, witnesses remarkable progress with the integration of artificial intelligence (AI). Early studies based on traditional machine learning (ML) rely on handcrafted features and classical classifiers to achieve automatic recognition and quantitative analysis of ultrasound images. However, such methods are limited in feature representation capacity and generalizability. With the advent of deep learning (DL), convolutional neural networks (CNNs), recurrent neural networks (RNNs), and attention-based architectures are widely applied to tasks such as segmentation, detection, and lesion classification, significantly improving diagnostic accuracy and robustness. More recently, large language models (LLMs) and multimodal foundation models open new avenues for intelligent ultrasound analysis. These models not only integrate imaging and textual information to support automated report generation and cross-modal reasoning but also offer enhanced interpretability and greater potential for clinical adoption. In this review, we provide a systematic review of the evolution of AI in ultrasound image analysis, spanning from traditional ML to deep learning and LLMs, outlining a complete trajectory of methodological advances.

With the rapid evolution of artificial intelligence (AI), its potential implications for higher education have become a focal point of interest. This study delves into the capabilities of AI in physics education and offers actionable AI policy recommendations. Using openAI’s flagship gpt-3.5-turbo large language model (LLM), we assessed its ability to answer 1337 physics exam questions spanning general certificate of secondary education (GCSE), A-Level, and introductory university curricula. We employed various AI prompting techniques: Zero Shot, in context learning, and confirmatory checking, which merges chain of thought reasoning with reflection. The proficiency of gpt-3.5-turbo varied across academic levels: it scored an average of 83.4% on GCSE, 63.8% on A-Level, and 37.4% on university-level questions, with an overall average of 59.9% using the most effective prompting technique. In a separate test, the LLM’s accuracy on 5000 mathematical operations was found to be 45.2%. When evaluated as a marking tool, the LLM’s concordance with human markers averaged at 50.8%, with notable inaccuracies in marking straightforward questions, like multiple-choice. Given these results, our recommendations underscore caution: while current LLMs can consistently perform well on physics questions at earlier educational stages, their efficacy diminishes with advanced content and complex calculations. LLM outputs often showcase novel methods not in the syllabus, excessive verbosity, and miscalculations in basic arithmetic. This suggests that at university, there’s no substantial threat from LLMs for non-invigilated physics questions. However, given the LLMs’ considerable proficiency in writing physics essays and coding abilities, non-invigilated examinations of these skills in physics are highly vulnerable to automated completion by LLMs. This vulnerability also extends to pysics questions pitched at lower academic levels. It is thus recommended that educators be transparent about LLM capabilities with their students, while emphasizing caution against overreliance on their output due to its tendency to sound plausible but be incorrect.

The integration of artificial intelligence (AI), particularly large language models (LLMs), into scientific writing has led to questions about its ethics, prevalence, and impact in orthopaedic literature. While tools have been developed to detect AI-generated content, the interpretation of AI detection percentages and their clinical relevance remain unclear. The aim of this study was to quantify AI involvement in published orthopaedic manuscripts and to establish a statistical threshold for interpreting AI detection percentages. To establish a baseline, 300 manuscripts published in the year 2000 were analyzed for AI-generated content with use of ZeroGPT. This was followed by an analysis of 3,374 consecutive orthopaedic manuscripts published after the release of ChatGPT. A 95% confidence interval was calculated in order to set a threshold for significant AI involvement. Manuscripts with AI detection percentages above this threshold (32.875%) were considered to have significant AI involvement in their content generation. Empirical analysis of the 300 pre-AI-era manuscripts revealed a mean AI detection percentage (and standard deviation [SD]) of 10.84% ± 11.02%. Among the 3,374 post-AI-era manuscripts analyzed, 16.7% exceeded the AI detection threshold of 32.875% (2 SDs above the baseline for the pre-AI era), indicating significant AI involvement. No significant difference was found between primary manuscripts and review studies (percentage with significant AI involvement, 16.4% and 18.2%, respectively; p = 0.40). Significant AI involvement varied significantly across journals, with rates ranging from 5.6% in The American Journal of Sports Medicine to 38.3% in The Journal of Bone & Joint Surgery (p < 0.001). This study examined AI assistance in the writing of published orthopaedic manuscripts and provides the first evidence-based threshold for interpreting AI detection percentages. Our results revealed significant AI involvement in 16.7% of recently published orthopaedic literature. This finding highlights the importance of clear guidelines, ethical standards, responsible AI use, and improved detection tools to maintain the quality, authenticity, and integrity of orthopaedic research.

Readability &amp; quality of large language model responses in CAR-T patient education

The implementation of electronic health records (EHRs) has revolutionized modern clinical practice, increasing efficiency, accessibility, and quality of care. Nevertheless, EHR-related workload has been considered as a significant contributor to healthcare professionals' burnout, a syndrome associated with emotional exhaustion, depersonalization, and reduced personal accomplishment. As modern health system explores technological solutions, artificial intelligence (AI) has gained attention for its potential to facilitate documentation processes and alleviate cognitive burden. This systematic review aims to explore and understand the impact of artificial intelligence on burnout associated with electronic health records among healthcare professionals. A systematic literature review was conducted following the PRISMA 2020 guidelines. Relevant studies published between 2019 and 2025 were retrieved from three electronic databases: PubMed, Scopus, and Web of Science. The search strategy included three main domains: artificial intelligence, electronic health records, and healthcare professional burnout. Eligible included studies are peer-reviewed original research articles that evaluated the impact of AI-based technologies on burnout among healthcare professionals. The screening and selection processes were carried out by following the PRISMA framework. Methodological quality assessment of the included studies was performed using the Joanna Briggs Institute Critical Appraisal Tools. Of the 287 records initially identified, eight studies met the inclusion criteria. The majority of identified studies were conducted in the United States and Canada. The identified interventions were categorized into four domains: ambient artificial intelligence scribes, clinical decision support systems, large language models, and natural language processing tools. Most studies focused on mitigating documentation or inbox-related burdens and reported positive outcomes, including decreased documentation time, enhanced workflow efficiency, and reduced symptoms of burnout among healthcare professionals. Nonetheless, several methodological limitations were observed, including the absence of control groups, small sample sizes, and short follow-up periods, which constrain the generalizability of the findings. The integration of artificial intelligence into electronic health record systems may have potential to alleviate documentation burden and inbox management burden. Although preliminary findings are promising, further methodologically robust research is necessary to evaluate long-term outcomes, assess usability across diverse clinical contexts, and ensure the safe and effective implementation of AI technologies in routine healthcare practice. https://osf.io/pevfj.

The development of smart product design through the integration of additive manufacturing (AM) and artificial intelligence (AI) has become a game changer in the production value chain of Industry 4.0. This is premised on today’s trend of moving away from mechanical technologies to digitization processes driven by AI. This trend has harnessed an AI-driven intelligent approach in creating new avenues for manufacturing process and system optimization in the era of Industry 4.0 and the emerging Industry 5.0. Conversely, there are concerns about how AI-driven design optimization can improve product manufacturability and performance. Thus, this study discusses the key processes, challenges, and opportunities in integrating AM and AI for smart product design. The study further suggests the possible utilization of the recent large language models (LLMs) and customized robots as designers to enable AM capabilities for optimizing smart product design and product performance, reducing production time, and possibly producing more product units at a much lower cost, instead of employing AM only. With the aid of this study and the AM-AI with LLMs taxonomy outlined, the convergence shows promising potential in synthesizing intelligent and smart product designs.