The data-driven InfraRed Small Target Detection (IRSTD) methods have witnessed remarkable advancements in performance. However, these methods typically rely on high-quality pixel-level mask labels, requiring substantial human effort and time for annotation. To tackle this challenge, we propose a Prior Knowledge Enhanced Learning Approach (PKELA), which contains two key strategies: the Prior Knowledge Enhanced Initial Pseudo-label Generation (PKEIPG) strategy and the Teacher Knowledge Guided Label Update (TKGLU) strategy. Specifically, for the PKEIPG strategy, we introduce a Local Contrast Enhancement (LCE) module based on prior knowledge to suppress background interference. Drawing inspiration from the human brain’s processing sequence of visual information, we locate an appropriate neighborhood containing the infrared small target by identifying the target’s edges. Within this neighborhood, high-quality initial pseudo labels are obtained through adaptive threshold segmentation, which provide strong supervisory signals for the data-driven IRSTD method during the initial training phase. For the TKGLU strategy, we employ an Exponential Moving Average (EMA) teacher model that dynamically updates its parameters based on the current model’s state. Furthermore, a memory bank is established to archive the teacher model’s performance, which is treated as prior knowledge. This knowledge is then systematically used to guide the refinement of pseudo labels. Experimental results on the SIRST, NUDT-SIRST, IRSTD-1k, and SIRST3 datasets indicate that our PKELA exhibits superior training performance with single-point labels. By incorporating our approach, the data-driven IRSTD methods could achieve near-full-supervised performance in terms of Probability of Detection (<italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Pd</i>) metric, with Intersection over Union (<italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">IoU</i>) and normalized Intersection over Union (<italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">nIoU</i>) reaching up to 95.75% and 95.82% of full-supervised performance, respectively. Our code is available at https://gitee.com/mynewspace/pkela.