Protein Microarray Substrates with High Interfacial Area Using Silica Colloidal Crystals

Abstract

Translate Article

Protein microarrays are growing in use in biomedical research because proteins are more directly representative of physiological processes. There is a need for higher sensitivity because proteins, unlike DNA, cannot be amplified in concentration as simply. A thin layer of silica colloidal crystal provides a combination of high surface area and high optical transparency, promising unprecedented sensitivities for protein microarrays.