• Home
  • Search
  • Proteomic Data Analysis Optimization Using a Parallel MPI C Approach
  • Cite Icon3
  • https://doi.org/10.1109/biosciencesworld.2010.11Copy DOI Icon

Proteomic Data Analysis Optimization Using a Parallel MPI C Approach

  • Mar 1, 2010
  • Razvan Bocu +1 more
Show More
  • Abstract
  • Literature Map
  • References
  • Citations
  • Similar Papers
Abstract

Proteins and the networks they determine, called interactome networks, have received attention at an important degree during the last years, because they have been discovered to have an influence on some complex biological phenomena, such as problematic disorders like cancer. This paper presents a new parallel computation technique that allows for an accurate and fast analysis of the human interactome network to be conducted. It constitutes, essentially, a proteomic data analysis process that takes into consideration the sparse nature of interactome networks. Thus, the first stage of the analysis involves the parallel computation of each proteins betweenness centrality measure through a parallel sparse networks-dedicated approach. Then, the second phase detects the functionally-related communities of proteins. In order to accomplish this purpose, we make use of a community detection algorithm that is based on the edge betweenness calculation and that has been already described in one of the authors previous papers. The new protein data analysis technique was carefully tested on real biological data and the results acknowledge the existence of some important properties of those proteins that participate in the carcinogenesis process. Apart from being particularly useful for research purposes, the novel technique also speeds up the proteomic databases analysis process, as compared to our own sequential approach. The results of the comprehensive battery of tests that were applied prove some unique topological features of cancer mutated proteins, and a possible optimization solution for cancer drugs design is suggested.

Similar Papers
  • Research Article
  • Citations62

Efficient algorithms for game-theoretic betweenness centrality

  • Nov 05, 2015
  • Artificial Intelligence
  • Piotr L Szczepański +2
  • Conference Article
  • Citations17

ONBRA: Rigorous Estimation of the Temporal Betweenness Centrality in Temporal Networks

  • Apr 25, 2022
  • Diego Santoro +1
  • Conference Article
  • Citations1

Identifying Asymptomatic Nodes in Network Epidemics using Betweenness Centrality

  • Jul 21, 2024
  • Conrado C Pinto +1
  • PDF
  • Research Article
  • Citations12

Optimal network-wide adjustments of initial airport slot allocations with connectivity and fairness objectives

  • Oct 14, 2023
  • Transportation Research Part B: Methodological
  • Merve Keskin +1
  • Video Transcripts

A Network-Based High-Level Data Classification Algorithm Using Betweenness Centrality

  • Oct 15, 2020
  • Underline Science Inc.
  • Liang Zhao +1
  • Research Article
  • Citations7

Group centralization of network indices

  • Feb 07, 2015
  • Discrete Applied Mathematics
  • Matjaž Krnc +1
  • Research Article
  • Citations87

Distributed Algorithms for Computation of Centrality Measures in Complex Networks

  • May 01, 2017
  • IEEE Transactions on Automatic Control
  • Keyou You +2
  • Research Article
  • Citations6

오피니언 마이닝과 네트워크 분석을 활용한 상품 커뮤니티 분석: 영화 흥행성과 예측 사례

  • Mar 28, 2014
  • Journal of Intelligence and Information Systems
  • Yu Jin +2
  • Research Article
  • Citations4

Application of Social Media Analytics in Assessing Decision Insights of Tourists under Disruption

  • Apr 29, 2022
  • NMIMS Management Review
  • Arup Kumar Baksi +2
  • Conference Article
  • Citations9

Effort: A New Metric for Roadside Unit Placement in 5G Enabled Vehicular Networks

  • Sep 01, 2020
  • 2020 IEEE 3rd 5G World Forum (5GWF)
  • Sarath Babu +2
  • PDF
  • Research Article
  • Citations2

Distributed Rendezvous placement for producer mobility support in NDN-IoT

  • Jan 01, 2023
  • ITM Web of Conferences
  • Mohammed Bellaj +2
  • Book Chapter

Strategic Public Health Interventions

  • Jan 01, 2013
  • Troy Tassier
  • Conference Article
  • Citations11

Visualization of Trace Links and Change Impact Analysis

  • Sep 01, 2016
  • Stefan Kugele +1
  • Book Chapter

Influence of a Topology of a Spring Network on its Ability to Learn Mechanical Behaviour

  • Jan 01, 2014
  • Maja Czoków +1
  • Research Article
  • Citations14

Application of the load flow and random flow models for the analysis of power transmission networks

  • Mar 03, 2012
  • Reliability Engineering & System Safety
  • Enrico Zio +4
Cactus Communications logo

Copyright 2026 Cactus Communications. All rights reserved.