This paper discusses the influence of different Radial Basis Function (RBF) in metamodel construction to be applied to 3D aerodynamic wing optimization problems using the Constrained Optimization with Response Surface (CORS) methodology in conjunction with a stochastic Controlled Random Search Algorithm (CRSA). CORS methodology is based on the iterative construction and optimization of response surfaces with a robust search pattern application. In the CORS methodology the response surface may be generate by at least three types of methods: (i) Classical (polynomials and parametric surfaces), (ii) Statistical (K-Nearest, Kriging and Gaussian Processes) and (iii) Advanced (RBF and Neural Network). The response surfaces used in this paper are constructed using six different types of RBF: Gaussian, Hardy’s Multiquadric and Inverse Multiquadric, which depend on a shape parameter, and linear, cubic and thin plate spline, which do not depend on a shape parameter. The RBF’s are directly applied on the response surface construction inside the CORS structure. Thus the choice of a RBF and of a shape parameter (being the case) may influence significantly the methodology efficiency. The CORS methodology is here applied for accelerating the optimization process of wing aerodynamic designs with a solver based on a first order 3D panel method and a 2D boundary layer model. Since the main objective of this paper is of prospective nature, the choice of a relatively low-fidelity flow computation solver is justified. One considers problems of minimizing the aerodynamic coefficient relation (CD/CL) and the inverse of lift coefficient (1/CL). Comparative influence of the RBF choice on the acceleration induced by CORS methodology is investigated taking into account the number of expensive objective function evaluations necessary to find the minimum value in each problem.