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<strong class="journal-contentHeaderColor">Abstract.</strong> Aerosol-cloud-precipitation interactions are assessed over the non-polar ocean from more than 11 years of combined Aqua-MODIS, CALIPSO-CALIOP, and CloudSat products. The analysis first shows the benefit of incorporating vertically resolved aerosol extinction coefficient (&sigma;<em>_ext</em>) in aerosol-cloud interactions (ACI) assessments, demonstrating that: &sigma;<em>_ext</em> vertically collocated with the cloud layer correlates best with cloud droplet number concentration (<em>N_d</em>), column-integrated aerosol optical depth (AOD) cannot explain the <em>N_d</em> variability in the extratropics, and the S-shape of the AOD-<em>N_d</em> relationship reported in previous studies is an unphysical feature that arises from using AOD as aerosol proxy over oceanic regions. ACI metric, estimated as the log-scale regression between &sigma;<em>_ext</em> vertically collocated with the cloud layer (&sigma;<em>_exi^CL</em>) and MODIS <em>N_d</em> reveals that the eastern Pacific is the region with the strongest ACI, followed by the Southern Ocean. The susceptibility of clouds to changes in their liquid water path (LWP) and frequency of precipitation followed a 2-step calculation by combining the <em>N_d</em>-&sigma;<em>_exi^CL</em> regression (ACI) with the regression between these macrophysical variables and <em>N_d</em>.LWP susceptibility is negative (LWP decreases with aerosol loading), and statistically significant over the eastern Pacific, eastern Atlantic, and extratropics. In contrast, vast areas of the tropical and subtropical ocean feature negligible changes in LWP with aerosol. Precipitation frequency susceptibility is negative, but the values are only significant over the coastal eastern Pacific and Atlantic. The findings suggest that previous modeling assessments relying on AOD may need to be revisited by taking advantage of the synergy between passive and active sensors.