Research progress and development prospects on critical challenges in deepwater riserless drill string dynamics

Sepsis is a life-threatening condition characterized by multiple organ dysfunction syndrome resulted from dysregulated host responses to infection. Sepsis-associated encephalopathy (SAE) is one of the most common symptoms of acute-phase sepsis, with nearly 70% of patients with sepsis ultimately developing SAE. Pyroptosis represents a type of cell death that is initiated by inflammation. This cell death type is associated with various infectious and noninfectious diseases. The gasdermin family proteins are crucial cell death executors and critical components in regulating the canonical pyroptosis pathway in microglia. In this review, we summarize the inhibitory effects of several drugs and genes on the pyroptosis pathway. Our findings suggest that several drugs (puerarin, VX765, HC067047, dexpramipexole, and Danhong injection), erbin gene, and TRIM45 knockdown improve SAE by suppressing the canonical pathway of NLRP3/caspase-1/gasdermin D-mediated pyroptosis. Therefore, they have significant importance in terms of brain protection. Moreover, we review the relevant literature published in recent years and summarize the research status and development prospects in this field to provide a basis for subsequent related research.

Vision technology is growing vigorously, but underwater vision remains challenges and problems, which is a field with application value and development prospects. The visual information obtained underwater is often color-biased and blurred, and it is highly susceptible to the influence of the surrounding environment and its stability cannot be controlled. Therefore, the current research and applications of vision technologies in underwater vision provide ways to solve the described problems, including image processing, target detection and recognition, localization and tracking technologies. The purpose of this review is to summarize the development of underwater vision technology and the results achieved. The mainstream underwater vision technologies are classified according to the different theories or algorithms used, and the current new research progress in each field is introduced in detail. By summarizing and analyzing the above research results, the application of each key technology of underwater vision is sorted out, and its further development direction is foreseen.

The in situ hydrogel drug delivery system is a hot research topic in recent years. Combining both properties of hydrogel and solution, in situ hydrogels can provide many advantages for drug delivery application, including easy application, high local drug concentration, prolonged drug retention time, reduced drug dose in vivo, good biocompatibility and improved patient compliance, thus has potential in tumor treatment. In this paper, the related literature reports in recent years were reviewed to summarize and discuss the research progress and development prospects in the application of in situ hydrogels in tumor treatment.

As a traditional industry, the petrochemical industry has serious energy consumption and environmental pollution problems, which do not meet the requirements of global sustainable development. Under the continuous promotion of ecological civilization construction, the principle of green chemistry should be effectively implemented in the petrochemical industry. Ionic liquid is a new type of “green solvent” that is colourless, odourless, and reused. It is completely composed of ions. It has the advantages of non-volatile, low vapour pressure and wide temperature range. It is often used to increase the yield of crude oil due to its special physical and chemical properties. Alternatively, a new surfactant was added to the emulsion crude oil production process, resulting in demulsification. This paper reviews the development history, physicochemical properties, and applications of ionic liquids. The development prospect and shortcomings of ionic liquids were discussed. In general, further research and innovation of ionic liquids will deeply understand the necessity of their development.

Progress and Prospects for Research and Technology Development of Supercritical CO2 Thermal Conversion Systems for Power, Energy Storage, and Waste Heat Recovery

MXene–2D layered electrode materials for energy storage

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Agaricus blazei is a rare medicinal and edible fungus with a crispy taste and delicious flavor. Both fruiting body and mycelium are rich in polysaccharides, sterols, terpenoids, peptides, lipids, polyphenols, and other active ingredients, which have strong pharmacological activities such as anti-tumor, lipid-lowering, glucose-lowering, immunomodulation, optimization of intestinal flora, and anti-oxidation. Therefore, it is a kind of fungal resource with a great prospect of edible and medicinal development. Among the reported chemical components of A. blazei, blazeispirol is a series of sterol compounds unique to A. blazei, which has a spiral structure and is different from classical steroids. It is an important active ingredient found in the mycelium of A. blazei and has significant hepatoprotective activity. It can be used as a phylogenetic and chemotaxonomic marker of A. blazei strains and is considered an excellent lead compound for drug development. According to the skeleton structure characteristics, the 17 discovered blazeispirol compounds can be divided into two types: blazeispirane and problazeispirane. In order to further explore the resource of blazeispirol compounds of A. blazei, the discovery, isolation, structure, biological activity, and biosynthetic pathways of blazeispirol compounds of A. blazei were systematically reviewed. Besides, the metabolic regulation strategies related to the fermentation synthesis of blazeispirol A by A. blazei were discussed. This review could provide a reference for the efficient synthesis and development of blazeispirol compounds, the research and development of related drugs and functional foods, and the quality improvement of A. blazei and other medicinal and edible fungi resources and derivatives.

Research progress and prospects for synergistic CO₂ enhanced oil recovery and sequestration technologies

Research progress on extraction, processing technology and pharmacological action of Polygonatum polysaccharides: A review.

With the continuous expansion of industrial enterprises, a large amount of difficult‐to‐treat high‐salt wastewater with complex components is produced. If it is not treated properly and discharged directly, it can not only be a wasted resource but also cause great damage to the ecological environment. Therefore, how to achieve zero discharge and resource utilization, reduce the treatment cost, and the generation of secondary pollution have become the bottlenecks that need to be broken through in current wastewater treatment. Among many methods, the concentrated crystallization coupling technology has broad development and application prospects due to its advantages such as low energy consumption, green economy, and high purity of salt‐separated products. Combining with source and composition of high‐salt wastewater, the research progress of wastewater treatment technology is reviewed, and its actual application status is analyzed, to provide a certain reference for the further resource treatment of high‐salt wastewater and the realization of true zero discharge in the future.

Clean utilization of coal depends on the quality of raw coal, which depends on the coal-forming parent materials (petrology and chemical composition of coal), the multiple media of the coal-forming environment, and some epigenetic conditions, such as thermal evolution (coalification), magmatic hydrothermal fluid, groundwater. Based on the research results of predecessors and prediction studies of coal resources since the founding of China, the present status of research on coal petrology, coal quality, coal metamorphism, and coal geochemistry in China is discussed in detail, with emphasis on research progress and the general situation of highly efficient and clean utilization of coal in the technical fields of coking, pyrolysis, combustion, gasification, and liquefaction, and the development prospects of coal petrology and coal quality in China are prospected.

Torsional vibrations experienced by drill strings can be detrimental to drilling operations. With a goal of understanding torsional vibrations experienced by drill strings and determining means to attenuate undesired vibrations, the authors have studied the effect of adding a sinusoidal modulation to a constant rotation speed of a drill string. A combination of modeling, analysis, and experiments is used to explore the influence of this rotation input modulation on the system response. The drill string is modeled as a modified Jeffcott rotor, which is described by a system with three degrees of freedom. Considering the case of forward whirling of a rotor in continuous contact with a stator, the equations of motion are reduced to a single degree-of-freedom nonlinear oscillator describing the torsional motions. In order to understand the fast time scale and slow time scale components of the motion, the method of direct partitions of motions is used to determine an approximate response to the nonlinear oscillator. The obtained results of the analysis illustrate that with the sinusoidal modulation of the rotor drive speed, the equivalent torsion stiffness can be enhanced and the character of the friction force at the contact can be made smooth. The analyses helps bring forth the stabilizing influence of the added sinusoidal input to the rotor drive speed. Over the considered parameter ranges, the numerical results obtained with the full three degree-of-freedom model and the reduced single degree-of-freedom model are found to be in agreement with each other. Furthermore, the results from these models are found to compare well with those obtained by using the method of direct partition of motions. Experiments with a laboratory scale drill-string arrangement are to be carried out to validate the analytical and numerical findings and further explore the effectiveness of the drive speed modulation on the rotor dynamics. Introduction Slender rotating structures are used in many engineering applications. Drill strings are long rotating slender structures, which are used in drilling operations. A schematic of a rotary drill rig is shown in Fig. 1 (e.g., Liao, Balachandran, Karkoub, and Abdel-Magid, 2011). Drill strings experience different types of vibrations (axial, torsional, and lateral vibrations) that may lead to detrimental failures of a drilling system. Drill-string vibrations have attracted the attention of many researchers, and many models have been developed to understand them. Since drill strings have a large length-to-diameter ratio, typically, the first torsional natural frequency and first lateral natural frequency are close to each other. This frequency proximity and the nature of the system allows for coupling and energy transfer between the associated vibration modes. Here, as a step towards developing further understanding, a drill string is modeled as an extended planar Jeffcott rotor with gravity acting normal to the rotor. Due to the planar motions, no gyroscopic effects are considered. The extended model, which was earlier considered in the work of Vlajic, Liu, Karki, and Balachandran (2014), is shown in Fig. 2. The model is described with three degrees of freedom (DOF), namely, x and y to account for lateral motions, and theta to account for torsional motion. A large number of research efforts have focused on controlling drill-string vibrations by using different feedback control algorithms, which need measurements along the drill string. In this work, the authors propose a different control approach to mitigate whirling motions during continuous rotor-stator contact. This can be compared to a situation of a drill string being in continuous contact with the borehole. The approach is open loop in implementation and this approach is based on adding a high frequency input to the drive speed of the drill string. Given the open-loop nature, the method does not depend on any measurements along the drill string or rotary table, which could be attractive for a practical stand point. Although the current focus is on motions of a rotor with continuous stator contact, it is planned to study stick-slip and non-contact cases in the future. System Modeling, Studies, and Results As previously mentioned, the drill string is modelled as a Jeffcott rotor with three DOF. Proceeding along the lines of the group's prior work (Vlajic, Liu, Karki, and Balachandran, 2014), after some approximations for the continuous rotor-stator contact case, the 3 DOF system is reduced to a single second-order nonlinear differential equation governing the torsional motion. In Fig. 3, for a representative case with a constant drive speed, the torsional state histories obtained for the full model and the reduced model are plotted. It is noted that the final state of the motion is captured quite well. To further analyze the response during forward whirling, the reduced-order model was nondimensionalized and an approximate solution was obtained by using the method of direct partitions. This method allows one to separate slow scale motions from fast scale motions. As discussed, in the group's prior work, this method can be useful to examine whirling motions. The results obtained by directly integrating the full model as well as the reduced-order model have been compared with that obtained by using the method of direct partitions of motions. It is seen that the perturbation analyses is able to provide an approximate solution that compares well with the numerical results obtained through direct integrations. Next, this analysis is used to examine the influence of the addition of secondary frequency component. It is seen that the addition of the secondary frequency, a high-frequency one, helps smooth out the friction coefficient variation with respect to the relative speed at contact. This is found to have a beneficial effect on the motion and helps suppress large-amplitude torsional motions. Stability analysis was also conducted to examine this effect. Concluding Remarks A study has been conducted to examine the influence of sinusoidal modulation of rotor drive speed in a system, wherein the rotor experiences continuous stator contact. A single degree of-freedom reduced model is developed to study the torsion response and it is found that the addition of a high frequency input can be beneficial in attenuating rotor motions. This is believed to be useful for developing open-loop control schemes for attenuating forward whirling motions of drill strings. Results obtained from a lab scale experimental arrangement will be used to examine the effect of this drive speed modulation further and they will be reported in the conference presentation. Future studies could build on the current effort to examine cases of backward whirling. Acknowledgment: The authors would like to gratefully acknowledge the support received from the Qatar National Research Fund for NPRP Project 7-083-2-041, to pursue this collaborative work between the University of Maryland, College Park, MD, USA and Qatar University, Doha, Qatar.

Partial discharges (PD) detection method based on optical fiber sensing technologies has the advantages of safety, insulation and anti-electromagnetic interference, so it is suitable to be designed as embedded or built-in sensors installed on the inner or outer shell of power equipment for PD on-line monitoring or live detection with prospects for development. In this paper, based on the introduction of the PD measurement method of optical fiber sensing technologies, the extrinsic Fabry-Perot interferometer (EFPI) optical fiber sensing for PD ultrasonic detection is introduced. The principle and research progress of detecting PD ultrasonic signal based on EFPI optical fiber sensor and its performance tests including amplitude-frequency response, static pressure, distance attenuation and directionality are described in detail. The key parameters and application problems in the development of the EFPI PD optical fiber sensor are analyzed. Finally, the development trend of the EFPI PD optical fiber sensor is expected.

With the unconventional energy sector (e.g., shale gas) increasingly focused on precision drilling and cost-effective extraction, slim-hole horizontal well technology is gaining prominence. However, drill string dynamics in narrow, complex fluid environments are not fully understood. This study presents a novel bidirectional fluid–structure interaction (FSI) model, uniquely integrating recursive algorithms with the Moving Particle Semi-implicit (MPS) method to couple drill string–wellbore contact with drilling fluid interactions. Key findings show that drilling fluid significantly impacts drill string behavior; for instance, it can reduce natural frequencies by 20–25%, while stiff formations amplify lateral resonance risks. Optimizing fluid properties can substantially cut energy losses, though TREE is marginally elevated when viscosity exceeds the threshold (2.5 × 10−5 m2/s). The drill string typically displaces rightward, but higher viscosity can shift it left; a moderate friction coefficient aids centering. Excessive lateral displacement impairs cuttings removal, affecting fracturing. These insights enable actionable strategies: adjusting fluid viscosity and drag reducers can optimize drill string position and enhance cleaning. This research provides a framework for energy-efficient drilling in complex reservoirs, balancing efficiency with wellbore integrity and improving outcomes in the unconventional energy sector.