Research Trends in Eye Gaze Tracking and its Implications: A Bibliometric Analysis

Gastrointestinal (GI) dysfunction represents a prevalent non-motor symptom of Parkinson’s disease (PD) that not only contributes significantly to disease progression but also substantially compromises patients’ quality of life. Over the past decade, research in this domain has expanded considerably. To systematically delineate the knowledge framework and evolving trends, we performed a bibliometric analysis of publications on GI and PD from 2015 to 2025. A total of 924 articles were retrieved from the Web of Science Core Collection (WoSCC). Co-occurrence, clustering, and collaboration network analyses were performed using VOSviewer, CiteSpace, and the R package Bibliometrix. For findings validation, the PubMed database was incorporated as an independent external validation dataset, providing complementary verification of keyword analyses derived from WoSCC. Our analysis revealed a steady annual increase in publication output. China and the United States emerged as the most prolific contributors globally, with the latter attaining the highest total citation count. At the institutional level, Capital Medical University led in publication output, whereas the University of Helsinki ranked highest in both total and average citations. Among journals, Parkinsonism & Related Disorders published the most papers on this topic, while Movement Disorders received the most citations. Keyword cluster analyses identified three primary research frontiers: (1) pathogenesis, focusing on α-synuclein (α-syn), the brain-gut-microbiome axis, and the enteric nervous system; (2) clinical manifestations, especially dysphagia and constipation; and (3) therapeutic interventions, particularly fecal microbiota transplantation and probiotics. By integrating established knowledge and highlighting emerging trends, this review aims to inform and guide future research and clinical practice in the field of gastrointestinal dysfunction in PD.

Alzheimer's disease (AD) is characterized by the presence of gray matter lesions and alterations in white matter. This study aims to investigate the research related to white matter in the context of AD from a Bibliometric standpoint. Regular and review articles focusing on the research pertaining to Alzheimer's disease (AD) and white matter were extracted from the Web of Science Core Collection (WOSCC) database, covering the period from its inception to 10th July 2023. The "Bibliometrix" R package was employed to summarize key findings, to quantify the occurrence of top keywords, and to visualize the collaborative network among countries. Furthermore, VOSviewer software was utilized to conduct co-authorship and co-occurrence analyses. CiteSpace was employed to identify the most influential references and keywords based on their citation bursts. The retrieval of AD- and white matter-related publications was conducted by the Web of Science Core Collection. Bibliometric analysis and visualization, including the examination of annual publication distribution, prominent countries, active institutions and authors, core journals, co-cited references, and keywords, were carried out by using VOSviewer, CiteSpace, the Bibliometrix Package, and the ggplot2 Package. The quality and impact of publications were assessed using the total global citation score and total local citation score. A total of 5,714 publications addressing the intersection of Alzheimer's disease (AD) and white matter were included in the analysis. The majority of publications originated from the United States, China, and the United Kingdom. Prominent journals were heavily featured in the publication output. In addition to "Alzheimer's disease" and "white matter," "mild cognitive impairment," "MRI" and "atrophy" had been frequently utilized as "keywords." This Bibliometric investigation delineated a foundational knowledge framework that encompasses countries, institutions, authors, journals, and articles within the AD and white matter research domain spanning from 1981 to 2023. The outcomes provide a comprehensive perspective on the broader landscape of this research field.

BackgroundTranscranial magnetic stimulation (TMS), as a rapidly advancing non-invasive brain stimulation technique, has demonstrated reliable therapeutic efficacy and significant potential in brain function assessment and research. However, comprehensive bibliometric analyses of the overall TMS field remain limited. Therefore, this study conducts a systematic analysis of TMS-related literature from 2004 to 2023, aiming to facilitate further advancements in TMS research and development.MethodsWe retrieved TMS-related literature from 2004 to 2023 in the Web of Science Core Collection. Using CiteSpace and R language, we constructed network visualizations to illustrate annual publication outputs and journal distributions, demonstrate co-occurrence and collaboration patterns among authors, countries, and institutions, and establish keyword co-occurrence and reference co-citation analyses.ResultsOur analysis incorporated 6,278 TMS-related articles. Despite fluctuations, the publication output demonstrated an overall upward trend over the 20-year period. Daskalakis Z.J. emerged as the most prolific author, while the United States and Harvard University were identified as the leading contributing country and institution, respectively. Brain Stimulation ranked first in publication volume, whereas Clinical Neurophysiology received the highest citation count. The work by Rossi S. achieved the highest co-citation frequency. Current research hotspots include intermittent theta-burst stimulation, cognitive impairment, systematic review, and mild cognitive impairment.ConclusionResearch related to TMS has been increasing annually and is a developing field. The United States leaded the way, while Harvard University was the most active institution. Daskalakis Z.J. (Canada) was the most prolific author. The most influential journals included Brain Stimulation, Clinical Neurophysiology, and Journal of Affective Disorders. Further deep collaboration among leading countries, institutions, and authors is needed. Current hotspots in TMS research involve integration with imaging techniques, clinical applications, optimization of parameters, and exploration of neurological modulation mechanisms.

This study aimed to explore the current status, hotspots, and trends in research on polyunsaturated fatty acids (PUFAs) and cardiovascular inflammation. Literature related to cardiovascular inflammation and PUFAs from the Web of Science Core Collection between January 1, 2009, and July 1, 2024, was retrieved using specific search terms, and the data were visualized and analyzed using CiteSpace (version 6.3.R3) and VOSviewer (version 1.6.20). PUFAs and cardiovascular inflammation publications have been found to grow over the past 15 years. The United States leads in this field, with Nutrients being the leading journal. Harvard University and the University of California system are the most influential institutions. Most publications are in immunology and medical journals, while citations are primarily in biology and nutrition journals. International collaboration is strong, with Mozaffarian and Calder making significant contributions. Bhatt et al. and Bosch et al. have the most citations and the highest centrality, respectively. Research trends focus on the relationship between PUFAs and inflammatory markers, the anti-inflammatory mechanisms of PUFAs, and their association with diseases. Omega-3 and omega-6 PUFAs show divergent impacts on inflammation and cardiovascular diseases (CVD) risk, with gut microbiota mediating bidirectional regulation. Emerging research directions in PUFAs' anti-inflammatory mechanisms encompass gut microbiota, oxidative stress, and pro-resolving mechanisms, with gut microbiota as the current focus. This bibliometric analysis has highlighted sustained growth and global collaboration in PUFAs-cardiovascular inflammation research. Key emerging mechanisms have been found to focus on the gut-microbiota-PUFAs axis, oxidative stress, and pro-resolving pathways, pointing towards future translational opportunities.

Smart heritage, an emerging and sustainable paradigm, utilises technology to conserve and enhance cultural heritage. Despite integration into smart city development, full implementation remains unrealised. Consequently, this study aims to investigate the status and trends of smart heritage research, explore the development direction of smart heritage, bridge existing knowledge gaps, and guide its integration into smart city development. This study employs a bibliometric analysis method, supported by machine algorithms, to obtain scientific and quantifiable results. The study utilises the bibliometric analysis software CiteSpace 6.2R6 to analyze 981 articles from the Web of Science Core Collection, covering 1994 to 2024. We observe a notable increase in scholarly output over time, especially in smart cities and digital cultural strategies, where smart heritage has emerged as a research hotspot across various disciplines and domains. Smart heritage crosses three stages: digital technology application, technology integration, and multidisciplinary integration, showcasing diverse technological applications, service scenarios, and application domains. Moving forward, we must prioritize a comprehensive research agenda, including theoretical constructs, smart cultural infrastructure, robust policy, public engagement, and expanded application realms. Additionally, fostering interdisciplinary collaboration between international entities and driving technological innovation is vital for promoting the sustainable development of cultural heritage.

IntroductionThe impact of music on children with autism—a condition marked by deficits in social interaction, communication, and behavior—has become a significant area of research. This study investigates current trends, key contributors, and emerging interests regarding music’s effects on this population.MethodsA comprehensive review of publications from 1953 to 2024 on the influence of music on children with autism was conducted using the Web of Science Core Collection. Bibliometric and visual analyses were performed with VOSviewer, CiteSpace, and R version 4.3.3.ResultsA total of 411 research papers were identified, with significant publication growth noted post-2009. The leading countries in this research include the United States, the United Kingdom, Canada, China, and Australia. McGill University ranked as the most prolific institution (23 publications), followed by the University of Montreal (17) and Vanderbilt University (12). The Journal of Autism and Developmental Disorders is the most influential journal, with an h-index of 19 and 1,706 citations. Professor Christian Gold emerged as the top author, with 12 papers totaling 599 citations. Key keywords included “children,” “autism,” and “therapy,” with a noted increase in terms like “social skills,” “communication,” and “engagement” since 2020.ConclusionThis study highlights music’s potential to enhance social and communication skills in children with autism. Future research should explore the long-term effects of music therapy on language, cognition, and behavioral outcomes, as well as its role in improving engagement in educational and therapeutic settings.

We hope to offer a comprehensive understanding of the advancements and patterns in research on PND. Methods: We performed a thorough search on the Web of Science Core Collection to locate relevant studies published from 1969 to 2022 and utilized four distinct tools, namely VOSviewer (J Data Inf Sci, 2017, 2, 1; J Am Soc Inf Sci, 1973, 24, 265; Amer Doc, 1963, 14, 10 and Scientometrics, 2010, 82, 581), CiteSpace (Scientometrics, 2010, 84, 523), Scimago Graphica, and R-bibliometrix which allowed us to examine various aspects. Results: We included a total of 6787 articles and reviews for analysis which described PND research, the sources, and the subfields; highlighted the significant developments in this field; identified three main directions in PND.Conclusion: This study highlights the rapid growth of research on PND in recent years and provided an overview of previous studies in the field of PND, thereby establishing the overall landscape of PND research and identifying potential avenues for future investigations. We performed a thorough search on the Web of Science Core Collection to locate relevant studies published from 1969 to 2022. To perform bibliometric analysis and network visualization, we utilized four distinct tools, namely VOSviewer (J Data Inf Sci, 2017, 2, 1; J Am Soc Inf Sci, 1973, 24, 265; Amer Doc, 1963, 14, 10 and Scientometrics, 2010, 82, 581), CiteSpace (Scientometrics, 2010, 84, 523), Scimago Graphica, and R-bibliometrix. These tools allowed us to examine various aspects, including the yearly publication output, the contribution of different countries or regions, the involvement of active journals, co-citation analysis, publication status, keywords, and terms, as well as scientific categories. We hope to offer a comprehensive understanding of the advancements and patterns in research on PND. The insights gained from this study can assist researchers and clinicians in enhancing the management and implementation of their work in this field. In this study, we included a total of 6787 articles and reviews for analysis. First, publication trends and contribution by country analysis described PND research. Second, a historical analysis described PND research, the sources, and the subfields. Third, an analysis of keywords highlighted the significant developments in this field. Fourth, an analysis of research themes identified three main directions in PND. In summary, the research volume exhibits exponential growth over time. Furthermore, the majority of contributions originate from Western countries and China. The interdisciplinary nature of the field is evident, with its roots in biology and medicine and further branching into psychology and social sciences. POCD, delirium-predominant associated clinical management were major research themes about PND.

Atopic dermatitis (AD) affects 5–20% of the global population, with moderate-to-severe cases frequently requiring systemic therapy. The introduction of Janus kinase inhibitors (JAKi) has transformed therapeutic options, warranting a comprehensive analysis of the evolving research landscape. This bibliometric and visualized review aimed to identify global research hotspots, collaboration networks, and influential contributors in JAKi-related AD research. Publications were retrieved from the Web of Science Core Collection (2014–2024) using the terms “(Janus kinase inhibitors OR JAK) AND (atopic dermatitis)”. Of 797 publications identified, 776 met inclusion criteria. Bibliometric mapping and visualization were conducted with VOSviewer, Excel, and Draw.io. The United States produced the most publications (34%), followed by Germany (12.62%), Japan (11.87%), and China (8.5%). The Icahn School of Medicine at Mount Sinai and Oregon Health & Science University led institutional output, while Kyoto University demonstrated the highest citation impact (82.57 citations per publication). Among authors, Emma Guttman-Yassky (25 publications) and Eric Simpson (22 publications) were the most prolific. Journal of Dermatological Treatment and Journal of the European Academy of Dermatology and Venereology were the leading publishing journals, while The Journal of Allergy and Clinical Immunology was the most co-cited. The most frequently cited reference was Oetjen (2017), with 674 citations. Keyword analysis highlighted “atopic dermatitis”, “JAK inhibitors”, “upadacitinib”, and “baricitinib” as central themes, with abrocitinib and biologics emerging as newer hotspots. This study provides an updated overview of global research activity on JAK inhibitors in AD, addressing knowledge gaps, collaboration patterns, and future directions in targeted therapy.

Background and PurposeChronic atrophic gastritis (CAG), affecting approximately 20–30% in high-risk populations, contributes to significant morbidity and mortality due to its progression to gastric cancer. Despite two decades of research into its pathogenesis, the vast body of literature has not yet been systematically mapped. A comprehensive bibliometric analysis mapping the field’s evolution, collaborative networks, and knowledge gaps remains lacking. Therefore, we conduct a 20-year bibliometric analysis (2005–2024) of research on the mechanism of CAG to identify seminal works, emerging themes, evaluate global collaboration networks, and highlight translational challenges and opportunities.Patients and MethodsData were retrieved from the Web of Science Core Collection (WoSCC) spanning from January 1, 2005, to December 31, 2024. Bibliometric analysis was performed using CiteSpace and VOSviewer to analyze publication trends, influential authors and institutions, keyword clusters, and citation bursts.ResultsA total of 954 papers were identified, with China leading in publication output (41.51%), followed by the USA (15.20%). The USA demonstrated high centrality in international collaboration. Key journals included WORLD J GASTROENTERO and GASTROENTEROLOGY. Prolific authors such as Liu Yuetao and co-cited authors like CORREA P were identified. Keyword analysis revealed “Helicobacter pylori” as the most prominent term, with clusters focusing on traditional Chinese medicine, macrophage biology, and gastric intestinal metaplasia.ConclusionThe study highlights the significant research output and collaboration in CAG, emphasizing the importance of interdisciplinary approaches and international partnerships. Future research should focus on integrating traditional knowledge with modern mechanistic studies and addressing emerging themes such as microbiome dysbiosis and precision medicine.

Aims: Three-dimensional (3D) printing of zirconia is an emerging domain in digital dentistry; however, its global research landscape, collaboration structure, and thematic focus have not been comprehensively mapped. The aim of this study was to characterize scientific output, collaboration patterns, citation impact, and major research themes in publications on 3D-printed zirconia in dentistry.Methods: A Web of Science Core Collection (WoS-CC) Topic Search was conducted in December 2025 using terms related to zirconia, additive manufacturing/3D printing, and dental applications. Of 584 retrieved records, 185 eligible articles on 3D-printed zirconia for dental use (2009–2025) were included. Descriptive indicators were calculated (annual production, journals, countries, institutions, authors, and citations). Co-authorship and keyword co-occurrence networks were generated with VOSviewer to visualize collaboration and identify thematic clusters.Results: Publication activity increased sharply after 2019, with 128/185 publications (69.2%) published in 2023–2025. Most documents were original research articles (n=159) or reviews (n=26); no case reports were identified in WoS-CC. The 185 articles involved 730 authors from 38 countries and were published in 48 journals. China and the United States were leading contributors. Network analyses identified three interconnected themes: digital/additive manufacturing workflows, implantprosthodontic applications, and biomechanical or accuracy-based evaluation. Evidence was predominantly in vitro and laboratory-based, with limited clinical data.Conclusion: Research on 3D-printed zirconia in dentistry is rapidly expanding but concentrated in a small set of countries, institutions, and journals. Future studies should prioritize clinical investigations and standardized reporting of printing and post-processing parameters to support translation into predictable outcomes.

A Bibliometric and Visualised Analysis of Proliferative Verrucous Leucoplakia From 2003 to 2023

To evaluate the global trends in and explore hotspots of high myopia (HM) research. This bibliometric analysis was used to reveal the publication trends in HM research field based on the Web of Science Core Collection (WoSCC). VOSviewer version 1.6.13 software was used to analyze the data and construct a knowledge map including the yearly publication number, journals, countries, international collaborations, authors, research hotspots, and intellectual base in HM. The search engine found 3544 peer-reviewed publications on HM between 2010 and 2019, and the yearly research output substantially elevated over the past decade. China is the top publishing country, and Sun Yat-sen University was the most active academic institution. Jonas JB is the top publishing scientist, and Investigative Ophthalmology and Visual Science (IOVS) was the most productive journal. The highest cited references mainly focused on epidemiology and management. The keywords formed 6 clusters: 1) refractive surgery; 2) etiology and clinical characteristics; 3) the mechanism of eye growth; 4) management for myopic maculopathy; 5) vitrectomy surgical treatment; 6) myopia-associated glaucoma-like optic neuropathy. The evaluation of development trends based on the data extracted from WoSCC can provide valuable information and guidance for ophthalmologists and public health researchers to improve management procedures in HM field.

Background:Radiomics has shown great potential in the clinical field of colorectal cancer (CRC). However, few bibliometric studies have systematically analyzed existing research in this field. The purpose of this study is to understand the current research status and future development directions of CRC.Methods:Search the English documents on the application of radiomics in the field of CRC research included in the Web of Science Core Collection from its establishment to October 2023. VOSviewer and CiteSpace software were used to conduct bibliometric and visual analysis of online publications related to countries/regions, authors, journals, references, and keywords in this field.Results:A total of 735 relevant documents published from Web of Science Core Collection to October 2023 were retrieved, and a total of 419 documents were obtained based on the screening criteria, including 376 articles and 43 reviews. The number of publications is increasing year by year. Among them, China publishes the most relevant documents (n = 238), which is much higher than Italy (n = 69) and the United States (n = 63). Tian Jie is the author with the most publications and citations (n = 17, citations = 2128), GE Healthcare is the most productive institution (n = 26), Frontiers in Oncology is the journal with the most publications (n = 60), and European Radiology is the most cited journal (n = 776). Hot spots for the application of radiomics in CRC include magnetic resonance, neoadjuvant chemoradiotherapy, survival, texture analysis, and machine learning. These directions are the current hot spots for the application of radiomics research in CRC and may be the direction of continued development in the future.Conclusion:Through bibliometric analysis, the application of radiomics in CRC has been increasing year by year. The application of radiomics improves the accuracy of preoperative diagnosis, prediction, and prognosis of CRC. The results of bibliometrics analysis provide a valuable reference for the research direction of radiomics. However, radiomics still faces many challenges in the future, such as the single nature of the data source which may affect the comprehensiveness of the results. Future studies can further expand the data sources and build a multicenter public database to more comprehensively reflect the research status and development trend of CRC radiomics.

Neutrophils have long been consistently adjudged to hold a dominant position in acute inflammation, which once led people to undervalue their role in chronic malignancy. It is now acknowledged that neutrophils also infiltrate into the tumor microenvironment in substantial quantities and form a highly abundant immune population within the tumor, known as tumor-associated neutrophils (TANs). There has been a surge of interest in researching the eminent heterogeneity and plasticity of TANs in recent years, and scholars increasingly cotton on to the multifaceted functions of TANs so that strenuous endeavors have been devoted to enunciating their potential as therapeutic targets. Yet it remains much left to translate TAN-targeted immunotherapies into clinical practice. Therefore, there is great significance to comprehensively appraise the research status, focal point, and evolution trend of TAN by using bibliometric analysis. Publications related to TAN research from 2000 to 2024 are extracted from the Web of Science Core Collection. Bibliometric analysis and visualization were performed by tools encompassing Microsoft Excel, VOSviewer, CiteSpace, R-bibliometrix, and so on. The bibliometric analysis included a total of 788 publications authored by 5291 scholars affiliated with 1000 institutions across 58 countries/regions, with relevant articles published in 324 journals. Despite China's maximum quantity of publications and top 10 institutions, the United States is the leading country with the most high-quality publications and is also the global cooperation center. FRONTIERS IN IMMUNOLOGY published the most papers, whereas CANCER RESEARCH is the highest co-cited journal. Israeli professor Fridlender, Zvi G. is the founder, pioneer, and cultivator with the highest citation counts and H-index in the TAN area. Our analysis prefigures the future trajectories: TAN heterogeneity, neutrophil extracellular trap, the crosstalk between TANs and immunocytes, and immunotherapy will likely be the focus of future research. A comprehensive bibliometric and visual analysis is first performed to map the current landscape and intellectual structure of TAN, which proffers fresh perspectives for further research. The accurate identification of distinct TAN subpopulations and the precise targeting of key pro-tumor/anti-tumor subpopulations hold immense potential to develop into a TAN-targeted immunotherapy.

Age-related macular degeneration (AMD) represents a significant clinical concern, particularly in aging populations, and recent advancements in artificial intelligence (AI) have catalyzed substantial research interest in this domain. Despite the growing body of literature, there remains a need for a comprehensive, quantitative analysis to delineate key trends and emerging areas in the field of AI applications in AMD. This bibliometric analysis sought to systematically evaluate the landscape of AI-focused research on AMD to illuminate publication patterns, influential contributors, and focal research trends. Using the Web of Science Core Collection (WoSCC), a search was conducted to retrieve relevant publications from 1992 to 2023. This analysis involved an array of bibliometric indicators to map the evolution of AI research in AMD, assessing parameters such as publication volume, national/regional and institutional contributions, journal impact, author influence, and emerging research hotspots. Visualization tools, including Bibliometrix, CiteSpace and VOSviewer, were employed to generate comprehensive assessments of the data. A total of 1,721 publications were identified, with the USA leading in publication output and the University of Melbourne as the most prolific institution. The journal Investigative Ophthalmology & Visual Science published the highest number of articles, and Schmidt-Eerfurth emerged as the most active author. Keyword and clustering analyses, along with citation burst detection, revealed three distinct research stages within the field from 1992 to 2023. Presently, research efforts are concentrated on developing deep learning (DL) models for AMD diagnosis and progression prediction. Prominent emerging themes include early detection, risk stratification, and treatment efficacy prediction. The integration of large language models (LLMs) and vision-language models (VLMs) for enhanced image processing also represents a novel research frontier. This bibliometric analysis provides a structured overview of prevailing research trends and emerging directions in AI applications for AMD. These findings furnish valuable insights to guide future research and foster collaborative advancements in this evolving field.