Retraction Notice to "Effect of subcutaneous lidocaine-hydroxypropyl-β-cyclodextrin (HP-β-CD) on quality of life in patients with post-COVID condition: a 36-week observational interrupted time series study" [eClinicalMedicine 90(2025) 103681

Qol-P-03 - Quality of life in patients with mycosis fungoides and Sézary syndrome: a review of the literature

P0166 Presence of stoma nurse and quality of life of colorectal cancer patients with fecal ostomy in the early postoperative phase

Patients with head and neck cancers (HNCs) are at an increased risk of developing functional symptoms associated with eating, speaking, and breathing along with symptoms caused by a fungating tumour (e.g., cosmetic change, malodor, and bleeding). These may substantially reduce their physical functioning and quality of life (QoL). This observational study aimed to find out the QoL in patients with HNC in a tertiary care oncology centre. A prospective observational study was conducted in adult patients diagnosed with HNC. The patients were divided depending upon their disease extent into early, advanced, and very advanced local disease. The physical, cognitive, emotional, financial and social domains were assessed using a validated Hindi version of the European Organisation for Research and Treatment of cancer (EORTC)- QoL 30 and EORTC H&N 35 at baseline and 3 months. A total of 100 patients were assessed with a mean age of 49.3 ± 12.4 years. Most of the patients had carcinoma buccal mucosa (42%) followed by carcinoma tongue (17%). The patients experienced difficulties with physical functioning and deterioration in emotional functioning. Pain and fatigue were the major problematic symptoms especially in advanced disease patients resulting in poor QoL. There was a significant improvement in various domains of QoL at 3 months follow-up in those with advanced disease. The fatigue scores at baseline and follow-up showed a positive correlation with other symptoms. Patients with HNC have a high symptom burden that leads to poor QoL. Appropriate palliative care interventions help to decrease symptom burden and prevent deterioration of their QoL in patients with HNC.

Stigma has been associated with health-related outcomes such as medication adherence and quality of life (QOL) in patients with tuberculosis (TB); however, the mechanisms via which TB-related stigma interferes with specific outcomes are unclear. This study aimed to determine whether depressive symptoms were one of the mechanisms that mediated the associations between TB-related stigma and both medication adherence and QOL in patients with TB. A cross-sectional survey was conducted between October 1, 2013, and March 31, 2014, in Hubei Province, central China, and data were collected from 1,342 patients with TB, using a structured questionnaire that measured TB-related stigma, depressive symptoms, medication adherence, and QOL. Multiple imputation was used to account for missing data. Structural equation modeling was performed to assess the mediating effect of depressive symptoms on the associations of TB-related stigma with medication adherence and QOL. Mediation analyses showed that depressive symptoms partially mediated the association between TB-related stigma and medication adherence (standardized indirect effect = -0.16, 95% bias-corrected confidence interval [CI] [-0.19, -0.13], P < 0.01). Moreover, depressive symptoms fully mediated the association between TB-related stigma and QOL (standardized indirect effect = -0.17, 95% bias-corrected CI [-0.21, -0.14], P < 0.01). The results suggest that depressive symptoms played a key role in the relationships among TB-related stigma, medication adherence, and QOL in patients with TB. Therefore, the alleviation of depressive symptoms could be an important strategy for improving medication adherence and QOL in patients with TB.

Hypertension is a cardiovascular disease that is a major concern because of the high morbidity and mortality rates. Uncontrolled hypertension will cause various complications will interfere quality of life the patient with hypertension. Quality of life in hypertensive patients is influenced by the severity and severity of complications experienced by the patient. Self management behavior as a disease management to support patients with chronic diseases, behavior modification is very useful to reduce or delay the adverse effects of hypertension. The purpose of this study was to determine the correlation between self-management behavior and quality of life in patients with primary hypertension at UPTD Puskesmas Manggis I Karangasem. This research is a descriptive quantitative correlational research with a cross sectional approach. The sample of this study was 79 respondents who were selected through simple random sampling technique, data analysis used Spearman Rank test. The results showed that 31 respondents (39.2%) had good self-management behavior and 34 respondents (43.1%) had good quality of life. The results of the Rank Spearman test, p value = 0.000 (≤0.05) showed a significant correlation between self-management behavior and quality of life in patients with primary hypertensive. The correlation coefficient value (r) 0.835 means a very strong correlation between self-management behavior and quality of life. Nurses are expected to be able to provide education about self-management behavior that they can improve the quality of life patients with hypertension.

To quantify the postoperative quality of life in patients following surgical treatment for vestibular schwannoma. Patient self-assessment using the short form 36 (SF36) multidimensional quality of life health questionnaire. Sex- and age-matched normalized scores were calculated using a standardized process and accepted normative data. Tertiary referral skull base unit. An 80% response rate (90 patients) was achieved. The postoperative quality of life in vestibular schwannoma patients, as quantified by seven of the eight SF36 health scales was less than the appropriate matched healthy standard. Comparison of a variety of preoperative patients and tumor factors-different operative approaches (translabyrinthine and retrosigmoid), tumor size (group cut of points of tumor diameter 1.5 mm and 2.5 mm), patient sex, and ranking of patient age-showed no statistically significant difference in measured quality of life outcomes for each of these traditional predictors. Reduced quality of life in patients after surgical treatment for vestibular schwannoma, coupled with the low tumor growth rates and minimal preoperative symptoms, supports a conservative approach to patient management. The advantages and disadvantages of a variety of approaches used to measure the quality of life after surgical treatment of vestibular schwannoma and their impact on clinical decision making for patients, are discussed.

Background and PurposeDopamine agonists are first-line drugs for treating the symptoms of restless legs syndrome (RLS). However, few studies have investigated the effect of dopamine agonists on the quality of life (QoL) in RLS patients. We conducted a study to determine whether ropinirole exerts positive effects on the QoL in RLS patients and to analyze the underlying factors.MethodsPrimary RLS patients from eight medical centers were recruited in the study. They were evaluated in the baseline phase using various questionnaires including the Korean versions of the International Restless Legs Scale (K-IRLS), RLS QoL questionnaire (K-RLSQoL), and the Short Form 36 Health Survey (SF-36). After taking ropinirole for 8 weeks the same questionnaires were again completed as a re-evaluation. We analyzed the statistical difference using a paired t-test, a Pearson's correlation, and a stepwise multiple regression in order to identify the factors associated with the QoL change.ResultsA total of 107 subjects, including 65 (60.7%) females, completed this study. They were aged 51.68±14.80 years (mean±SD) and had a symptom duration of 8.8±9.0 months. After treatment with ropinirole, there were significant improvements on the K-RLSQoL, SF-36, and K-IRLS. The Pearson's correlation analysis showed that the improvement of QoL in RLS patients was significantly correlated with the severity of RLS (r=0.236, p<0.014) at baseline.ConclusionsThe results from this study suggest that treatment with ropinirole can improve the QoL in RLS patients. The improvement in the QoL is more related with the improvement of RLS symptoms.

To investigate the correlation between preoperative vitamin D levels and postoperative pain and quality of life in young and middle-aged patients with lumbar degenerative disease (LDD). The 228 young and middle-aged LDD patients treated in Shanghai Sixth People's Hospital (China) between January 2022 and December 2023 were chosen for the research. The patients were categorized into an insufficient/deficient group as well as an adequate group on the basis of 25-(OH)D levels. Visual analogue scale (VAS), Japanese Orthopaedic Association (JOA) score, Oswestry disability index (ODI), and quality of life score (SF-12) of the two groups were compared, respectively. To assess the correlation between preoperative vitamin D and postoperative pain and quality of life in LDD patients. Preoperative 25-(OH)D was positively correlated with postoperative lumbar spine function and life quality, and negatively correlated with postoperative pain and ODI index (P&lt;0.05). The results of multiple linear regression analysis showed that the serum 25-(OH)D level was the main influencing factor for postoperative pain and quality of life in patients with LDD. For every 1ng/mL increase in 25-(OH)D level, the VAS score decreased by 0.091 points and the quality of life score increased by 0.349 points. The lower the preoperative serum vitamin D level in LDD patients, the higher the risk of postoperative pain, the more serious the dysfunction of patients, and the worse the quality of life.

Expanded Prostate Cancer Index Composite for Clinical Practice: Development and Validation of a Practical Health Related Quality of Life Instrument for Use in the Routine Clinical Care of Patients With Prostate Cancer

Survey of Qol (quality of life) on Patients Receiving Tyrosine Kinase Inhibitors for Chronic Myeloid Leukemia: Korean CML Working Party Group

Cutaneous T‐cell Lymphoma’s (CTCL) are a rare, heterogeneous group of T‐cell lymphomas that primarily manifest in the skin. Mycosis fungoides (MF) and Sézary syndrome (SS) are considered the classic types of CTCL. The diverse manifestation of CTCL results in a wide range of symptoms with a possible mild to severe impact on Quality of Life (QoL) depending on the disease stage. Previous studies on QoL in CTCL patients report diverse patient populations and use many different QoL instruments. In the current literature, a clear overview on the influence of the different stages of disease (early MF, late‐stage MF/SS or total group) on the QoL is lacking. Therefore, a systematic search of the literature was conducted using the PubMed, Embase, PsycINFO and Web of Science databases. Studies were included if they described QoL in patients with MF and SS retrieved by standardized instruments or qualitative interviews. In total, 24 studies were included using 18 different questionnaires to report on dermatology‐specific, cancer‐specific and generic QoL. The effect on QoL was found to be greater in patients with late‐stage disease as compared to early stage disease, with significant impairments on functional, emotional and physical domains. Nonetheless, even in patients with limited disease, QoL was mildly to moderately affected. Overall, pruritus was the most frequent reported and most bothersome symptom. Significant influence of the disease on daily life activities were found, not only in patients but also on caregivers and family. This broad, structured overview on QoL in MF and SS patients underlines the influence of disease stage on QoL, and therefore, recommends future studies to distinguish between disease stages when reporting results. Furthermore, this overview can inform clinicians in clinical practice by creating awareness of QoL deficits according to disease stage.

Health-related quality of life in patients undergoing chronic hemodialysis has become a fundamental criterion for evaluating the effectiveness of treatments, promoting the overall well-being of this population. The study aims to identify the factors associated with health-related quality of life in patients with chronic kidney disease undergoing hemodialysis in Huancayo, Peru, from September to November 2022. Observational, descriptive, single-center, cross-sectional study in which sociodemographic data associated with health-related quality of life in hemodialysis patients were identified using the SF-36 instrument. The SF-36 questionnaire on health-related quality of life (HRQoL) was administered to 88 hemodialysis patients, of whom 68.2% were men, and 87.5% were undergoing outpatient dialysis. The main cause of chronic kidney disease was hypertension, affecting 46.6% of participants. Additionally, 80.7% had been on hemodialysis treatment for less than five years. In the bivariate analysis, significant differences were observed in the vitality dimension concerning educational level (p = 0.011) and sex (p = 0.049). Likewise, there was a significant difference between the average values of the emotional role dimension (p = 0.038) of the SF-36 in the nutritional status levels and a significant difference between the average total scores of the SF-36 in the salary levels (p = 0.048). The multivariate analysis identified correlations between nutritional status and pain; educational level and vitality; nutritional status and physical role; economic income; educational level and social function; and nutritional status and emotional role. Patients on hemodialysis have a total health-related quality of life score ranging from low to moderate (90.8%). The factors associated with a lower quality of life are being male, poor nutrition, low educational level, and a poor emotional state. Early identification of these factors will allow the development of interventions to improve these patients' quality of life. It is crucial to design interventions focused on improving nutrition and preventing mental health disorders, paying special attention to men with low educational levels.

Self-esteem is a way of coping with stress for cancer patients and this improves their quality of life. It was aimed to determine the relationship between type A personality traits and self-esteem and quality of life in women with breast cancer and to determine the effective factors. 154 women with breast cancer and 78 healthy women were included. Bortner's Rating scale, Rosenberg’s Self-Esteem scale, and EORTC QOL-C30 scale were used. The relationship between the presence of hobbies, self-esteem, quality of life, and personality type was examined. Mann–Whitney U, Kruskal–Wallis, Fisher's Exact, and Spearman Rank correlation tests were performed. Independent factors affecting personality type, self-esteem, and quality of life were determined by multivariate logistic (binary) regression analysis. The p < 0.05 value was significant in the SPSS v19 program. There was no age difference between the patients (54 ± 11 years) and the control group (42 ± 8 years) (p = 0.108). The rate of type A personality was 69% in patients and 58% in controls (p = 0.093). Similarly, the rate of high self-esteem was 93% in patients and 96% in controls (p = 0.098). Besides personality type and self-esteem, there was no relationship between personality type and quality of life in cancer patients (p = 0.960 and p = 0.946, respectively). A relationship was established between self-esteem and quality of life (p = 0.018) in patients. In patients with type A personality, hobbies providing socially active communication were common (p = 0.039), and had more than two hobbies (p = 0.015). Type A personality trait was independently effective on self-esteem (p = 0.046). Hobby orientation and the number of hobbies had independent effects on self-esteem (p = 0.032, p = 0.041), quality of life (respectively, p = 0.004, p = 0.007), and personality type (respectively, p = 0.014, p = 0.027). Hobbies that provide active social communication may have important effects on changes in personality traits, self-esteem, and quality of life in patients with breast cancer.

Quality of life and organization of care in patients with chronic myeloid leukemia (CML) within the lombardy hematologic network (REL): The CML-OPERAP study

Patients with schizophrenia experience low quality of life (QoL) and poor physical health, which is explained, in part, by unhealthy lifestyle, tobacco smoking, poor diet and sedentary behavior. To measure QoL and physical health in patients with schizophrenia and to quantify associations between QoL and physical health. This was a naturalistic longitudinal 30-month follow-up study including individual guidance, group sessions and treatment as usual. We included 190 patients. QoL was low among newly diagnosed patients. Higher body mass index was significantly associated with lower QoL. Newly diagnosed male patients showed lower QoL compared with females. Newly diagnosed patients experienced worsened health during the study period. In contrast, long-term schizophrenic patients started with worse physical health but improved with regard to weight, waist circumferences, intake of fast food and soft drinks, and light physical activity level. Newly diagnosed patients improved their QoL ( p = .056), and the psychological domain improved by 8.0 points ( p = .003). The number of interventions was positively associated with QoL. Patients with schizophrenia presented with low QoL and elevated risk factors for poor physical health. The intervention added onto 'treatment as usual' improved some risk factors for poor physical health among long-term patients. The number of interventions had an elevating effect on QoL in patients.