Scientometric Trends and Knowledge Gaps of Zero-Emission Campuses

Background and objectivesMetabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is one of the leading causes of hepatocellular carcinoma (HCC). Over the years, significant progress has been made in diagnosing and treating MASLD. However, there is a lack of bibliometric analysis exploring the relationship between MASLD and HCC. This study aims to comprehensively analyze the knowledge structure and research status of MASLD-related HCC using bibliometric methods.MethodsThe study was conducted using the Web of Science Core Collection (WoSCC) database, retrieving literature related to MASLD and HCC from 2020 to 2024. VOSviewer, CiteSpace, and the R package “bibliometrics” were used for data analysis.ResultsThe study included 2,576 articles from 97 countries. The results showed that the number of publications related to MASLD and HCC increased steadily until 2023, after which there was a slight decline. China (The People’s Republic of China) is the country with the highest volume of research output, while the United States is the country with the highest number of citations. The University of California System, the Chinese University of Hong Kong, and the Egyptian Knowledge Bank were the leading contributing institutions. The International Journal of Molecular Sciences, Cancers, and Liver International were the most influential journals in this field, with the International Journal of Molecular Sciences being the most co-cited journal, and the Journal of Hepatology had the highest local impact in the field, as evaluated by the H-index. The publications were authored by 13,851 researchers, with Vincent Wai-Sun Wong, Masato Yoneda, and Rohit Loomba being the most influential authors in the field of MASLD and HCC. Rohit Loomba and Hashem B. El-Serag were the most cited authors. Trend analysis indicated that “tissue”, “element-binding protein”, and “contributes” were the most frequently studied topics in 2024, suggesting emerging research trends.ConclusionThis study provides a comprehensive summary of the research trends and developments in HCC related to MASLD over the past five years. The findings reveal the latest research frontiers and hotspots in this field, offering valuable insights for future research. However, it should be noted that although the WoSCC is a widely recognized and authoritative database, it may have limitations related to regional bias, language coverage, and metadata accuracy, which could potentially affect the comprehensiveness of our analysis.

BackgroundDepressive disorder is one of the most common mental health conditions with significant repercussions on both the physical and psychological health of affected individuals. In recent years, an increasing number of studies have been undertaken to evaluate nanomaterials for the diagnosis and treatment of depression. This study aims to objectively and comprehensively summarize the research advances and future perspectives of nanomaterials for depression therapy via scientometric analysis.MethodsLiterature related to nanomaterials for depression therapy was retrieved from Web of Science Core Collection, Scopus, and PubMed databases. Scientometric analysis and visualization were primarily performed using Bibliometrix and included publications, research topics, countries, institutions, journals, high-frequency keyword analysis, and keyword cluster analysis. Based on the results of this scientometric analysis, the article presents a detailed discussion and summary of the potential of nanomaterials for the diagnosis and treatment of depression.ResultsA total of 343 articles related to the applications of nanomaterials in the treatment of depression were included, with an increasing number of publications noted each year. These studies focused primarily on three areas: materials science, nanotechnology, and pharmacy/chemistry. China, India, and Iran are the top three countries in this field. The most influential institutions are the Egyptian Knowledge Bank, Cairo University, Chinese Academy of Sciences, and Tehran University of Medical Sciences. The top three journals are Microchimica Acta, International Journal of Pharmaceutics, and Journal of Nanoscience and Nanotechnology. The results of keyword analysis revealed that the main areas of interest are diagnosis, nanomaterials with antidepressant activity, nano-drug delivery systems, and nanotoxicity.ConclusionBased on the results of the scientometric analysis, this study discusses the diagnosis, treatment, and current limitations of nanomaterials for depression therapy. This review will inspire novel ideas for the development of nanomaterials with applications in depression therapy.Graphical

This study aimed to explore the current status, hotspots, and trends in research on polyunsaturated fatty acids (PUFAs) and cardiovascular inflammation. Literature related to cardiovascular inflammation and PUFAs from the Web of Science Core Collection between January 1, 2009, and July 1, 2024, was retrieved using specific search terms, and the data were visualized and analyzed using CiteSpace (version 6.3.R3) and VOSviewer (version 1.6.20). PUFAs and cardiovascular inflammation publications have been found to grow over the past 15 years. The United States leads in this field, with Nutrients being the leading journal. Harvard University and the University of California system are the most influential institutions. Most publications are in immunology and medical journals, while citations are primarily in biology and nutrition journals. International collaboration is strong, with Mozaffarian and Calder making significant contributions. Bhatt et al. and Bosch et al. have the most citations and the highest centrality, respectively. Research trends focus on the relationship between PUFAs and inflammatory markers, the anti-inflammatory mechanisms of PUFAs, and their association with diseases. Omega-3 and omega-6 PUFAs show divergent impacts on inflammation and cardiovascular diseases (CVD) risk, with gut microbiota mediating bidirectional regulation. Emerging research directions in PUFAs' anti-inflammatory mechanisms encompass gut microbiota, oxidative stress, and pro-resolving mechanisms, with gut microbiota as the current focus. This bibliometric analysis has highlighted sustained growth and global collaboration in PUFAs-cardiovascular inflammation research. Key emerging mechanisms have been found to focus on the gut-microbiota-PUFAs axis, oxidative stress, and pro-resolving pathways, pointing towards future translational opportunities.

The growth of waste generation is a global problem. Developing effective waste management methods is challenging for companies and the government. This research aims to provide a global perspective regarding scientific research on zero-waste management and sustainable consumption by identifying years of evolution, the most relevant and influential keywords, articles, journals, universities, countries, and authors. This research examines 2534 publications from the Web of Science Core Collection from 2011 to 2021. Numerous bibliometric indices, including the number of publications, the h-index, and citation requirements, have been used as evaluating techniques. Additionally, a relational technique has been developed through graphical maps using the VOS viewer Software. Results show a growing trend in the number of zero-waste management’s publications and citations. Regarding the h-index, the five most relevant journals are the Journal of Cleaner Production, Resources Conservation and Recycling, Waste Management, Waste Management Research, and Sustainability. The most outstanding author is Tsang Dan from Zhejiang University, and the leading university is the Chinese Academy of Science, China. Furthermore, the principal regions and continents are China—Asia, USA—America, and Italy—Europe. The most important keywords are waste management, sustainability, circular economy, and sustainable development. This article is the first quantitative study focused on contributing a complete overview of the progress of zero-waste management and sustainable consumption, providing a collaborative network of researchers for future use in generating knowledge.

IntroductionThis study aims to systematically map the intellectual landscape and emerging trends in lipid metabolism research within hepatocellular carcinoma from 2014 to 2024.MethodsA total of 607 peer-reviewed publications were retrieved from the Web of Science Core Collection and PubMed. Bibliometric and visualization tools, including VOSviewer and CiteSpace, were employed to perform data analysis, including keyword co-occurrence and cluster analysis.ResultsWe identified a significant surge in research activity, with 53.05% of the total literature published in the last three years. China and the USA emerged as the leading contributors, with the University of California System and the journal Cancers being the most prolific institution and publication outlet, respectively. Current research hotspots are centered on the mechanisms by which oxidative stress drives the transformation of non-alcoholic fatty liver disease into hepatocellular carcinoma. Furthermore, three critical frontiers for future investigation were identified: (1) the regulatory role of PPARγ in lipid metabolic reprogramming and its therapeutic implications; (2) the molecular mechanisms of the farnesoid X receptor in modulating bile acid metabolism during hepatocarcinogenesis; and (3) the NF-κB signaling pathways that mediate metabolic shifts and confer chemoresistance in liver cancer.DiscussionThese findings provide a comprehensive reference for prioritizing research directions and therapeutic target discovery in the metabolic-related oncology domain.

Current Global Research Trends of Tethered Cord Syndrome Surgery: A Scientometric and Visual Analysis

Artificial intelligence in sepsis management: A bibliometric analysis

In recent decades, dramatic changes in modern environmental exposures and lifestyles have resulted in a steep rise in the prevalence of allergic diseases such as asthma, allergic rhinitis, atopic dermatitis and food allergies. Evidence is mounting that the microbiota plays a crucial role in allergic disorder development and evolution. Therefore, a better understanding of allergic diseases within the context of the microbiota is urgently needed. This work aimed to comprehensively outline general characteristics, research hotspots, evolution routes, and emerging trends in this area. Relevant publications from January 2002 to December 2021 were obtained from the Web of Science Core Collection on 5 August 2022. Bibliometric and visual analyses were performed using CiteSpace; VOSviewer; an online bibliometric platform; and Microsoft Excel 2019. In total, 2535 documents met the requirements. The annual number of publications has shown rapid growth in the last two decades. The USA, University of California System, and Isolauri E of the University of Turku were the most productive and influential country, institution, and author, respectively. The Journal of Allergy and Clinical Immunology was the most prolific and most cocited journal. High-frequency keywords included "gut microbiota", "asthma", "atopic dermatitis", "children", and "probiotics". Recent studies have focused on "atopic dermatitis", "skin", "asthma", and "probiotics", according to the cocitation analysis of references. Burst detection analysis of keywords showed that "community", "skin microbiome", "microbiome", "Staphylococcus aureus", and "chain fatty acid" were emerging research frontiers, which currently have ongoing bursts. In the last 20 years, studies of the microbiota in allergic diseases have been flourishing, and the themes have been increasing in depth. These findings provide valuable references on the current research hotspots and gaps and development trends in the link between the microbiota and allergic diseases.

Parkinson's disease (PD) is a neurodegenerative disorder that significantly impacts patients' quality of life. Recent evidence has highlighted a complex relationship between the gut microbiota (GM) and PD. Understanding this relationship is crucial for potentially targeting GM in PD treatment and expanding therapeutic options. This study aimed to comprehensively analyze the global landscape, trends, and research focus on GM and PD using bibliometric analysis. Utilizing publications from the Web of Science Core Collection (WsSCC), bibliometric tools such as the R package 'Bibliometrix,' VOS viewer, and CiteSpace software were employed to assess parameters like yearly publications, countries/regions, institutions, and authors. Research trends and hotspots were identified through keyword analysis. The results revealed 1,161 articles published between 2013-2023, with China leading in publications (n=352, 30.31% of total), while the United States had a higher influence (H-index=58). The University of California System was the top institution in terms of publications (n=35), with the National Natural Science Foundation of China funding the most projects (n=172). Keshavarzian A and Sampson TR were the authors with the highest publication and co-citation counts, respectively. The International Journal of Molecular Sciences had the most articles published (n=48). Keyword analysis identified parkinson's disease, gut microbiota, short-chain fatty acids, inflammation, and probiotics as main research topics. Biomarkers, ketogenic diet, and NF-κB were recent research hotspots and trends (2021-2023). The current study conducts an objective and comprehensive analysis of these publications, identifying trends and hotspots in the field of research. The findings offer valuable insights to scholars globally and in-vestigate potential therapeutic strategies for Parkinson's Disease.

Research on One-hole Split Endoscope (OSE) technology is garnering increasing attention. This study aims to delineate the global landscape and emerging trends within this field. Literature publications on OSE from January 1, 1992, to March 1, 2025, were retrieved from the Web of Science Core Collection's Science Citation Index Expanded. The sourced data were examined and indexed utilizing bibliometric methodologies. For the visualization analysis, VOSviewer software (version 1.6.19) was employed to conduct co-authorship, co-occurrence, bibliographic coupling, and co-citation analyses, thereby elucidating the overarching trends in OSE research in recent years.A total of 819 articles were retrieved. The volume of global OSE research and publications has demonstrated a consistent annual increase. The United States contributed the most significantly to global OSE research, attaining the highest citation counts and the highest h-index. Springer Nature and Elsevier published the highest number of relevant articles. Wooridul Spine Hospital, the University of California System, Seoul National University (SNU), and Seoul St. Mary's Hospital were identified as the four most prolific institutions. Research foci could be categorized into three primary clusters: neurosciences, surgical procedures, and orthopedics. Surgical procedures are projected to be the next prominent hotspot in the field. Based on current global research trends, the number of publications related to OSE is anticipated to continue rising. The United States currently stands as the leading contributor to this domain. The majority of future research efforts are expected to concentrate on clinical studies, particularly OSE surgical techniques, which are likely to represent the next research frontier. The findings of this study provide clinicians and researchers with a comprehensive overview of the global development of OSE technology, its core research entities, and future directions, thereby offering a bibliometric evidence base for tracking technological frontiers, selecting international collaborators, and determining priorities in clinical research.

In the combination antiretroviral therapy era, HIV-associated neurocognitive disorder (HAND) is still widespread among HIV-infected individuals. However, there is no effective treatment for HAND, and the exact pathogenic mechanism of HAND remains unknown. This paper aims to provide a reference for further exploration in the field of HAND research. We used CiteSpace software to collect 3057 articles related to HAND in the Web of Science Core Collection for comprehensive analysis. Betweenness centrality, count, and burst values were used as indicators in the visualization analysis, aiming to predict future new directions and cutting-edge trends. The last decade has been the peak period of HAND research, with the most prominent contributions by authors, countries, and institutions being Grant, Igor (135), the USA (2211), and the University of California System (758), respectively. The most frequently cited article is "HIV-associated neurocognitive disorders persist in the area of potent antiretroviral therapy: CHARTER Study." The hotspots in this field are "neurocognitive impairment," "central nervous system," "cerebrospinal fluid," "HIV-1 tat," "SIV," "inflammation," "infection," and "pathogenesis." The current research direction of HAND is focused on exploring the pathogenic mechanism underlying HIV-associated neurocognitive impairment and potential therapeutic targets. This study provides a bibliometric visualization of HAND-related literature to gain insight into the development and frontiers of this research field. The study also provides scholars with detailed references and identifies future research directions to better promote the development of this field of research.

BackgroundMyocardial fibrosis is a critical link in preventing the progression of heart disease. This study conducted a bibliometric analysis of its mechanism to identify trends and hotspots, aiming to provide valuable references for heart disease prevention and treatment.MethodsThis research relies on the Web of Science Core Collection, capturing all related publications on the mechanism of myocardial fibrosis up to November 11, 2023. For the bibliometric analysis, CiteSpace 6.2.R5 (64-bit) and VOSviewer 1.6.19 software tools were utilized.ResultsThe mechanism of myocardial fibrosis research involves 14,931 authors from 2,370 institutions in 71 countries/regions, resulting in 2,431 published studies. Nattel Stanley is the most prolific author, while Francogianis Ng is noted for the highest co-publication frequency. The United States leads in countries/regions, with the University of California System being the top institution. Cardiovascular Research is a primary outlet for new studies, and Circulation is a key reference in this research community. Current research primarily examines how myocardial fibrosis contributes to heart failure, myocardial infarction, and myocardial hypertrophy. This emerging field also explores the role of fibroblasts in myocardial injury and investigates innovative treatments to reduce myocardial fibrosis.ConclusionsPreventing myocardial fibrosis is a crucial strategy in the fight against heart disease. This study utilises bibliometric analysis to explore the vast array of literature on the mechanism of myocardial fibrosis, mapping the research landscape and provide literature references for potential breakthroughs in heart disease prevention and treatment strategies.

Trends in research on the carbon footprint of higher education: A bibliometric analysis (2010–2019)

BackgroundInvestigating gut microbiota during pregnancy is vital for understanding maternal–infant health, pregnancy-related disease mechanisms, and offspring development. While research in this field has grown rapidly, systematic analyses of global trends, collaborative networks, and thematic evolution remain limited. This bibliometric study maps the developmental landscape of “gut microbiota during pregnancy,” identifying research priorities and future directions.MethodsA bibliometric analysis of pregnancy and gut microbiota studies (1991–2025) was conducted using the Web of Science Core Collection and Scopus databases. Publications were analyzed using bibliometrix, VOSviewer, and CiteSpace to evaluate publication trends, research contributions, collaboration networks, keyword co-occurrence patterns, and thematic evolution.ResultsThe analysis encompassed 5,432 (Web of Science Core Collection) and 5,542 (Scopus) publications, with an annual growth rate exceeding 15%. Research output has grown exponentially since 2014. The China and United States were the most productive countries, with the United States demonstrating the highest total citations and a central role in global collaborative networks. Key influential institutions included the University of Turku, University College Cork, and the Chinese Academy of Sciences. Leading authors were Collado, Maria Carmen; Tain, You-Lin; and Cryan, John F. The research was highly interdisciplinary, spanning microbiology, nutrition, immunology, and medicine. Core journals disseminating knowledge were Nutrients, Frontiers in Microbiology, and Gut Microbes. High-impact and co-cited references established the knowledge foundation, focusing on maternal microbiome remodeling, delivery mode’s impact, and the gut-brain axis. Keyword analysis revealed a thematic evolution from initial descriptive studies of microbial composition to recent investigations into mechanisms linking microbiota to gestational diabetes mellitus, preeclampsia, preterm birth, and neurodevelopmental outcomes via the gut-brain axis.ConclusionThis study presents an integrative bibliometric analysis of global research on gut microbiota during pregnancy, delineating its rapid evolution and current intellectual structure. The field has matured from descriptive ecology to mechanistic and translational research, with strong international collaboration and interdisciplinary integration. The identified research fronts, including the interplay between microbial dysbiosis and specific pregnancy complications, as well as the influence of the maternal gut microbiome on offspring neurodevelopment, represent promising avenues for future investigation.

Increasing research efforts are focused on studying the synthesis and mechanisms of nanomedicine in urologic cancer. We performed a bibliometric study of the literature on nanomedicine in urologic cancer over the last 23 years, focusing on aspects such as researchers, institutions, nations, and keywords. We searched for papers in the Web of Science Core Collection from January 1, 2001, to December 29, 2023. Only reviews and original articles written in English were considered. A total of 2386 papers satisfied the given criteria for inclusion. The publications included in the study originated from 90 nations. The United States had the largest number of published papers, accounting for more than 31.01% of the total. The leading institution in this field is the Chinese Academy of Sciences, with a publishing output of 2.35%. Farokhzad, Omid C., is the most prolific author, with 21 articles, and has garnered the most citations, totaling 6271. The latest phrase to enter the top ten most common lists was "gold nanoparticles." We searched for papers in the Web of Science Core Collection from January 1, 2000, to November 28, 2023. Only reviews and original articles written in English were considered. This is the first bibliometric study of nanomedicine in urologic cancer. This article provides a comprehensive analysis of the current state of research on nanomedicine in urologic cancer over the last 23 years. On the basis of this study, future researchers can identify noteworthy publications, journals, and potential collaborators and explore cutting-edge research directions.