Simple, practical and efficient synthesis of triarylmethanes

Simple donor-acceptor molecule with long exciton diffusion length for organic photovoltaics

Simple and efficient synthesis of O-unprotected glycosyl thiourea and isourea derivatives from glycosylamines

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Synthetic studies on neomarinone: practical and efficient stereoselective synthesis of the side chain

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAn efficient and practical total synthesis of (+)-vincamine from L-aspartic acidPeter Gmeiner, Paul L. Feldman, Margaret Y. Chu-Moyer, and Henry RapoportCite this: J. Org. Chem. 1990, 55, 10, 3068–3074Publication Date (Print):May 1, 1990Publication History Published online1 May 2002Published inissue 1 May 1990https://doi.org/10.1021/jo00297a023RIGHTS & PERMISSIONSArticle Views2743Altmetric-Citations89LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1016 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts

An efficient and practical synthesis of BINAM derivatives by diastereoselective [3,3]-rearrangement

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA simple and practical synthesis of olivetolAntonio Focella, Sidney Teitel, and Arnold BrossiCite this: J. Org. Chem. 1977, 42, 21, 3456–3457Publication Date (Print):October 1, 1977Publication History Published online1 May 2002Published inissue 1 October 1977https://doi.org/10.1021/jo00441a036RIGHTS & PERMISSIONSArticle Views1805Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (328 KB) Get e-Alerts Get e-Alerts

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCorrection. A Simple and Practical Synthesis of OlivetolAntonio Focella, Sidney Teitel, and Arnold BrossiCite this: J. Org. Chem. 1978, 43, 26, 5027Publication Date (Print):December 1, 1978Publication History Published online16 October 2003Published inissue 1 December 1978https://doi.org/10.1021/jo00420a612RIGHTS & PERMISSIONSArticle Views125Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (160 KB) Get e-Alerts Get e-Alerts

The title compounds are prepared from N-acylethoxymethylene hydrazones and nitrogen-containing nucleophiles (ammonia, primary or secondary amines). An efficient and simple synthesis is described.

We report here a practical and efficient synthesis of α-aminophosphonic acid incorporated into 1,2,3,4-tetrahydroquinoline and 1,2,3,4-tetrahydroisoquinoline heterocycles, which could be considered to be conformationally constrained analogues of pipecolic acid. The principal contribution of this synthesis is the introduction of the phosphonate group in the N-acyliminium ion intermediates, obtained from activation of the quinoline and isoquinoline heterocycles or from the appropriate δ-lactam with benzyl chloroformate. Finally, the hydrolysis of phosphonate moiety with simultaneous cleavage of the carbamate afforded the target compounds.

A practical and efficient synthesis of (±)-rivastigmine, which is an acetyl cholinesterase inhibitor of the carbamate family and has been approved for the treatment of Alzheimer’s disease in more than 60 countries, was developed in three steps from cheap and commercially available 3-ethylphenol. The key step of the synthesis involved the NBS-promoted benzylic bromination of 3-ethylphenyl ethyl(methyl)carbamate. The target molecular was obtained in 71% overall yield without any traditional purification (column chromatography or crystallization). The reactions include esterification, benzylic bromination, substitution reaction.

[reaction: see text] A practical and efficient synthesis of aryl triflates under biphasic basic aqueous conditions is described. The current methodology provides entry into these valuable substrates that omits the use of amine bases and allows facile isolation by simple solvent evaporation after phase separation. Good yields can also be obtained without the use of organic solvent.

A practical and efficient synthesis of 6-carboalkoxy-13-cycloalkyl-5H-indolo[2,1-a][2]benzazepine-10-carboxylic acid derivatives

The synthesis of a 4,4-difluoropiperidine intermediate, a key component of an MRGPRX2 antagonist, is challenging due to the presence of a gem-difluoro moiety adjacent to a stereocenter which also bears a reactive pyridine N-oxide motif. The initial discovery chemistry route required chiral supercritical fluid chromatography (SFC) at the end of the synthesis to provide enantiopure product. XtalFluor-E was used for deoxyfluorination on a ketone adjacent to a p-pyridylmethyl position, resulting in very low yields due to the elimination of HF. After several unsuccessful attempts for a de novo asymmetric synthesis, we focused our attention on the process development for a more practical synthesis than the existing route. A much higher yielding deoxyfluorination was enabled by SF4 and HF. Furthermore, the chiral SFC was replaced by an efficient classical resolution at a much earlier stage of the synthesis, taking advantage of the basicity of the pyridine moiety before oxidation to the pyridine N-oxide. Although not all stages have been scaled up in the plant scale, the new synthesis is much more practical and has improved the overall yield from 12% to 23% for this challenging molecule.

A practical and efficient synthesis of 4‐(triphenylen‐2‐yl)dibenzothiophene, a phosphorescent host, has been established via ligand‐free palladium on carbon (Pd/C) catalyst mediated Suzuki coupling reaction. The process allowed us to recover and reuse the heterogeneous Pd/C catalyst for cost‐effectiveness with a conversion yield greater than 90 %. Moreover, interesting results on solid‐state studies of the sublimed title material have been captured along with its photo‐physical and electrochemical properties, which are appropriate for its use as a host material. Finally, we have fabricated solution‐processed organic light‐emitting diodes (OLEDs) by using the title material as a host and bis(4‐phenylthieno[3,2‐c]pyridinato‐N,C2′) (acetylacetonate) iridium(III) (PO‐01), as a phosphorescent dopant. The devices exhibited efficiencies of ∼9 cd/A at 1000 cd/m 2 , and the results were comparable with the traditional host, 4,4′‐bis( N ‐carbazolyl)‐1,1′‐biphenyl (CBP).