Support Vector Machine, Naive Bayes, and Artificial Neural Network Back Propagation Comparison in Detecting Brain Tumor

Solid waste bin level detection using gray level co-occurrence matrix feature extraction approach

Objective: Using methylation characteristics of human genes to construct machine learning predictive models for screening cervical cancer and precancerous lesions. Methods: Human DNA methylation detection was performed on 224 cervical exfoliated cell specimens from the Cancer Hospital of the Chinese Academy of Medical Sciences, Tianjin Central Hospital of Gynecology Obstetrics, Xinmi Maternal and Child Health Hospital of Henan Province, West China Second Affiliated Hospital of Sichuan University, and Heping Hospital Affiliated to Changzhi Medical College collected during April 2014 and March 2015. The hypermethylated gene fragments related to cervical cancer were selected by high-density, high-association, and hypermethylated gene fragment screening and the LASSO regression algorithm. Taking cervical intraepithelial neoplasia grade 2 (CIN2) or more severe lesions as the research outcome, machine learning predictive models based on the random forest (RF), naive Bayes (NB), and support vector machine (SVM) algorithm, respectively, were constructed. A total of 144 outpatient specimens were used as the training set and 80 cervical exfoliated cell specimens from women participating in the cervical cancer screening program were used as the test set to verify the predictive models. Using histological diagnosis results as the gold standard, the detection efficacy for CIN2 or more severe lesions of the three machine learning predictive models were compared with that of the human papilloma virus (HPV) detection and cytological diagnosis. Results: In the training set of 144 cases, there were 34 cases of HPV positivity, with a positive rate of 23.61%. Cytologically, there were 37 cases diagnosed as no intraepithelial lesion or malignancy (NILM), and 107 cases diagnosed as atypical squamous cells of undetermined significance (ASC-US) or above. Histologically, there were 28 cases without cervical intraepithelial neoplasia or benign cervical lesions, 31 cases of CIN1, 18 cases of CIN2, 31 cases of CIN3, and 36 cases of squamous cell carcinoma. Seven hypermethylated gene fragments were selected from 45 genes, and three machine learning prediction models based on the RF, NB, and SVM algorithm, respectively, were constructed. In the validation set of 80 cases, there were 28 cases of HPV positivity, with a positive rate of 35.00%. Cytologically, there were 65 cases diagnosed as NILM and 15 cases as ASC-US or above. Histologically, there were 39 cases without cervical intraepithelial neoplasia or benign cervical lesions, 10 cases of CIN1, 10 cases of CIN2, 11 cases of CIN3, and 10 cases of squamous cell carcinoma. In the validation set, the area under the curve (AUC) values of the RF model, NB model, SVM model, HPV detection, and cytological diagnosis of CIN2 or above were 0.90, 0.88, 0.82, 0.68, and 0.45, respectively. The DeLong test showed that there was no statistically significant difference in the AUC values between the RF, NB, and SVM models (all P＞0.05), and the AUC values of the RF and NB models were higher than that of HPV detection (both P＜0.01), and the AUC values of the RF, NB, and SVM models were higher than that of cytological diagnosis (all P＜0.01). Compared with the NB model, the sensitivity of the RF model was similar (80.65% vs. 77.42%), but the specificity of the NB model was much higher than that of the RF model (93.88% vs. 73.47%). Conclusion: Among the machine learning prediction models for cervical cancer and precancerous lesions constructed based on human DNA methylation, the NB model has good predictive performance for CIN2 and above lesions, and may be used for screening of cervical cancer and precancerous lesions.

According to statistics from the Global Burden of Cancer Study (Globocon) of the World Health Organization (WHO), cancer, particularly breast cancer, is a severe health issue in Indonesia with 68,858 new cases and 22,000 deaths recorded in 2020. Ultrasonography (USG) technology is acknowledged as one of the potentials to support early detection, which is vital in reducing mortality from breast cancer. This study focuses on classifying ultrasound images using the Support Vector Machine (SVM) algorithm, GLCM feature extraction, Min-Max normalization, and Mutual Information with SelectKBest Feature Selection. From several experiments using the SVM algorithm with various combinations of parameter values that have been set and different Tests, namely using a Train/Test Split with a proportion of 80/20 and K-Fold Cross Validation, it shows that the SVM algorithm is capable of classifying ultrasound images of breast cancer. into two categories (Benign Tumor and Malignant Tumor) with the same maximum accuracy of 79% after applying the SMOTE Balancing Data technique or without using the Balancing Data technique. As a result, the Support Vector Machine (SVM) algorithm has the potential to be an effective model for identifying breast cancer ultrasound images, both on data from the original set that has not been balanced and data from the set that has been balanced.

Among the list of dreadful diseases, 'Brain Tumor and Brain Cancer' is one of them. According to survival rate, after the detection of cancerous Brain or Central Nervous System (CNS) tumor, 34% of men and 36% of women survive at least 5 years. Therefore, 'Early Detection of tumor' can be a savior for so many lives and artificial intelligence will make the way very accurate and appropriate. A new non-invasive approach to detect brain tumors in early-stage, cost-efficiently with the lowest risk factor is-'Liquid Biopsy'. It is a technique for analyzing non-solid biological tissue, i.e. - blood, plasma, cerebrospinal fluid (CSF). As human inspection maybe error full and inaccurate, in this paper, we have used 'k-means clustering' in 'Image Processing' as visual perception of artificial intelligence for detection of 'CTC' and we have used the technique 'Convolutional Neural Network' (CNN) for ctDNA detection and 'Support Vector Machine'(SVM) algorithm for classification of ctDNA and normal cell-free DNA (cfDNA). 'ctDNA' could provide clues for growth factor of cancerous cells, type of tumors, location, etc. Therefore, our work provides a new way to early detection and a new prospect for early cure.

Brain tumor is the phenomenal growth of abnormal tissues in the human brain. A malignant tumor is known as a cancerous cell, and it is the major cause of death among people across the globe. Nowadays, the detection and classification of brain tumors from Magnetic Resonance Images (MRI) is a very crucial task. This chapter addresses various computing methods such as Edge Detection (ED), feature extraction, and classification techniques for the detection and classification of brain tumor regions from MRI datasets. Initially, MRI images are collected, and then various pre-processing steps such as filtering and edge detection are applied. Then, different edge detection methods such as Sobel ED, Robert’s ED, Prewitt ED, Canny ED, Laplacian ED, and Laplacian of Gaussian (LoG) with sigma 3 are applied for the MRI datasets. Subsequently, segmentation techniques are applied for detecting tumor regions from MRI, and essential features are extracted using Discrete Wavelet Transform (DWT) method. Otsu’s thresholding and K-means clustering segmentation methods are used for the investigation. Further, the support vector machines (SVMs), Naïve Bayes (NB), K-nearest neighbors (KNN), Back Propagation Neural Network (BPNN), and feedforward neural networks (FFNN) classifiers are employed for the MRI classification purpose. The experiments are 146conducted using the brain tumor dataset in the MATLAB 2019a software environment. The experimental results are analyzed in multiple dimensions, and it shows that the SVM with Otsu’s thresholding method exhibits better performance with 86.11% accuracy during the classification.

Anemia is one of the common adverse reactions after hip fracture surgery. The traditional method to solve anemia is allogeneic transfusion. However, the transfusion may lead to some complications such as septicemia and fever. So far, few studies have reported roles of machine learning in predicting whether blood transfusion is needed or not after hip fracture surgery. Therefore, the purpose of this study is to develop machine learning models to predict the likelihood of postoperative blood transfusion in patients undergoing hip fracture surgery. This study enrolled 1355 patients who underwent hip fracture surgery at the Affiliated Hospital of Qingdao University from January 2016 to December 2021. Among all patients, 210 cases received postoperative blood transfusion. All patients were randomly divided into a training group and a testing group at a ratio of 7:3. In the training group, univariate and multivariate logistic regression analyses were used to determine independent risk factors for the postoperative transfusion. Then, based on these independent risk factors, tenfold cross-validation method was utilized to develop five machine learning models, including logistic, multilayer perceptron (MLP), extreme gradient boosting (XGBoost), random forest (RF), and support vector machine (SVM). The receiver operating characteristic (ROC) curve, area under ROC curve (AUC), and Matthews correlation coefficient (MCC) were generated to evaluate the performance of the models. Calibration plot and decision curve analysis (DCA) were used to test the performance, stability, and clinical applicability of the models. The models were validated using the testing group; and the ROC curve, MCC, calibration plot, and DCA curves were also generated to validate the performance, stability, and clinical applicability of the models. To further verify the robustness of the model, we randomly grabbed 70% of the samples in the testing set, performed 1000 iterations, and calculated the AUC and confidence interval of the five models. Finally, we used SHapley Additive exPlanations (SHAP) to explain these models. Multivariate logistic regression analysis showed that there were 8 independent risk factors, including age, blood transfusion history, albumin (ALB), globulin (GLO), total bilirubin (TBIL), indirect bilirubin (IBIL), hemoglobin (HB), and blood loss > 200ml. We finally selected five independent risk factors including HB, GLO, age, IBIL, and blood loss > 200ml. Based on these five independent risk factors, we generated six characteristic variables, namely HB, HB × HB, HB × blood loss, GLO × HB, age, age × IBIL, and established five machine learning models using a tenfold cross-validation method. In the training group, the AUC values of logistic, RF, MLP, SVM, and XGB were 0.9320, 0.8911, 0.9327, 0.9225, and 0.8825, respectively, and the average AUC was 0.9122 ± 0.0212. The MCC values were 0.65, 0.77, 0.65, 0.66, and 0.68, respectively, and the calibration plot and DCA performed well. In the testing group the AUC values of logistic, RF, MLP, SVM, and XGB were 0.8483, 0.7978, 0.8576, 0.8598, and 0.8216, respectively. The average AUC was 0.8370 ± 0.0238, and the MCC values were 0.41, 0.35, 0.40, 0.41, and 0.41, respectively. The calibration plot and DCA in the testing group also showed good performance. The AUC values and confidence intervals of the 1000-iteration model were: logistic (AUC, min confidence interval [CI]-max confidence interval [CI] 0.848, 0.804-0.903), RF (AUC, minCI-maxCI 0.797, 0.734-0.857), MLP (AUC, minCI-maxCI 0.858, 0.812-0.902), SVM (AUC, minCI-maxCI 0.859, 0.819-0.910), and XGB (AUC, minCI-maxCI 0.821, 0.764-0.894). The model performed well. Finally, according to SHAP, among all five models, HB played the most important role in model prediction and interpretation. The five models we developed all performed well in predicting the likelihood of blood transfusion after hip fracture surgery. Therefore, we believed that the prediction model based on machine learning had great application prospects in clinical practice, which could help clinicians better predict the risk of blood transfusion after hip fracture surgery.

In recent times, the detection of brain tumour is a common fatality in the field of the health community. Generally, the brain tumor is an abnormal mass of tissue where the cells grow up and increase uncontrollably, apparently unregulated by mechanisms that control cells. A number of techniques have been developed so far; however, the time consumption in detecting brain tumor is still a challenge in the field of image processing. This paper intends to propose a new detection model even accurately. The model includes certain processes like Preprocessing, Segmentation, Feature Extraction and Classification. Particularly, two extreme processes like contrast enhancement and skull stripping are processed under initial phase, in the segmentation process, this paper uses Fuzzy Means Clustering (FCM) algorithm. Both Gray Level Co-occurrence Matrix (GLCM) as well as Gray-Level Run-Length Matrix (GRLM) features are extracted in feature extraction phase. Moreover, this paper uses Deep Belief Network (DBN) for classification. The DBN is integrated with the optimization approach, and hence this paper introduces the optimized DBN, for which Grey Wolf Optimization (GWO) is used here. The proposed model is termed as GW-DBN model. The proposed model compares its performance over other conventional methods in terms of Accuracy, Specificity, Sensitivity, Precision, Negative Predictive Value (NPV), F 1 Score and Matthews Correlation Coefficient (MCC), False negative rate (FNR), False positive rate (FPR) and False Discovery Rate (FDR), and proven the superiority of proposed work.

Diagnosing Brain Tumor with the aid of Magnetic Resonance Imaging (MRI) has gained enormous prominence over the years, primarily in the field of medical science. Detection and/or partitioning of brain tumors solely with the aid of MR imaging is achieved at the cost of immense time and effort and demands a lot of expertise from engaged personnel. This substantiates the necessity of fabricating an autonomous model brain tumor diagnosis. Our work involves implementing a deep convolutional neural network (DCNN) for diagnosing brain tumors from MR images. The dataset used in this paper consists of 253 brain MR images where 155 images are reported to have tumors. Our model can single out the MR images with tumors with an overall accuracy of 96%. The model outperformed the existing conventional methods for the diagnosis of brain tumor in the test dataset (Precision = 0.93, Sensitivity = 1.00, and F1-score = 0.97). Moreover, the proposed model's average precision-recall score is 0.93, Cohen's Kappa 0.91, and AUC 0.95. Therefore, the proposed model can help clinical experts verify whether the patient has a brain tumor and, consequently, accelerate the treatment procedure.

Integrating near-infrared hyperspectral imaging with machine learning and feature selection: Detecting adulteration of extra-virgin olive oil with lower-grade olive oils and hazelnut oil

Enzymes play an important role in metabolism that helps in catalyzing bio-chemical reactions. Predicting functions of enzymes by experiments is costly and time consuming. Hence a computational method is required to predict the function of enzymes. This paper presents a supervised machine learning approach to predict the functional classes and subclass of protein sequences including enzymes and non-enzymes based on 857 sequence derived features. This paper used seven sequence derived properties including amino acid composition, dipeptide composition, correlation feature, composition, transition, distribution and pseudo amino acid composition. We have used recursive feature elimination technique (RFE), in order to select optimal number of features. The support vector machine (SVM) has been used to construct a three level model with optimal number of features selected by SVM-RFE, where top (first) level distinguish a query protein as an enzyme or nonenzyme, the next (second) level predicts the enzyme functional class and the last (third) level predict the subfunctional class. The proposed model reported overall accuracy of 97.6%, precision of 97.8%and Matthew Correlation Coefficient (MCC) value of 0.93 for the first level, whereas accuracy of 87.3%, precision of 87.7% and MCC value of 0.84 for second level and accuracy of 85.6%, precision of 87.9% and MCC value of 0.86 for the third level.

Brain tumors are among the deadliest diseases in the modern world. This study proposes an optimized machine-learning approach for the detection and identification of the type of brain tumor (glioma, meningioma, or pituitary tumor) in brain images recorded using magnetic resonance imaging (MRI). The Gaussian features of the image are extracted using speed-up robust features (SURF), whereas its non-linear features are obtained using KAZE, owing to their high performance against rotation, scaling, and noise problems. To retrieve local-level information, all brain MRI images are segmented into an 8 × 8 pixel grid. To enhance the accuracy and reduce the computational time, the variance-based k-means clustering and PSO-ReliefF algorithms are employed to eliminate the redundant features of the brain MRI images. Finally, the performance of the proposed hybrid optimized feature vector is evaluated using various machine learning classifiers. An accuracy of 96.30% is obtained with 169 features using a support vector machine (SVM). Furthermore, the computational time is also reduced to 1 min compared to the non-optimized features used for training of the SVM. The findings are also compared with previous research, demonstrating that the suggested approach might assist physicians and doctors in the timely detection of brain tumors.

Machine learning algorithms such as support vector machine (SVM) have been widely used to detect brain tumors in big data environments. However, the SVM classifier is unsuitable for a large dataset as the complexity involved is found to be high. Therefore, in this article, a MapReduce model is introduced with SVM to handle large-scale data and deal with this issue. In this article, a framework called mutual informative MapReduce and minimum quadrangle classification (MIMR-MQC) is introduced for brain tumor detection to handle challenges associated with big data classification. Here, preprocessing is performed using MIMR, which removes unwanted and redundant attributes in the brain tumor dataset. This technique reduces the computation complexity and time using a big dataset for detecting the brain tumors. Then, the minimum quadrangle support vector machine model is created using Lagrange multipliers and radial basis kernel function for improving the efficiency of the classification process. The MIMR-MQC framework is validated on a standard dataset called Central Brain tumor Registry of the United States (CBTRUS). Results show that the proposed model observed 21% of higher detection accuracy by minimizing the computational complexity and detection time by 37% and 27%, respectively in comparison with existing models. A comparison with state-of-the-art machine learning techniques, the MIMR-MQC framework performs better in terms of brain tumor detection time and accuracy due to the better distribution of data.

Detection of brain tumor is very challenging task in today’s medical world. Nowadays, many doctors prefer ready-made methods to diagnose the tumor from given magnetic resonance imaging (MRI) images. Accurate and less time-consuming methods are used frequently to identify it. This paper introduces new techniques for finding and differentiating brain tumors. The new methods include support vector machine (SVM) and convolution neural network (CNN) with Softmax classifier. The SVM uses histogram of oriented gradients (HOGs) as a feature to label the given dataset. Further, the same feature of the test image is verified against labeled sets and classified. The SVM gives accuracy of 87.33%. In CNN, multilayer structure is used. It contains a convolution layer followed by the pooling layer and finally fully connected layer. In CNN, specifically, Alexnet is preferred for classification. In Alexnet, rectified linear unit (ReLU) is used as an activation function. At the output of it, Softmax is used as activation to classify the images. The CNN with Softmax classifier gives improved accuracy of 98.68%. In addition, the performance measures are also found out such as specificity, sensitivity, and precision. The sensitivity with SVM is 93.18%, and with CNN, it increases up to 100%. Comparing both methods with the obtained results, the CNN with Softmax classifier gives better results. Proposed method with CNN produces only one misclassified image as an advantage over the existing method, while SVM gives nine misclassified images. The methods are tested on 253 MRI images which are detected and classified correctly with Matlab.KeywordsSVMCNNHOGMRI

MRI is the most important technique, in detecting the brain tumor. In this paper data mining methods are used for classification of MRI images. A new hybrid technique based on the support vector machine (SVM) and fuzzy c-means for brain tumor classification is proposed. The purposed algorithm is a combination of support vector machine (SVM) and fuzzy c-means, a hybrid technique for prediction of brain tumor. In this algorithm the image is enhanced using enhancement techniques such as contrast improvement, and mid-range stretch. Double thresholding and morphological operations are used for skull striping. Fuzzy c-means (FCM) clustering is used for the segmentation of the image to detect the suspicious region in brain MRI image. Grey level run length matrix (GLRLM) is used for extraction of feature from the brain image, after which SVM technique is applied to classify the brain MRI images, which provide accurate and more effective result for classification of brain MRI images.

An emerging machine learning (ML) strategy for the fabrication of nanozyme sensor based on multi-walled carbon nanotubes (MWCNTs)/graphene oxide (GO)/dendritic silver nanoparticles (AgNPs) nanohybrid and the voltametric determination of benomyl (BN) residues in tea and cucumber samples is proposed. Nanohybrid is prepared by the electrodeposition of dendritic AgNPs on the surface of MWCNTs/GO obtained by a simple mixed-strategy. The orthogonal experiment design combined with back propagation artificial neural network with genetic algorithm is used to solve multi-factor problems caused by the fabrication of nanohybrid sensor for BN. Both support vector machine (SVM) algorithm and least square support vector machine (LS-SVM) algorithm are used to realize the intelligent sensing of BN compared with the traditional method. The as-fabricated electrochemical sensor displays high electrocatalytic capacity (excellent voltammetric response), unique oxidase-like characteristic (nanozyme), wide working range (0.2–122.2 μM), good practicability (satisfactory recovery). It is feasible and practical that ML guides the fabrication of nanozyme sensor and the intelligent sensing of BN compared with the traditional method. This work will open a new avenue for guiding the synthesis of sensing materials, the fabrication of sensing devices and the intelligent sensing of target analytes in the future.