Supporting Development of AI-Based Applications in Electronic Systems Domain Using a Modular Platform Approach

The paper considers the architectural template and methods of building a module for organizing the work of the window information web-system for the formation of medical certificates. To solve this problem, modern tools of web programming and software development are used: a module with the im-plementation of JavaScript objects – window manager and a class of window interactive interface, which allow the web application to function in the organization of cloud technologies. The software implementation is considered and the results of practical use of the developed module with objects and classes are given. The proposed architecture template of the module for the implementation of the man-ager and the functionality of the user window interface allowed to create a module of the information system for the organization of business logic when working with medical certificates. The modular ap-proach has had a positive effect on the sensitivity of the user interface and the ability to scale the func-tionality of the system itself in the implementation of cloud technologies. Due to the modular ap-proach, the rendering time of web-forms with the original data in most cases is very small compared to the time required by the browser to parse and display the entire database array, which has a positive ef-fect on the sensitivity of the user interface. The generation of web-forms is of great practical im-portance, because debugging in this software structure is a weak point for many frameworks. The re-sults of use showed that the mechanism of modular creation of the manager and the window interactive interface of web-forms not only organically fits into already existing technologies of construction of web-applications, but also has sufficient potential to become the core of cloud technologies of develop-ment of multiuser information systems and web- services.

The Indian Head Division, Naval Surface Warfare Center (IHDIV, NSWC) is sponsoring a program to design, develop, and implement a family of electronic time delay cartridges for a wide variety of aircrew escape and other cartridge applications throughout the U.S. Department of Defense. Currently, pyrotechnic cartridges, utilizing either a “pressed column” delay or a small column insulated delay (SCID), provide the time delays required for these applications. Implementing an electronic time delay (or digital delay) cartridge, which maintains the form, fit, and function as the current pyrotechnic cartridges while providing longer useful lifetimes and more precise time delays is the primary objective of this program. This paper presents the program approach adopted for this effort and the successes achieved by the selected contractor Special Devices, Inc. and its partner Scot Inc. to develop an electronic time delay cartridge family. BACKGROUND: Cartridge Actuated Devices and Propellant Actuated Devices (CAD/PAD) are utilized for various applications throughout the U.S. military. A cartridge is defined as an energy source utilizing one or more energetic materials. A Cartridge Actuated Device (CAD) is defined as a device releasing cartridge energy to perform a work function. A Propellant Actuated Device (PAD) is defined as a rocket powered device releasing controlled propellant energy to perform a work function. Also, an Aircrew Escape Propulsion Systems (AEPS) is a “PAD” specifically designed for aircrew systems applications. For example, on the F/A-18E/F aircraft, there are over sixty-six (66) cartridges, CADs, and AEPS (Figure (1) on the next page). As shown, the F/A-18E/F utilizes a NACES (Navy Aircrew Common Ejection Seat) ejection seat to provide the pilot escape capability during an emergency situation. In addition, as part of the overall escape system, delay cartridges are utilized to provide optimized timing for all required events. The MC50 Cartridge Actuated Initiator (Photo (1) and Figure (2)) provides supplemental ballistic pressure to the system after a 0.3 second delay. Photo 1: MC50 Cartridge Actuated Initiator For this initiator, ballistic pressure is used as the stimulus to actuate a percussion primer. This primer, in turn, initiates a pyrotechnic column that provides the required 0.3 second time delay before initiating the output charge which provides ballistic pressure to the remainder of the system. Figure 2: MC50 Cartridge Actuated Initiator Schematic 1 43rd AIAA/ASME/SAE/ASEE Joint Propulsion Conference & Exhibit 8 11 July 2007, Cincinnati, OH AIAA 2007-5133 This material is declared a work of the U.S. Government and is not subject to copyright protection in the United States. 43 AIAA/ASME/SAE/ASEE JPC AIAA 2007-5133 Figure 1: F/A-18 E/F CAD/PADs Currently, pyrotechnic cartridges provide the required time delays for a wide range of CAD/PAD systems. These cartridges contain energetic materials that burn in a column at a controlled rate and provide ballistic output after the required system delay has been achieved. These current cartridges fall into two basic categories: “pressed column” type cartridges and “small column insulated delay (SCID)” type cartridges. One example of the “pressed column” type cartridges is the CCU-40A/A (Figure (3)). This cartridge is used on the AV8B aircraft and provides a 0.575 second delay prior to generating ballistic pressure to deploy the ejection seat parachutes. Figure 3: CCU-40A/A Delay Cartridge As shown, the CCU-40A/A delay cartridge is 1.095 inches long and 0.379 inches in diameter. Included in this cartridge are the percussion primer, the delay column, and the output charge that generates the required ballistic pressure for system operation. The CCU-40A/A Delay Cartridge is the smallest of the family of current U. S. Navy and U. S. Air Force delay cartridges or initiators. By maintaining the physical envelope of the CCU-40A/A cartridge, the selected technology can be rapidly implemented into larger cartridge or initiator applications. Thusly, maintaining this physical envelope, while implementing an alternate electronic time delay technology, has been identified as the primary design challenge of this program. A critical secondary design challenge is the packaging of the sub-components that comprise the selected alternate technology. Both of these current types of delay cartridges are expensive to produce, provide imprecise delay times (a tolerance of 25% for the “pressed column” type cartridges and a tolerance of 8% for the SCID-type cartridges are considered acceptable over a standard aircraft environmental temperature range), and require change-out as often as every 18-months during the maintenance cycle for some aircraft applications. Implementing cartridges that replace the pyrotechnical delays with electronic technologies

World's largest ATR-based gas-to-gasoline plant has been put into successful operation by Haldor Topsoe

Neutral, water-soluble poly(ester amide) hydrogels for cell encapsulation

Bispecific immune cell engagers are showing promise in cancer immunotherapy. To achieve optimal efficacy, there is a growing need for patient personalization, tackling intra-tumor heterogeneity, and simplified combination therapies. Here, we present a novel modular anti-P329G adaptor platform aiming to address these issues, which is based on the recognition of the P329G mutation in the Fc portion of a targeting adaptor antibody. This P329G mutation can serve to recruit different anti-P329G effector cell engagers, including innate cell engagers, T cell engagers, costimulators or immunocytokines. Specifically, upon identifying patient-specific tumor surface targets, the primary antigen-binding IgG1 antibodies bearing Fc-silencing P329G LALA mutations are applied. Subsequently, based on the tumor’s immune profile, the best-suited anti-tumoral effector cell type is chosen for recruitment and activation. Based on this information, the secondary antibody recognizing the P329G mutation is chosen from an array of effector cell engagers with different modes of action: P329G-T cell bispecifics (P329G-TCB), ADCC-competent P329G innate cell engagers (P329G-ICE), P329G costimulatory molecules (P329G-CD28/4-1BBL) or P329G immunocytokines (P329G-IL2v). In vitro assays showed all P329G modalities inducing anti-tumoral and/or immunomodulatory cell activity. Anti-tumoral efficacy of secondary antibodies was observed only in presence of tumor-targeted P329G adaptors, while no effect was observed in their absence. The readouts consisted of tumor killing quantification, CD4+ and CD8+ T cell activation, cytokine release and cytokine receptor signaling. As a proof of concept study in vivo, an experiment in MKN-45 (CEACAM5+)-bearing humanized mice was performed, using an anti-CEACAM5 P329G-IgG adaptor and a P329G-TCB. Both tumor volume shrinkage and T cell infiltration into the tumor confirmed anti-tumoral efficacy of the platform, as compared to a conventional CEACAM5-targeted TCB. Neither the individual P329G IgG nor the individual P329G-TCB induced anti-tumoral efficacy, validating the requirement for primary and secondary antibody binding for T cell engaging activity. These results provide in vitro and in vivo evidence that the universal P329G engager platform can be used as an efficacious cancer treatment. Ultimately, this modular approach may enable off-the-shelf personalization via combination of patient-specific antibodies and universal effector cell engagers based on the patient’s tumor target and immune profile. Citation Format: Marlena Surowka, Idil Hutter-Karakoc, Diana Darowski, Christina Claus, Claudia Ferrara Koller, Anne Freimoser-Grundschober, Thomas Hofer, Andrzej Sobieniecki, Denis Assisi, Stephane Leclair, Ekkehard Moessner, Pablo Umaña, Maria Amann, Christian Klein. P329G-Engager: A novel universal antibody-based adaptor platform for cancer immunotherapy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 6709.

Target tracking and vehicle navigation systems involve some kind of nonlinearities. Estimation of these nonlinearities in practical system is unavoidable. A modular approach is obtained by applying kalman filtering to a tightly coupled system which makes navigation more simpler and more precise. This paper conceptualizes a portable and flexible system which is designed by integrating a low grade inertial measurement unit and GPS onto FPGA and is calibrated using kalman filter. A single kalman filter is used to process both the data from GPS and Inertial Measurement Unit and the GPS signal is used as the reference. Proposed short time system provides a real time Position accuracy far more better than the existing systems decreasing the cost by using MEMS devices.

In this paper , a user-friendly Geographic Information Systems (GIS) program was developed to manipulate the property listing for sale geographically, to display the property listing in relation to other social and environmental features including topography, ways, types of unit ,ways, gardens and/or shopping centers, and to provide tools for the houses buyers to search and inspect properties and make choices without the need of getting into the houses or without their need to travel to place of houses. This study combines four luminous areas Geographic Information Systems (GIS), Electronic business System, Management Information System (MIS) and Internet and applies the combined technology in the business of real state to make system this system called (GEMI).The first section explains the methodology and prototypes development for Sherouk Beach Resort Planning and Management (SBRPM) with GIS and how the GIS software program was developed. Secondly various application scenarios were provided to test the program developed. It proves that the GIS program developed in this paper provides a good and convenient option in the search of properties based on different selection criteria as concluded in the final sections. Keywords - Geographic Information Systems (GIS), Electronic business, MIS, Real state, GEMI, SBRPM. I. Introduction The following section will address issues that are raised in each of these three stages in the program development. The GIS program was developed in three stages. The first stage is in system planning that is, to identify what functions will be required by the program and how they are to be incorporated into the software program. To do this, first is to become more familiar with the existing functions and tools in MapInfo 7(1) and then to identify what other functions are needed in this System. The second, stage is to design the interface of the software program and to write codes using PHP to integrate the functions required into the MapInfo software program (2). The software program can be applicable to other regions if similar datasets can be used for those regions. In the third stage, the software program developed in this paper is applied to assist in the search of buying units in Sherouk Beach Resort Region (SBRR). By using different search criteria for the search, the software program is tested which demonstrates that the program is capable of assisting in buying in the real estate industry. Through this testing process, limitations of the software program and possible improvement solutions are also explored.

Collections are commonly implemented as libraries by data structure experts, and are relied on heavily by application developers. The expert’s task is to implement a wide range of collections, and the application developer’s task is to pick an appropriate collection for each usage scenario. The design space for collections is huge, as data structures in practice implement not only their semantics, but also several performance-related concerns like memory layout and (im)mutability. This paper presents C♭, pronounced “C-flat”, a novel way to implement collections that lets experts implement the semantics of a collection data structure, in a way that is decoupled from its data representation. This simplifies collection implementation, and allows a collection’s performance to be tuned, for example, moving from a dense to a sparse representation, without changing its abstract specification. We describe C♭, both abstractly and in terms of a specific prototype implementation in Java. We use our prototype implementation to show that C♭ is expressive enough to implement common collections, that the code is straightforward, and that the performance of C♭ collections is close to Java’s standard collections for most operations, and much higher for some.

The experience of the Moscow Aviation Institute in terms of advanced training of higher school teachers as part of the implementation of the strategy for the exchange of experience with universities of related fields of training is described. The basic principles of the formation of a bank of professional development programs, the methodology for developing the content of programs, and the main aspects of the organization of training are described. The preferred form of training for advanced training of teachers has been identified — full-time and part-time with the use of e-learning and distance learning technologies. The mechanism of orientation of the content of teacher training programs to the requirements of the Unified Qualification Directory of positions of managers, specialists and employees (EXD) through the formulation of knowledge and skills, competencies based on it, as well as the mechanism of using a modular approach in the formation of the content of the program, which allows to introduce variability and create an individual learning trajectory for teachers. The statistics of the training of internal and external teachers over the past 3–4 years at the Moscow Aviation Institute on the quantitative composition and the most popular subjects of training are presented. The positive role of the Priority–2030 program in the formation and development of the strategy was noted. Based on the experience of the Moscow Aviation Institute, the advantages provided by the strategy, the difficulties that have to be overcome in the process of its implementation, as well as possible prospects are formulated.

Smart cities solutions are often monolithically implemented, from sensors data handling through to the provided services. The same challenges are regularly faced by different developers, for every new solution in a new city. Expertise and know-how can be re-used and the effort shared. In this article we present the methodologies to minimize the efforts of implementing new smart city solutions and maximizing the sharing of components. The final target is to have a live technical community of smart city application developers. The results of this activity comes from the implementation of 35 city services in 27 cities between Europe and South Korea. To share efforts, we encourage developers to devise applications using a modular approach. Single-function components that are re-usable by other city services are packaged and published as standalone components, named Atomic Services. We identify 15 atomic services addressing smart city challenges in data analytics, data evaluation, data integration, data validation, and visualization. 38 instances of the atomic services are already operational in several smart city services. We detail in this article, as atomic service examples, some data predictor components. Furthermore, we describe real-world atomic services usage in the scenarios of Santander and three Danish cities. The resulting atomic services also generate a side market for smart city solutions, allowing expertise and know-how to be re-used by different stakeholders.

PurposeThe purpose of this paper is to consider the problem of university lecture timetabling. Timetabling deals with the problem of placing certain resources into a limited number of time slots, subject to given constraints, in order to satisfy a set of stated objectives to the highest possible extent. It is a well‐known and established NP‐hard problem. University timetabling is a major administrative activity especially in the third world universities. Solving the problem requires dynamic heuristics with predictable performance especially as the number of courses increases without corresponding increase in needed resources.Design/methodology/approachA genetic algorithm metaheuristic is designed to handle a real‐life case study. Given the present structure of the case study, a modular approach to the design of the timetable schedules is adopted. The approach considers timetable in a bottom‐up fashion at the various levels of department, faculty or entire university. Simulation study is conducted using the open source Java IDE, Eclipse® 3.0 in a window XP/vista environment running on a processor of 1.12 GHz.FindingsUsing the data sub‐set from the case study, simulation experiments are conducted based on the proposed method and obtained promising results.Research limitations/implicationsGiven the modular approach, the timetable system can easily be adapted to other various levels in the institution.Originality/valueWith reference to the case study, this is believed to be the first application of metaheuristics to a timetabling problem. The sensitivity analysis of the algorithm parameters is very valuable in guiding actual application development for the problem.

Microfabrication technologies initially developed for integrated electronics have been successfully applied to batch-fabricate a wide variety of micromechanical structures for sensing, actuating, or signal-processing functions such as filters. By appropriately combining the deposition, etching, and lithography steps for microelectromechanical devices with those needed for microelectronic devices, it is possible to fabricate an integrated microsystem in a single process sequence. This paper reviews the strategies for cofabrication, with an emphasis on modular approaches that do not mix the two process sequences. The integrated processes are discussed using examples of physical sensors (infrared imagers and inertial sensors), chemical and biochemical sensors, electrostatic and thermal actuators for displays and optical switching, and nonvolatile memories. By adding new functionality to integrated electronics, the use of microelectromechanical systems is opening new applications in sensing and actuating, as well as enhancing the performance of analog and digital integrated circuits.

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