The author replies.

Important Outcomes for Parents of Critically Ill Children.

ObjectiveTo identify the neonatal, pediatric and mixed (neonatal and pediatric) intensive care units in Brazil that use cuffed tracheal tubes in clinical practice and to describe the characteristics related to the use of protocols and monitoring.MethodsTo identify the intensive care units in Brazil, the Ministry of Health’s National Registry of Health Facilities was accessed, and information was collected on 693 registered intensive care units. This was an analytical cross-sectional survey conducted through electronic questionnaires sent to 298 neonatal, pediatric and mixed intensive care units in Brazil.ResultsThis study analyzed 146 questionnaires (49.3% from neonatal intensive care units, 35.6% from pediatric intensive care units and 15.1% from mixed pediatric intensive care units). Most of the participating units (78/146) used cuffed tracheal tubes, with a predominance of use in pediatric intensive care units (52/78). Most of the units that used cuffed tracheal tubes applied a cuff pressure monitoring protocol (45/78). The use of cuff monitoring protocols was observed in intensive care units with a physical therapy service exclusive to the unit (38/61) and in those with a physical therapist present 24 hours/day (25/45). The most frequent cause of extubation failure related to the use of cuffed tracheal tubes in pediatric intensive care units was upper airway obstruction.ConclusionIn this survey, the use of cuffed tracheal tubes and the application of a cuff pressure monitoring protocol was predominant in pediatric intensive care units. The use of a monitoring protocol was more common in intensive care units that had a physical therapist who was exclusive to the unit and was present 24 hours/day.

Successful Integration of Advanced Practice Providers Into a Pediatric Academic Community Intensive Care Unit

Les clowns en réanimation pédiatrique : état des lieux en France

Department of Pediatrics - Pediatric Intensive Care Unit, Universidade de Sao Paulo, São Paulo, Brazil The author has disclosed that she does not have any potential conflicts of interest.

Mycoses are diseases caused by fungi that involve different parts of the body and can generate dangerous treatment complications. This study aims to analyze fungal infection epidemiology in intensive care units (Pediatric and Cardiac Surgery Intensive Care Units—PCICU) and the Neonatal Intensive Care Unit (NICU) in one large pediatric center in the period 2015–2020 compared with 2005. The year 2005 was randomly selected as a historical time reference to notice possible changes. In 2005 and 2015–2020, 23,334 mycological tests were performed in intensive care units. A total of 4628 tests (19.8%) were performed in the intensive care units. Microbiological diagnostics involved mycological and serological testing. Of the 458 children hospitalized in the NICU, positive results in the mycological tests in the studied years were found in 21–27% of the children and out of 1056 PCICU patients, positive results were noticed in 18–29%. In both departments, the main detected pathogen was Candida albicans which is comparable with data published in other centers. Our experience indicates that blood cultures as well as the detection of antifungal antibodies do not add important information to mycological diagnostics. For the years of observation, only a few positive results were detected, even in patients with invasive fungal diseases. To our knowledge, this is one of a few similar studies over recent years and it provides contemporary reports of mycoses in pediatric ICU patients.

Comparison of severity and diagnosis-adjusted mortality rates from pediatric intensive care units (ICUs) staffed by physicians training in pediatric critical care, as well as pediatric residents, with mortality rates from pediatric ICUs staffed with only pediatric residents. Cohort study. Sixteen volunteer pediatric ICUs, eight with critical care fellowships, and eight without such programs. Consecutive admissions until at least 14 deaths occurred at each site. None. Descriptive data and Pediatric Risk of Mortality scores were collected. Severity and diagnosis-adjusted mortality risk for each patient was computed by a predictor developed in an independent sample. The effect of fellowship programs was analyzed at the institution level by ranking the pediatric ICUs in terms of observed/predicted mortality rates, and, at the patient level, by including a training factor into the predictor model. The use of monitoring and therapeutic modalities was compared in the two types of pediatric ICUs by severity-adjusted odds ratios. There were 2,744 admissions (145 deaths) to the eight fellowship pediatric ICUs and 3,006 admissions (150 deaths) to the eight nonfellowship pediatric ICUs. Institutional characteristics were not different between the two pediatric ICU sets. The raw mortality rates were similar (fellowship 5.28%; nonfellowship 4.99%, p = .714). Institution-level analyses indicated that fellowship pediatric ICUs performed better than nonfellowship pediatric ICUs; fellowship pediatric ICUs ranked better than pediatric ICUs without such programs (Wilcoxon rank-sum test, p = .020). However, both the best and the worst ranked pediatric ICUs had fellowships. Patient-level analyses also indicated that outcome was significantly influenced by the fellowship status of the pediatric ICU. Using two different patient-level analytic approaches, the odds of dying in a fellowship pediatric ICU vs. a nonfellowship pediatric ICU were 0.592 (95% confidence interval 0.468 to 0.749, p = .0001) and 0.714 (95% confidence interval 0.529 to 0.964, p = .028). Pediatric ICUs with fellowship programs performed more (p < .05) invasive monitoring, including intra-arterial catheters and central venous pressure catheters, and more technological therapies such as mechanical ventilation. Pediatric ICUs with critical care fellowship programs are generally associated with better risk-adjusted mortality rates than pediatric ICUs without such fellowship training programs. The cause for this effect requires a more in-depth study. The presence or absence of such training programs does not guarantee superior or inferior performance.

PurposeSerratia marcescens is a well-recognized hospital-acquired pathogen frequently implicated in outbreaks in neonatal and pediatric intensive care units. We compared clinical characteristics of infants with Serratia bloodstream infections (BSI) to those with non-Serratia gram-negative BSI.MethodsA retrospective case-control study comparing infants (0-2 y/o) hospitalized at our referral pediatric cardiac intensive care unit (PCICU), who acquired gram-negative blood cultures, during 2012-2022. Patients were categorized into two groups: S. marcescens BSI versus non-Serratia gram-negative BSI. Demographic and clinical data were extracted from our medical databases.ResultsOf 112 patients meeting inclusion criteria, 40 (36%) had Serratia BSI and 72 (64%) non-Serratia gram-negative BSI. Blood stream infection with Serratia occurred later postoperatively (median 15 vs 7 days, p < .01), were associated with less pre-infection inotropic support (median VIS 0 vs 5, p < .01) and higher rates of multisite involvement (35% vs 18%, p = .04). Duration of indwelling vascular catheters at time of infection was longer in the Serratia group (median 10 vs 7 days, p = .03). No associated mortality was attributed to Serratia BSI, as compared to a 5.6% mortality rate in the non-Serratia group.ConclusionsSerratia BSI in the PCICU tends to develop later during hospitalization, involves more multiple infection sites, and is associated with longer vascular catheters dwell durations at the time of infection. Serratia infections appeared sporadically throughout the year without seasonal clustering. This supports the importance of stringent infection control practices and warrants prospective studies on prevention strategies.

Computed radiography in neonatal and pediatric intensive care units: A comparison of 2.5 K × 2 H soft copy images vs digital hard-copy film

BackgroundResearch on pediatric intensive care unit (PICU) readmission is lacking in China. This study was conducted to describe the risk factors associated with PICU readmission within 1 year after PICU discharge.MethodsThis retrospective case-control study included patients aged from 1 month to 16 years who were discharged between January 2018 and May 2020. The case group included readmitted patients with two or more PICU admissions within 1 year during the study period. The control group included survivors with only one PICU admission during the same study period, and the controls were matched on age and sex. Demographic and clinical variables were collected from the electronic administrative database. Risk factors were analyzed by univariate and multivariate analyses.ResultsFrom January 2018 to May 2020, 2,529 patients were discharged from the PICU, and 103 (4.07%) were readmitted within 1 year. In the univariate analysis, PICU readmission within 1 year was associated with lower weight, the presence of chronic conditions, a higher StrongKids score on admission, length of PICU stay of more than 2 weeks, the presence of dysfunction at discharge, sedation medications use, vasopressor use, and invasive mechanical ventilation in the first PICU stay. Patients had a higher StrongKids score as a surrogate for increased risk of malnutrition. In the multivariate analysis, the factors most significantly associated with PICU readmission within 1 year were the presence of chronic conditions, a higher StrongKids score on admission, and length of PICU stay of more than 2 weeks in the first PICU stay. In the subgroup analysis, compared with the control group, the factors most significantly associated with readmission within 48 h of discharge were the presence of chronic conditions, a higher StrongKids score on admission, and vasopressor use during the first PICU stay. The mortality rate was 8.74% (9/103) in patients with PICU readmission. The overall PICU mortality rate was 7.39% (201/2,721) during the study period.ConclusionsPatients with chronic conditions, a higher StrongKids score on admission, and length of PICU stay of more than 2 weeks were at much higher risk for PICU readmission within 1 year. Patients with vasopressor use during the first PICU hospitalization were more likely to be readmitted within 48 h of discharge.

Essentials of Paediatric Intensive Care

The prevalence of delirium in intensive care units (ICUs) is high and has a major impact on patient outcomes. To describe delirium assessment instruments, prevalence, interventions and barriers in delirium management in adult and paediatric ICUs; and to explore the association between delirium prevalence and reported interventions and barriers at unit level. A secondary analysis of the cross-sectional World Delirium Awareness Day Delirium Survey on 15 March 2023. This was a prospective study to assess the one-day point delirium prevalence, practices and quality improvement efforts across healthcare systems. Data was analysed descriptively and using multiple linear regression. Data of 1612 assessments in 123 ICUs from three German-speaking countries were analysed. The most frequently used delirium assessment instrument was the Intensive Care Delirium Screening Checklist (43.9%, n = 54). The prevalence of delirium at 8 AM was 18.6% and at 8 PM 20.4% from the 94 ICUs included in the regression analyses. Prevalence for adult and paediatric and mixed ICUs are comparable. Main reported over all unit-level interventions were 'pain management' (95.9%, n = 118), 'mobilization' (94.3%, n = 116) and 'verbal re-orientation' (84.6%, n = 104). Main reported over all unit-level barriers were 'shortage of staff' (53.7%, n = 66) and 'patients who are difficult to assess' (44.7%, n = 55). Interventions such as 'avoidance of bladder tubes/catheters' in all ICUs, 'use of ear plugs and/or sleep glasses' in adult ICUs and 'mobilization' in paediatric and mixed ICUs were associated with reduced delirium prevalence. Across all ICUs, as well as in both adult and paediatric ICUs, 'lack of appropriate scores for delirium assessment' was identified as a significant barrier. One fifth of assessed ICU patients suffer from delirium. Several reported unit-level interventions and barriers may have an impact on delirium prevalence, suggesting an approach for future studies and clinical practice. In clinical practice, unit-level 'avoidance of bladder tubes/catheters', 'use of ear plugs and/or sleep glasses' and 'mobilization' may be used as delirium prevention and treatment interventions.

Infectious Diseases in the Pediatric Intensive Care Unit is a comprehensive collection of infectious disease topics in the paediatric intensive care unit (PICU) and in the neonatal intensive care unit (NICU) written by different experts. The chapters cover a broad range of interest, from the development of the immune system to diagnosis, treatment and prophylaxis of various infectious diseases including sepsis. The chapters on immunology, including the immunosuppressed host – with abundant information about congenital immunodeficiencies and HIV – are more comprehensive than other topics covered. There is further emphasis on potentially life-threatening tropical infections such as malaria, dengue, tetanus and Japanese encephalitis. The purpose of the book is to provide a comprehensive overview of infectious diseases in critically ill neonates and infants. The scope of the book is broad, and it aims to provide information on pathophysiology as well as to serve as a practical manual on diagnosis, therapy and prevention of infectious diseases in the PICU and the NICU. Infectious Diseases in the Pediatric Intensive Care Unit is primarily directed at physicians working with children in intensive care facilities who are not infectious diseases specialists. Most chapters of the book could also reach out to a larger audience, including medical students and infectious disease fellows who are not paediatricians. The short chapter on infection control might be of interest for nonspecialists; however, several of its paragraphs and references (for example, hand hygiene, epidemiology, antibiotic control) are outdated. Most chapters of the book are quite basic and therefore cannot replace currently available standard textbooks or state-of-the-art reviews. Overall, this book does a good job of summarising and presenting the essentials of infectious diseases in the PICU and in the NICU in 580 pages. Moreover, it gives useful and practical information about diagnostic and therapeutic challenges. While some chapters are excellent, however, others are less so and – as the one about fungal infections – are partially outdated and somewhat inaccurate due to recent publications in this field. Furthermore, the merged discussion of issues related to the NICU and the PICU makes some chapters difficult to read because there is considerable variation among differential diagnoses, therapies and prevention strategies among neonates versus older children. Finally, several chapters could have benefited from more illustrations and summary tables to facilitate quick reading. This first edition of the Infectious Diseases in the Pediatric Intensive Care Unit provides comprehensive information about infectious diseases in paediatric and neonatal intensive care facilities. It is a useful guide for paediatric intensive care fellows and physicians in order to gain an overview of specific infectious disease topics in their daily practice.

AimTo optimise smart-pump functionality as part of an ongoing multi-phase project to develop a national smart-pump drug library of standard concentration infusions (SCIs) suitable for paediatric and neonatal patients in...

From the Paediatric Intensive Care Unit, Our Lady's Children's Hospital Crumlin, Dublin, Ireland (DP, SC) Correspondence to Suzanne Crowe, Consultant in Paediatric Intensive Care Medicine, Our Lady's Children's Hospital Crumlin, Dublin 12, Ireland Tel: +35 3868328930; e-mail: [email protected]