The Hidden Impact: Insulin Lipohypertrophy

Abstract

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Insulin lipohypertrophies (LH) consist of soft-tissue nodules caused by insulin's anabolic properties, potentially leading to erratic insulin absorption, hypoglycemia, and uncontrolled diabetes. A thorough physical examination of insulin injection and pump-insertion sites is crucial for detecting such changes in patients with diabetes. Counseling on rotating injection sites helps prevent LH. Here, we present 2 cases of LH, one in a Hispanic man and one in an African American man, both with long-standing type 1 diabetes mellitus.