The sarcopenia artificial intelligence diagnostic decision support system (SAID DSS) – a multimodal deep learning model

Phenotypic Characteristics Associated With Reduced Short Physical Performance Battery Score in COPD

Introduction This study aimed to estimate the association between Sarcopenic Obesity (SO) and physical performance among patients with stroke. Methods This retrospective cohort study was conducted on patients with stroke. SO was defined using the European Society for Clinical Nutrition and Metabolism and the European Association for the Study of Obesity criteria under two conditions, with and without Body Mass Index (BMI) screening. The primary outcome was the Short Physical Performance Battery (SPPB) score at discharge. Multiple regression analysis was performed to determine the relationship between SO and SPPB score. Results This study included 199 patients with stroke (median age: 74.0 [67.5–81.5] years). The prevalence of SO was 9.0% and 28.1% with and without BMI screening, respectively. Multiple regression analysis showed that SO without screening was negatively associated with SPPB score. Discussion SO without BMI screening was associated with a decline in physical performance among patients with stroke.

BackgroundIn older patients with polypharmacy and multiple comorbidities, even low grades of statin-associated muscle symptoms may have clinical implications. The aim of this study was therefore to investigate the potential associations between statin use and measures of physical performance and muscle function.MethodsParticipants were aged 70+, treated with at least seven regular systemic medications, and not expected to die or become institutionalized within 6 months. Physical performance measured as gait speed and Short Physical Performance Battery (SPPB) score, and muscle function measured as grip strength, were compared between users and non-users of statins. In the subgroup of statin users, the dose-response relationship was assessed using harmonized simvastatin equivalents adjusted for statin potency, pharmacokinetic interactions and SLCO1B1 c.521 T > C genotype. Multiple linear regression analyses were applied to investigate potential associations between stain use and exposure as independent variables, and physical performance and muscle function as outcomes, adjusted for age, gender, body mass, comorbidity, disability and dementia.Results174 patients (87 users and 87 non-users of statins) with a mean (SD) age of 83.3 (7.3) years were included. In analyses adjusted only for gender, grip strength was significantly higher in users than in non-users of statins [regression coefficient (B) 2.7, 95% confidence interval (CI) 1.0 to 4.4]. When adjusted for confounders, the association was no longer statistically significant (B 1.1, 95% CI − 0.5 to 2.7). SPPB and gait speed was also better in statin users than in non-users, but the differences were not statistically significant. In dose-response analyses adjusted for confounders, we found a statistically significant increase in SPPB score (B 0.01, 95% CI 0.00 to 0.02) and gait speed (B 0.001, 95% CI 0.000 to 0.002) per mg increase in simvastatin equivalents.ConclusionsIn contrast to our hypothesis, statin use and exposure was associated with better measures of physical performance and muscle function in older patients with complex drug treatment. The unexpected findings of this cross-sectional, observational study should be further investigated by comparing physical performance before and after statin initiation or statin withdrawal in prospective studies.Trial registrationClinicalTrials.gov identifier: NCT02379455, registered March 5, 2015.

BackgroundExercise rehabilitation may help maintain physical function in chronic kidney disease (CKD), but long-term clinical effectiveness is unknown. We evaluated the effect of an exercise rehabilitation program on physical function over 1 year in individuals with CKD.MethodsThis clinical program evaluation included adults with CKD (any stage) registered in a provincial renal program from 1 January 2011 to 31 March 2016. Attenders were referred to and attended a 10-week exercise rehabilitation program (n = 117). Nonattenders were referred, but did not attend the program (n = 133). Individuals enrolled in a longitudinal frailty study (n = 318) composed a second control group. Primary outcome: Change in physical function [short physical performance battery (SPPB) score]. Secondary outcomes included change in health-related quality of life, physical activity, exercise behaviour, hospitalization over 1 year. Predictors of improved SPPB were assessed using logistic regression.ResultsIn sum, 53, 40 and 207 participants completed 1-year follow-up in attender, nonattender and second control groups, respectively. Baseline median SPPB [interquartile range (IQR)] scores were 10.5 (9–12), 10 (8–12) and 9 (7–11) in attender, nonattender and second control groups, respectively (P = 0.02). Mean change in SPPB score over 1 year was not significantly different between groups (P = 0.7). Attenders with baseline SPPB score <12, trended toward increased likelihood of improved SPPB score at 1 year [odds ratio (OR) 2.18; 95% confidence interval (CI) 0.95–5.02; P = 0.07]. More attenders (60%) exercised regularly at 1 year than nonattenders (35%) (P = 0.03).ConclusionsThe impact of clinical exercise rehabilitation programs on physical function at 1 year needs further delineation. However, our observation of improved exercise behaviour at 1 year suggests sustained benefits with such programs in CKD.

Physical function across the lifespan in adults with multiple sclerosis: An application of the Short Physical Performance Battery.

BACKGROUND: Strength and balance training are critical to maintaining physical function and delaying the onset of major mobility disability in older adults (OAs). The minimum amount of this training required to yield clinically meaningful improvements in physical function is not clear. PURPOSE: To evaluate the effect of two low dose strength/balance programs on physical function in mobility-limited OAs. METHODS: Twenty community-dwelling OAs with mobility limitations were randomized to one of two strength/balance doses (n=10/dose), held 3x/week at a local YMCA for 10 wks. Eligible participants were ≥ 65 yrs of age, exhibited mild to moderate mobility impairment (short physical performance battery (SPPB) score of 3-9 out of 12), sedentary (<125 minutes/week of any kind of physical activity, determined by 7-day pre-baseline accelerometry), and had no major medical issues that would preclude exercise. Exercise doses were as follows: Low dose (L): 1 set each of chair stands, hip abduction, step-up and back with head turns, toe raises, and a balance stand). Higher dose (H): 2 sets of the previous mentioned exercises were performed. Each exercise had three variations of difficulty to accommodate different participant abilities and the number of reps were based on an RPE of 7 out of 10. Participants were assessed on SPPB score and 400m walk speed before and after the intervention by individuals blinded to which dose that participant was randomized to. Clinically meaningful improvements were defined as an SPPB improvement of 0.5 points and a 400m walk speed improvement of 0.05 m/sec. Data was analyzed using a t-paired test. Results are expressed as means (+ std deviation). RESULTS: SPPB score improved by 2.5 (+ 1.1) points among the entire cohort (p<0.001). Improvement was significant for each dose alone (L: 1.5 (+ 0.6), p<0.05), (H: 3.0 (+ 0.82), p<0.001). The improvement in SPPB score in the higher dose was significantly different from that observed with the lower dose (p<0.05). There was no significant effect of either dose on 400m walk speed. CONCLUSION: A 10 wk strength/balance program performed 3x/week and consisting of a single set each of select strength/balance exercises was sufficient to elicit clinically meaningful improvements in physical function for OAs with mild to moderate mobility limitations.

Hyperglycemia with high hemoglobin A1c (HbA1c) levels is associated with significant health risks. However, the relationship between HbA1c levels and the physical functioning status in later life remains uncertain and so is the possible underlying mechanism. We conducted a prospective study of 2,565 initially well-functioning community-dwelling older adult aged 55 years and older from the Healthy Aging Longitudinal Study in Taiwan. Each participant received baseline measurements of blood HbA1c and inflammatory markers levels and repeated assessments of physical functioning over a mean follow-up period of 5.3 years. We used generalized linear mixed-effects regression to estimate the adjusted changes in the odds ratio for self-reported physical functioning impairment and Short Physical Performance Battery (SPPB) score according to baseline HbA1c levels (categorized into 0.5% increments from <5.5% to ≥7.0%). HbA1c levels showed a U-shaped relationship with changes in the odds ratio for physical functioning impairment and SPPB score (p for quadratic term < .001). Compared with participants with an HbA1c of 5.5% to <6.0%, those with an HbA1c of <5.5% or ≥7.0% had a higher annual increase in the odds ratio for physical functioning impairment (odds ratio [95% confidence interval] per year, 1.25 [1.04-1.50] and 1.21 [1.04-1.41]) and a higher annualized decrease in SPPB score (coefficient [95% confidence interval], -0.05 [-0.10 to 0.00] and -0.04 [-0.08 to 0.00]). These relationships were nonlinear only in participants with high soluble interleukin-6 receptor levels (>48,124 pg/mL; p for interaction < .05). High and low HbA1c levels at baseline are associated with faster physical functioning decline, particularly among individuals with elevated circulating soluble interleukin-6 receptor, a sign of enhanced interleukin-6 trans-signaling.

Sarcopenia is a common complication in patients with liver cirrhosis and is associated with reduced quality of life and poor prognosis. Exercise and nutritional therapy are recommended; however, their efficacy in patients with cirrhosis-associated sarcopenia remains unclear. This study evaluated the efficacy and safety of a home-based exercise program in this population. In this prospective, single-arm study, 20 patients with cirrhosis and sarcopenia underwent a 12-week home-based program combining elastic band resistance training, walking, and nutritional therapy. The primary outcome was a change in 6-m walking speed at a normal pace. Secondary outcomes included handgrip strength, skeletal muscle index, short physical performance battery (SPPB) score, adherence, and safety. Seventeen participants completed the intervention. In the overall cohort, no significant improvements were observed in the walking speed, handgrip strength, skeletal muscle index, or SPPB score. In an exploratory post-hoc analysis of participants with greater than or equal to 80% adherence (n = 12), improvements were observed in handgrip strength (P = 0.034) and SPPB score (P = 0.016), with a trend toward improved walking speed (P = 0.077). Factors associated with high adherence included better lower limb function and a lower prevalence of severe sarcopenia. No serious exercise-related adverse events were observed. The 12-week home-based exercise and nutritional intervention did not demonstrate clinically meaningful improvements in the overall cohort. Exploratory post-hoc analyses suggest potential functional benefits among participants with high adherence.

Comments on “Predictors of Change in Physical Function in Older Adults in Response to Long-Term, Structured Physical Activity: The LIFE Study”

Whether sustained physical activity prevents cardiovascular disease (CVD) events in older adults is uncertain. To test the hypothesis that cardiovascular morbidity and mortality would be reduced in participants in a long-term physical activity program. The Lifestyle Interventions and Independence for Elders (LIFE) study was a multicenter, randomized trial. Participants were recruited at 8 centers in the United States. We randomized 1635 sedentary men and women aged 70 to 89 years with a Short Physical Performance Battery (SPPB) score of 9 or less but able to walk 400 m. The physcial activity (PA) intervention was a structured moderate-intensity program, predominantly walking 2 times per week on site for 2.6 years on average. The successful aging intervention consisted of weekly health education sessions for 6 months, then monthly. Total CVD events, including fatal and nonfatal myocardial infarction, angina, stroke, transient ischemic attack, and peripheral artery disease, were adjudicated by committee, and silent myocardial infarction was assessed by serial electrocardiograms. A limited outcome of myocardial infarction, stroke, and CVD death was also studied. Outcome assessors and adjudicators were blinded to intervention assignment. The 1635 LIFE study participants were predominantly women (67%), with a mean (SD) age of 78.7 (5.2) years; 20% were African-American, 6% were Hispanic or other race or ethnic group, and 74% were non-Latino white. New CVD events occurred in 121 of 818 PA participants (14.8%) and 113 of 817 successful aging participants (13.8%) (HR, 1.10; 95% CI, 0.85-1.42). For the more focused combined outcome of myocardial infarction, stroke, or cardiovascular death, rates were 4.6% in PA and 4.5% in the successful aging group (HR, 1.05; 95% CI, 0.67-1.66). Among frailer participants with an SPPB score less than 8, total CVD rates were 14.2% in PA vs 17.7% in successful aging (HR, 0.76; 95% CI, 0.52-1.10), compared with 15.3% vs 10.5% among those with an SPPB score of 8 or 9 (HR, 1.59; 95% CI, 1.09-2.30) (P for interaction = .006). With the limited end point, the interaction was not significant (P = .59), with an HR of 0.94 (95% CI, 0.50-1.75) for an SPPB score less than 8 and an HR of 1.20 (95% CI, 0.62-2.34) for an SBBP score of 8 or 9. Among participants in the LIFE Study, an aerobically based, moderately intensive PA program was not associated with reduced cardiovascular events in spite of the intervention's previously documented ability to prevent mobility disability. clinicaltrials.gov Identifier: NCT00116194.

WeChat provides the chance for online caring program to improve physical recovery and quality of life (QoL) in patients with cardio/cerebral vascular diseases, especially in special period such as coronavirus disease 2019 (COVID-19) spread time. This study intended to evaluate the influence of the WeChat-based education and rehabilitation program (WERP) on physical performance and QoL in patients with acute coronary syndrome (ACS) post percutaneous coronary intervention (PCI). Totally, 180 patients with ACS after PCI were randomized to the WERP (N = 90) and control care (CC) (N = 90) groups, then received corresponding caring program for 3 months. Short physical performance battery (SPPB) score, 6-minute walking distance (6MWT), EuroQol-5 dimensions (EQ-5D) score, and EuroQol-5 Visual Analog Scale (EQ-VAS) score were assessed at discharge, month (M)1, M2, and M3, respectively. Our study showed that SPPB score at M1 ( P = 0.029), M2 (P = 0.048), and M3 (P = 0.030) was higher in WERP group than in CC group. Besides, 6MWT at M1 (P = 0.026), M2 (P = 0.023), and M3 (P = 0.041) were longer in WERP group than in CC group. Finally, EQ-5D score at M1 (P = 0.022) and M3 (P = 0.023) was lower, while EQ-VAS score at M1 (P = 0.020), M2 (P = 0.013), and M3 (P = 0.039) was higher in WERP group than in CC group. Subgroup analyses further showed that patients with baseline SPPB score ≤ 9 benefited more from WERP. Conclusively, WERP could be an option to improve physical performance and QoL in patients with ACS after PCI.

BackgroundLimited mobility is a risk factor for developing chronic obstructive pulmonary disease (COPD)-related disabilities. Little is known about the validity of the Short Physical Performance Battery (SPPB) for identifying mobility limitations in patients with COPD.ObjectiveTo determine the clinical validity of the SPPB summary score and its three components (standing balance, 4-meter gait speed, and five-repetition sit-to-stand) for identifying mobility limitations in patients with COPD.MethodsThis cross-sectional study included 137 patients with COPD, recruited from a hospital in Spain. Muscle strength tests and SPPB were measured; then, patients were surveyed for self-reported mobility limitations. The validity of SPPB scores was analyzed by developing receiver operating characteristic curves to analyze the sensitivity and specificity for identifying patients with mobility limitations; by examining group differences in SPPB scores across categories of mobility activities; and by correlating SPPB scores to strength tests.ResultsOnly the SPPB summary score and the five-repetition sit-to-stand components showed good discriminative capabilities; both showed areas under the receiver operating characteristic curves greater than 0.7. Patients with limitations had significantly lower SPPB scores than patients without limitations in nine different mobility activities. SPPB scores were moderately correlated with the quadriceps test (r>0.40), and less correlated with the handgrip test (r<0.30), which reinforced convergent and divergent validities. A SPPB summary score cutoff of 10 provided the best accuracy for identifying mobility limitations.ConclusionThis study provided evidence for the validity of the SPPB summary score and the five-repetition sit-to-stand test for assessing mobility in patients with COPD. These tests also showed potential as a screening test for identifying patients with COPD that have mobility limitations.

The objective of this study was to test the hypothesis that exercise would be more effective than a support group plus Fitbit (SG+Fitbit) program in improving functional outcomes in older breast cancer survivors (BCSs) and that race would moderate the exercise effect on outcomes. Older African American (AA) and non-Hispanic White (NHW) BCSs were purposively recruited and enrolled into the 52-week randomized controlled trial. The interventions included 20 weeks of supervised moderate-intensity aerobic and resistance training followed by 32 weeks of unsupervised exercise called IMPROVE (n = 108) and a 20-week SG+Fitbit program followed by 32 weeks of unsupervised activity (n = 105). Study outcomes were assessed at 20 and 52 weeks. The primary outcome was the change in Short Physical Performance Battery (SPPB) scores 20 weeks from the baseline between arms. Secondary outcomes included change in the 6-Minute Walk Test (6MWT) in meters 20 weeks from the baseline between arms. General linear regression and multivariable logistic regression analyses were used. The mean age was 71.9 years (SD, 5.9 years), and 44% were AA. SPPB scores did not differ between arms (adjusted difference in mean change, 0.13; 95% CI, -0.28 to 0.55; P = .53). However, the exercise arm (vs the SG+Fitbit arm) improved on the 6MWT (21.6 m; 95% CI, 2.5-40.6 m; P = .03). Race moderated the exercise effect on the 6MWT (adjusted interaction effect, 43.3 m; 95% CI, 6.3-80.2 m; P = .02); this implied that the change in the adjusted mean for the 6MWT at 20 weeks from the baseline was 43.3 m higher in AA exercise participants versus NHW exercise participants. Combined aerobic and resistance exercise appears to improve physical performance in older BCSs, and the exercise effect might be moderated by race, with AAs appearing to derive larger benefits in comparison with NHWs. Larger studies are warranted to confirm the study findings.

The role of grip strength and short physical performance battery test in predicting chemotherapy-related outcomes in older adults with cancer

We aimed to examine whether the Framingham Cardiovascular Risk Profile Score (FCRP) moderates the effect of progressive resistance training (RT) on mobility in older adult women. This is an exploratory analysis of a single-blind, 12-month randomized controlled trial in 155 omen, aged 65 to 75 years old, who were randomized to: 1x/week progressive RT; or 2x/week progressive RT program; or 2x/week balance and tone (BAT). At baseline and trial completion, mobility was measured using the Short Physical Performance Battery (SPPB). The SPPB is a composite measure of usual gait speed, standing balance, and sit to stand performance; scores < 9/12 are indicative of functional decline. Baseline 10-year cardiovascular risk was calculated using the FCRP. Participants were classified as either low risk (<16.5% FCRP score; LCVR) or high risk ≥16.5% FCRP score; HCVR). A complete case analysis (n=126) was conducted using a two-way analysis of covariance (ANCOVA) to evaluate the interaction effect of group by FCRP risk on SPPB scores at trial completion; baseline SPPB scores and age in years were entered as covariates. There was a significant interaction effect (F(1,126)=3.74, p=0.027). At trial completion, both 1x/RT and 2x/RT participants with HCVR demonstrated greater SPPB scores than those with LCVR (11.59 vs. 11.38 for 1x/week; 11.86 vs 11.46 for 2x/week). In contrast, BAT participants with HCVR demonstrated worse SPPB scores than those with LCVR (11.18 vs 11.66). Our data suggest that RT may be more efficacious for improving mobility in older women with higher cardiovascular risk than women with lower risk.