TheoremLlama: Transforming General-Purpose LLMs into Lean4 Experts

Evaluating gpt-4 for zero-shot classification of bleeding and clotting events: Can large language models serve as second reviewers?

Generative large language models (LLMs) are a subset of transformers-based neural network architecture models. LLMs have successfully leveraged a combination of an increased number of parameters, improvements in computational efficiency, and large pre-training datasets to perform a wide spectrum of natural language processing (NLP) tasks. Using a few examples (few-shot) or no examples (zero-shot) for prompt-tuning has enabled LLMs to achieve state-of-the-art performance in a broad range of NLP applications. This article by the American Medical Informatics Association (AMIA) NLP Working Group characterizes the opportunities, challenges, and best practices for our community to leverage and advance the integration of LLMs in downstream NLP applications effectively. This can be accomplished through a variety of approaches, including augmented prompting, instruction prompt tuning, and reinforcement learning from human feedback (RLHF). Our focus is on making LLMs accessible to the broader biomedical informatics community, including clinicians and researchers who may be unfamiliar with NLP. Additionally, NLP practitioners may gain insight from the described best practices. We focus on 3 broad categories of NLP tasks, namely natural language understanding, natural language inferencing, and natural language generation. We review the emerging trends in prompt tuning, instruction fine-tuning, and evaluation metrics used for LLMs while drawing attention to several issues that impact biomedical NLP applications, including falsehoods in generated text (confabulation/hallucinations), toxicity, and dataset contamination leading to overfitting. We also review potential approaches to address some of these current challenges in LLMs, such as chain of thought prompting, and the phenomena of emergent capabilities observed in LLMs that can be leveraged to address complex NLP challenge in biomedical applications.

Interacting with Large Language Models (LLMs) via declarative queries is increasingly popular for tasks like question answering and data extraction, thanks to their ability to process vast unstructured data. However, LLMs often struggle with answering complex factual questions, exhibiting low precision and recall in the returned data. This challenge highlights that executing queries on LLMs remains a largely unexplored domain, where traditional data processing assumptions often fall short. Conventional query optimization, typically cost-driven, overlooks LLM-specific quality challenges such as contextual understanding. Just as new physical operators are designed to address the unique characteristics of LLMs, optimization must consider these quality challenges. Our results highlight that adhering strictly to conventional query optimization principles fails to generate the best plans in terms of result quality. To tackle this challenge, we present a novel approach to enhance SQL results by applying query optimization techniques specifically adapted for LLMs. We introduce a database system, GALOIS, that sits between the query and the LLM, effectively using the latter as a storage layer. We design alternative physical operators tailored for LLM-based query execution and adapt traditional optimization strategies to this novel context. For example, while pushing down operators in the query plan reduces execution cost (fewer calls to the model), it might complicate the call to the LLM and deteriorate result quality. Additionally, these models lack a traditional catalog for optimization, leading us to develop methods to dynamically gather such metadata during query execution. Our solution is compatible with any LLM and balances the trade-off between query result quality and execution cost. Experiments show up to 144% quality improvement over questions in Natural Language and 29% over direct SQL execution, highlighting the advantages of integrating database solutions with LLMs.

Large language models (LLMs) are increasingly adopted in educational contexts to provide personalized support to students and teachers. The unprecedented capacity of LLM‐based applications to understand and generate natural language can potentially improve instructional effectiveness and learning outcomes, but the integration of LLMs in education technology has renewed concerns over algorithmic bias, which may exacerbate educational inequalities. Building on prior work that mapped the traditional machine learning life cycle, we provide a framework of the LLM life cycle from the initial development of LLMs to customizing pre‐trained models for various applications in educational settings. We explain each step in the LLM life cycle and identify potential sources of bias that may arise in the context of education. We discuss why current measures of bias from traditional machine learning fail to transfer to LLM‐generated text (eg, tutoring conversations) because text encodings are high‐dimensional, there can be multiple correct responses, and tailoring responses may be pedagogically desirable rather than unfair. The proposed framework clarifies the complex nature of bias in LLM applications and provides practical guidance for their evaluation to promote educational equity. Practitioner notes What is already known about this topic The life cycle of traditional machine learning (ML) applications which focus on predicting labels is well understood. Biases are known to enter in traditional ML applications at various points in the life cycle, and methods to measure and mitigate these biases have been developed and tested. Large language models (LLMs) and other forms of generative artificial intelligence (GenAI) are increasingly adopted in education technologies (EdTech), but current evaluation approaches are not specific to the domain of education. What this paper adds A holistic perspective of the LLM life cycle with domain‐specific examples in education to highlight opportunities and challenges for incorporating natural language understanding (NLU) and natural language generation (NLG) into EdTech. Potential sources of bias are identified in each step of the LLM life cycle and discussed in the context of education. A framework for understanding where to expect potential harms of LLMs for students, teachers, and other users of GenAI technology in education, which can guide approaches to bias measurement and mitigation. Implications for practice and/or policy Education practitioners and policymakers should be aware that biases can originate from a multitude of steps in the LLM life cycle, and the life cycle perspective offers them a heuristic for asking technology developers to explain each step to assess the risk of bias. Measuring the biases of systems that use LLMs in education is more complex than with traditional ML, in large part because the evaluation of natural language generation is highly context‐dependent (eg, what counts as good feedback on an assignment varies). EdTech developers can play an important role in collecting and curating datasets for the evaluation and benchmarking of LLM applications moving forward.

Background and Aims Large language models (LLMs) have gained significant attention in the field of natural language processing (NLP), marking a shift from traditional techniques like Term Frequency-Inverse Document Frequency (TF-IDF). We developed a traditional NLP model to predict arteriovenous fistula (AVF) failure within next 30 days using clinical notes. The goal of this analysis was to investigate whether LLMs would outperform traditional NLP techniques, specifically in the context of predicting AVF failure within the next 30 days using clinical notes. Method We defined AVF failure as the change in status from active to permanently unusable status or temporarily unusable status. We used data from a large kidney care network from January 2021 to December 2021. Two models were created using LLMs and traditional TF-IDF technique. We used “distilbert-base-uncased”, a distilled version of BERT base model [1], and compared its performance with traditional TF-IDF-based NLP techniques. The dataset was randomly divided into 60% training, 20% validation and 20% test dataset. The test data, comprising of unseen patients’ data was used to evaluate the performance of the model. Both models were evaluated using metrics such as area under the receiver operating curve (AUROC), accuracy, sensitivity, and specificity. Results The incidence of 30 days AVF failure rate was 2.3% in the population. Both LLMs and traditional showed similar overall performance as summarized in Table 1. Notably, LLMs showed marginally better performance in certain evaluation metrics. Both models had same AUROC of 0.64 on test data. The accuracy and balanced accuracy for LLMs were 72.9% and 59.7%, respectively, compared to 70.9% and 59.6% for the traditional TF-IDF approach. In terms of specificity, LLMs scored 73.2%, slightly higher than the 71.2% observed for traditional NLP methods. However, LLMs had a lower sensitivity of 46.1% compared to 48% for traditional NLP. However, it is worth noting that training on LLMs took considerably longer than TF-IDF. Moreover, it also used higher computational resources such as utilization of graphics processing units (GPU) instances in cloud-based services, leading to higher cost. Conclusion In our study, we discovered that advanced LLMs perform comparably to traditional TF-IDF modeling techniques in predicting the failure of AVF. Both models demonstrated identical AUROC. While specificity was higher in LLMs compared to traditional NLP, sensitivity was higher in traditional NLP compared to LLMs. LLM was fine-tuned with a limited dataset, which could have influenced its performance to be similar to that of traditional NLP methods. This finding suggests that while LLMs may excel in certain scenarios, such as performing in-depth sentiment analysis of patient data for complex tasks, their effectiveness is highly dependent on the specific use case. It is crucial to weigh the benefits against the resources required for LLMs, as they can be significantly more resource-intensive and costly compared to traditional TF-IDF methods. This highlights the importance of a use-case-driven approach in selecting the appropriate NLP technique for healthcare applications.

Introduction Game theory has long served as a foundational tool in cybersecurity to test, predict, and design strategic interactions between attackers and defenders. The recent advent of Large Language Models (LLMs) offers new tools and challenges for the security of computer systems. In this work, we investigate whether classical game-theoretic frameworks can effectively capture the behaviors of LLM-driven actors and bots. Methods Using a reproducible framework for game-theoretic LLM agents, we investigate two canonical scenarios—the one-shot zero-sum game and the dynamic Prisoner's Dilemma—and we test whether LLMs converge to expected outcomes or exhibit deviations due to embedded biases. We experiments on four state-of-the-art LLMs and five natural languages (English, French, Arabic, Vietnamese, and Mandarin Chinese) to assess linguistic sensitivity. Results For both games, we observe that the final payoffs are influenced by agents characteristics such as personality traits or knowledge of repeated rounds. We also uncover an unexpected sensitivity of the final payoffs to the choice of languages, which should warn against indiscriminate application of LLMs in cybersecurity applications and call for in-depth studies, as LLMs may behave differently when deployed in different countries. We also employ quantitative metrics to evaluate the internal consistency and cross-language stability of LLM agents. Discussion In addition to uncovering unexpected behaviors requiring attention by scholars and practitioners, our work can help guide the selection of the most stable LLMs and optimizing models for secure applications.

Designing preference elicitation (PE) methodologies that can quickly ascertain a user’s top item preferences in a cold-start setting is a key challenge for building effective and personalized conversational recommendation (ConvRec) systems. While large language models (LLMs) enable fully natural language (NL) PE dialogues, we hypothesize that monolithic LLM NL-PE approaches lack the multi-turn, decision-theoretic reasoning required to effectively balance the exploration and exploitation of user preferences towards an arbitrary item set. In contrast, traditional Bayesian optimization PE methods define theoretically optimal PE strategies, but cannot generate arbitrary NL queries or reason over content in NL item descriptions – requiring users to express preferences via ratings or comparisons of unfamiliar items. To overcome the limitations of both approaches, we formulate NL-PE in a Bayesian Optimization (BO) framework that seeks to actively elicit NL feedback to identify the best recommendation. Key challenges in generalizing BO to deal with natural language feedback include determining: (a) how to leverage LLMs to model the likelihood of NL preference feedback as a function of item utilities, and (b) how to design an acquisition function for NL BO that can elicit preferences in the infinite space of language. We demonstrate our framework in a novel NL-PE algorithm, PEBOL, which uses: 1) Natural Language Inference (NLI) between user preference utterances and NL item descriptions to maintain Bayesian preference beliefs, and 2) BO strategies such as Thompson Sampling (TS) and Upper Confidence Bound (UCB) to guide LLM query generation. We numerically evaluate our methods in controlled simulations, finding that after 10 turns of dialogue, PEBOL can achieve an MRR@10 of up to 0.27 compared to the best monolithic LLM baseline’s MRR@10 of 0.17, despite relying on earlier and smaller LLMs.1

Recent advances in Multimodal Large Language Models (MLLMs) have achieved remarkable progress in general domains and demonstrated promise in multimodal mathematical reasoning. However, applying MLLMs to geometry problem solving (GPS) remains challenging due to lack of accurate step-by-step solution data and severe hallucinations during reasoning. In this paper, we propose GeoGen, a pipeline that can automatically generates step-wise reasoning paths for geometry diagrams. By leveraging the precise symbolic reasoning, GeoGen produces large-scale, high-quality question-answer pairs. To further enhance the logical reasoning ability of MLLMs, we train GeoLogic, a Large Language Model (LLM) using synthetic data generated by GeoGen. Serving as a bridge between natural language and symbolic systems, GeoLogic enables symbolic tools to help verifying MLLM outputs, making the reasoning process more rigorous and alleviating hallucinations. Experimental results show that our approach consistently improves the performance of MLLMs, achieving remarkable results on benchmarks for geometric reasoning tasks. This improvement stems from our integration of the strengths of LLMs and symbolic systems, which enables a more reliable and interpretable approach for the GPS task. Codes are available at https://github.com/ycpNotFound/GeoGen.

DialogueLLM: Context and emotion knowledge-tuned large language models for emotion recognition in conversations.

Large Language Models (LLMs) have emerged as a promising alternative to traditional static program analysis methods, such as symbolic execution, offering the ability to reason over code directly without relying on theorem provers or SMT solvers. However, LLMs are also inherently approximate by nature, and therefore face significant challenges in relation to the accuracy and scale of analysis in real-world applications. Such issues often necessitate the use of larger LLMs with higher token limits, but this requires enterprise-grade hardware (GPUs) and thus limits accessibility for many users. In this paper, we propose LLM-based symbolic execution —a novel approach that enhances LLM inference via a path-based decomposition of the program analysis tasks into smaller (more tractable) subtasks. The core idea is to generalize path constraints using a generic code-based representation that the LLM can directly reason over, and without translation into another (less-expressive) formal language. We implement our approach in the form of AutoBug, an LLM-based symbolic execution engine that is lightweight and language-agnostic, making it a practical tool for analyzing code that is challenging for traditional approaches. We show that AutoBug can improve both the accuracy and scale of LLM-based program analysis, especially for smaller LLMs that can run on consumer-grade hardware.

Abstract. Large language models (LLMs) have revolutionized the field of natural language processing (NLP), demonstrating remarkable capabilities in understanding, generating, and manipulating human language. This comprehensive review explores the development, applications, optimizations, and challenges of LLMs. This paper begin by tracing the evolution of these models and their foundational architectures, such as the Transformer, GPT, and BERT. We then delve into the applications of LLMs in natural language understanding tasks, including sentiment analysis, named entity recognition, question answering, and text summarization, highlighting real-world use cases. Next, we examine the role of LLMs in natural language generation, covering areas such as content creation, language translation, personalized recommendations, and automated responses. We further discuss LLM applications in other NLP tasks like text style transfer, text correction, and language model pre-training. Subsequently, we explore techniques for optimizing and improving LLMs, including model compression, explainability, robustness, and security. Finally, we address the challenges posed by the significant computational requirements, sample inefficiency, and ethical considerations surrounding LLMs. We conclude by discussing potential future research directions, such as efficient architectures, few-shot learning, bias mitigation, and privacy-preserving techniques, which will shape the ongoing development and responsible deployment of LLMs in NLP.

Mathematical Problem Solving in Arabic: Assessing Large Language Models

Many critical business and societal decisions in areas such as supply chain and healthcare involve numerous potential actions, complex constraints, and goals that can be modeled as objective functions. Mathematical optimization, a core area in Operations Research (OR), provides robust, mathematically grounded methodologies to address such decisions and has shown tremendous benefits in many applications. However, its application requires the creation of accurate and efficient optimization models, necessitating rare expertise and considerable time, creating a barrier to widespread adoption in decision-making. Thus, it is a long-standing goal to make these capabilities widely accessible. The advent of Large Language Models (LLMs) has made advanced Artificial Intelligence (AI) capabilities widely accessible through natural language. LLMs can accelerate expert work in creating formal models like computer programs, and emerging research indicates they can also speed up the development of optimization models by OR experts. We, therefore, propose integrating and advancing LLM and optimization modeling to empower organizational decision-makers to model and solve such complex problems without requiring deep expertise in optimization. In this work, we present our vision for democratizing optimization modeling for organizational decision-making by such a combination of LLMs and optimization modeling. We identify a set of fundamental requirements for the vision's implementation and describe the state of the art through a literature survey and some experimentation. We show that a) LLMs already provide substantial novel capabilities relevant to realizing this vision, but that b) major research challenges remain to be addressed. We also propose possible research directions to overcome these gaps. We would like this work to serve as a call to action to bring together the LLM and OR optimization modeling communities to pursue this vision, thereby enabling much more widespread improved decision-making and increasing by orders of magnitude the benefits AI and OR can bring to enterprises and society.

Computer-aided diagnosis (CAD) has advanced medical image analysis, while large language models (LLMs) have shown potential in clinical applications. However, LLMs struggle to interpret medical images, which are critical for decision-making. Here we show a strategy integrating LLMs with CAD networks. The framework uses LLMs’ medical knowledge and reasoning to enhance CAD network outputs, such as diagnosis, lesion segmentation, and report generation, by summarizing information in natural language. The generated reports are of higher quality and can improve the performance of vision-based CAD models. In chest X-rays, an LLM using ChatGPT improved diagnosis performance by 16.42 percentage points compared to state-of-the-art models, while GPT-3 provided a 15.00 percentage point F1-score improvement. Our strategy allows accurate report generation and creates a patient-friendly interactive system, unlike conventional CAD systems only understood by professionals. This approach has the potential to revolutionize clinical decision-making and patient communication.

The utility of machine learning, specifically large language models (LLMs), in the medical field has gained considerable attention. However, there is a scarcity of studies that focus on the application of LLMs in generating custom subspecialty radiology impressions. The primary objective of this study is to evaluate and compare the performance of multiple LLMs in generating specialized, accurate, and clinically useful radiology impressions for degenerative cervical spine MRI reports. The study employed a comparative analysis of multiple LLMs, including OpenAI's ChatGPT-3.5 and GPT-4 (OpenAI, San Francisco, CA), Antrhopic's Claude 2 (Anthropic PBC, San Francisco, CA), Google's Bard (Google Inc., Mountain View, CA), and Meta's Llama 2 (Meta Platforms, Inc., Menlo Park, CA). This was performed during January-February 2024. These models were evaluated using a few-shot learning approach on a dataset consisting of 10 examples from 50 synthetically generated MRI reports. Performance metrics evaluated were diagnostic accuracy, stylistic accuracy, and redundancy. While Claude 2 maintained consistent high performance across 40 cases, GPT-4 required midway re-training to improve its declining scores. Both Claude 2 and GPT-4 demonstrated the ability to generate structured impressions, but Claude 2's specialized summarization capabilities provided an edge in maintaining accuracy without continuous feedback. The other LLMs' performance was subpar. The findings of this study suggest that LLMs can be a valuable tool in automating the generation of radiology impressions. Claude 2, in particular, exhibited promising results, indicating its potential for clinical implementation. However, the study also points to the necessity for further research, especially in optimizing model performance and evaluating real-world applicability.