The present lecture summarizes some of the most recent joint research results from the cooperation between the Federal University of Rio de Janeiro, Brasil, and the University of Miami, USA, on the transient analysis of both fluid flow and heat transfer within microchannels. This collaborative link is a natural extension of a long term cooperation between the two groups, in the context of fundamental work on transient forced convection, aimed at the development of hybrid numerical-analytical techniques and the experimental validation of proposed models and methodologies [19]. The motivation of this new phase of the cooperation was thus to extend the previously developed hybrid tools to handle both transient flow and transient convection problems in microchannels within the slip flow regime. The analysis of internal flows in the slip-flow regime recently gained an important role in association with the fluid mechanics of various microelectromechanical systems (MEMS) applications, as well as in the thermal control of microelectronics, as reviewed in different sources [10-16]. For steady-state incompressible fully developed flow situations and laminar regime within simple geometries such as circular microtubes and parallel-plate microchannels, explicit expressions for the velocity field in terms of the Knudsen number are readily obtainable, and have been widely employed in the heat transfer analysis of microsystems, such as in [17-23]. Only quite recently, attention has been directed to the analysis of transient flow in microchannels [24-33]. Unsteady one-dimensional models have been extended from classical works, and analytical solutions have been sought for fully developed flows in simple geometries. These recent works are also concerned with situations in which a simple and well-defined functional form for the pressure gradient time variation is prescribed or for the time dependence of the wall imposed velocity, in the case of a Couette flow application. Research findings are yet to be further pursued in the analytical and robust solution of more generalized models, which will accommodate more general conditions and parameter specifications, and thus offer a wider validation range for the automatic general purpose numerical codes. Mikhailov and Ozisik [34] presented a unified solution for transient one-dimensional laminar flow models, with the usual no-slip boundary condition, based on the classical integral transform method. Their solution was then specialized to two situations: step change and periodically varying pressure gradient. The knowledge in regular size channels is therefore fairly well consolidated for models that use simple functional forms for the pressure gradient variation such as for the two cases cited above. One of the objectives of this paper is to illustrate the solution of a onedimensional mathematical model for transient laminar incompressible flow in microchannels such as circular tubes and parallel-plate channels, that accounts for a source term time variation in any functional form, including electrokinetic effects for liquid flows, by making use of the Generalized Integral Transform Technique (GITT) [35-40], and thus yielding analytical expressions for the time and space dependence of the velocity fields in the fully developed region. We then demonstrate this hybrid numerical-analytical solution for transient internal slip flow, obtained employing mixed symbolic-numerical computations with the Mathematica platform [41]. The goal here is to improve and complement existing analytical solution implementations to study laminar fully developed flows in micro-ducts subjected to arbitrary source term disturbances in space and time. On the other hand, the heat transfer literature of the last decade has demonstrated a vivid and growing interest in thermal analysis of flows in micro-channels, both through experimental and analytical approaches, in connection with cooling techniques of micro-electronics and with the development of micro-electromechanical sensors and actuators (MEMS), as also pointed out in recent reviews [12-16]. Since the available analytical information on heat transfer in ducts could not be directly extended to flows within microchannels with wall slip, a number of contributions have been recently directed towards the analysis of internal forced convection in the micro-scale. In the paper by Barron et al.
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