Visual analysis of coronavirus disease 2019 (COVID-19) studies based on bibliometrics

Hypertension during pregnancy (HDP) is one of the common and serious complications during pregnancy. Its etiology involves placental dysfunction, vascular endothelial injury, immune disorder and oxidative stress, and its pathogenesis is complex. Western medicine believes that the treatment of HDP is mainly based on drug intervention, but it has limitations and side effects. Traditional Chinese medicine, on the basis of syndrome differentiation and treatment, combines traditional Chinese medicine for internal and external use, and combines acupuncture, moxibustion and other methods to effectively improve the circulation of qi and blood and the function of internal organs. The combination of traditional Chinese and Western medicine fully reflects the respective therapeutic advantages of traditional Chinese and Western medicine, and has shown significant efficacy in clinical practice. At the same time, it can effectively reduce the side effects of Western medicine treatment and improve maternal and infant safety. Through further analysis of experimental studies on the combination of traditional Chinese and Western medicine for the treatment of hypertension during pregnancy, the mechanism of action of Chinese medicine monomers and compounds in regulating oxidative stress, inflammatory factors and vascular function is revealed, which provides a scientific basis for the treatment of HDP by combining traditional Chinese and Western medicine. However, the integrated Chinese and Western medicine treatment model still faces challenges in the individualized treatment of HDP. In the future, multi-center large-sample clinical studies are still needed to further verify its efficacy and safety, so as to optimize the diagnosis and treatment plan and promote the widespread application of integrated Chinese and Western medicine treatment, and provide more comprehensive and effective health protection for HDP patients.

Taking the process of treating coronavirus disease 2019 (COVID-19) with Western medicine and traditional Chinese medicine (TCM) as the research object, this article compares the characteristics of Western medicine and TCM from the perspectives of aetiology, pathogenesis, diagnosis, and treatment. Western medicine and TCM each has its own theoretical system. Each has its own exposition in explaining the etiology and pathogenesis of the disease, and each has its own characteristics and advantages in diagnosis and treatment. Integrating TCM and Western medicine can improve the effect of treatment by forming a coordinated traditional Chinese and Western medicine treatment method.

Considerations about treatment programs of elderly patients with hypertension

Coronavirus disease 2019 (COVID-19) which brings the epidemic situation to the public has spread rapidly and produce multiple variations. At present, Western medicine still lacks the specific medicine or vaccines for coronavirus. However, amount of evidence shows that traditional Chinese medicine (TCM) has advantages in releasing the symptoms of mild-to-moderate COVID patients. Those treatments are not only improving the course of the primary disease but also curb progress to severe pneumonia or acute respiratory distress syndrome. Therefore, taking TCM intervention or combined treatments appropriately to prevent worsening illness is of vital significance. This study mainly focuses on the data analysis on the effects of TCM in restoring the immune balance of COVID patients. By collecting clinical data from mild to moderate patients, we expected to figure out if TCM only plays the role of curbing inflammation or having a two-way influence in balancing the immune microenvironment. Seven digital databases including PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure, China Science and Technology Journal Database (VIP), Wanfang Database, and China Biology Medicine were searched from December 2019 to August 2022 nothingness of language restrictions. The studies retrieved from the database were selected and the data extracted to assess the methodological quality of the included randomized controlled trials (RCTs). Statistical analysis was completed. Pulmonary computed tomography, clinical cure rate, rate of conversion to severe cases, length of hospital stay, and scores of TCM syndrome were defined as the primary outcomes, the secondary outcomes were white blood cell count, lymphocyte (LYM) count, and C-reactive protein (CRP). This study was registered with PROSPERO (CRD42022341482). Nine eligible RCTs including 1159 participants were included in this meta-analysis. Compared with Western medicine treatment alone, our meta-analyses found that traditional Chinese combined Western medicine treatment has a higher clinical cure rate, better absorption of lung inflammation, and significantly shorter hospital stay. In terms of inflammatory factors, TCM can significantly reduce the CRP content compared with Western medicine methods, but the leukocyte and LYM content was not significantly different between the two treatments. In some research, TCM even has a trend accelerating the inflammation process on some specific stages of the disease. Chinese herbal medicine combined with conventional therapy is significantly effective and invulnerable in the treatment of mild-to-moderate COVID-19. In terms of control inflammation, TCM does not only block the disease onset by simply inhibiting inflammation but balancing the human environment through bidirectional regulation of inflammatory cells. However, considering of the lack of research into how TCM could activate the natural immune response, the discussion of the mechanism cannot be stretched, more high-quality RCTs are still needed in the future.

Objective: To observe and compare whether the combination of traditional Chinese and Western medicine can achieve more satisfactory results in the treatment of patients with chronic ulcerative rectitis (UR). Methods: 70 cases of chronic ulcerative rectitis were selected in all hospitals of our hospital for comparison. Observation and control were set up. The number of people was the same, but there were differences in methods. The control group retained enema, and the observation group was treated with traditional Chinese medicine. Rectal mucosa scores after different treatments were compared to evaluate the effect of intervention. Results: It was found that the observation group scored lower (P < 0.05), and the effect was better. Conclusion: For the treatment of patients with chronic ulcerative rectitis, the combination of traditional Chinese and Western medicine will help to promote the prognosis of the disease, improve the problem of ulcer, promote the improvement of gastrointestinal function and bring a more positive impact.

The main cause of infertility in elderly women is poor ovarian function, decreased quality and number of oocytes, which ultimately leads to poor fertility. Low ovarian function is the most difficult point in the research of reproductive medicine and reproductive health. At present, the treatment of integrated traditional Chinese and Western medicine has gradually achieved results. Western medicine mainly regulates endocrine and assisted reproductive treatment by supplementing estrogen and progesterone, while traditional Chinese medicine (TCM) mainly focuses on invigorating the kidney, adding and subtracting according to the syndrome. The treatment effect of TCM or western medicine alone is not significant. Many clinical observations show that integrated TCM and western medicine focuses on the specialties of western medicine, which not only makes up for the insufficiency of the slow action of TCM, but also improves its clinical efficacy when combined with western medicine. Based on domestic and foreign research, this article summarizes the treatment of infertility in elderly women with integrated TCM and western medicine.

Combating COVID-19 with integrated traditional Chinese and Western medicine in China

ContextIntestinal fibrosis, a severe complication of Crohn's disease (CD), arises from multifactorial interactions, including chronic inflammation, genetic predisposition, gut microbiota dysbiosis, and impaired mucosal barrier function.ObjectivesSince intestinal fibrosis often leads to irreversible stenosis and obstruction symptoms, this article will focus on a series of reviews on the progress of traditional Chinese and Western medicine in the diagnosis and treatment of intestinal fibrosis in CD.MethodsWe conducted a systematic literature search in PubMed, CNKI, and Wanfang databases using the keywords: 'Crohn's disease', 'intestinal fibrosis', and 'Traditional Chinese Medicine (TCM)'. The initial search yielded 216 articles. After removing duplicates (n = 146), 70 articles underwent full-text screening based on predefined criteria.ResultsCurrent diagnostic modalities for CD-related intestinal fibrosis are well-established. However, neither pharmacological agents nor TCM therapies have demonstrated definitive efficacy in reversing fibrosis in clinical settings.ConclusionsDespite the current absence of clinically approved antifibrotic drugs, this review synthesizes critical advances in mechanistic understanding and emerging therapeutic strategies. We highlight the urgent unmet clinical need and propose integrative medicine as a promising paradigm shift for fibrosis management. While no therapies yet fully reverse established fibrosis, this review provides three key contributions: Systematically maps molecular pathways from inflammation to fibrosis, identifies knowledge gaps in TCM translational research, and proposes a “control-prevent-reverse” framework for future drug development. These insights are timely given the rising CD prevalence in China and increasing NIH funding for antifibrotic research.

Viral hepatitis is clinical multiple strong infectious disease, to know characteristics of traditional Chinese medicine and western medicine clinical use in patients with viral hepatitis, the research object of this study is 41 180 cases of hospitalized patients with viral hepatitis in hospital information system from 17 grade A hospitals, using frequency statistics and association rules method to analyze the traditional Chinese medicine and western medicine clinical use information, the drug kinds analysis results: western medicine of reduced glutathione tablets use frequency is highest, 14 079 cases (34.61%), traditional Chinese medicine of diammonium glycyrrhizinateuse frequency is highest, 14 058 cases (34.56%); traditional Chinese medicine and western medicine drug combination in diammonium glycyrrhizinate combined with reduced glutathione tabletsuse frequency is highest, 8 607 cases (25.09%). The mechanism of drug classification results :both traditional Chinese medicine and western medicine are the sort of educed enzyme medicine that has the highest percentage of drug use, traditional Chinese medicine 10 983 cases (27.01%), western medicine, 9 595 cases (23.59%); traditional Chinese medicine and western medicine combination in a kind of medicine to clear heat and promote diuresis combined with educed enzyme drug use frequency is highest, 5 621 cases (13.82%). Through the analysis above, combine traditional Chinese and western medicine therapy for the treatment of viral hepatitis should be given priority. Traditional Chinese medicine to clear heat and promote diuresis combined with western medicine of educed enzyme drug is the most commonly appear in clinical two drug combination scheme, traditional Chinese medicine to clear heat and promote diuresis combined with western medicine of educed enzyme drug and nucleustide analogsis the most commonly appear in clinical three drug combination scheme.

Gastric cancer is a common and highly malignant tumor of the digestive system, which seriously threatens human health. The benefit of surgical treatment is limited. The effect of radiotherapy and chemotherapy is not significant, and the toxic and side effects are large. Although the diagnosis and treatment modes of molecular targeting and multidisciplinary cooperation have also been further developed and applied, a relatively unified comprehensive treatment standard scheme has not been formed. Traditional Chinese medicine (TCM), as complementary and alternative medicine, has unique advantages in the development of diagnosis and treatment of diseases in China. Therefore, the Chinese Association of Integrative Medicine formed “Expert Consensus for Diagnosis and Treatment of Gastric Cancer with Integrated Traditional Chinese and Western Medicine” on the basis of clinical practice and experience. In this article, the consensus is interpreted from the perspective of nursing, focusing on the pathogenesis, high-risk factors, characteristic therapies of TCM, and nursing of integrated traditional Chinese and Western medicine for gastric cancer, to provide a reference for front-line medical personnel in the roots in the future nursing care of gastric cancer.

Ulcerative colitis (UC) is a chronic nonspecific intestinal inflammatory disease of unclear etiology, characterized by continuous and diffuse inflammatory changes of colorectal mucosa. In recent years, the incidence rate of UC in China has increased year by year, but there is no effective cure method in Western medicine. Traditional Chinese medicine treatment based on syndrome differentiation has the unique advantages of simplicity, convenience, effectiveness, and low cost. Therefore, integration of Chinese and Western medicine has become an important strategy for UC diagnosis and treatment, and has made significant progress in UC. On the basis of learning from a number of consensuses at home and abroad, combined with Chinese research results and the actual clinical situation of traditional Chinese and Western medicine, the UC group of the Chinese Association of Integrative Medicine has formulated the expert consensus on the diagnosis and treatment of UC with integrated traditional Chinese and Western medicine. In this consensus, the pathogenesis, etiology and pathogenesis, diagnosis, integrated traditional Chinese and Western medicine treatment, and chronic disease management with integrated traditional Chinese and Western medicine for UC were recommended by experts. This article interprets the consensus from the perspective of nursing in order to provide reference basis for clinical nursing workers.

<p><strong>Objective:</strong> To investigate the clinical effect of integrated traditional Chinese and western medicine in treating acute cervicitis. <strong>Methods:</strong> 81 cases of patients with acute cervicitis which were treated in our hospital from September 2013 to March 2015 were selected as research objects. According to the method of random sampling, the patients were divided to A group (Integrated traditional Chinese and western medicine treatment), B group (Western medicine treatment) and C group (TCM treatment) with 27 cases in each group.<strong> Results:</strong> The treatment of integrated traditional Chinese and western medicine is much easier to get patients’ acceptance and affirmation. Besides that, the clinical effect of feedback is better than the single use of traditional Chinese medicine or western medicine treatment. <strong>Conclusion:</strong> The clinical effect of integrated traditional Chinese and western medicine in the treatment of acute cervicitis is better than the use of traditional Chinese medicine or western medicine.</p>

Liver cirrhosis is the terminal stage of various acute and chronic liver diseases and ranks 11th among the most common causes of death worldwide. In recent years, with the progress of clinical research, there has been increasing support from evidence-based medicine for the treatment of liver cirrhosis with integrated traditional Chinese and Western medicine. In 2023, the Chinese Association of Integrative Medicine, the China Association of Chinese Medicine, and the Chinese Medical Association jointly released the first evidence-based guideline in this field, the Guidelines for Integrated Traditional Chinese and Western Medicine Diagnosis and Treatment of Liver Cirrhosis. By combining the latest research at home and abroad, this article provides a detailed interpretation of the highlights in the guideline, including traditional Chinese medicine etiology and pathogenesis, diagnostic progress, disease and syndrome combination, stage-based diagnostic mode, and treatment strategies of integrated traditional Chinese and Western medicine. The aim is to enhance understanding of this guideline among health workers and promote the improvement of the diagnosis and treatment of liver cirrhosis with integrated traditional Chinese and Western medicine.

Chronic atrophic gastritis of spleen and stomach deficiency cold type is a common digestive disease in clinical practice, and significant progress has been made in its treatment research in recent years. This condition is mainly caused by the weakness of spleen and stomach function and the internal generation of cold, with clinical manifestations including dull pain in the stomach area, preference for warmth and pressure, loss of appetite, and fatigue. In modern medicine, Western medicine often employs methods such as eradicating Helicobacter pylori, promoting gastric motility, and inhibiting gastric acid, but these approaches have issues such as numerous adverse reactions and a high tedency for recurrence. Traditional Chinese medicine has shown unique advantages in the treatment of chronic atrophic gastritis of spleen and stomach deficiency cold type. Therefore, the combination of traditional Chinese and Western medicine has also become a major trend. This article provides a review of the research on the treatment of chronic atrophic gastritis of spleen and stomach deficiency cold type.

Innovative drugs are defined as new chemical entities that play a vital role in the treatment and maintenance of human health. While single-target innovative drugs have achieved notable success, they face limitations in addressing the increasingly complex and precise spectra of diseases. The advent of multi-target innovative drugs offers new opportunities, supported by a growing body of pharmacological evidence. Herbal medicines are recognized as valuable sources of multi-target therapeutics due to their proven efficacy in treating complex diseases. However, the identification and validation of such drugs from herbal sources continue to pose significant challenges. This paper presents a comprehensive review of the literature on traditional Chinese medicine, integrated medicine, chemistry, and biology from 2015 to 2025. It summarizes the strategies employed in integrating traditional Chinese and Western medicine for innovative drug development, along with successful application cases. We believe these efforts will deepen understanding of the current landscape, accelerate the discovery of multi-target innovative drugs from herbal medicine, and contribute to addressing major human health challenges.