White-Light Interference Microscopy Image Super-Resolution Using Generative Adversarial Networks

Super resolution (SR) techniques play a critical role in enhancing the quality of satellite imagery by reconstructing high resolution (HR) images from low resolution (LR) inputs. This study investigates the application of the Enhanced Super Resolution Generative Adversarial Network (ESRGAN) to improve the spatial resolution of satellite images. The ESRGAN framework integrates a Residual-in-Residual Dense Block (RRDB) generator, a Relativistic average GAN (RaGAN) discriminator, and an improved perceptual loss function to achieve sharper textures and more realistic structures. The 4× Satellite Image Super Resolution dataset, consisting of paired LR (2 m/pixel) and HR (0.5 m/pixel) images, was employed. Quantitative evaluation was conducted using the Peak Signal-to-Noise Ratio (PSNR), with Lanczos5 interpolation used as a baseline for comparison. Experimental results on ten test images demonstrate that ESRGAN consistently outperforms Lanczos5. Qualitative assessments further confirm that ESRGAN effectively restores high frequency details, enhances fine textures, and preserves object boundaries more accurately than the interpolation method. These findings highlight ESRGAN’s potential as an advanced solution for improving visual quality and detail preservation in high resolution satellite imagery applications.

Learning based single image super-resolution (SISR) for real-world images has been an active research topic yet a challenging task, due to the lack of paired low-resolution (LR) and high-resolution (HR) training images. Most of the existing unsupervised real-world SISR methods adopt a two-stage training strategy by synthesizing realistic LR images from their HR counterparts first, then training the super-resolution (SR) models in a supervised manner. However, the training of image degradation and SR models in this strategy are separate, ignoring the inherent mutual dependency between downscaling and its inverse upscaling process. Additionally, the ill-posed nature of image degradation is not fully considered. In this paper, we propose an image downscaling and SR model dubbed as SDFlow, which simultaneously learns a bidirectional many-to-many mapping between real-world LR and HR images unsupervisedly. The main idea of SDFlow is to decouple image content and degradation information in the latent space, where content information distribution of LR and HR images is matched in a common latent space. Degradation information of the LR images and the high-frequency information of the HR images are fitted to an easy-to-sample conditional distribution. Experimental results on real-world image SR datasets indicate that SDFlow can generate diverse realistic LR and SR images both quantitatively and qualitatively.

Deep Learning image processing methods are gradually gaining popularity in a number of areas including medical imaging. Classification, segmentation, and denoising of images are some of the most demanded tasks. In this study, we aim at enhancing optic nerve head images obtained by Optical Coherence Tomography (OCT). However, instead of directly applying noise reduction techniques, we use multiple state-of-the-art image Super-Resolution (SR) methods. In SR, the low-resolution (LR) image is upsampled to match the size of the high-resolution (HR) image. With respect to image enhancement, the upsampled LR image can be considered as low quality, noisy image, and the HR image would be the desired enhanced version of it. We experimented with several image SR architectures, such as super-resolution Convolutional Neural Network (SRCNN), very deep Convolutional Network (VDSR), deeply recursive Convolutional Network (DRCN), and enhanced super-resolution Generative Adversarial Network (ESRGAN). Quantitatively, in terms of peak signal-to-noise ratio (PSNR) and structural similarity index (SSIM), the SRCNN, VDSR, and DRCN significantly improved the test images. Although the ERSGAN showed the worst PSNR and SSIM, qualitatively, it was the best one.

Single Image Super-Resolution (SISR) stands at the forefront of image processing, offering a transformative solution to elevate low-resolution images to a higher fidelity.Leveraging deep neural networks, particularly Generative Adversarial Networks (GANs), this study aims to enrich the quality of images, especially in domains like medical imaging, public surveillance, and historical image restoration. Traditional methods often fail to preserve crucial details during up scaling, prompting the adoption of deep learning techniques which have demonstrated remarkable breakthroughs in accuracy and efficiency. By harnessing the adversarial training process inherent in GANs, we seek to propel the boundaries of image enhancement, striving to faithfully reconstruct high-resolution renditions while retaining essential nuances from their low-resolution counterparts. Through comprehensive performance evaluations utilizing publicly available datasets, we conduct rigorous quantitative and qualitative analyses to gauge the efficacy of various GAN architectures in SISR. This meticulous examination allows us to assess not only the fidelity of the reconstructed images but also the computational efficiency and scalability of each approach, essential considerations for real-world applications. However, alongside the promises of GAN-based SISR come inherent challenges that warrant attention. Issues such as training instability, mode collapse, and imageartifacts present hurdles that must be addressed to fully harness the potential of GANs in image enhancement.Additionally, the integration of domain-specific expertise, particularly in fields like medical imaging, can further enhance the utility and efficacy of GAN-based super-resolution techniques.In conclusion, while the journey towards achieving high-quality, high-resolution images may be fraught with challenges, the integration of GANs into SISR represents a significant leap forward, promising to revolutionize various industries and deepen our understanding of visual data.

Advanced imaging in medical has become crucial in the early identify diseases because they reveal the important structural features of the human body. But it is almost impossible to get such high resolution images in real life situation due to the factors such as image capture and processing equipment, and environmental factors that affect the outcome of the image. This work proposes a sub-type of GAN that is used in enhancement of images particularly in medical fields. The generator of the Med-GAN extracts a high-resolution image from a low-resolution one with the help of novel features learned by the model. The approach of reconstructing high resolution from multiple parallel streams of lower resolution employs deconvolution algorithms with multiple scale fusions that produce better high resolution representations as compared to the technique of bilinear interpolation. The performances of the proposed Med-GAN are tested on two publicly available COVID-19 CT datasets and one private medical image dataset which shows that the proposed method outperforms the existing methods in performance comparisons. Consequently, for PSNR, the score improves from 24.103 dB corresponding to the Initial Approach of the “BRaTS (FLAIR)” dataset to 25.496 dB for the Proposed Method; whereas for SSIM the score increases from 0.782 to 0.812.se types of high-resolution images are usually impossible to get due to limits in imaging devices, environmental conditions, and human factors. This work proposes the Med-GAN: an Enhanced Super-Resolution Generative Adversarial Network tuned for medical image enhancement. The Med-GAN generator learns high-resolution representations from low-resolution images via advanced feature extraction methods. Deconvolution algorithms with multi-scale fusions recover better high-resolution representations from multiple parallel streams of lower resolutions in this approach compared to traditional bilinear interpolation methods. Evaluated on two publicly available COVID-19 CT datasets and one custom medical image dataset, the proposed Med-GAN significantly outperforms existing techniques in performance comparisons. In particular, PSNR rises from 24.103 dB for the BRaTS (FLAIR) dataset in the Initial Approach to 25.496 dB in the Proposed Method, while SSIM increases from 0.782 to 0.812. If that is the case then it could be said that the solution of the proposed Med-GAN is one of the most realistic means for improving the quality of medical images and therefore contributes to better diagnostics of diseases

We explore in this paper an efficient algorithmic solution to single image super-resolution (SR). We propose the gCLSR, namely graph-Constrained Least Squares Regression, to super-resolve a high-resolution (HR) image from a single low-resolution (LR) observation. The basic idea of gCLSR is to learn a projection matrix mapping the LR image patch to the HR image patch space while preserving the intrinsic geometric structure of the original HR image patch manifold. Even if gCLSR resembles other manifold learning-based SR methods in preserving the local geometric structure of HR and LR image patch manifolds, the innovation of gCLSR lies in that it preserves the intrinsic geometric structure of the original HR image patch manifold rather than the LR image patch manifold, which may be contaminated by image degeneration (e.g., blurring, down-sampling and noise). Upon acquiring the projection matrix, the target HR image can be simply super-resolved from a single LR image without the need of HR-LR training pairs, which favors resource-limited applications. Experiments on images from the public database show that gCLSR method can achieve competitive quality as state-of-the-art methods, while gCLSR is much more efficient in computation than some state-of-the-art methods.

Deep convolutional neural networks (CNNs), trained on corresponding pairs of high- and low-resolution images, achieve state-of-the-art performance in single-image super- resolution and surpass previous signal-processing based approaches. However, their performance is limited when applied to real photographs. The reason lies in their train- ing data: low-resolution (LR) images are obtained by bicu- bic interpolation of the corresponding high-resolution (HR) images. The applied convolution kernel significantly differs from real-world camera-blur. Consequently, while current CNNs well super-resolve bicubic-downsampled LR images, they often fail on camera-captured LR images. To improve generalization and robustness of deep super- resolution CNNs on real photographs, we present a ker- nel modeling super-resolution network (KMSR) that incor- porates blur-kernel modeling in the training. Our pro- posed KMSR consists of two stages: we first build a pool of realistic blur-kernels with a generative adversarial net- work (GAN) and then we train a super-resolution network with HR and corresponding LR images constructed with the generated kernels. Our extensive experimental vali- dations demonstrate the effectiveness of our single-image super-resolution approach on photographs with unknown blur-kernels.

The single image super resolution recovers missing high resolution details so as to reconstruct a high resolution image from a single low resolution image. This paper proposes a novel directionally adaptive, learning-based, single image super resolution method using multiple direction wavelet transform, called directionlets. Here, critically sampled directionlets are used to capture directional features effectively and to extract edge information along different directions from a set of available high resolution images. This information is used as the training set for super resolving a low resolution input image. The directionlet coefficients at finer scales of its high resolution image are learned locally from this training set and the inverse directionlet transform recovers the super resolved high resolution image. The simulation results showed that the proposed directionlet approach outperforms standard interpolation techniques like cubic spline interpolation as well as standard wavelet-based learning, both visually and in terms of the mean squared error (MSE) values. The SNR scores for cubic spline interpolation, wavelet and directionlet method are 13.6998 dB, 23.8324 dB and 30.8654 dB respectively for Barbara.

Image super-resolution is of great interest in medical imaging field. However, different from natural images studied in computer vision field, the low-resolution (LR) medical imaging data is often a stack of high-resolution (HR) 2D slices with large slice thickness. Consequently, the goal of super-resolution for medical imaging data is to reconstruct the missing slice(s) between any two consecutive slices. Since some modalities (e.g., T1-weighted MR image) are often acquired with high-resolution (HR) image, it is intuitive to harness the prior self-similarity information in the HR image for guiding the super-resolution of LR image (e.g., T2-weighted MR image). The conventional way is to find the profile of patchwise self-similarity in the HR image and then use it to reconstruct the missing information at the same location of LR image. However, the local morphological patterns could vary significantly across the LR and HR images, due to the use of different imaging protocols. Therefore, such direct (un-supervised) adaption of self-similarity profile from HR image is often not effective in revealing the actual information in the LR image. To this end, we propose to employ the existing image information in the LR image to supervise the estimation of self-similarity profile by requiring it not only being optimal in representing patches in the HR image, but also producing less reconstruction errors for the existing image information in the LR image. Moreover, to make the anatomical structures spatially consistent in the reconstructed image, we simultaneously estimate the self-similarity profiles for a stack of patches across consecutive slices by solving a group sparse patch representation problem. We have evaluated our proposed super-resolution method on both simulated brain MR images and real patient images with multiple sclerosis lesion, achieving promising results with more anatomical details and sharpness.

Single image super-resolution based on compressive sensing and improved TV minimization sparse recovery

Single image super-resolution (SISR) is of great importance as a low-level computer vision task. The fast development of Generative Adversarial Network (GAN) based deep learning architectures realises an efficient and effective SISR to boost the spatial resolution of natural images captured by digital cameras. However, the SISR for medical images is still a very challenging problem. This is due to (1) compared to natural images, in general, medical images have lower signal to noise ratios, (2) GAN based models pre-trained on natural images may synthesise unrealistic patterns in medical images which could affect the clinical interpretation and diagnosis, and (3) the vanilla GAN architecture may suffer from unstable training and collapse mode that can also affect the SISR results. In this paper, we propose a novel lesion focused SR (LFSR) method, which incorporates GAN to achieve perceptually realistic SISR results for brain tumour MRI images. More importantly, we test and make comparison using recently developed GAN variations, e.g., Wasserstein GAN (WGAN) and WGAN with Gradient Penalty (WGAN-GP), and propose a novel multi-scale GAN (MS-GAN), to achieve a more stabilised and efficient training and improved perceptual quality of the super-resolved results. Based on both quantitative evaluations and our designed mean opinion score, the proposed LFSR coupled with MS-GAN has performed better in terms of both perceptual quality and efficiency.

A new multi-frame image super resolution (SR) algorithm via Bayesian modeling with natural image prior modeled by fields of experts (FoE) is proposed. Multi-frame SR can be used to obtain a high resolution (HR) image from a set of degraded low resolution (LR) images without changing any hardware device. However, SR is well known to be an ill-posed problem. So state-of-the-art solutions usually formulate the problem with Bayesian modeling techniques, which infer the HR image based on not only the LR input images but also on prior information about the HR image. Current Bayesian SR approaches typically use simple prior models such as L1 norm, TV prior and Laplacian prior, which cannot exploit the statistics of natural scenes well. In this paper, a Bayesian multi-frame image SR approach using a FOE model as the prior for natural images is presented. The Maximum a Posteriori (MAP) framework is used for estimating the HR image. The proposed method cannot only capture the statistics of natural images well, but also require less computational power than the other Bayesian modelling methods such as Sampling methods and Approximate inference. The proposed method shows superior or comparable results to the state-of-art multi-frame SR methods.

Single Image Super-Resolution (SISR) using Convolutional Neural Networks (CNNs) for many applications in <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">supervised</i> manner has resulted in state-of-the-art results. Such supervised models achieve remarkable accuracy; albeit their poor generalization ability for real-world Low-Resolution (LR) images. Supervised training in many SR works involves synthetically generated LR images from its corresponding High-Resolution (HR) images. As the distribution of such LR observation is relatively different from that of real LR image, the supervised training in SISR task results degradation when applied on real-world data. SISR has been scaled to real-world data recently by posing the unsupervised problem into a supervised one through learning the distribution of noisy LR observation first, following which supervised training is performed to obtain the SR image. It therefore involves two steps where the accuracy of SR image relies on how closely the LR’s distribution is learnt in the first step. In this work, we overcome such limitation by introducing unsupervised denoising network to transform real noisy LR image to clean image and then pre-trained SR network is utilised to increase the spatial resolution of cleaned LR image to generate SR image. Thus, instead of evaluating the denoised image in LR space to train the denoising network, we inspect the denoised image in SR space which allows to overcome the SR network’s generalization problem. The proposed Unsupervised Denoising framework for Super-Resolution ( <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">UDSR</i> ) is validated on real-world datasets (NTIRE-2020 Real-World SR Challenge validation and testing dataset (Track-1)) by comparing it with many recent unsupervised SISR methods. The performance of denoising and SR networks is superior in terms of various perceptual indices such as Perceptual Index (PI) and Ma Score in addition to numerous non-references metrics.

Example learning-based image super-resolution (SR) is recognized as an effective way to produce a high-resolution (HR) image with the help of an external training set. The effectiveness of learning-based SR methods, however, depends highly upon the consistency between the supporting training set and low-resolution (LR) images to be handled. To reduce the adverse effect brought by incompatible high-frequency details in the training set, we propose a single image SR approach by learning multiscale self-similarities from an LR image itself. The proposed SR approach is based upon an observation that small patches in natural images tend to redundantly repeat themselves many times both within the same scale and across different scales. To synthesize the missing details, we establish the HR-LR patch pairs using the initial LR input and its down-sampled version to capture the similarities across different scales and utilize the neighbor embedding algorithm to estimate the relationship between the LR and HR image pairs. To fully exploit the similarities across various scales inside the input LR image, we accumulate the previous resultant images as training examples for the subsequent reconstruction processes and adopt a gradual magnification scheme to upscale the LR input to the desired size step by step. In addition, to preserve sharper edges and suppress aliasing artifacts, we further apply the nonlocal means method to learn the similarity within the same scale and formulate a nonlocal prior regularization term to well pose SR estimation under a reconstruction-based SR framework. Experimental results demonstrate that the proposed method can produce compelling SR recovery both quantitatively and perceptually in comparison with other state-of-the-art baselines.

Existing single image super-resolution (SISR) methods usually focus on Low-Resolution (LR) images which are artificially generated from High-Resolution (HR) images by a down-sampling process, but are not robust for unmatched training set and testing set. This paper proposes a GAN Flexible Lmser (GFLmser) network that bidirectionally learns the High-to-Low (H2L) process that degrades HR images to LR images and the Low-to-High (L2H) process that recovers the LR images back to HR images. The two directions share the same architecture, added with the gated skip connections from the H2L-net to the L2H-net in order to enhance information transferring for super-resolution. In comparison with several related state-of-the-art methods, experiments demonstrate that not only GFLmser is the most robust method on images of unmatched training set and testing set, but also its performance on real-world face LR images is best in PSNR and reasonably good in FID.