What is anisodamine and what are its clinical applications?

Answer from top 1 papers

Anisodamine is a tropine alkaloid with a variety of clinical applications, including the treatment of pain, motion sickness, pupil dilation, detoxification of organophosphorus poisoning, and improvement of blood flow in circulatory disorders ( and ). It functions as an antagonist to muscarinic acetylcholine receptors (mAChRs) and has been shown to have therapeutic effects in conditions such as airway spasms and acute lung injury (ALI) ( and ).
Interestingly, while anisodamine has demonstrated beneficial effects in various therapeutic contexts, it also presents potential toxicity at high doses, as evidenced by developmental toxicity in zebrafish embryos (). Additionally, it has been suggested as a potential treatment for COVID-19 due to its antiviral activity (), and it has shown protective effects against hypoxic injury in brain microvascular endothelial cells (). Moreover, anisodamine has been found to inhibit apoptosis in cardiomyocytes and reduce inflammatory responses in overtrained rats ().
In summary, anisodamine is a multifaceted drug with a range of pharmacological effects and potential therapeutic applications. However, its use must be carefully managed due to the risk of toxicity at high doses. Further research is warranted to fully understand its mechanisms of action and to optimize its clinical use ((Xia et al., 2024) and ).

Source Papers

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10.1002/cbdv.202301477

A Review on the Chemical Properties, Plant Sources, Anti-shock Effects, Pharmacokinetics, Toxicity, and Clinical Applications of Anisodamine.

May 09, 2024
Chemistry & biodiversity
Qiurui Xia + 7 more +7

Alkaloids are natural products that occur widely in many herbal plants. Anisodamine, widely present in the Solanaceae family, is an alkaloid extracted from the roots of the Anisodus tanguticus Maxim. It is an antagonist to M-choline receptors and exhibits diverse pharmacological effects, such as cholinolytic effect, calcium antagonist effect, anti-oxygenation effect. Anisodamine, a prominent constituent of the tropine alkaloid family, exhibits a range of pharmacological effects akin to those of atropine and scopolamine. owing to its low toxicity and moderate efficacy in clinical to wide applications, especially for varieties of shock treatment. However, there remains a dearth of research regarding the in vivo pharmacokinetics, mechanism of action, and toxicity of anisodamine. Consequently, this paper provides a comprehensive review of the anti-shock effects, toxicity, and pharmacokinetic characteristics of anisodamine to increase the understanding of its medicinal value, and provide reference and inspiration for the clinical application and further in-depth research of anisodamine.