What is the potential of cyclodextrins in clinical diagnosis?

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Cyclodextrins (CDs) have been explored for their potential in clinical diagnosis due to their ability to form host-guest interactions with hydrophobic molecules. In the context of clinical diagnosis, a study demonstrated the use of succinyl-β-CD modified gold biochips for seroimmunological detection of Lyme disease, showing enhanced detection sensitivity for VlsE protein and anti-VlsE IgG antibody (). This suggests that CDs can be integral to developing sensitive diagnostic platforms.
Interestingly, while CDs are beneficial in enhancing the sensitivity of diagnostic assays, their applications are not universal for all antigens, as indicated by the unsuitability of the mentioned biochip platform for loading flagellin and OspC (). Additionally, the formation of CD complexes can sometimes lead to transient clusters and nanoparticles, which may interfere with analytical results, posing a challenge for clinical diagnosis ().
In summary, CDs offer promising avenues for improving clinical diagnostic techniques, particularly through the enhancement of assay sensitivity and specificity. However, their application is not without limitations, as certain antigens may not be suitable for CD-based platforms, and the formation of transient particulate matter could potentially affect analytical outcomes. Further research and development are required to optimize CD-based diagnostic tools and mitigate these challenges ( and ).