ADVERTISEMENT RETURN TO ARTICLES ASAPEditorialNEXTA Celebration of the Publication of the 100th Volume of Organic SynthesesMargaret M. Faul*Margaret M. FaulProcess Development, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, United States*Email: [email protected]More by Margaret M. Faul and Kay M. Brummond*Kay M. BrummondUniversity of Pittsburgh, Department of Chemistry, 219 Parkman Avenue, Pittsburgh, Pennsylvania 15260, United States*Email: [email protected]More by Kay M. Brummondhttps://orcid.org/0000-0003-3595-6806Cite this: ACS Org. Inorg. Au 2023, XXXX, XXX, XXX-XXXPublication Date (Web):November 17, 2023Publication History Received25 October 2023Published online17 November 2023https://doi.org/10.1021/acsorginorgau.3c00057Published 2023 by American Chemical Society. This publication is licensed under CC-BY-NC-ND 4.0. License Summary*You are free to share (copy and redistribute) this article in any medium or format within the parameters below:Creative Commons (CC): This is a Creative Commons license.Attribution (BY): Credit must be given to the creator.Non-Commercial (NC): Only non-commercial uses of the work are permitted. No Derivatives (ND): Derivative works may be created for non-commercial purposes, but sharing is prohibited. View full license*DisclaimerThis summary highlights only some of the key features and terms of the actual license. It is not a license and has no legal value. Carefully review the actual license before using these materials. This publication is Open Access under the license indicated. Learn MoreArticle Views-Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-AlertscloseSUBJECTS:Computational chemistry,Organic chemistry,Organic compounds,Organic reactions,Organic synthesis Get e-Alerts

ADVERTISEMENT RETURN TO ARTICLES ASAPEditorialNEXTEmpowering Women in Organic Chemistry (EWOC) at Five Years: Giving Back and Getting BackElinor H. Cantor*Elinor H. CantorPhiladelphia Chapter, Association for Women in Science, Phoenixville, Pennsylvania 19460, United States*[email protected]More by Elinor H. Cantor, Margaret M. Faul*Margaret M. FaulProcess Development, Amgen Inc., Thousand Oaks, California 91320, United States*[email protected]More by Margaret M. Faul, Donna M. Huryn*Donna M. HurynDepartment of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19194, United States*[email protected]More by Donna M. Hurynhttps://orcid.org/0000-0001-5542-4968, Lara Kallander*Lara KallanderThriving Through Adversity Coaching, Lexington, Massachusetts 02420, United States*[email protected]More by Lara Kallanderhttps://orcid.org/0000-0002-6369-7031, Rebecca T. Ruck*Rebecca T. RuckProcess Research & Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States*[email protected]More by Rebecca T. Ruckhttps://orcid.org/0000-0001-9980-9675, and Mary P. Watson*Mary P. WatsonDepartment of Chemistry & Biochemistry, University of Delaware, Newark, Delaware 19716, United States*[email protected]More by Mary P. Watsonhttps://orcid.org/0000-0002-1879-5257Cite this: ACS Org. Inorg. Au 2023, XXXX, XXX, XXX-XXXPublication Date (Web):September 29, 2023Publication History Received14 September 2023Published online29 September 2023https://doi.org/10.1021/acsorginorgau.3c00050Copyright © 2022 The Authors. Published by American Chemical Society. This publication is licensed under CC-BY-NC-ND 4.0. License Summary*You are free to share (copy and redistribute) this article in any medium or format within the parameters below:Creative Commons (CC): This is a Creative Commons license.Attribution (BY): Credit must be given to the creator.Non-Commercial (NC): Only non-commercial uses of the work are permitted. No Derivatives (ND): Derivative works may be created for non-commercial purposes, but sharing is prohibited. View full license*DisclaimerThis summary highlights only some of the key features and terms of the actual license. It is not a license and has no legal value. Carefully review the actual license before using these materials. This publication is Open Access under the license indicated. Learn MoreArticle Views-Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (912 KB) Get e-AlertscloseSUBJECTS:Chemical biology,Medicinal chemistry,Natural organic matter,Organic chemistry,Students Get e-Alerts

High-quality density functional theory calculations underscore a nearly 6 eV range for the ionization potentials (IPs) of neutral, low-valent carbon compounds, including carbenes, ylides, and zero-valent carbon compounds (carbones) such as carbodiphosphoranes (CDPs) and carbodicarbenes. Thus, adiabatic IPs as low as 5.5 ± 0.1 eV are predicted for CDPs, which are about 0.7-1.2 eV lower than those of simple phosphorus and sulfur ylides. In contrast, the corresponding values for N-heterocyclic carbenes are about 8.0 eV while those for simple singlet carbenes such as dichlorocarbene and difluorocarbene range from about 9.0 eV to well over 11.0 eV.

The presence of oxo-ligandsis one of the main requiredcharacteristicsfor polyoxometalates (POMs), although some oxygen ions in a metallicenvironment can be replaced by other nonmetals, while maintainingthe POM structure. The replacement of oxo-ligands offers a valuableapproach to tune the charge distribution and connected propertieslike reducibility and hydrolytic stability of POMs for the developmentof tailored compounds. By assessing the reported catalytic and biologicalapplications and connecting them to POM structures, the present reviewprovides a guideline for synthetic approaches and aims to stimulatefurther applications where the oxo-replaced compounds are superiorto their oxo-analogues. Oxo-replacement in POMs deserves more attentionas a valuable tool to form chemically activated precursors for thesynthesis of novel structures or to upgrade established structureswith extraordinary properties for challenging applications.

The exploration of 1,2-radical shift (RS) mechanismsin photoinducedorganic reactions has provided efficient routes for the generationof important radical synthons in many chemical transformations. Inthis Review, the basic concepts involved in the traditional 1,2-spin-centershift (SCS) mechanisms in recently reported studies are discussed.In addition, other useful 1,2-RSs are addressed, such as those proceedingthrough 1,2-group migrations in carbohydrate chemistry, via 1,2-boronshifts, and by the generation of α-amino radicals. The discussionbegins with a general overview of the basic aspects of 1,2-RS mechanisms,followed by a demonstration of their applicability in photoinducedtransformations. The sections that follow are organized accordingto the mechanisms operating in combination with the 1,2-radical migrationevent. This contribution is not a comprehensive review but ratheraims to provide an understanding of the topic, focused on the morerecent advances in the field, and establishes a definition for thenomenclature that has been used to describe such mechanisms.

The mixed anion material Bi4O4SeCl2 has an ultralow thermal conductivity of 0.1 W m–1 K–1 along its stacking axis (c axis) at room temperature, which makes it an ideal candidate forelectronic band structure optimization via doping to improve its thermoelectricperformance. Here, we design and realize an optimal doping strategyfor Bi4O4SeCl2 from first principlesand predict an enhancement in the density of states at the Fermi levelof the material upon Sn and Ge doping. Experimental work realizesthe as-predicted behavior in Bi4–xSnxO4SeCl2 (x = 0.01) through the precise control of composition. Carefulconsideration of multiple accessible dopant sites and charge statesallows for the effective computational screening of dopants for thermoelectricproperties in Bi4O4SeCl2 and maybe a suitable route for assessing other candidate materials.

Salinomycin, a naturalcarboxylic polyether ionophore, shows avery interesting spectrum of biological activities, including selectivetoxicity toward cancer stem cells (CSCs). Recently, we have developeda C20-propargylamine derivative of salinomycin (ironomycin) that exhibitsmore potent activity in vivo and greater selectivityagainst breast CSCs compared to the parent natural product. Sinceironomycin contains a terminal alkyne motif, it stands out as beingan ideal candidate for further functionalization. Using copper-catalyzedazide–alkyne cycloaddition (CuAAC), we synthesized a seriesof 1,2,3-triazole analogs of ironomycin in good overall yields. The in vitro screening of these derivatives against a well-establishedmodel of breast CSCs (HMLER CD24low/CD44high) and its corresponding epithelial counterpart (HMLER CD24high/CD44low) revealed four new products characterized byhigher potency and improved selectivity toward CSCs compared to thereference compound ironomycin. The present study highlights the therapeuticpotential of a new class of semisynthetic salinomycin derivativesfor targeting selectively the CSC niche and highlights ironomycinas a promising starting material for the development of new anticancerdrug candidates.