: Esophageal cancer is an aggressive malignancy. Many patients are found to have metastatic, unresectable disease at the time of diagnosis. Surgery is generally necessary as part of a multimodal treatment approach to non-metastatic esophageal cancer, but is associated with significant potential morbidity. During the operation, the surgeon must achieve an adequate cancer resection and then perform concomitant reconstruction of the gastrointestinal tract, which contributes to the high complexity of esophageal cancer surgery. The operation typically requires access to multiple body cavities, including some combination of the thorax, the abdomen, and the neck. Several options to accomplish esophageal resection and reconstruction exist, including Ivor Lewis esophagectomy, McKeown (three field) esophagectomy, transhiatal esophagectomy, and thoracoabdominal esophagectomy. The optimal approach for a specific patient will be dependent on patient, cancer, surgeon, and institution characteristics. This clinical practice review will explore the general epidemiology, work-up, and overall treatment of esophageal cancer, as well as outline the factors that impact surgical approach selection. The review describes the details as well as the advantages and disadvantages of each possible approach, and gives an overview of the spectrum of possible postoperative complications. An improved understanding of this topic can allow non-surgical specialists to better support their patients.
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