the effect attributed to the presence of flavonoids and phenolic compounds present in extract.

Phenolic composition and quantitative evaluation of herbal part and root extracts for Reynoutria sachalinensis studied by HPLC method. Using the same method, we also established the antioxidant activity of R. sachalinensis raw materials. Six phenolic compounds were idenified for herbal part of R. sachalinensis as, gallic acid, chlorogenic acid, trans-cinnamic acid, rutin, hyperoside and isoquercitrin at total amount of 885.3721.25 mg/kg. Neochlorogenic acid and rutin were found as main compounds for herbal part of R. sachalinensis, and gallic acid and 6,7-dihydroisoflavone were determined for root of R. sachalinensis. In R. sachalinensis roots we found gallic acid and 6,7-dihydroisoflavone.

The proposed research work aimed to design, formulate and finally to evaluate sustained released matrix tablets of propranolol hydrochloride using the combination of hydrophilic and hydrophobic polymers. Formulation and optimization of Propranolol HCl was done by direct compression technique using 3 2 factorial design. The amount of polymer Mastic gum (X 1 ) and HPMC (X 2 ) were chosen as independent variables and their effect on amount of drug release at 2 hours (Y 1 ) , 4 hours (Y 2 ) and 8 hours (Y 3 ) at three levels low (-1), medium(0) and high(+1) was taken as dependent variable. Drug-excipient compatibility studies were performed by FTIR and DSC analysis. A total of 9 combinations of sustained released tablets were formulated and evaluated for both pre and post compression parameters. Design expert software version 10 was used to evaluate the effect of independent variable over dependent variable and to generate polynomial equation to represent experimental results. The B7 formulation containing 5 % of mastic gum and 25% of HPMC K-15 combination showed 60.13% drug release in 8 hours and was chosen as optimized formulation. Release kinetic mechanism indicated that the optimized formulation fitted well into Kosmeyer Peppas model (R 2 = 0.9974). Stability studies indicated that selected formulation was stable for 90 days. Formulation containing 5% of mastic gum and 25% HPMC was found to be effective and can be explored further to develop sustained released formulations.