The main objective of the present study was to developed and evaluated the Bifonazole (BFZ) loaded Nanostructured lipid carriers (NLCs) for topical delivery of BFZ. BFZ-NLCs were deve26ted for Particle size, EE, DL and drug release profiles. The invitro release studies show better drug release over 24h as compared to the marketed formulation. Ex-vivo skin permeation and Pharmacodynamic studies indicated that NLCs get effectively reduced the fungal infection. In-vitro antifungal activity study shows that the BFZ-NLCs were more effective in inhibiting the growth of Candida Albicans. Therefore, the study concludes that NLCs showed a continuous release profile and has the prospective for treatment of topical fungal infections.

The present study reflects the effect of plant extracts of Salvia officinalison neuromodulating and oxidative stress status of Male Albino Wistar rats intoxicated with Aluminium chloride.

The goal of this work was to evaluate in vitro antioxidant, anti-urease and anticholinesterase activities of Ruscus aculeatus L. using a variety of extracts.Antioxidant activities of different extracts from plant were evaluated using DPPH, FRAP, ABTS/ TEAC and CUPRAC methods.In addition, the anti-urease and anticholinesterase activities of the different extracts were compared by Indophenol and Ellman tests, respectively.In the present study, Soxhlet chloroform extract showed stronger antioxidant (DPPH, FRAP, CUPRAC) and anticholinesterase activity than other extracts.It was also found that the maceration ethanol extract showed the most potent anti-urease activity.The Soxhlet chloroform and maceration ethanol extracts from this species may be a natural resource candidate for the pharmaceutical and food industry due to the pharmacological effects (antioxidant, anticholinesterase and anti-urease effect).

This study was performed to investigate the consequences of severe maternal hyperglycemia induced by streptozotocin in Wistar rats on postnatal development of offspring. Besides, the ability of a ginger extract to restore glycemic balance in dams and prevent the appearance of disorders in offspring. Diabetes was induced in dams before pregnancy by a single injection of streptozotocin at a dose of 50 mg / kg. Ginger was orally administered from the fourteenth (14th) to the nineteenth (19th) day of pregnancy. Two tests before and after weaning were performed to monitor the offspring development. Our study clearly showed that treatment of diabetic pregnant rats with a ginger extract lowers blood glucose levels and help prevent disorders in offspring.

Trichilia monadelpha (TM) is a plant commonly used to treat gastrointestinal disorders, inflammatory diseases and pain. This study evaluated the effect of aqueousmethanol extract of stem bark of TM (MeTM) on trinitrobenzene sulfonic acid (TNBS) induced rat colitis. Thirty male Wistar rats (180-200 g) were randomly distributed into six groups (n=5): non-colitic, colitic untreated or treated with prednisolone (2 mg/kg) and MeTM (100 -400 mg/kg, given orally 2 days pre-and 7 days post-induction). Response to treatment was assessed. GC-MS analysis of MeTM was done.

Macaranga hurifolia Beille (Euphorbiaceae) is used in Nigerian ethnobotany for treating several diseases. This work was designed to determine the phytochemical composition, as well as, investigate the anti-inflammatory and hypoglycaemic activities of Macaranga hurifolia extract (MHE). MHE was evaluated for its anti-inflammatory and antidiabetic potentials using the egg albumin inflammatory model and alloxan-induced diabetic rat model, respectively. MHE produced both dose-dependent and time-dependent inhibition of oedema development with its maximum effect (69.6%) produced at the dose of 300 mg/kg. The acute in vivo antidiabetic study revealed that MHE produced significant hypoglycaemic effects at doses of 200 mg/kg (54% reduction) and 400 mg/kg (59% reduction), comparable to glibenclamide (5 mg/kg) which caused a 42% decrease, while all the treatment groups produced at least 25% reduction in blood glucose level for the chronic study. This study established, for the first time, the anti-inflammatory and antidiabetic potentials of Macaranga hurifolia.

Combretum genus (Combretaceae) is used locally in the treatment of various diseases including malaria.Current study aimed to investigate the antiplasmodial activities of methanol extract of C. zenkeri in Plasmodium falciparum chloroquine sensitive (D10) and resistant (W2) strains and identify the bioactive principles.Repeated chromatographic separation was carried out on the chloroform fraction to afford the isolation of bioactive compounds which was characterized by application of spectroscopic techniques (ESI-MS, HR-ESIMS, 1D and 2D NMR).Antiplasmodial activities of chloroform fraction (D10; IC 50 = 12.571.57g/mL and W2; IC 50 = 12.140.95g/mL) showed more activity than the n-butanol fraction (D10; IC 50 = 61.983.25 g/mL and W2; IC 50 = 61.268.64g/mL).Phytochemical investigation of the extract afforded isolation of two triterpenes with antimalarial activities.This paper identified for the first time the antimalarial principles in C. zenkeri as ursolic and oleanolic acids; which justified the local use of the plant in the treatment of malaria.

This study aims to co-process native Ipomea batatas starch (NPS) with colloidal silicon dioxide and evaluate the properties of the co-processed excipient (CPS). The powder morphology was determined by scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and X-Ray Diffraction (XRD) measurements. The compressional, mechanical and release properties of metronidazole tablet formulations were evaluated. NPS was predominantly oval in shape while CPS had more large truncated ellipsoidal granules. Both NPS and CPS exhibited spectra typical of a Type A XRD pattern, but CPS has a sharp peak with strong intensity at 27 0 2q which was absent in NPS. Although NPS had a faster onset of plastic deformation, the overall amount of plastic deformation was higher in CPS. Tablets formulated with CPS had faster dissolution than those containing similar concentration of NPS. The co-processing of Ipomea batatas starch with colloidal silicon dioxide resulted in modification of its powder and tableting properties.

Sedum spurium M. Bieb. (Crassulaceae) is a common ornamental plant, whereas, Melampyrum arvense L. var. elatius Boiss. (Orobanchaceae) is a semi-parasitic plant and grows naturally in the fields. In this study, the dichloromethane and ethyl acetate extracts of M. arvense and S. spurium were evaluated for their in vitro antioxidant and antimicrobial activities. The antioxidant activity was evaluated by DPPH -ABTS methods. The antimicrobial activity of S. spurium and M. arvense extracts was determined using the in vitro broth microdilution assay against following human pathogenic strains; Staphylococcus aureus ATCC 6538, Enterococcus faecalis ATCC 29212, Escherichia coli NRLL B-3008, Helicobacter pylori ATCC 43504, Mycobacterium smegmatis ATCC 25291, Mycobacterium avium ssp. avium and Pseudomonas aeruginosa ATCC 10145.

This research includes synthesis of new heterocyclic derivatives of disubstituted 1,3-oxazepine-5-one.Azomethine compounds (N1-N5) were synthesized by the reaction of aromatic aldehydes with primary aromatic amines, in the presence of glacial acetic acid as a catalyst in absolute ethanol.The synthesized compounds were identified via spectral methods viz., FT-IR, 1H-NMR, and 13C-NMR and measurements of some physical properties.The prepared oxazepine compounds (N6-N10) were obtained from treatment of azomethine compounds with phthalide.N9 and N7 derivatives have recorded the higher zone of inhibition 15 mm against Candida guilliermondii and Candida zeylanoides respectively.The lower zone of inhibition was 8.0 mm and 9.3 mm by N7 toward the growth of Candida albicans and Candida guilliermondii respectively.Slight variation in the structure of those derivatives can show the very dramatic effect on the efficiency of these compounds in their bio-activity and may be helpful in designing more antifungal agents for therapeutic use in future.