- Research Article
2
- 10.5114/areh.2025.149343
Non-pharmacological interventions targeting working memory in mild cognitive impairment: a systematic review and meta-analysis
- Jan 01, 2025
- Advances in Rehabilitation
- Seyed Sahaf + 2 more +2
Objective: This study aims to evaluate the effects of non-pharmacological cognitive interventions on working memory (WM) in individuals with Mild Cognitive Impairment (MCI).Given WM's critical role in cognitive functioning and its predictive value for daily activities, this meta-analysis focuses on assessing the effectiveness of various interventions to enhance WM in MCI patients.Method: A systematic search was conducted in PubMed, Scopus, Google Scholar, ScienceDirect, and SID until March 2024.Eligible studies were randomized controlled trials assessing non-pharmacological cognitive interventions on working memory in Mild Cognitive Impairment.Effect sizes were calculated using the Standardized Mean Difference (Hedges' g), and heterogeneity was assessed using the I statistic with Comprehensive Meta-Analysis Software (CMA2).Results: From 1,509 identified studies, 27 met the inclusion criteria, and 7 were eligible for meta-analysis.Cognitive interventions, particularly digital-based programs, showed significant improvements in working memory.The effect size was moderate (0.456, p < 0.05) with low to moderate heterogeneity (I = 35%).Risk of bias was generally low, supporting the reliability of findings.Cognitive interventions show significant potential in enhancing WM among individuals with MCI.Our meta-analysis reveals a moderate effect size, supporting the efficacy of nonpharmacological approaches.Cognitive interventions may serve as a valuable tool for delaying cognitive decline.Future research should investigate optimal intervention strategies and long-term effects to maximize cognitive benefits.
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