ABSTRACT Porous crystalline materials traditionally rely on robust coordination or covalent bonds. Herein, we report a new C 3 ‐symmetric molecular nanographene 1 containing three hexabenzocoronene (HBC) units that self‐organizes into a permanently porous framework exclusively using weak van der Waals interactions. Single‐crystal x‐ray diffraction results reveal a propeller geometry with C 3 symmetry, forming two‐dimensional honeycomb sheets parallel to the ab plane stabilized by π···π and C–H···π interactions. Nitrogen adsorption measurements at 77 K confirm a Type I(b) isotherm with a record‐breaking Brunauer–Emmett–Teller (BET) surface area of 1108 m 2 g −1 , the highest reported to date for purely organic van der Waals frameworks. Furthermore, compound 1 exhibits aggregation‐induced emission (AIE) and remarkable thermal stability up to 290° C. These results demonstrate that carefully designed nanographenes can achieve high structural predictability and robust porosity without the need for metal nodes or covalent linkages, opening new avenues for gas storage applications.

ABSTRACT Supported boron oxide catalysts have demonstrated ultra‐high selectivity in the oxidative dehydrogenation of propane (ODHP), but their practical deployment is severely limited by poor thermal stability and rapid deactivation, primarily due to the hydrolysis of active B–O sites forming volatile boric acid. Here, we develop a catalyst comprising a crystalline LaAlO 3 (LAO) perovskite coated with an amorphous LaAlBO x overlayer, achieved through the thermal treatment of physically mixed H 3 BO 3 and LAO. During reaction, the amorphous LaAlBO x overlayer grows in thickness, wherein the concurrent formation of strong M–O–B (M = La, Al) bonds effectively suppress boron volatilization, ensuring long‐term structural stability. The optimized catalyst achieves a propylene yield of 21% and a total olefin selectivity of 97% during continuous operation at 500°C for 100 h, which ranks among the top‐tier performance reported in the literature. Density functional theory (DFT) calculations demonstrate that the formation of M–O–B bonds not only stabilizes boron species from volatilization but also lowers the energy barrier of the rate‐determining‐step in ODHP, thereby leading to remarkable catalytic performance. Importantly, this strategy is found to be extendable to other perovskites (e.g., SmAlO 3 , SrTiO 3 , BaTiO 3 ), underscoring its generality for designing durable boron‑based catalysts.

ABSTRACT Cullin‐RING Ligase 4 Cereblon (CRL4 CRBN )‐mediated targeted protein degradation (TPD) via cereblon (CRBN) E3 ligase modulatory drugs (CELMoDs) or ligand‐directed degraders (LDDs) represents a new modality in modern drug discovery. However, the CRBN‐binding portion of these degraders has been limited to flat, rigid architectures of conventional glutarimide scaffolds. This study presents a modular route to C3(sp 3 )–C(sp 3 ) linked glutarimides via a redox‐neutral cross‐coupling/palladium‐catalyzed hydrogenation sequence. This two‐step protocol is operationally simple, chemoselective, and broadly tolerant of diverse functional groups. It delivers sp 3 ‐rich, three‐dimensional scaffolds that access previously untapped chemical space. The resulting building blocks are ready for immediate use in the CELMoD and LDD arena and provide a versatile platform for next‐generation TPD design. Preliminary studies of BRD4‐targeting LDDs derived from C3(sp 3 )–C(sp 3 ) linked glutarimides demonstrate CRBN‐dependent degradation of BRD4, underscoring their translational potential.

ABSTRACT The synthesis of aromatic amines requires harsh conditions or the use of fossil‐derived hydrogen (H 2 ). Here, we address this limitation by demonstrating photocatalytic transfer hydrogenation (PTH) of nitroarenes into anilines employing plastic hydrolysates as electron and proton (hydrogen) donors under ambient temperature and pressure. PTH is achieved using a cobalt‐promoted molybdenum sulfide ( Co MoS 2 ) electrocatalyst integrated with a carbon nitride (CN x ) semiconductor photocatalyst in acidic aqueous solution. Co MoS 2 reduces nitroarenes to anilines at –0.7 V versus RHE with a Faradaic yield of 70% and superior activity to platinum. The Co MoS 2 ‐CN x photocatalyst produces anilines under simulated solar light (AM 1.5 G, 25°C), achieving 83%–99% yield from 24 nitroarenes using 4‐methylbenzyl alcohol as a model hydrogen donor. Acid hydrolysis of condensation polymers provides a source of alcoholic monomers in aqueous solution that can be used as a sustainable hydrogen donor for PTH in >80% yield using AM 1.5G or LED (405 nm, 33 mW cm −2 ) irradiation. A technoeconomic analysis (TEA) at pilot scale producing 1 t aniline day − 1 using polyethylene terephthalate (PET) reveals a cut in cradle‐to‐gate emissions by ∼77% using PTH with Co MoS 2 ‐CN x compared to conventional Pd/C hydrogenation with H 2 from steam methane reforming (SMR‐H 2 ) and a revenue‐generating levelized cost of aniline (LCOA) when co‐produced with terephthalic, acetic, and formic acids.

ABSTRACT This study employs a template‐directed assembly strategy to synthesize the first In 3+ /Cu 2+ heterometallic oxo cluster, {InCu 6 } . {InCu 6 } costabilized by l ‐(+)‐tartaric and acetic acids, features a central InO 6 octahedron surrounded by six Cu 2+ ions. Benchmarked against structurally analogous heterometallic oxo clusters, {InCu 6 } demonstrates superior proton conductivity of 7.95 × 10 −2 S cm −1 at 30°C and 90% relative humidity (RH). DFT calculations indicate that the introduction of In 3+ significantly reduces the energy barrier for proton detachment from the oxygen atoms in {InCu 6 } , thus elucidating the kinetic mechanism by which In 3+ /Cu 2+ synergy enhances the conduction efficiency. To translate this molecular performance into a functional device for humidity gradient‐based power generators (HGPGs), a novel cationic polymer ( PVA‐CTPP + Br − ) was designed and synthesized as the matrix to form a uniform PVA‐CTPP + ‐{InCu 6 } composite film. The resulting planar generator demonstrated stable performance, delivering an output of 0.63 V and 14.3 µA cm −2 at 92% RH and room temperature.

ABSTRACT High‐potential organic redox‐active molecules are crucial for high‐energy‐density aqueous organic flow batteries (AOFBs). Azopyridine (AZO) derivatives with high redox potential (0.86 V vs. SHE) suffer from structural rearrangement instability and slow redox kinetics during the oxidation process. Herein, we achieve dual‐target modulation of the electronic structure and dynamic steric hindrance, which increases the bond energy of the azo bond and buffers the drastic change of redox‐induced molecular structure. Thus, the azo bond cleavage and nucleophilic side reactions were suppressed, thereby simultaneously promoting the redox potential (0.9 V vs. SHE) and stability. Further modulation of the solvation shell anions also alleviates molecular aggregation and minimizes solvation reorganization energy, thereby markedly increasing the cell energy efficiency by ∼60%. The AZO‐based AOFB demonstrated robust durability for 7000 cycles (>1400 h). Impressively, the cell sustained over 1250 cycles at high electron concentrations of 2.4 M, achieving an energy density of 70.4 Wh L catholyte −1 . This work establishes an integrated molecular and solvation‐structure design paradigm for realizing durable and high‐energy‐density AOFBs.

ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are an emerging therapeutic modality via targeted protein degradation, but plagued by concerns about systemic toxicity and a poor pharmacokinetic profile. To tackle the issues, we have devised a photo‐click proteolysis targeting chimera (PCPTAC) that enables spatiotemporally controllable intracellular synthesis of PROTACs by photo‐triggered bioorthogonal ligation. A photocaged dibenzosilacycloheptyne (photo‐DBSH) and the complementary azide were deployed to tag the oncoprotein ligands (i.e., (+)‐JQ1 for BRD4 and Olaparib for PARP1) and the E3 ligase ligand (i.e., Pomalidomide for CRBN), respectively, for a proof‐of‐concept study and potential treatment for triple‐negative breast cancer (TNBC). Upon light irradiation, photo‐DBSH‐JQ1/‐Olap was rapidly uncaged to give the reactive cycloalkyne‐JQ1/‐Olap, which immediately underwent a strain‐promoted azide–alkyne cycloaddition with azide‐Pomalidomide, in situ generating dual PROTACs for simultaneous degradation of BRD4 and PARP1 in TNBC MDA‐MB‐231 cells, with 25‐ and 2.4‐fold more potent antiproliferative activity than the un‐irradiated inhibitors and the corresponding PROTAC combination, respectively (IC 50 = 0.032 µM vs. 0.846 µM and 0.075 µM). Further in zebrafish models, PCPTAC promoted BRD4 degradation leading to thinner yolk sac extension and achieved 94% tumor inhibition in HeLa xenografts. This split‐and‐photoclick strategy paves a new avenue for developing safer and more efficacious PROTACs with synergistic antitumor effects.

ABSTRAKT Diese Studie befasst sich mit der Formulierung neuartiger Elektrolyte, die darauf ausgelegt sind, die Sicherheit, Nachhaltigkeit und Kompatibilität mit der LiNi 0.92 Mn 0.04 Co 0.04 O 2 (NMC92)‐Kathode zu verbessern. Es wird die Kombination eines biobasierten Lösungsmittels (γ‐Valerolacton, GVL) mit einem sicheren, stabilen, innovativen Hilfslösungsmittel (Diethylenglycolbutylethylether, DEGBEE) sowie mit Salzen auf Imid‐ und Boratbasis untersucht. Die resultierenden Elektrolytsysteme weisen eine geringere Entflammbarkeit und verbesserte Transporteigenschaften auf. Molekulardynamische Simulationen zeigen ein günstiges Solvatationsverhalten und eine erhöhte Lithium‐Ionen‐Beweglichkeit in GVL‐basierten Elektrolyten aufgrund einer verringerten Ionenaggregation. Die untersuchten Elektrolytsysteme zeichnen sich zudem durch eine ausgeprägte elektrochemische Leistung sowie eine gesteigerte Ratenfähigkeit in Halbzellen mit NMC92‐Kathoden aus. Nach 300 galvanostatischen Zyklen bei der Rate von 1 C bleiben 80 % der Anfangskapazität erhalten. Dies wird auf die anorganische Beschaffenheit der Kathoden‐Elektrolyt‐Grenzschicht zurückgeführt, was durch Ex‐situ ‐Röntgenphotoelektronen‐Spektroskopie nahegelegt wird. Abschließend wird die Eignung dieser neuartigen Elektrolytsysteme für großtechnische Anwendungen in Pouch‐Zellen bewertet. Sie erreichen nicht nur eine mit herkömmlichen Elektrolyten vergleichbare Leistung, sondern verbessern auch die allgemeine Sicherheit und Nachhaltigkeit der Zellen.

ABSTRACT Electron‐transfer‐involved persulfate‐based advanced oxidation processes (ET‐AOPs) are attractive for wastewater treatment because of their high selectivity and environmental robustness. However, ET‐AOPs are intrinsically dual‐site reaction requiring efficient electron transfer between persulfate‐binding and pollutant‐binding sites. This constraint is often obscured in powder catalysts but becomes critical when reactions in integrated catalytic membranes or devices, where spatial separation of active sites and discontinuous conductive pathways can electronically isolate internal regions, substantially limiting reaction site utilization. Here we report an interfused nitrogen‐doped reduced graphene oxide fiber (N‐rGOF) membrane that overcomes this by unifying long‐range electronic continuity with internal site accessibility. Fused junctions between fibers form a continuous, low resistance conductive network, while the layered rGO structure enables persulfate entry into interlayers to activate otherwise inaccessible internal nitrogen sites through an interlayer entry‐induced site activation (IESA) mechanism. The N‐rGOF membrane degraded bisphenol A (BPA) ∼5.2 times faster than a noninterfused counterpart and maintained excellent removal of trace organic pollutants in real livestock wastewater with high ionic strength and organic loading. Furthermore, the intrinsic potential difference generated during catalysis enables a floatable, self‐powered setup that couples pollutant degradation with real‐time electrical signaling, illustrating the conceptional feasibility of integrated monitoring and remediation based on one single system.

ABSTRACT Achieving organic phosphorescence that remains stable at elevated temperatures is challenging because thermally activated molecular motions typically accelerate non‐radiative decay of triplet excitons. Here, we report a topology‐driven conformational constraint strategy to enable high‐temperature organic phosphorescence. A hydrogen‐bonded supramolecular framework constructed from melamine and terephthalic acid serves as a rigid scaffold that imposes topological confinement on embedded terphenyl‐based emitters. Comparative studies using emitters with linear, bent, and trigonal‐like geometries reveal a clear geometry‐dependent trend in phosphorescence performance, suggesting that increased connectivity within the hydrogen‐bonded network strengthens conformational constraint and reduces non‐radiative relaxation pathways. Consistent with this topology–phosphorescence relationship, the system integrating trigonal‐like emitters exhibits persistent phosphorescence with a lifetime of up to 1.22 s at room temperature and retains long‐lived emission of 344 ms even at 150°C. Benefiting from the excellent environmental stability, the phosphorescent materials can be integrated into polymer matrices to fabricate flexible luminescent films that operate under high‐temperature conditions. This work highlights topology‐driven conformational constraint as an effective design strategy for developing environmentally robust organic phosphorescent materials.