Radiofrequency ablation of benign and malignant thyroid nodules: updates and current status
: Thyroid ablation techniques, both thermal and chemical, have emerged as minimally invasive therapeutic tools to treat benign and malignant disease in the appropriate setting. Radiofrequency ablation (RFA), in particular, has seen recent international adoption, and offers a targeted approach to thyroid nodules in patients who may decline or are considered high risk for surgery. This review provides a summary of updated evidence for the efficacy and safety of RFA across benign and malignant pathologies of the thyroid gland. The most robust data available pertains to the use of RFA in benign, non-functional thyroid nodules, in which RFA reliably results in significant volume reduction associated with improvement in compressive and/or cosmetic concerns. Autonomously functional nodules may also be targets for RFA. However, as the ability to achieve durable euthyroidism is variable and potentially more successful in smaller nodules, RFA may be a more appropriate second line therapeutic approach in this population, Ablation of recurrent well-differentiated malignancy can be offered for patients who are ineligible for surgery, particularly those with isolated, low volume lesions. Due to anatomic changes resulting from prior surgery and the typical location of recurrent disease, advanced techniques are often required to minimize complications in this context. The role of RFA in primary cancer is still being explored, and, to date, has been described most extensively in papillary microcarcinoma. Overall, the application of this technology differs according to the clinical context, and a comprehensive understanding of the indications, considerations, and expectations in each setting are critical to appropriate patient selection and successful procedural execution.
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