Introdução: extensas ressecções e transplantes de partes do fígado são possíveis, graças à sua capacidade regenerativa que é dependente da ativação do fator de crescimento vascular endotelial (VEGF) o qual também regula angiogênese. O bevacizumabe (BV), anticorpo monoclonal inibidor do VEGF é neoadjuvante amplamente utilizado no tratamento de cânceres restringindo a densidade microvascular, podendo causar efeitos indesejáveis na cicatrização pós-operatória e na regeneração hepática. Objetivo: Avaliar a regeneração hepática, pós-hepatectomia a 70%, sob ação de 1 dose (5 mg/kg) de BV em modelo experimental murino, durante 15 dias. Método: Utilizaram-se 32 ratos Wistar submetidos à hepatectomia parcial (HP), separados em 2 grupos conforme o tratamento controle (C) tratados com solução fisiológica e BV tratados com bevacizumabe, subdivididos conforme o tempo de observação (48 h e 15 dias). Os efeitos dele na regeneração hepática foram avaliados nas avaliações ponderais e função hepática. No fígado remanescente avaliaram-se atividade mitótica, densidade microvascular (angiogênese), proliferação nuclear, histopatologia para investigar fibrose, edema e congestão. Resultado: No 15º dia e tratamento com BV, não ocorreram diferenças nas avaliações ponderais, na função hepática e nos índices mitóticos. Porém, houve diminuição na viabilidade celular, densidade microvascular e piora na ocorrência de alterações histopatológicas como fibrose, edema e congestão hepáticas. Conclusão: A dose única de bevacizumabe não causou ao 15º dia alterações ponderais, bioquímicas séricas e dos índices mitóticos. Contudo induziu diminuição da densidade microvascular, viabilidade celular e alterações histopatológicas hepáticas como edema, congestão e fibrose.

Introduction: Prostate adenocarcinoma is one of the most prevalent malignancies worldwide. Despite often having a slow evolution, it still represents an important cause of death in oncology. Since its clinical results are very heterogeneous, there is a need to identify prognostic markers. Biomarkers are tools and technologies that can aid in this understanding. Objective: To evaluate the presence of c-MET and ABCB5 in prostate adenocarcinoma and to analyze whether their expression correlates with prognostic factors. Method: 170 cases were selected through an active search in electronic medical records and review of physical records and anatomopathological reports. Immunohistochemistry was performed for the biomarkers c-MET and ABCB5 in all samples. Retrospective clinical data were collected and plotted in tables. Through TMA (tissue microarray) the tissues were submitted to immunohistochemistry by the peroxidase technique. Clinical and epidemiological information was cross-referenced with the result obtained by immunostaining and its statistical analysis. Result: Forty-seven men with a mean age of 61.6±6.9 (48-75), with a mean PSA of 11±9.7 (2.4-60.5) were included in this study. 2% had a Gleason score of 5 or 6 and 29, 1%, 7 or 8. Regarding tumor classification, 6 cases had T3a and 2 T3b staging. None had a tumor greater than T3b and there was 1 case of metastasis. With regard to biomarkers, there was positive labeling of c-MET in 32 cases and of ABCB5 in 5. Positive labeling had no statistically significant association with any of the prognostic factors evaluated. Conclusion: There was expression of c-MET and ABCB5 in the prostate cancer, but without association of them with prognostic factors.

Introdução: Todo e qualquer tratamento de risco deve ser precedido do consentimento informado do paciente. Objetivo: Analisar o dever de informação sobre os preenchimentos faciais com ácido hialurônico injetável. Método: Estudo transversal com questionário autoaplicado online. Resultados: Amostra composta por 257 participantes, mulheres (91,4%), que realizaram procedimentos com médicos (77,4%) e não médicos (22,6%) mediante informação (77,8%), consentimento assinado (69,3%), documentação fotográfica (89,1%), avaliação prévia (76,3%), recomendações pré e pós-tratamento (75,1%). Houve maior satisfação com os resultados entre aqueles que realizaram o procedimento com base em indicações de amigos e família (p = 0,001) e na formação acadêmica do profissional (p = 0,005) do que aqueles que escolheram pelo preço e imagens de antes e depois. Conclusão: Na maioria dos casos o procedimento foi realizado por médico e ocorreu mediante esclarecimento verbal e consentimento assinado.

As environmental degradation continues at local, regional, and global levels, people's accepted norms for natural environmental conditions are likely to decline. This phenomenon, known as shifting baseline syndrome (SBS), is increasingly recognized as a likely major obstacle to addressing global environmental challenges. However, the prevalence of SBS remains uncertain. We conducted an extensive systematic review, synthesizing existing research on people's perceived environmental baselines. Our analysis, based on 73 case studies, suggests that SBS is a widespread global phenomenon, occurring across diverse socioeconomic, environmental, and cultural settings. We observed that younger individuals tend to hold lower environmental baselines across various environmental contexts, including climate change, natural resource depletion, biodiversity loss, and pollution. An upward shift in perceived environmental baselines among younger generations was rarely observed. These results underscore the challenge that SBS poses when policy and management responses to environmental degradation are influenced by perceived natural environmental norms.

Global biodiversity is in decline, and businesses and society are being required to urgently create new operating models to ameliorate the crisis. Among the strategies proposed to do this, implementing the concept of nature positive has captured worldwide attention. Critical to its success will be effective collaboration between ecologists and businesspeople, driven by a shared understanding of key nature positive terminology, concepts, and risks. To this end, we introduce three core aspects: the ecological concepts in the definition of nature positive (health, abundance, diversity, and resilience), a typology of financial instruments that may be applied to achieving nature positive, and an overview of risks to biodiversity and society. The pivotal findings include that ecological complexity and uncertainty belie the simplicity of the definition of nature positive and that managing risk requires embedding aspirations into existing and emerging biodiversity conservation and restoration science and policy. Although it is challenging, nature positive deserves pursuit.

Understanding the magnitude of biosecurity risks in aquatic environments is increasingly complex and urgent because increasing volumes of international shipping, rising demand for aquaculture products, and growth in the global aquarium trade, are accelerating invasive alien species spread worldwide. These threats are especially pressing amid climate and biodiversity crises. However, global and national biosecurity systems are poorly prepared to respond because of fragmented research and policy environments, that often fail to account for risks across sectors or across stakeholder needs and fail to recognize similarities in the processes underpinning biological invasions. In the present article, we illustrate the complex network of links between biosecurity threats across human, animal, plant, and environment sectors and propose a universal approach to risk assessment. One Biosecurity is a holistic, interdisciplinary approach that minimizes biosecurity risks across human, animal, plant, algal, and ecosystem health and is critical to reduce redundancy and increase cross-sectoral cohesion to improve policy, management, and research in aquatic biosecurity.

Scientific history has many examples of profound statements that are later found to be unsubstantiated. The consequences of such misinformation can be dire. In the present article, we present a case where an unevidenced estimate of global lichen coverage proliferated through both scientific literature and popular media. We traced this estimate to a non-peer-reviewed publication from 1987. We found 76 academic articles (collectively cited 4125 times) and 13 other academic documents citing the statistic, citation chains without source attribution, and instances where the number or context was changed. We also found the statistic 37 times in popular media, which is especially concerning, given that these media communicate science to the broader public. We demonstrate how an unevidenced statement can spread, change through time, and ultimately be repeated without demand for evidence. We hope this case unplugs the telephone and provides a cautionary tale for researchers to ensure critical evaluation of citation and communication practices.