All Research Papers Published In Cell Host & Microbe

Research Article
11
10.1016/j.chom.2021.07.005

Diarrheal pathogens trigger rapid evolution of the guanylate cyclase-C signaling axis in bats

Aug 05, 2021
Cell Host & Microbe
Clayton M Carey + 4 more +4

Supplementary Content
3
10.1016/j.chom.2021.07.010

License to LAP

Aug 01, 2021
Cell Host & Microbe
Larissa D Cunha

Research Article
21
10.1016/j.chom.2021.04.008

Pre-clinical evaluation of a whole-parasite vaccine to control human babesiosis

May 13, 2021
Cell Host & Microbe
Hanan A Al-Nazal + 14 more +14

Research Article
29
10.1016/j.chom.2021.03.011

Partial protection against P. vivax infection diminishes hypnozoite burden and blood-stage relapses

Apr 14, 2021
Cell Host & Microbe
Carola Schäfer + 10 more +10

Research Article
35
10.1016/j.chom.2021.02.004

Il4ra-independent vaginal eosinophil accumulation following helminth infection exacerbates epithelial ulcerative pathology of HSV-2 infection

Apr 01, 2021
Cell Host & Microbe
Alisha Chetty + 16 more +16

SummaryHow helminths influence the pathogenesis of sexually transmitted viral infections is not comprehensively understood. Here, we show that an acute helminth infection (Nippostrongylus brasiliensis [Nb]) induced a type 2 immune profile in the female genital tract (FGT). This leads to heightened epithelial ulceration and pathology in subsequent herpes simplex virus (HSV)-2 infection. This was IL-5-dependent but IL-4 receptor alpha (Il4ra) independent, associated with increased FGT eosinophils, raised vaginal IL-33, and enhanced epithelial necrosis. Vaginal eosinophil accumulation was promoted by IL-33 induction following targeted vaginal epithelium damage from a papain challenge. Inhibition of IL-33 protected against Nb-exacerbated HSV-2 pathology. Eosinophil depletion reduced IL-33 release and HSV-2 ulceration in Nb-infected mice. These findings demonstrate that Nb-initiated FGT eosinophil recruitment promotes an eosinophil, IL-33, and IL-5 inflammatory circuit that enhances vaginal epithelial necrosis and pathology following HSV-2 infection. These findings identify a mechanistic framework as to how helminth infections can exacerbate viral-induced vaginal pathology.

Research Article
18
10.1016/j.chom.2021.03.004

Argonaute-CLIP delineates versatile, functional RNAi networks in Aedes aegypti, a major vector of human viruses

Mar 31, 2021
Cell Host & Microbe
Kathryn Rozen-Gagnon + 11 more +11

Supplementary Content
10.1016/j.chom.2021.02.015

RNA modification to the rescue!

Mar 01, 2021
Cell Host & Microbe
Lacey J Luense + 1 more +1

Supplementary Content
10.1016/j.chom.2021.02.013

My Old World chap, this α-gal is not for you

Mar 01, 2021
Cell Host & Microbe
Luis B Barreiro + 1 more +1

Supplementary Content
12
10.1016/j.chom.2021.01.008

Giant DNA viruses make big strides in eukaryote evolution

Feb 01, 2021
Cell Host & Microbe
Shifeng Cheng + 2 more +2

Research Article
46
10.1016/j.chom.2020.12.006

Maturation of the neonatal oral mucosa involves unique epithelium-microbiota interactions

Jan 06, 2021
Cell Host & Microbe
Noam Koren + 15 more +15