All Research Papers Published In Cell reports

Research Article
10.1016/j.celrep.2026.117293

RLF/ZFP292 stabilize CoREST-linked LSD1 engagement at bivalent promoters to safeguard pluripotency.

Apr 16, 2026
Cell reports
Takamasa Ito + 3 more +3

Research Article
10.1016/j.celrep.2026.117270

Blocking apoptosis promotes survival and alters developmental dynamics of human retinal ganglion cells in retinal organoids

Apr 16, 2026
Cell reports
Jingliang Simon Zhang + 7 more +7

SUMMARYRetinal ganglion cells (RGCs) are the projection neurons connecting the retina to the brain. In many species, a substantial proportion of RGCs are eliminated by programmed cell death during development to regulate their final number, but how cell death impacts human RGC development remains poorly understood. Here, we characterized cell death in human fetal retinas and retinal organoids. Both retinas and organoids exhibited two waves of apoptosis: an early wave targeting neurogenic retinal progenitor cells and neuronal precursors and a late wave affecting RGCs and other neurons. Additionally, organoids displayed a distinct wave of necrosis. Blocking apoptosis in organoids via BAX/BAK double knockout improved RGC survival but delayed RGC neurogenesis and maturation. Our results highlight the roles of apoptosis in human RGC development and the challenges in retinal organoid design. Addressing these limitations will improve the utility of organoids for studying human retinal development and modeling optic neuropathies such as glaucoma.

Research Article
10.1016/j.celrep.2026.117282

Low expression levels of the conserved nuclear histone acetyltransferase 1 restrict virus infection in plants.

Apr 16, 2026
Cell reports
Laihua Dong + 18 more +18

Research Article
10.1016/j.celrep.2026.117276

OsALY4 acts as an m5C-mRNA reader facilitating mRNA export and contributing to chilling and salt tolerance in rice.

Apr 16, 2026
Cell reports
Ying Gao + 6 more +6

Research Article
10.1016/j.celrep.2026.117259

Dynamic heterogeneity in an E. coli stress response regulon mediates gene activation and antimicrobial peptide tolerance.

Apr 16, 2026
Cell reports
Caroline M Blassick + 4 more +4

Addendum
10.1016/j.celrep.2026.117318

PFKFB3 activates CAD to enhance de novo pyrimidine synthesis for cell growth.

Apr 15, 2026
Cell reports
Qingen Da + 24 more +24

Research Article
10.1016/j.celrep.2026.117173

Hyperdiploidy impairs fetal hematopoietic progenitor fitness and differentiation enabling persistence of rare preleukemic aneuploid clones.

Apr 01, 2026
Cell reports
Namitha Thampi + 15 more +15

Research Article
10.1016/j.celrep.2026.117261

Structural mechanism of 3'3'-cGAMP-induced filamentation and phospholipid hydrolysis by CapV in bacterial antiphage defense.

Apr 01, 2026
Cell reports
Yun Lv + 14 more +14

Research Article
10.1016/j.celrep.2026.117230

Pan-cancer macrophage atlas uncovers that MHC-IIhigh TAMs induce Treg activation through physical interactions.

Apr 01, 2026
Cell reports
Naixue Yang + 10 more +10

Research Article
10.1016/j.celrep.2026.117144

Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes.

Apr 01, 2026
Cell reports
Miguel A Medina-Serpas + 15 more +15