To present the longitudinal MR imaging of 4 children with an acquired corpus callosum hump, in order to demonstrate graphically that this represents a dysmorphology caused through a constellation of pre-existing pathology, timing, and complications of treatment. Four cases with a corpus callosum hump were evaluated for common findings in the clinical history and on MRI scans. Those patients with available follow-up imaging were specifically evaluated for the presence of the hump on initial neonatal imaging and for evidence of development and progression of the deformity over time. Corpus callosum length was measured and compared against normal standards. Congenital hydrocephalus, chronic ventricular over-shunting, white matter volume loss, and lateral ventricle communication were common to all cases. Corpus callosum length was above normal values. The corpus callosum hump term was previously described as dysplasia but was not present on initial scans in our cases. We conclude that the corpus callosum hump can be acquired as a complication of over-shunting in children with congenital hydrocephalus. Thus, we present our examples as "acquired hump of the corpus callosum," which differs from the prior example. We postulate that the lengthening of the stretched corpus callosum due to chronic hydrocephalus in the pre-myelinated state renders it unable to return to its normal shape when the ventricles are drained. Over-shunting of both lateral ventricles simultaneously in the absence of a septum pellucidum results in collapse and folding in of the corpus callosum on itself, resulting in the hump.

Quantitative mass spectrometry (MS)-based approaches have allowed further characterization of medulloblastoma (MB) classification and clinical/biological behavior. By investigating protein expression, as well as the role of post-translational modifications in shaping cellular activity, novel avenues of research will clarify the current subgrouping, providing elements for tumor treatment-new molecular targets and signaling cascades-and introducing serum, urinary, and CSF markers of tumor growth and recurrence. We systematically searched and reviewed original research articles treating MB proteomics on PubMed. Reviews, opinion papers, and abstracts were excluded from the final work. A total of 30 novel articles treating the proteomic characterization of MB were included in our review. Research conducted on tissue samples, cell lines, CSF, and urine, as well as exosome and medullospheres, was considered, to picture a broad view of the different directions MS-based proteomic analysis is moving toward. In this review, we collect, summarize, and interpret the current literature on this topic. Significant progress has been achieved in the last decade in MB characterization, paving the way for further exploration of large biobanks of MB and other tissues that will allow a more systematic understanding of MB functioning and clinical progression.