This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effects of prophylactic immunoglobulin therapy for the prevention of infections in people with haematological malignancies and post‐haematopoietic stem cell transplantation.

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To evaluate the comparative effectiveness and safety of immunotherapy (anti PD‐1, anti PD‐L1, or anti CTLA‐4) plus chemotherapy compared to chemotherapy alone for the first‐line systemic treatment of extensive‐stage small cell lung cancer with a network meta‐analysis, and to identify relevant biomarkers or clinical factors.

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effects of local and systemic oestrogen therapy in preventing pelvic organ prolapse in postmenopausal women.

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To investigate comparative medium‐ and long‐term effects and safety, and to obtain a clinically meaningful ranking of different metabolic bariatric surgery procedures (adjustable gastric banding, sleeve gastrectomy, Roux‐en‐Y gastric bypass, one‐anastomosis gastric bypass, gastric plication, biliopancreatic diversion with duodenal switch, and their variations) compared to each other and to non‐surgical treatment (e.g. usual care with intensive lifestyle interventions or pharmacotherapy) on outcomes relevant to adults with obesity and type 2 diabetes, by considering both randomised controlled trials and cohort studies.

Community views on mass drug administration for soil-transmitted helminths: a qualitative evidence synthesis (Protocol).

There is currently moderate- to very low-certainty evidence available regarding the benefits and harms of maintenance therapy in people with CLL. Anti-CD20 mAbs maintenance improved PFS, but also increased grade 3/4 AEs and all AEs. IMiD maintenance had a large effect on PFS, but also increased grade 3/4 AEs. However, none of the above-mentioned maintenance interventions show differences in OS between the maintenance and control groups. The effects of alemtuzumab maintenance are uncertain, coupled with a warning for drug-related infectious toxicity. We found no studies evaluating other novel maintenance interventions, such as B-cell receptor inhibitors, B-cell leukaemia-2/lymphoma-2 inhibitors, or obinutuzumab.

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effects of a transanal tube for the prevention of anastomotic leakage in people undergoing rectal cancer surgery.

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: This review aims to evaluate the safety, efficacy and patient‐reported tolerability of interventions used to prevent UTIs in kidney transplant recipients.

This is a protocol for a Cochrane Review (prognosis). The objectives are as follows: To identify and meta‐analyse prognostic factors for efficacy and safety of CAR T‐cell therapy for treating aggressive large B‐cell lymphomas before therapy has started.

Antibiotic treatment to reduce the duration and severity of travellers' diarrhoea (Protocol).